MYOCD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description myocardin|This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 93649)
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Genes

304 genes differentially expressed following the MYOCD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SIX1 SIX homeobox 1 3.43096
GJB5 gap junction protein, beta 5, 31.1kDa 3.43096
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.43096
WFDC13 WAP four-disulfide core domain 13 3.43096
CD300LF CD300 molecule-like family member f 3.43096
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.43096
CPA4 carboxypeptidase A4 3.43096
RIMBP2 RIMS binding protein 2 3.43096
S100A1 S100 calcium binding protein A1 3.43096
CDHR5 cadherin-related family member 5 3.43096
BCAS1 breast carcinoma amplified sequence 1 3.43096
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.43096
TLR7 toll-like receptor 7 3.43096
SLFN11 schlafen family member 11 3.43096
CATSPER1 cation channel, sperm associated 1 3.43096
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.43096
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.43096
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.43096
CCN5 cellular communication network factor 5 3.43096
PRR29 proline rich 29 3.43096
ITGA8 integrin, alpha 8 3.43096
AVP arginine vasopressin 3.43096
LGALS14 lectin, galactoside-binding, soluble, 14 3.43096
DAW1 dynein assembly factor with WDR repeat domains 1 3.43096
CNGB1 cyclic nucleotide gated channel beta 1 3.43096
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.3963
BATF basic leucine zipper transcription factor, ATF-like 3.3963
TREM2 triggering receptor expressed on myeloid cells 2 3.3963
ZNF503 zinc finger protein 503 3.3963
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.3963
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.3963
NAPSA napsin A aspartic peptidase 3.3963
PTGER4 prostaglandin E receptor 4 (subtype EP4) 3.3963
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.3963
OC90 otoconin 90 3.3963
TMPRSS11A transmembrane protease, serine 11A 3.3963
HORMAD1 HORMA domain containing 1 3.3963
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.3963
NXPH4 neurexophilin 4 3.3963
FABP1 fatty acid binding protein 1, liver 3.3963
MFAP5 microfibrillar associated protein 5 3.3963
MYCT1 myc target 1 3.3963
CEP295NL CEP295 N-terminal like 3.3963
MYOM2 myomesin 2 3.3963
PAX6 paired box 6 3.3963
MYOM3 myomesin 3 3.3963
SLC25A47 solute carrier family 25, member 47 3.3963
OTUD6A OTU deubiquitinase 6A 3.3963
C8ORF48 chromosome 8 open reading frame 48 3.3963
PTGFR prostaglandin F receptor (FP) 3.3963
OR5A1 olfactory receptor, family 5, subfamily A, member 1 3.3963
CELA3B chymotrypsin-like elastase family, member 3B 3.3963
ADIPOQ adiponectin, C1Q and collagen domain containing 3.3963
CXCL9 chemokine (C-X-C motif) ligand 9 3.3963
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.3963
NDRG1 N-myc downstream regulated 1 3.3963
ERLN endoregulin 3.3963
TMEM273 transmembrane protein 273 3.3963
TAFA3 TAFA chemokine like family member 3 3.3963
CLXN calaxin 3.3963
CCN6 cellular communication network factor 6 3.3963
VSIR V-set immunoregulatory receptor 3.3963
GIPC3 GIPC PDZ domain containing family, member 3 3.3963
PLG plasminogen 3.3963
ZNF726 zinc finger protein 726 3.3963
H2BW1 H2B.W histone 1 3.3963
PEAK3 PEAK family member 3 3.3963
TEX53 testis expressed 53 3.3963
DEFB109B defensin beta 109B 3.3963
PRRT1B proline rich transmembrane protein 1B 3.3963
H4C14 H4 clustered histone 14 3.3963
RHEX regulator of hemoglobinization and erythroid cell expansion 3.3963
TMEM238L transmembrane protein 238 like 3.3963
AKAIN1 A-kinase anchor inhibitor 1 3.3963
LHFPL7 LHFPL tetraspan subfamily member 7 3.3963
MCHR2 melanin-concentrating hormone receptor 2 3.3963
CATSPERH catsper channel auxiliary subunit eta 3.3963
SPATA31C1 SPATA31 subfamily C, member 1 3.3963
TBX3 T-box 3 3.3963
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.3963
GOLGA7B golgin A7 family, member B 3.3963
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.3963
TMEM236 transmembrane protein 236 3.3963
CCDC17 coiled-coil domain containing 17 3.3963
PTPRH protein tyrosine phosphatase, receptor type, H 3.3963
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.3963
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 3.3963
EXOC3L4 exocyst complex component 3-like 4 3.3963
SMLR1 small leucine-rich protein 1 3.3963
ASB4 ankyrin repeat and SOCS box containing 4 3.3963
GPR37L1 G protein-coupled receptor 37 like 1 3.3963
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.3963
CSAG2 CSAG family, member 2 3.3963
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.3963
STARD6 StAR-related lipid transfer (START) domain containing 6 3.3963
PTH parathyroid hormone 3.3963
SLCO1B3 solute carrier organic anion transporter family, member 1B3 3.3963
LONRF3 LON peptidase N-terminal domain and ring finger 3 3.3963
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.3963
SLITRK6 SLIT and NTRK-like family, member 6 3.3963
MUC17 mucin 17, cell surface associated 3.3963
GH1 growth hormone 1 3.3963
CHAT choline O-acetyltransferase 3.3963
LAMP5 lysosomal-associated membrane protein family, member 5 3.3963
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.3963
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.3963
COL6A5 collagen, type VI, alpha 5 3.3963
CCL22 chemokine (C-C motif) ligand 22 3.3963
MSLN mesothelin 3.3963
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.3963
LRRC15 leucine rich repeat containing 15 3.3963
SAMD5 sterile alpha motif domain containing 5 3.3963
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.3963
NUTM2A NUT family member 2A 3.3963
TTC9B tetratricopeptide repeat domain 9B 3.3963
CT55 cancer/testis antigen 55 3.3963
PALMD palmdelphin 3.3963
EFCAB3 EF-hand calcium binding domain 3 3.3963
CTAGE4 CTAGE family, member 4 3.3963
PHOSPHO1 phosphatase, orphan 1 3.3963
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.3963
CIDEC cell death-inducing DFFA-like effector c 3.3963
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.3963
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.3963
CD5L CD5 molecule-like 3.3963
C9ORF57 chromosome 9 open reading frame 57 3.3963
CDH12 cadherin 12, type 2 (N-cadherin 2) 3.3963
SMR3B submaxillary gland androgen regulated protein 3B 3.3963
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.3963
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.3963
RHO rhodopsin 3.3963
BTBD16 BTB (POZ) domain containing 16 3.3963
ATOH8 atonal homolog 8 (Drosophila) 3.3963
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 3.3963
BMP3 bone morphogenetic protein 3 3.3963
RGS8 regulator of G-protein signaling 8 3.3963
JCHAIN joining chain of multimeric IgA and IgM 3.3963
CLEC14A C-type lectin domain family 14, member A 3.3963
LIMS3 LIM and senescent cell antigen-like domains 3 3.3963
GPHA2 glycoprotein hormone alpha 2 3.3963
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.3963
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.3963
CAPSL calcyphosine-like 3.3963
ABI3 ABI family, member 3 3.3963
ZC2HC1B zinc finger, C2HC-type containing 1B 3.3963
TEX38 testis expressed 38 3.3963
PRH2 proline-rich protein HaeIII subfamily 2 3.3963
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.3963
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 3.3963
TAGAP T-cell activation RhoGTPase activating protein 3.3963
ISX intestine-specific homeobox 3.3963
ADAM29 ADAM metallopeptidase domain 29 3.3963
SIDT1 SID1 transmembrane family, member 1 3.3963
CLEC18A C-type lectin domain family 18, member A 3.3963
BHMT2 betaine--homocysteine S-methyltransferase 2 3.3963
SLC38A3 solute carrier family 38, member 3 3.3963
CD33 CD33 molecule 3.3963
RUNX3 runt-related transcription factor 3 3.32934
GPALPP1 GPALPP motifs containing 1 3.14406
ACRBP acrosin binding protein 3.1217
FAM120B family with sequence similarity 120B 2.96991
CALR3 calreticulin 3 2.92071
ANGPTL4 angiopoietin-like 4 2.82633
PM20D1 peptidase M20 domain containing 1 2.82633
MED17 mediator complex subunit 17 2.78726
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 2.75985
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 2.7015
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 2.65895
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 2.65488
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.63338
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 2.61003
VCP valosin containing protein 2.595
TM7SF2 transmembrane 7 superfamily member 2 2.59388
SDC2 syndecan 2 2.51706
ZFP42 ZFP42 zinc finger protein 2.41646
NELFB negative elongation factor complex member B 2.39379
CDON cell adhesion associated, oncogene regulated 2.39337
LYPLA1 lysophospholipase I 2.38108
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 2.31814
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.30795
CEP89 centrosomal protein 89kDa 2.30767
CLBA1 clathrin binding box of aftiphilin containing 1 2.2958
NHLH1 nescient helix loop helix 1 2.2958
CLU clusterin 2.29281
FBXO34 F-box protein 34 2.28568
EHD4 EH-domain containing 4 2.27519
SNTN sentan, cilia apical structure protein 2.27328
GYPE glycophorin E (MNS blood group) 2.27328
CCDC38 coiled-coil domain containing 38 2.26328
AFF4 AF4/FMR2 family, member 4 2.25141
NDRG4 NDRG family member 4 2.24386
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 2.24386
ACAN aggrecan 2.23609
ZRANB1 zinc finger, RAN-binding domain containing 1 2.22665
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.22118
KHNYN KH and NYN domain containing 2.20765
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 2.18508
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.18061
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 2.16907
JKAMP JNK1/MAPK8-associated membrane protein 2.16266
CHPF2 chondroitin polymerizing factor 2 2.14767
LRATD1 LRAT domain containing 1 2.14344
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.12534
ATP13A2 ATPase type 13A2 2.10979
UBE2H ubiquitin-conjugating enzyme E2H 2.10549
TLL1 tolloid-like 1 2.08404
CA8 carbonic anhydrase VIII 2.08404
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 2.08092
SYNGR3 synaptogyrin 3 2.04603
MED28 mediator complex subunit 28 2.03459

decreased expression

Symbol Name Standardized Value
JSRP1 junctional sarcoplasmic reticulum protein 1 -3.43096
LOC124906010 uncharacterized LOC124906010 -3.3963
KIF20B kinesin family member 20B -3.3963
OR4D9 olfactory receptor, family 4, subfamily D, member 9 -3.3963
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial -3.3963
KLHL25 kelch-like family member 25 -3.3963
TTC36 tetratricopeptide repeat domain 36 -3.3963
FOXA2 forkhead box A2 -3.3963
ZBED6 zinc finger, BED-type containing 6 -3.3963
OR56A3 olfactory receptor, family 56, subfamily A, member 3 -3.3963
BTC betacellulin -3.3963
SCN2B sodium channel, voltage gated, type II beta subunit -3.3963
PLAAT5 phospholipase A and acyltransferase 5 -3.3963
CCDC198 coiled-coil domain containing 198 -3.3963
PLAAT4 phospholipase A and acyltransferase 4 -3.3963
GBP4 guanylate binding protein 4 -3.3963
FGFBP1 fibroblast growth factor binding protein 1 -3.3963
MGAM maltase-glucoamylase -3.3963
RPS14 ribosomal protein S14 -3.3963
HLF hepatic leukemia factor -3.3963
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -3.3963
HPX hemopexin -3.3963
TRADD TNFRSF1A-associated via death domain -3.3963
CFAP47 cilia and flagella associated protein 47 -3.3963
TEAD2 TEA domain family member 2 -3.3963
IL9R interleukin 9 receptor -3.3963
PLA1A phospholipase A1 member A -3.3963
PLA2G12B phospholipase A2, group XIIB -3.3963
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -3.3963
NLRP14 NLR family, pyrin domain containing 14 -3.3963
METTL25B methyltransferase like 25B -3.23382
C19ORF53 chromosome 19 open reading frame 53 -3.20447
GSTM3 glutathione S-transferase mu 3 (brain) -3.15413
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 -2.94597
TRIM58 tripartite motif containing 58 -2.91309
UBXN2B UBX domain protein 2B -2.78726
RNF114 ring finger protein 114 -2.72453
ANKRD46 ankyrin repeat domain 46 -2.70825
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -2.60529
PAQR3 progestin and adipoQ receptor family member III -2.49817
FKBP1B FK506 binding protein 1B, 12.6 kDa -2.4574
OSBPL7 oxysterol binding protein-like 7 -2.4574
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.41946
PAM peptidylglycine alpha-amidating monooxygenase -2.35922
AK7 adenylate kinase 7 -2.31814
ELF4 E74-like factor 4 (ets domain transcription factor) -2.31814
ADRB2 adrenoceptor beta 2, surface -2.31814
S100B S100 calcium binding protein B -2.31814
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -2.31814
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.31814
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) -2.31403
RPL10 ribosomal protein L10 -2.2958
ASXL3 additional sex combs like transcriptional regulator 3 -2.2958
CIZ1 CDKN1A interacting zinc finger protein 1 -2.2958
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -2.2958
A1CF APOBEC1 complementation factor -2.2868
ANKRD7 ankyrin repeat domain 7 -2.2868
PMVK phosphomevalonate kinase -2.2764
KLK4 kallikrein-related peptidase 4 -2.26328
COPG2 coatomer protein complex, subunit gamma 2 -2.26328
SMOX spermine oxidase -2.26328
CCDC13 coiled-coil domain containing 13 -2.26328
CIMAP2 ciliary microtubule associated protein 2 -2.26328
FLAD1 flavin adenine dinucleotide synthetase 1 -2.26139
SPG11 spastic paraplegia 11 (autosomal recessive) -2.24506
EXOSC4 exosome component 4 -2.22793
NAGA N-acetylgalactosaminidase, alpha- -2.22478
CRLF2 cytokine receptor-like factor 2 -2.22478
MOG myelin oligodendrocyte glycoprotein -2.22478
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 -2.22478
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.22471
CHMP3 charged multivesicular body protein 3 -2.22118
PLIN3 perilipin 3 -2.20841
MRPS16 mitochondrial ribosomal protein S16 -2.20071
MEIS2 Meis homeobox 2 -2.19265
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -2.16907
ZFYVE16 zinc finger, FYVE domain containing 16 -2.16815
ADPRS ADP-ribosylserine hydrolase -2.16785
KDM2A lysine (K)-specific demethylase 2A -2.16785
HMOX1 heme oxygenase 1 -2.16245
ELN elastin -2.16076
FBXL7 F-box and leucine-rich repeat protein 7 -2.15271
PROSER3 proline and serine rich 3 -2.11707
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.11419
RPL26 ribosomal protein L26 -2.09583
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.08539
KIAA1586 KIAA1586 -2.0771
SPATA24 spermatogenesis associated 24 -2.07512
DYNLT2B dynein light chain Tctex-type 2B -2.0598
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -2.05257
TTC5 tetratricopeptide repeat domain 5 -2.04603
PRSS53 protease, serine, 53 -2.02924
MFN1 mitofusin 1 -2.02005
MRPL30 mitochondrial ribosomal protein L30 -2.014