MYO1C Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description myosin IC|This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4641)
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Genes

356 genes differentially expressed following the MYO1C gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 3.96372
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.96372
SLAMF1 signaling lymphocytic activation molecule family member 1 3.96372
EXTL1 exostosin-like glycosyltransferase 1 3.96372
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.96372
MROH5 maestro heat-like repeat family member 5 3.96372
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 3.96372
KLK13 kallikrein-related peptidase 13 3.96372
TBX1 T-box 1 3.96372
SEMG1 semenogelin I 3.96372
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.96372
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.96372
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 3.96372
CYSRT1 cysteine-rich tail protein 1 3.96372
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 3.96372
DNAH8 dynein, axonemal, heavy chain 8 3.96372
TNS2 tensin 2 3.96372
TDRD9 tudor domain containing 9 3.96372
GREM1 gremlin 1, DAN family BMP antagonist 3.96372
CSTL1 cystatin-like 1 3.96372
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 3.96372
KRT81 keratin 81, type II 3.96372
LRRC24 leucine rich repeat containing 24 3.96372
BTG4 B-cell translocation gene 4 3.96372
FCRLB Fc receptor-like B 3.96372
NOTCH2NLB notch 2 N-terminal like B 3.96372
CCDC197 coiled-coil domain containing 197 3.96372
CCL5 chemokine (C-C motif) ligand 5 3.85119
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.85119
HBA1 hemoglobin, alpha 1 3.85119
IFNA5 interferon, alpha 5 3.85119
TMEM270 transmembrane protein 270 3.85119
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.85119
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.85119
PNMA5 paraneoplastic Ma antigen family member 5 3.85119
LRRC73 leucine rich repeat containing 73 3.85119
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.85119
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.85119
ZNF503 zinc finger protein 503 3.85119
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.85119
ENTHD1 ENTH domain containing 1 3.85119
GSTT4 glutathione S-transferase theta 4 3.85119
DNASE1L2 deoxyribonuclease I-like 2 3.85119
BATF basic leucine zipper transcription factor, ATF-like 3.85119
MYCT1 myc target 1 3.85119
MYOM2 myomesin 2 3.85119
LVRN laeverin 3.85119
C2ORF78 chromosome 2 open reading frame 78 3.85119
DIO3 deiodinase, iodothyronine, type III 3.85119
LOC124903233 uncharacterized LOC124903233 3.85119
SETSIP SET-like protein 3.85119
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.85119
NEUROG2 neurogenin 2 3.85119
TTLL2 tubulin tyrosine ligase-like family member 2 3.85119
CPB1 carboxypeptidase B1 (tissue) 3.85119
SPNS2 spinster homolog 2 (Drosophila) 3.85119
SPAAR small regulatory polypeptide of amino acid response 3.85119
LY6L lymphocyte antigen 6 family member L 3.85119
MUCL3 mucin like 3 3.85119
STRA8 stimulated by retinoic acid 8 3.85119
TCAF2 TRPM8 channel-associated factor 2 3.85119
LRRC10B leucine rich repeat containing 10B 3.85119
IL18R1 interleukin 18 receptor 1 3.85119
SLCO1B3 solute carrier organic anion transporter family, member 1B3 3.85119
ACR acrosin 3.85119
SPATA22 spermatogenesis associated 22 3.85119
STING1 stimulator of interferon response cGAMP interactor 1 3.85119
GATA3 GATA binding protein 3 3.85119
LRRN4CL LRRN4 C-terminal like 3.85119
ACE2 angiotensin I converting enzyme 2 3.85119
ROPN1 rhophilin associated tail protein 1 3.85119
CBLIF cobalamin binding intrinsic factor 3.85119
PLEK2 pleckstrin 2 3.85119
TREX2 three prime repair exonuclease 2 3.85119
BGN biglycan 3.85119
DUSP8 dual specificity phosphatase 8 3.85119
HBG2 hemoglobin, gamma G 3.85119
DNAAF1 dynein, axonemal, assembly factor 1 3.85119
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.85119
CALHM5 calcium homeostasis modulator family member 5 3.85119
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.85119
TMPRSS6 transmembrane protease, serine 6 3.85119
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 3.85119
IL1RN interleukin 1 receptor antagonist 3.85119
WIPF2 WAS/WASL interacting protein family, member 2 3.85119
CFAP141 cilia and flagella associated protein 141 3.85119
PSAPL1 prosaposin-like 1 (gene/pseudogene) 3.85119
DAO D-amino-acid oxidase 3.85119
AMBP alpha-1-microglobulin/bikunin precursor 3.85119
CFAP206 cilia and flagella associated protein 206 3.85119
ITK IL2-inducible T-cell kinase 3.85119
NKX2-4 NK2 homeobox 4 3.85119
PVRIG poliovirus receptor related immunoglobulin domain containing 3.85119
UROC1 urocanate hydratase 1 3.85119
CCDC190 coiled-coil domain containing 190 3.85119
TACR2 tachykinin receptor 2 3.85119
SPDYC speedy/RINGO cell cycle regulator family member C 3.85119
TBX3 T-box 3 3.85119
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 3.85119
CLXN calaxin 3.85119
MIP major intrinsic protein of lens fiber 3.85119
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.85119
CXCL16 chemokine (C-X-C motif) ligand 16 3.85119
MGAT4D MGAT4 family, member D 3.85119
EOMES eomesodermin 3.85119
AQP8 aquaporin 8 3.85119
OTC ornithine carbamoyltransferase 3.85119
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.85119
CTLA4 cytotoxic T-lymphocyte-associated protein 4 3.85119
ERICH3 glutamate-rich 3 3.85119
CNTF ciliary neurotrophic factor 3.85119
CXCR6 chemokine (C-X-C motif) receptor 6 3.85119
C17ORF107 chromosome 17 open reading frame 107 3.85119
IL12B interleukin 12B 3.85119
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.85119
MC5R melanocortin 5 receptor 3.85119
ADIRF adipogenesis regulatory factor 3.85119
NUTM2B NUT family member 2B 3.85119
SP100 SP100 nuclear antigen 3.85119
SLITRK6 SLIT and NTRK-like family, member 6 3.85119
SLITRK1 SLIT and NTRK-like family, member 1 3.85119
SMIM23 small integral membrane protein 23 3.85119
ERICH6B glutamate-rich 6B 3.85119
ANKRD20A1 ankyrin repeat domain 20 family, member A1 3.85119
CLEC18B C-type lectin domain family 18, member B 3.85119
FAM151A family with sequence similarity 151, member A 3.85119
GJB6 gap junction protein, beta 6, 30kDa 3.85119
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 3.85119
HMGB4 high mobility group box 4 3.85119
FLRT3 fibronectin leucine rich transmembrane protein 3 3.85119
PRTN3 proteinase 3 3.85119
SI sucrase-isomaltase (alpha-glucosidase) 3.85119
ANKRD53 ankyrin repeat domain 53 3.85119
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.85119
FGR FGR proto-oncogene, Src family tyrosine kinase 3.85119
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.85119
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.85119
ASTL astacin-like metallo-endopeptidase (M12 family) 3.85119
C20ORF144 chromosome 20 open reading frame 144 3.85119
EGR2 early growth response 2 3.85119
VTCN1 V-set domain containing T cell activation inhibitor 1 3.85119
LRRC74A leucine rich repeat containing 74A 3.85119
TTC36 tetratricopeptide repeat domain 36 3.85119
VPREB3 pre-B lymphocyte 3 3.85119
NLRP9 NLR family, pyrin domain containing 9 3.85119
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.85119
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.85119
PLA2G1B phospholipase A2, group IB (pancreas) 3.85119
TRAF3IP3 TRAF3 interacting protein 3 3.85119
TAS2R43 taste receptor, type 2, member 43 3.85119
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.85119
HEPN1 hepatocellular carcinoma, down-regulated 1 3.85119
AREG amphiregulin 3.85119
IFNK interferon, kappa 3.85119
TGM7 transglutaminase 7 3.85119
TMPRSS15 transmembrane protease, serine 15 3.85119
EMCN endomucin 3.85119
GCM2 glial cells missing homolog 2 (Drosophila) 3.85119
SMCO1 single-pass membrane protein with coiled-coil domains 1 3.85119
FAM81B family with sequence similarity 81, member B 3.85119
SYTL4 synaptotagmin-like 4 3.85119
TWIST1 twist family bHLH transcription factor 1 3.85119
ALLC allantoicase 3.85119
OR5A1 olfactory receptor, family 5, subfamily A, member 1 3.85119
FAM209B family with sequence similarity 209, member B 3.78196
CDH26 cadherin 26 3.78196
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 3.56827
CBX1 chromobox homolog 1 3.3811
SLC16A6 solute carrier family 16, member 6 3.37315
SIRT1 sirtuin 1 3.23925
ATG2B autophagy related 2B 3.20201
MARS1 methionyl-tRNA synthetase 1 3.18093
RASL11A RAS-like, family 11, member A 2.72335
GADL1 glutamate decarboxylase-like 1 2.72335
TEX46 testis expressed 46 2.72335
THSD1 thrombospondin, type I, domain containing 1 2.72335
ZNHIT2 zinc finger, HIT-type containing 2 2.7225
SDCCAG8 serologically defined colon cancer antigen 8 2.70515
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 2.69755
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.67674
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) 2.67225
RAB27A RAB27A, member RAS oncogene family 2.6403
ZNF525 zinc finger protein 525 2.62426
NR6A1 nuclear receptor subfamily 6, group A, member 1 2.61858
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.48415
TMF1 TATA element modulatory factor 1 2.47631
NEIL1 nei endonuclease VIII-like 1 (E. coli) 2.47535
PLCG1 phospholipase C, gamma 1 2.42883
PGP phosphoglycolate phosphatase 2.41538
ISCA1 iron-sulfur cluster assembly 1 2.38595
NOL4L nucleolar protein 4-like 2.33679
BANK1 B-cell scaffold protein with ankyrin repeats 1 2.33261
CAPRIN1 cell cycle associated protein 1 2.32454
FAXDC2 fatty acid hydroxylase domain containing 2 2.32454
SATL1 spermidine/spermine N1-acetyl transferase-like 1 2.31572
RLBP1 retinaldehyde binding protein 1 2.30792
APOB apolipoprotein B 2.30792
NUP160 nucleoporin 160kDa 2.3063
ZBED4 zinc finger, BED-type containing 4 2.30494
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.30479
TMEM134 transmembrane protein 134 2.26448
YIPF2 Yip1 domain family, member 2 2.26227
MAN2B1 mannosidase, alpha, class 2B, member 1 2.26044
TMEM170B transmembrane protein 170B 2.2459
SMAD3 SMAD family member 3 2.23533
STPG4 sperm-tail PG-rich repeat containing 4 2.2192
ZNF404 zinc finger protein 404 2.2192
RAG2 recombination activating gene 2 2.2192
PCNX4 pecanex 4 2.21543
DHRS12 dehydrogenase/reductase (SDR family) member 12 2.21467
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) 2.20447
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.19408
IMPACT impact RWD domain protein 2.15005
ZDHHC2 zinc finger, DHHC-type containing 2 2.14193
CNTROB centrobin, centrosomal BRCA2 interacting protein 2.14139
KIF3A kinesin family member 3A 2.13041
FBXL13 F-box and leucine-rich repeat protein 13 2.1226
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 2.10143
CHRAC1 chromatin accessibility complex 1 2.10143
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.09745
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.07745
FLII flightless I homolog (Drosophila) 2.07711
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.0763
ARID5B AT rich interactive domain 5B (MRF1-like) 2.03635
NPAT nuclear protein, ataxia-telangiectasia locus 2.02337
LETM2 leucine zipper-EF-hand containing transmembrane protein 2 2.01631
NBPF12 neuroblastoma breakpoint family, member 12 2.00152
ATAD2B ATPase family, AAA domain containing 2B 2.00107
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 2.00003

decreased expression

Symbol Name Standardized Value
RRH retinal pigment epithelium-derived rhodopsin homolog -3.96372
KRT222 keratin 222, type II -3.96372
DMBX1 diencephalon/mesencephalon homeobox 1 -3.96372
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -3.96372
SPATA2L spermatogenesis associated 2-like -3.96372
WNT3A wingless-type MMTV integration site family, member 3A -3.85119
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -3.85119
HAS1 hyaluronan synthase 1 -3.85119
CIITA class II, major histocompatibility complex, transactivator -3.85119
POU3F2 POU class 3 homeobox 2 -3.85119
CCNB3 cyclin B3 -3.85119
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -3.85119
VWC2L von Willebrand factor C domain containing protein 2-like -3.85119
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -3.85119
RGPD4 RANBP2-like and GRIP domain containing 4 -3.85119
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -3.85119
NWD2 NACHT and WD repeat domain containing 2 -3.85119
BRICD5 BRICHOS domain containing 5 -3.85119
SOX6 SRY (sex determining region Y)-box 6 -3.85119
EFCAB12 EF-hand calcium binding domain 12 -3.85119
LRRC8C-DT LRRC8C divergent transcript -3.85119
SPATS1 spermatogenesis associated, serine-rich 1 -3.85119
CBX8 chromobox homolog 8 -3.85119
SDS serine dehydratase -3.85119
GPR149 G protein-coupled receptor 149 -3.85119
PDZRN4 PDZ domain containing ring finger 4 -3.85119
SNX13 sorting nexin 13 -3.8472
KANK3 KN motif and ankyrin repeat domains 3 -3.72716
EDARADD EDAR-associated death domain -3.36951
FAM114A2 family with sequence similarity 114, member A2 -3.30234
OTX2 orthodenticle homeobox 2 -3.29431
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -3.23925
CNTN4 contactin 4 -3.15076
TONSL tonsoku-like, DNA repair protein -3.06297
VEPH1 ventricular zone expressed PH domain-containing 1 -2.97638
ARL4C ADP-ribosylation factor-like 4C -2.97386
RHOT2 ras homolog family member T2 -2.97047
EIF4A3 eukaryotic translation initiation factor 4A3 -2.96315
STON2 stonin 2 -2.86359
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 -2.86359
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.83182
MMP23B matrix metallopeptidase 23B -2.80442
GRAMD1B GRAM domain containing 1B -2.80092
BHMT betaine--homocysteine S-methyltransferase -2.79871
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.79871
MSR1 macrophage scavenger receptor 1 -2.79871
SOWAHD sosondowah ankyrin repeat domain family member D -2.79871
C2CD4D C2 calcium-dependent domain containing 4D -2.79871
CDK14 cyclin-dependent kinase 14 -2.59111
DCP1A decapping mRNA 1A -2.55198
MTMR2 myotubularin related protein 2 -2.55186
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 -2.54346
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 -2.47631
ZNF473 zinc finger protein 473 -2.47447
INPP5K inositol polyphosphate-5-phosphatase K -2.45432
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 -2.44585
ITM2B integral membrane protein 2B -2.44181
SCAF11 SR-related CTD-associated factor 11 -2.44181
C19ORF73 chromosome 19 open reading frame 73 -2.44181
SLC41A3 solute carrier family 41, member 3 -2.42969
CIT citron rho-interacting serine/threonine kinase -2.41494
TNRC6B trinucleotide repeat containing 6B -2.41494
PFAS phosphoribosylformylglycinamidine synthase -2.41126
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) -2.39524
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.38639
MAPK15 mitogen-activated protein kinase 15 -2.38279
LINC02560 long intergenic non-protein coding RNA 2560 -2.38279
PCDHA9 protocadherin alpha 9 -2.38279
ACSS1 acyl-CoA synthetase short-chain family member 1 -2.35647
JOSD2 Josephin domain containing 2 -2.35347
RFX2 regulatory factor X, 2 (influences HLA class II expression) -2.32454
PALM3 paralemmin 3 -2.32454
EMX1 empty spiracles homeobox 1 -2.31937
DHRSX dehydrogenase/reductase (SDR family) X-linked -2.31929
CFAP73 cilia and flagella associated protein 73 -2.30771
KREMEN2 kringle containing transmembrane protein 2 -2.30771
TSHR thyroid stimulating hormone receptor -2.30771
ZNF433 zinc finger protein 433 -2.30479
PIGC phosphatidylinositol glycan anchor biosynthesis, class C -2.29398
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) -2.28039
NBR1 neighbor of BRCA1 gene 1 -2.26518
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -2.25495
VSTM2B V-set and transmembrane domain containing 2B -2.25495
ZBTB16 zinc finger and BTB domain containing 16 -2.25495
C11ORF71 chromosome 11 open reading frame 71 -2.25482
HARS1 histidyl-tRNA synthetase 1 -2.24596
MOCOS molybdenum cofactor sulfurase -2.24317
DENND1C DENN/MADD domain containing 1C -2.23822
CLMB calcimembrin -2.22757
SAXO4 stabilizer of axonemal microtubules 4 -2.22687
APOH apolipoprotein H (beta-2-glycoprotein I) -2.22687
PCDHGC3 protocadherin gamma subfamily C, 3 -2.22687
ZC3H11A zinc finger CCCH-type containing 11A -2.22687
SLC38A6 solute carrier family 38, member 6 -2.21543
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.21543
XPO1 exportin 1 -2.21372
UBE2S ubiquitin-conjugating enzyme E2S -2.21314
MOCS2 molybdenum cofactor synthesis 2 -2.21314
STON1 stonin 1 -2.21069
TMEM14B transmembrane protein 14B -2.19709
ATP5F1A ATP synthase F1 subunit alpha -2.19242
CYFIP2 cytoplasmic FMR1 interacting protein 2 -2.18153
SNX25 sorting nexin 25 -2.16999
LY6E lymphocyte antigen 6 complex, locus E -2.15922
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.15052
TMEM205 transmembrane protein 205 -2.14908
SCG3 secretogranin III -2.14193
SPON1 spondin 1, extracellular matrix protein -2.13205
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -2.12916
EFR3B EFR3 homolog B (S. cerevisiae) -2.12493
RSPO4 R-spondin 4 -2.09791
LIN37 lin-37 DREAM MuvB core complex component -2.09494
CHD9NB CHD9 neighbor -2.07745
DCXR dicarbonyl/L-xylulose reductase -2.0687
XIRP2 xin actin binding repeat containing 2 -2.05243
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase -2.02762
PANK2 pantothenate kinase 2 -2.02762
ZBTB46 zinc finger and BTB domain containing 46 -2.0245
PLAG1 pleiomorphic adenoma gene 1 -2.02337
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) -2.02337
AIRIM AFG2 interacting ribosome maturation factor -2.01839
VWCE von Willebrand factor C and EGF domains -2.01697
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -2.0113
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -2.00791
INTS14 integrator complex subunit 14 -2.00223
SEPHS1 selenophosphate synthetase 1 -2.00223
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 -2.00003