MYRF Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description myelin regulatory factor|This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 745)
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Genes

346 genes differentially expressed following the MYRF gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 3.38694
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.38694
TBX22 T-box 22 3.38694
CLEC4M C-type lectin domain family 4, member M 3.38694
PCDHGA3 protocadherin gamma subfamily A, 3 3.38694
TMEM236 transmembrane protein 236 3.38694
GATA3 GATA binding protein 3 3.38694
ADAD2 adenosine deaminase domain containing 2 3.38694
CLEC9A C-type lectin domain family 9, member A 3.38694
SIX1 SIX homeobox 1 3.38694
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.38694
RAI2 retinoic acid induced 2 3.38694
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 3.38694
MYO1G myosin IG 3.38694
MMP20 matrix metallopeptidase 20 3.38694
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.38694
CCDC38 coiled-coil domain containing 38 3.38694
RBP4 retinol binding protein 4, plasma 3.38694
AGR2 anterior gradient 2 3.38694
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 3.38694
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.38694
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.38694
SLC25A34 solute carrier family 25, member 34 3.38694
CSF1R colony stimulating factor 1 receptor 3.38694
KRT222 keratin 222, type II 3.38694
STRIT1 small transmembrane regulator of ion transport 1 3.38694
TTLL2 tubulin tyrosine ligase-like family member 2 3.28008
SPAAR small regulatory polypeptide of amino acid response 3.28008
TRIM42 tripartite motif containing 42 3.28008
RAB4A-AS1 RAB4A antisense RNA 1 3.28008
DRGX dorsal root ganglia homeobox 3.28008
WASL-DT WASL divergent transcript 3.28008
CRX cone-rod homeobox 3.28008
DYNLT4 dynein light chain Tctex-type 4 3.28008
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.28008
GIMAP8 GTPase, IMAP family member 8 3.28008
MYOM2 myomesin 2 3.28008
CRYAA crystallin, alpha A 3.28008
GYPB glycophorin B (MNS blood group) 3.28008
CIROP ciliated left-right organizer metallopeptidase 3.28008
C8ORF48 chromosome 8 open reading frame 48 3.28008
DLL4 delta-like 4 (Drosophila) 3.28008
MISP mitotic spindle positioning 3.28008
CCDC83 coiled-coil domain containing 83 3.28008
FAM161B family with sequence similarity 161, member B 3.28008
TDO2 tryptophan 2,3-dioxygenase 3.28008
RTP5 receptor (chemosensory) transporter protein 5 (putative) 3.28008
RTP3 receptor (chemosensory) transporter protein 3 3.28008
PRR29 proline rich 29 3.28008
OR1R1 olfactory receptor family 1 subfamily R member 1 3.28008
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.28008
TG thyroglobulin 3.28008
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.28008
RNF151 ring finger protein 151 3.28008
TAS2R10 taste receptor, type 2, member 10 3.28008
ATOH7 atonal homolog 7 (Drosophila) 3.28008
FAM240A family with sequence similarity 240 member A 3.28008
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 3.28008
SETSIP SET-like protein 3.28008
MBLAC1 metallo-beta-lactamase domain containing 1 3.28008
FGL2 fibrinogen-like 2 3.28008
SPINK4 serine peptidase inhibitor, Kazal type 4 3.28008
MAL mal, T-cell differentiation protein 3.28008
RHCE Rh blood group, CcEe antigens 3.28008
IL5 interleukin 5 3.28008
TBX3 T-box 3 3.28008
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 3.28008
PGLYRP2 peptidoglycan recognition protein 2 3.28008
FMR1NB fragile X mental retardation 1 neighbor 3.28008
PLEK2 pleckstrin 2 3.28008
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.28008
OR7D2 olfactory receptor, family 7, subfamily D, member 2 3.28008
SPRR2A small proline-rich protein 2A 3.28008
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.28008
SMPX small muscle protein, X-linked 3.28008
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 3.28008
IMPG1 interphotoreceptor matrix proteoglycan 1 3.28008
OR51M1 olfactory receptor, family 51, subfamily M, member 1 3.28008
MTNR1B melatonin receptor 1B 3.28008
OTOS otospiralin 3.28008
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.28008
ZACN zinc activated ligand-gated ion channel 3.28008
SOX1 SRY (sex determining region Y)-box 1 3.28008
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.28008
SLFN11 schlafen family member 11 3.28008
SMIM38 small integral membrane protein 38 3.28008
FOLR1 folate receptor 1 (adult) 3.28008
MYOCOS myocilin opposite strand 3.28008
KLHL35 kelch-like family member 35 3.28008
TBX20 T-box 20 3.28008
STING1 stimulator of interferon response cGAMP interactor 1 3.28008
FPR1 formyl peptide receptor 1 3.28008
KLF17 Kruppel-like factor 17 3.28008
RGS9BP regulator of G protein signaling 9 binding protein 3.28008
MT3 metallothionein 3 3.28008
RS1 retinoschisin 1 3.28008
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 3.28008
SOST sclerostin 3.28008
DLX5 distal-less homeobox 5 3.28008
KLF2 Kruppel-like factor 2 3.28008
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.28008
CFP complement factor properdin 3.28008
LYPD5 LY6/PLAUR domain containing 5 3.28008
QRFP pyroglutamylated RFamide peptide 3.28008
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 3.28008
EFCC1 EF-hand and coiled-coil domain containing 1 3.28008
CH25H cholesterol 25-hydroxylase 3.28008
RAB6C RAB6C, member RAS oncogene family 3.28008
SH2D1B SH2 domain containing 1B 3.28008
PMP2 peripheral myelin protein 2 3.28008
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.28008
DES desmin 3.28008
GPR50 G protein-coupled receptor 50 3.28008
ZMYND10 zinc finger, MYND-type containing 10 3.28008
GOLGA6B golgin A6 family, member B 3.28008
TDRD10 tudor domain containing 10 3.28008
GLT1D1 glycosyltransferase 1 domain containing 1 3.28008
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.28008
MAGED4B melanoma antigen family D4B 3.28008
LRRC10 leucine rich repeat containing 10 3.28008
FAM135B family with sequence similarity 135, member B 3.28008
KLK15 kallikrein-related peptidase 15 3.28008
LHX2 LIM homeobox 2 3.28008
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.28008
NRIP2 nuclear receptor interacting protein 2 3.28008
IL19 interleukin 19 3.28008
MUC17 mucin 17, cell surface associated 3.28008
WNT7B wingless-type MMTV integration site family, member 7B 3.28008
PCDHGA2 protocadherin gamma subfamily A, 2 3.28008
PSKH2 protein serine kinase H2 3.28008
NIPAL4 NIPA-like domain containing 4 3.28008
NPFFR1 neuropeptide FF receptor 1 3.28008
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.28008
DMTN dematin actin binding protein 3.28008
PGPEP1L pyroglutamyl-peptidase I-like 3.28008
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.28008
GOLGA8J golgin A8 family, member J 3.28008
CD8B CD8b molecule 3.28008
GPR61 G protein-coupled receptor 61 3.28008
IL33 interleukin 33 3.28008
GOLGA8K golgin A8 family, member K 3.28008
CIB4 calcium and integrin binding family member 4 3.28008
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 3.28008
CLEC1A C-type lectin domain family 1, member A 3.28008
TGM4 transglutaminase 4 3.28008
LMX1A LIM homeobox transcription factor 1, alpha 3.28008
ACKR2 atypical chemokine receptor 2 3.28008
ANGPTL3 angiopoietin-like 3 3.28008
GRAPL GRB2-related adaptor protein-like 3.28008
TBC1D26 TBC1 domain family, member 26 3.28008
POU3F2 POU class 3 homeobox 2 3.28008
MEPE matrix extracellular phosphoglycoprotein 3.28008
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.28008
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 3.25127
NOTO notochord homeobox 3.23002
PRRC2C proline-rich coiled-coil 2C 3.23002
AXDND1 axonemal dynein light chain domain containing 1 3.23002
PEX5L peroxisomal biogenesis factor 5-like 3.17792
CENPB centromere protein B, 80kDa 2.97092
KIF1A kinesin family member 1A 2.96907
REEP2 receptor accessory protein 2 2.91122
UNC5CL unc-5 homolog C (C. elegans)-like 2.89783
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.89603
CALHM2 calcium homeostasis modulator 2 2.88554
DUSP15 dual specificity phosphatase 15 2.83763
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 2.80398
MCUR1 mitochondrial calcium uniporter regulator 1 2.74664
BBS2 Bardet-Biedl syndrome 2 2.52232
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.50524
RASA1 RAS p21 protein activator (GTPase activating protein) 1 2.50161
BHLHE40 basic helix-loop-helix family, member e40 2.44293
ZDHHC9 zinc finger, DHHC-type containing 9 2.40042
ADGRE2 adhesion G protein-coupled receptor E2 2.35652
NPAS3 neuronal PAS domain protein 3 2.35652
TMEM39A transmembrane protein 39A 2.35652
HDAC6 histone deacetylase 6 2.35624
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 2.33333
ZNF446 zinc finger protein 446 2.33333
CATSPERT catsper channel auxiliary subunit tau 2.33333
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.33333
MMP19 matrix metallopeptidase 19 2.33333
TMT1B thiol methyltransferase 1B 2.33333
SHISAL2A shisa like 2A 2.33333
LBP lipopolysaccharide binding protein 2.33333
ARHGAP30 Rho GTPase activating protein 30 2.33333
PNMA8C PNMA family member 8C 2.33333
VTCN1 V-set domain containing T cell activation inhibitor 1 2.33333
SP1 Sp1 transcription factor 2.33333
STK17B serine/threonine kinase 17b 2.33333
MEI1 meiosis inhibitor 1 2.33333
DNAAF8 dynein axonemal assembly factor 8 2.31036
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.31036
ZNF875 zinc finger protein 875 2.29617
UST uronyl-2-sulfotransferase 2.2789
TAL2 T-cell acute lymphocytic leukemia 2 2.27841
ZNF644 zinc finger protein 644 2.26238
KIF27 kinesin family member 27 2.25263
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.24769
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 2.21044
ULK2 unc-51 like autophagy activating kinase 2 2.19141
PAQR5 progestin and adipoQ receptor family member V 2.19141
RFX7 regulatory factor X, 7 2.18719
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 2.17803
FMN1 formin 1 2.13751
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.13353
MCM8 minichromosome maintenance complex component 8 2.12945
NOVA2 neuro-oncological ventral antigen 2 2.12945
CCR10 chemokine (C-C motif) receptor 10 2.12945
RPAIN RPA interacting protein 2.12945
HTT huntingtin 2.12945
NR5A2 nuclear receptor subfamily 5, group A, member 2 2.12602
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.10369
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.10073
NISCH nischarin 2.07828
PODXL2 podocalyxin-like 2 2.07828
TBCD tubulin folding cofactor D 2.07171
F13A1 coagulation factor XIII, A1 polypeptide 2.07171
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 2.06706
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 2.05373
SFXN5 sideroflexin 5 2.04497
FAT1 FAT atypical cadherin 1 2.02604
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 2.01981
BBS9 Bardet-Biedl syndrome 9 2.0167

decreased expression

Symbol Name Standardized Value
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -3.38694
TYMP thymidine phosphorylase -3.33216
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -3.33216
TAS2R31 taste receptor, type 2, member 31 -3.33216
PCDH9 protocadherin 9 -3.33216
CERCAM cerebral endothelial cell adhesion molecule -3.33216
SRPRB signal recognition particle receptor, B subunit -3.28008
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -3.23851
LRRC63 leucine rich repeat containing 63 -3.23002
CSNK2A3 casein kinase 2, alpha 3 polypeptide -3.23002
H4C11 H4 clustered histone 11 -3.23002
BTBD19 BTB (POZ) domain containing 19 -3.23002
AHSG alpha-2-HS-glycoprotein -3.23002
SPDYE2B speedy/RINGO cell cycle regulator family member E2B -3.23002
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -3.23002
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -3.23002
RTN4RL1 reticulon 4 receptor-like 1 -3.23002
DRP2 dystrophin related protein 2 -3.23002
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 -3.23002
PVALEF parvalbumin like EF-hand containing -3.23002
SMIM31 small integral membrane protein 31 -3.23002
ACP4 acid phosphatase 4 -3.23002
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -3.23002
C3ORF80 chromosome 3 open reading frame 80 -3.23002
DAO D-amino-acid oxidase -3.23002
IRF4 interferon regulatory factor 4 -3.23002
CCDC13 coiled-coil domain containing 13 -3.23002
LBHD1 LBH domain containing 1 -3.23002
UPK3A uroplakin 3A -3.23002
BTLA B and T lymphocyte associated -3.23002
MTTP microsomal triglyceride transfer protein -3.23002
ALOX15B arachidonate 15-lipoxygenase, type B -3.23002
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -3.23002
SLA Src-like-adaptor -3.23002
CLRN1 clarin 1 -3.23002
RANBP3L RAN binding protein 3-like -3.23002
SV2B synaptic vesicle glycoprotein 2B -3.23002
RASA4 RAS p21 protein activator 4 -3.23002
GTF2A1L general transcription factor IIA, 1-like -3.23002
LCNL1 lipocalin-like 1 -3.23002
TREH trehalase (brush-border membrane glycoprotein) -3.23002
INSYN1 inhibitory synaptic factor 1 -3.23002
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -3.23002
CSDC2 cold shock domain containing C2, RNA binding -3.23002
HIGD2B HIG1 hypoxia inducible domain family, member 2B -3.23002
BEAN1 brain expressed, associated with NEDD4, 1 -3.23002
ZNF497 zinc finger protein 497 -3.17792
HPF1 histone PARylation factor 1 -3.06937
RPL23A ribosomal protein L23a -2.95253
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) -2.9399
MAP7D3 MAP7 domain containing 3 -2.87121
ECT2L epithelial cell transforming 2 like -2.76548
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 -2.6896
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.61009
RBMX2 RNA binding motif protein, X-linked 2 -2.52778
ECRG4 ECRG4 augurin precursor -2.52383
SLC49A3 solute carrier family 49 member 3 -2.51285
IFT57 intraflagellar transport 57 -2.50658
NXNL2 nucleoredoxin-like 2 -2.50524
MRPL52 mitochondrial ribosomal protein L52 -2.43986
ZFP36L2 ZFP36 ring finger protein-like 2 -2.41067
PP2D1 protein phosphatase 2C-like domain containing 1 -2.35942
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.33492
CALHM6 calcium homeostasis modulator family member 6 -2.33333
RPS15A ribosomal protein S15a -2.33333
PBRM1 polybromo 1 -2.33333
ACAT2 acetyl-CoA acetyltransferase 2 -2.31669
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -2.31665
JPH2 junctophilin 2 -2.29617
RBP5 retinol binding protein 5, cellular -2.29617
IL32 interleukin 32 -2.29617
GPAT3 glycerol-3-phosphate acyltransferase 3 -2.28711
DCXR dicarbonyl/L-xylulose reductase -2.27841
MBTPS2 membrane-bound transcription factor peptidase, site 2 -2.26606
MTA2 metastasis associated 1 family, member 2 -2.25454
ACBD3 acyl-CoA binding domain containing 3 -2.25263
DUT deoxyuridine triphosphatase -2.24769
TSPAN18 tetraspanin 18 -2.24769
TTLL11 tubulin tyrosine ligase-like family member 11 -2.2445
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.21424
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -2.21406
PTMS parathymosin -2.20903
ZNF469 zinc finger protein 469 -2.18719
BTBD3 BTB (POZ) domain containing 3 -2.18016
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -2.17882
FOXH1 forkhead box H1 -2.17803
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.17803
MAP10 microtubule-associated protein 10 -2.1681
GLB1L3 galactosidase, beta 1-like 3 -2.16787
PWP2 PWP2 periodic tryptophan protein homolog (yeast) -2.15881
MFSD6 major facilitator superfamily domain containing 6 -2.15257
EXOC2 exocyst complex component 2 -2.14263
METTL25B methyltransferase like 25B -2.14133
FANCF Fanconi anemia, complementation group F -2.13353
ALX1 ALX homeobox 1 -2.12945
STRC stereocilin -2.12945
CCK cholecystokinin -2.12945
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -2.12945
CLUL1 clusterin-like 1 (retinal) -2.12945
BTBD18 BTB (POZ) domain containing 18 -2.12945
MUC16 mucin 16, cell surface associated -2.12945
NRG2 neuregulin 2 -2.12945
RPLP2 ribosomal protein, large, P2 -2.12945
NINJ1 ninjurin 1 -2.12945
LRRC19 leucine rich repeat containing 19 -2.12945
HNRNPK heterogeneous nuclear ribonucleoprotein K -2.12945
ARMCX6 armadillo repeat containing, X-linked 6 -2.12945
C4ORF51 chromosome 4 open reading frame 51 -2.12945
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) -2.12945
RHD Rh blood group, D antigen -2.12945
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.11813
HSPA9 heat shock 70kDa protein 9 (mortalin) -2.08551
NEK4 NIMA-related kinase 4 -2.08546
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.06424
PSMC3IP PSMC3 interacting protein -2.05476
TTF1 transcription termination factor, RNA polymerase I -2.05476
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) -2.05373
ADCY2 adenylate cyclase 2 (brain) -2.03735
RADX RPA1 related single stranded DNA binding protein, X-linked -2.03491
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -2.03388
CHRAC1 chromatin accessibility complex 1 -2.02604
OSBPL6 oxysterol binding protein-like 6 -2.01972
DOC2B double C2-like domains, beta -2.01638