MYD88 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description myeloid differentiation primary response 88|This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] (NCBI Entrez Gene Database, 4615)
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Genes

298 genes differentially expressed following the MYD88 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CLDN2 claudin 2 2.77831
CTRC chymotrypsin C (caldecrin) 2.77831
SPINK4 serine peptidase inhibitor, Kazal type 4 2.77831
SPINK6 serine peptidase inhibitor, Kazal type 6 2.77831
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.77831
PDYN prodynorphin 2.77831
PCDHB1 protocadherin beta 1 2.77831
SLC35G5 solute carrier family 35, member G5 2.77831
PCDHGB3 protocadherin gamma subfamily B, 3 2.77831
ZNF503 zinc finger protein 503 2.77831
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.77831
MYBPHL myosin binding protein H-like 2.77831
NKX2-2 NK2 homeobox 2 2.77831
PCDHA7 protocadherin alpha 7 2.77831
PCDHA2 protocadherin alpha 2 2.77831
LIPJ lipase, family member J 2.77831
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.77831
WEE2 WEE1 homolog 2 (S. pombe) 2.77831
TPBGL trophoblast glycoprotein-like 2.77831
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.77831
C8ORF48 chromosome 8 open reading frame 48 2.77831
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.77831
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.77831
SOWAHB sosondowah ankyrin repeat domain family member B 2.77831
DLL4 delta-like 4 (Drosophila) 2.77831
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.77831
RFX6 regulatory factor X, 6 2.77831
MUC22 mucin 22 2.77831
TBATA thymus, brain and testes associated 2.77831
TAS2R13 taste receptor, type 2, member 13 2.77831
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.77831
MLNR motilin receptor 2.77831
TMEM89 transmembrane protein 89 2.77831
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.77831
APOA2 apolipoprotein A-II 2.77831
GFAP glial fibrillary acidic protein 2.77831
SSMEM1 serine-rich single-pass membrane protein 1 2.77831
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.77831
GPR21 G protein-coupled receptor 21 2.77831
TCAF2 TRPM8 channel-associated factor 2 2.77831
BIRC3 baculoviral IAP repeat containing 3 2.77831
ZNF556 zinc finger protein 556 2.77831
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 2.77831
LY6S lymphocyte antigen 6 family member S 2.77831
TCIM transcriptional and immune response regulator 2.77831
DERPC DERPC proline and glycine rich nuclear protein 2.77831
ANGPTL8 angiopoietin like 8 2.77831
H1-6 H1.6 linker histone, cluster member 2.77831
ALDOB aldolase B, fructose-bisphosphate 2.77831
GBP6 guanylate binding protein family, member 6 2.77831
C3AR1 complement component 3a receptor 1 2.77831
ROPN1L rhophilin associated tail protein 1-like 2.77831
CCN4 cellular communication network factor 4 2.77831
MINAR2 membrane integral NOTCH2 associated receptor 2 2.77831
CCDC187 coiled-coil domain containing 187 2.77831
EPCIP exosomal polycystin 1 interacting protein 2.77831
TBC1D3I TBC1 domain family member 3I 2.77831
WASL-DT WASL divergent transcript 2.77831
GNG5B G protein subunit gamma 5B 2.77831
H3-7 H3.7 histone (putative) 2.77831
MYMK myomaker, myoblast fusion factor 2.77831
LHFPL7 LHFPL tetraspan subfamily member 7 2.77831
GARIN4 golgi associated RAB2 interactor family member 4 2.77831
CLDN16 claudin 16 2.77831
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.77831
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.77831
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.77831
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.77831
BARHL1 BarH-like homeobox 1 2.77831
TLR4 toll-like receptor 4 2.77831
TEKTL1 tektin like 1 2.77831
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.77831
IDO2 indoleamine 2,3-dioxygenase 2 2.77831
DSG1 desmoglein 1 2.77831
GSC goosecoid homeobox 2.77831
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.77831
ADIG adipogenin 2.77831
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.77831
IQCF1 IQ motif containing F1 2.77831
SAG S-antigen; retina and pineal gland (arrestin) 2.77831
MYEOV myeloma overexpressed 2.77831
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.77831
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.77831
DYNAP dynactin associated protein 2.77831
PLEK2 pleckstrin 2 2.77831
VSX2 visual system homeobox 2 2.77831
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.77831
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.77831
BCO1 beta-carotene oxygenase 1 2.77831
DHH desert hedgehog 2.77831
PRDM9 PR domain containing 9 2.77831
EGR4 early growth response 4 2.77831
SST somatostatin 2.77831
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.77831
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.77831
PCDHGA3 protocadherin gamma subfamily A, 3 2.77831
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.77831
ECM1 extracellular matrix protein 1 2.77831
PRSS54 protease, serine, 54 2.77831
SOWAHA sosondowah ankyrin repeat domain family member A 2.77831
POF1B premature ovarian failure, 1B 2.77831
MUC17 mucin 17, cell surface associated 2.77831
KLHL6 kelch-like family member 6 2.77831
BTNL2 butyrophilin-like 2 2.77831
OR9A2 olfactory receptor, family 9, subfamily A, member 2 2.77831
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.77831
HSF4 heat shock transcription factor 4 2.77831
GJB6 gap junction protein, beta 6, 30kDa 2.77831
SFTA2 surfactant associated 2 2.77831
C22ORF31 chromosome 22 open reading frame 31 2.77831
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.77831
GOLGA8K golgin A8 family, member K 2.77831
GOLGA8R golgin A8 family, member R 2.77831
OR52N5 olfactory receptor, family 52, subfamily N, member 5 2.77831
CFI complement factor I 2.77831
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.77831
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.77831
PLA2G12B phospholipase A2, group XIIB 2.77831
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.77831
IBSP integrin-binding sialoprotein 2.77831
SLC38A3 solute carrier family 38, member 3 2.77831
TCAP titin-cap 2.77831
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.77831
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.77831
CAPSL calcyphosine-like 2.77831
STMND1 stathmin domain containing 1 2.77831
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.77831
LRRC74A leucine rich repeat containing 74A 2.77831
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.77831
KCNK16 potassium channel, two pore domain subfamily K, member 16 2.77831
MAGEA12 melanoma antigen family A12 2.77831
DNAH8 dynein, axonemal, heavy chain 8 2.77831
N4BP3 NEDD4 binding protein 3 2.77831
NEUROD4 neuronal differentiation 4 2.77831
DEFB123 defensin, beta 123 2.77831
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 2.77831
TTC36 tetratricopeptide repeat domain 36 2.77831
CDCP2 CUB domain containing protein 2 2.77831
ADAM29 ADAM metallopeptidase domain 29 2.77831
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.77831
FAM81B family with sequence similarity 81, member B 2.77831
POU3F4 POU class 3 homeobox 4 2.77831
SLITRK1 SLIT and NTRK-like family, member 1 2.77831
MYO1A myosin IA 2.77831
MYL7 myosin, light chain 7, regulatory 2.77831
RTP4 receptor (chemosensory) transporter protein 4 2.77831
STAP1 signal transducing adaptor family member 1 2.77831
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.77831
MMP12 matrix metallopeptidase 12 2.77831
NPR3 natriuretic peptide receptor 3 2.77831
AMIGO3 adhesion molecule with Ig-like domain 3 2.77831
CD34 CD34 molecule 2.77831
MMRN1 multimerin 1 2.77831
MXD3 MAX dimerization protein 3 2.72295
ZSWIM7 zinc finger, SWIM-type containing 7 2.67519
SRXN1 sulfiredoxin 1 2.672
HSF2 heat shock transcription factor 2 2.672
DCLK3 doublecortin-like kinase 3 2.66602
RP9 retinitis pigmentosa 9 (autosomal dominant) 2.55388
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.52519
PRDM14 PR domain containing 14 2.51568
DHRS13 dehydrogenase/reductase (SDR family) member 13 2.49612
CARMIL1 capping protein regulator and myosin 1 linker 1 2.49582
ANKRD6 ankyrin repeat domain 6 2.3841
SLC25A53 solute carrier family 25, member 53 2.36203
SCYL3 SCY1-like 3 (S. cerevisiae) 2.33763
STARD3 StAR-related lipid transfer (START) domain containing 3 2.3367
NEXN nexilin (F actin binding protein) 2.33089
PDE7A phosphodiesterase 7A 2.2952
RANBP3 RAN binding protein 3 2.2828
RHOBTB1 Rho-related BTB domain containing 1 2.27957
TUBB4B tubulin, beta 4B class IVb 2.27217
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.25949
JAK3 Janus kinase 3 2.25766
ALAD aminolevulinate dehydratase 2.25608
DCDC1 doublecortin domain containing 1 2.23162
DBF4B DBF4 zinc finger B 2.21007
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 2.19157
ATP11B ATPase, class VI, type 11B 2.17342
ZNF830 zinc finger protein 830 2.14813
NPPA natriuretic peptide A 2.14157
RPIA ribose 5-phosphate isomerase A 2.13346
C1ORF35 chromosome 1 open reading frame 35 2.12492
SERAC1 serine active site containing 1 2.11046
USPL1 ubiquitin specific peptidase like 1 2.11046
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.10147
RNF212B ring finger protein 212B 2.09916
PNPLA6 patatin-like phospholipase domain containing 6 2.08325
LYN LYN proto-oncogene, Src family tyrosine kinase 2.0821
CSNK1G1 casein kinase 1, gamma 1 2.07233
SLC30A7 solute carrier family 30 (zinc transporter), member 7 2.0568
DNASE1 deoxyribonuclease I 2.03601
NFRKB nuclear factor related to kappaB binding protein 2.01552
TMEM41A transmembrane protein 41A 2.0151

decreased expression

Symbol Name Standardized Value
CLEC19A C-type lectin domain family 19, member A -2.77831
NRSN1 neurensin 1 -2.77831
PCDHA3 protocadherin alpha 3 -2.77831
IL17B interleukin 17B -2.77831
ICA1L islet cell autoantigen 1,69kDa-like -2.77831
ACOT1 acyl-CoA thioesterase 1 -2.77831
POTEF POTE ankyrin domain family, member F -2.77831
ZNF24 zinc finger protein 24 -2.77831
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -2.77831
GRM6 glutamate receptor, metabotropic 6 -2.77831
FPR2 formyl peptide receptor 2 -2.77831
SLC25A41 solute carrier family 25, member 41 -2.77831
PNMA5 paraneoplastic Ma antigen family member 5 -2.77831
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.77831
TRIM15 tripartite motif containing 15 -2.77831
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.77831
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) -2.77831
N4BP1 NEDD4 binding protein 1 -2.77831
SYCP2 synaptonemal complex protein 2 -2.77831
ZMYND10 zinc finger, MYND-type containing 10 -2.77831
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.77831
VGLL4 vestigial-like family member 4 -2.77831
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -2.77831
MAT1A methionine adenosyltransferase I, alpha -2.77831
TMEM178B transmembrane protein 178B -2.77831
FNDC11 fibronectin type III domain containing 11 -2.77831
ABR active BCR-related -2.77831
TEKT2 tektin 2 (testicular) -2.77831
TMEM139 transmembrane protein 139 -2.77831
GPR37L1 G protein-coupled receptor 37 like 1 -2.77831
PIERCE2 piercer of microtubule wall 2 -2.77831
OOSP1 oocyte secreted protein 1, pseudogene -2.77831
C11ORF16 chromosome 11 open reading frame 16 -2.77831
PDGFA platelet-derived growth factor alpha polypeptide -2.77831
SPAAR small regulatory polypeptide of amino acid response -2.77831
STRIP1 striatin interacting protein 1 -2.76998
SLC35F1 solute carrier family 35, member F1 -2.76767
UBE2H ubiquitin-conjugating enzyme E2H -2.71648
GEM GTP binding protein overexpressed in skeletal muscle -2.68707
ZBTB43 zinc finger and BTB domain containing 43 -2.672
LRRIQ1 leucine-rich repeats and IQ motif containing 1 -2.66852
RP1L1 retinitis pigmentosa 1-like 1 -2.65934
TRAPPC12 trafficking protein particle complex 12 -2.65934
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.52519
NECTIN1 nectin cell adhesion molecule 1 -2.52519
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -2.52519
DYDC1 DPY30 domain containing 1 -2.52519
BRICD5 BRICHOS domain containing 5 -2.51009
DPF3 D4, zinc and double PHD fingers, family 3 -2.51009
ABHD4 abhydrolase domain containing 4 -2.50769
CKAP4 cytoskeleton-associated protein 4 -2.44368
RGPD6 RANBP2-like and GRIP domain containing 6 -2.44368
PTPRG protein tyrosine phosphatase, receptor type, G -2.37286
ZNF302 zinc finger protein 302 -2.36203
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 -2.33452
GRM3 glutamate receptor, metabotropic 3 -2.30163
MCM6 minichromosome maintenance complex component 6 -2.27957
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -2.27402
THSD7B thrombospondin, type I, domain containing 7B -2.27295
CD37 CD37 molecule -2.25766
CAT catalase -2.2477
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) -2.24575
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 -2.24289
ARMH3 armadillo like helical domain containing 3 -2.23553
TTLL11 tubulin tyrosine ligase-like family member 11 -2.22281
TVP23A trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) -2.21794
TMF1 TATA element modulatory factor 1 -2.20222
FAM43B family with sequence similarity 43, member B -2.19374
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -2.18724
BOLA2B bolA family member 2B -2.17821
FAM107A family with sequence similarity 107, member A -2.175
COL8A1 collagen, type VIII, alpha 1 -2.17342
NLGN3 neuroligin 3 -2.16435
RUNX3 runt-related transcription factor 3 -2.15554
CPB2 carboxypeptidase B2 (plasma) -2.15554
RNF130 ring finger protein 130 -2.14813
ZNF804A zinc finger protein 804A -2.14813
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -2.14506
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -2.13139
DMC1 DNA meiotic recombinase 1 -2.11951
IPMK inositol polyphosphate multikinase -2.10303
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -2.10147
LRMDA leucine rich melanocyte differentiation associated -2.10147
PBX4 pre-B-cell leukemia homeobox 4 -2.0821
CMTR2 cap methyltransferase 2 -2.07307
XTBD1 XRN2 binding domain containing 1 -2.07233
SEPTIN8 septin 8 -2.07233
APTX aprataxin -2.06971
FGD4 FYVE, RhoGEF and PH domain containing 4 -2.06474
RBMX2 RNA binding motif protein, X-linked 2 -2.06099
EHBP1 EH domain binding protein 1 -2.06066
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -2.0568
TAFA2 TAFA chemokine like family member 2 -2.05531
SPATA21 spermatogenesis associated 21 -2.05531
H4C3 H4 clustered histone 3 -2.04516
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.04346
ATRAID all-trans retinoic acid-induced differentiation factor -2.03183
SFTPD surfactant protein D -2.01883
HIC1 hypermethylated in cancer 1 -2.01883
PACRG PARK2 co-regulated -2.01883
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.01883
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -2.01883
PCDHA11 protocadherin alpha 11 -2.01883
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) -2.0151