MYCN Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog|This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] (NCBI Entrez Gene Database, 4613)
External Link http://www.ncbi.nlm.nih.gov/gene/4613
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Genes

31 interacting proteins for MYCN from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AURKA aurora kinase A
CCNA2 cyclin A2
CCNB1 cyclin B1
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GRK5 G protein-coupled receptor kinase 5
GSK3B glycogen synthase kinase 3 beta
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC5 histone deacetylase 5
KAT5 K(lysine) acetyltransferase 5
MAX MYC associated factor X
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MXD1 MAX dimerization protein 1
NGFR nerve growth factor receptor
NMI N-myc (and STAT) interactor
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
PIAS2 protein inhibitor of activated STAT, 2
SIRT1 sirtuin 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SP1 Sp1 transcription factor
TRIM32 tripartite motif containing 32
UBC ubiquitin C
YAF2 YY1 associated factor 2
YEATS4 YEATS domain containing 4
ZBTB17 zinc finger and BTB domain containing 17