MYD88 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description myeloid differentiation primary response 88|This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] (NCBI Entrez Gene Database, 4615)
External Link http://www.ncbi.nlm.nih.gov/gene/4615
Similar Terms
Downloads & Tools

Genes

83 interacting proteins for MYD88 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BST2 bone marrow stromal cell antigen 2
BTK Bruton agammaglobulinemia tyrosine kinase
CAMLG calcium modulating ligand
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD14 CD14 molecule
CD93 CD93 molecule
CHUK conserved helix-loop-helix ubiquitous kinase
CISH cytokine inducible SH2-containing protein
CYTH2 cytohesin 2
DOCK8 dedicator of cytokinesis 8
FADD Fas (TNFRSF6)-associated via death domain
FLII flightless I homolog (Drosophila)
HDAC6 histone deacetylase 6
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL1R1 interleukin 1 receptor, type I
IL1RAP interleukin 1 receptor accessory protein
IL33R interleukin 33 receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF4 interferon regulatory factor 4
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
LY96 lymphocyte antigen 96
MAL mal, T-cell differentiation protein
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MBIP MAP3K12 binding inhibitory protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
PELI1 pellino E3 ubiquitin protein ligase 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PFKL phosphofructokinase, liver
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PRDX1 peroxiredoxin 1
PTK2B protein tyrosine kinase 2 beta
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIPK2 receptor-interacting serine-threonine kinase 2
SARM1 sterile alpha and TIR motif containing 1
SASH1 SAM and SH3 domain containing 1
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SMAD3 SMAD family member 3
SMAD6 SMAD family member 6
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOCS1 suppressor of cytokine signaling 1
SPOP speckle-type POZ protein
SQSTM1 sequestosome 1
STAP2 signal transducing adaptor family member 2
SYK spleen tyrosine kinase
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TICAM1 toll-like receptor adaptor molecule 1
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNIP1 TNFAIP3 interacting protein 1
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TXN thioredoxin
UBC ubiquitin C
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)