MYD88 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description myeloid differentiation primary response 88|This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] (NCBI Entrez Gene Database, 4615)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_MYD88
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Genes

60 co-expressed genes for MYD88 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
C20ORF24 chromosome 20 open reading frame 24
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD53 CD53 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CNPY3 canopy FGF signaling regulator 3
CORO1A coronin, actin binding protein, 1A
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYTH4 cytohesin 4
DAZAP2 DAZ associated protein 2
DOCK2 dedicator of cytokinesis 2
ELF4 E74-like factor 4 (ets domain transcription factor)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FKBP15 FK506 binding protein 15, 133kDa
FMNL1 formin-like 1
GMIP GEM interacting protein
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-B major histocompatibility complex, class I, B
IQGAP1 IQ motif containing GTPase activating protein 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LSP1 lymphocyte-specific protein 1
LST1 leukocyte specific transcript 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN2B1 mannosidase, alpha, class 2B, member 1
MCL1 myeloid cell leukemia 1
MX2 MX dynamin-like GTPase 2
MYD88 myeloid differentiation primary response 88
OSTF1 osteoclast stimulating factor 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PRKCD protein kinase C, delta
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTPRE protein tyrosine phosphatase, receptor type, E
PYCARD PYD and CARD domain containing
RAB8A RAB8A, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RHOA ras homolog family member A
RIN3 Ras and Rab interactor 3
RNASET2 ribonuclease T2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SELL selectin L
SELPLG selectin P ligand
SH2B3 SH2B adaptor protein 3
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SKAP2 src kinase associated phosphoprotein 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THEMIS2 thymocyte selection associated family member 2
TMEM127 transmembrane protein 127
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TYROBP TYRO protein tyrosine kinase binding protein
USP3 ubiquitin specific peptidase 3
WAS Wiskott-Aldrich syndrome