| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension. (Chemical Entities of Biological Interest Ontology, CHEBI_76607) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/16004692 |
| Similar Terms | |
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198 proteins with high or low expression in Macitentan relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC25A39 | solute carrier family 25, member 39 | 0.98 |
| MCOLN2 | mucolipin 2 | 0.84 |
| ALPK3 | alpha-kinase 3 | 0.75 |
| ZNF12 | zinc finger protein 12 | 0.7 |
| PMF1 | polyamine-modulated factor 1 | 0.58 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.55 |
| ZNF451 | zinc finger protein 451 | 0.53 |
| FAM117B | family with sequence similarity 117, member B | 0.5 |
| RNF115 | ring finger protein 115 | 0.47 |
| CCDC91 | coiled-coil domain containing 91 | 0.42 |
| DMWD | dystrophia myotonica, WD repeat containing | 0.42 |
| HFE | hemochromatosis | 0.41 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.4 |
| KIF27 | kinesin family member 27 | 0.39 |
| DCAF4 | DDB1 and CUL4 associated factor 4 | 0.39 |
| CDK18 | cyclin-dependent kinase 18 | 0.37 |
| KLC1 | kinesin light chain 1 | 0.37 |
| CDC25A | cell division cycle 25A | 0.36 |
| CCDC150 | coiled-coil domain containing 150 | 0.36 |
| ATXN7L3 | ataxin 7-like 3 | 0.36 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.35 |
| PTMA | prothymosin, alpha | 0.34 |
| C1ORF122 | chromosome 1 open reading frame 122 | 0.34 |
| MT2A | metallothionein 2A | 0.33 |
| RNF146 | ring finger protein 146 | 0.33 |
| WTIP | Wilms tumor 1 interacting protein | 0.32 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.32 |
| CXXC5 | CXXC finger protein 5 | 0.32 |
| E2F8 | E2F transcription factor 8 | 0.32 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.31 |
| UBTD1 | ubiquitin domain containing 1 | 0.31 |
| SYN1 | synapsin I | 0.3 |
| GLMP | glycosylated lysosomal membrane protein | 0.3 |
| ARHGEF17 | Rho guanine nucleotide exchange factor (GEF) 17 | 0.3 |
| AMACR | alpha-methylacyl-CoA racemase | 0.29 |
| MYH15 | myosin, heavy chain 15 | 0.29 |
| VIM | vimentin | 0.28 |
| TPM4 | tropomyosin 4 | 0.28 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.28 |
| PROSER3 | proline and serine rich 3 | 0.28 |
| YAP1 | Yes-associated protein 1 | 0.28 |
| ZNF655 | zinc finger protein 655 | 0.28 |
| ARL2BP | ADP-ribosylation factor-like 2 binding protein | 0.27 |
| SHROOM1 | shroom family member 1 | 0.27 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | 0.27 |
| PET117 | PET117 homolog (S. cerevisiae) | 0.27 |
| IL6ST | interleukin 6 signal transducer | 0.26 |
| LAMC3 | laminin, gamma 3 | 0.26 |
| H3C1 | H3 clustered histone 1 | 0.26 |
| ING4 | inhibitor of growth family, member 4 | 0.26 |
| SCAND1 | SCAN domain containing 1 | 0.26 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.26 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | 0.25 |
| PEX19 | peroxisomal biogenesis factor 19 | 0.25 |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | 0.25 |
| AHI1 | Abelson helper integration site 1 | 0.25 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.25 |
| DNAJC24 | DnaJ (Hsp40) homolog, subfamily C, member 24 | 0.25 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | 0.25 |
| SZT2 | seizure threshold 2 homolog (mouse) | 0.24 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 0.24 |
| RELT | RELT tumor necrosis factor receptor | 0.24 |
| ENTR1 | endosome associated trafficking regulator 1 | 0.24 |
| CCDC57 | coiled-coil domain containing 57 | 0.24 |
| PWWP2B | PWWP domain containing 2B | 0.24 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.24 |
| SNX33 | sorting nexin 33 | 0.24 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | 0.24 |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | 0.24 |
| GCH1 | GTP cyclohydrolase 1 | 0.24 |
| ZNF428 | zinc finger protein 428 | 0.23 |
| TNNI3K | TNNI3 interacting kinase | 0.23 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.23 |
| DMTN | dematin actin binding protein | 0.23 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.23 |
| TPM1 | tropomyosin 1 (alpha) | 0.23 |
| KAT5 | K(lysine) acetyltransferase 5 | 0.23 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.23 |
| ZNF57 | zinc finger protein 57 | 0.22 |
| DNAH6 | dynein, axonemal, heavy chain 6 | 0.22 |
| UST | uronyl-2-sulfotransferase | 0.22 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.22 |
| ZDHHC12 | zinc finger, DHHC-type containing 12 | 0.22 |
| CRELD1 | cysteine-rich with EGF-like domains 1 | 0.22 |
| SPHK2 | sphingosine kinase 2 | 0.22 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 0.22 |
| ALPK1 | alpha-kinase 1 | 0.22 |
| HELQ | helicase, POLQ-like | 0.21 |
| XIRP2 | xin actin binding repeat containing 2 | 0.21 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.21 |
| TFAP2E | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) | 0.21 |
| ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | 0.21 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.21 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | 0.21 |
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | 0.21 |
| CDX2 | caudal type homeobox 2 | 0.21 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.21 |
| MT1E | metallothionein 1E | 0.21 |
| AFG1L | AFG1 like ATPase | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ARG2 | arginase 2 | -0.94 |
| SNX16 | sorting nexin 16 | -0.77 |
| ENO1 | enolase 1, (alpha) | -0.67 |
| CFAP410 | cilia and flagella associated protein 410 | -0.66 |
| PIP | prolactin-induced protein | -0.58 |
| ZNF37A | zinc finger protein 37A | -0.57 |
| TEX15 | testis expressed 15 | -0.51 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | -0.51 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | -0.44 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | -0.43 |
| IFFO1 | intermediate filament family orphan 1 | -0.42 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.41 |
| SH3BGRL2 | SH3 domain binding glutamate-rich protein like 2 | -0.4 |
| HBB | hemoglobin, beta | -0.4 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.39 |
| CYP2U1 | cytochrome P450, family 2, subfamily U, polypeptide 1 | -0.38 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | -0.38 |
| ZNF729 | zinc finger protein 729 | -0.37 |
| ZNF263 | zinc finger protein 263 | -0.37 |
| TRAPPC6A | trafficking protein particle complex 6A | -0.37 |
| TTYH2 | tweety family member 2 | -0.36 |
| MIIP | migration and invasion inhibitory protein | -0.36 |
| BTBD11 | BTB (POZ) domain containing 11 | -0.36 |
| RHOD | ras homolog family member D | -0.36 |
| GGT7 | gamma-glutamyltransferase 7 | -0.35 |
| ZFP64 | ZFP64 zinc finger protein | -0.34 |
| DGAT1 | diacylglycerol O-acyltransferase 1 | -0.34 |
| GANC | glucosidase, alpha; neutral C | -0.34 |
| COP1 | COP1 E3 ubiquitin ligase | -0.33 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.32 |
| TMEM39B | transmembrane protein 39B | -0.32 |
| HBA1 | hemoglobin, alpha 1 | -0.32 |
| KCTD18 | potassium channel tetramerization domain containing 18 | -0.31 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | -0.31 |
| HAUS1 | HAUS augmin-like complex, subunit 1 | -0.3 |
| MITD1 | MIT, microtubule interacting and transport, domain containing 1 | -0.3 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.3 |
| C2CD3 | C2 calcium-dependent domain containing 3 | -0.3 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -0.28 |
| LENG9 | leukocyte receptor cluster (LRC) member 9 | -0.28 |
| TMEM38B | transmembrane protein 38B | -0.28 |
| MRPL50 | mitochondrial ribosomal protein L50 | -0.28 |
| HYKK | hydroxylysine kinase | -0.27 |
| TBRG1 | transforming growth factor beta regulator 1 | -0.27 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | -0.26 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | -0.26 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.26 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | -0.26 |
| ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | -0.26 |
| ZSCAN5A | zinc finger and SCAN domain containing 5A | -0.25 |
| SPICE1 | spindle and centriole associated protein 1 | -0.25 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.25 |
| PML | promyelocytic leukemia | -0.25 |
| CEP120 | centrosomal protein 120kDa | -0.25 |
| HAL | histidine ammonia-lyase | -0.25 |
| RTL8C | retrotransposon Gag like 8C | -0.24 |
| CPPED1 | calcineurin-like phosphoesterase domain containing 1 | -0.24 |
| TMEM94 | transmembrane protein 94 | -0.24 |
| GPRASP2 | G protein-coupled receptor associated sorting protein 2 | -0.24 |
| NF1 | neurofibromin 1 | -0.24 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.24 |
| RNF41 | ring finger protein 41, E3 ubiquitin protein ligase | -0.24 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.24 |
| FAT2 | FAT atypical cadherin 2 | -0.23 |
| KIZ | kizuna centrosomal protein | -0.23 |
| LMF1 | lipase maturation factor 1 | -0.23 |
| ZCCHC17 | zinc finger, CCHC domain containing 17 | -0.23 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.23 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.23 |
| ZFP36 | ZFP36 ring finger protein | -0.23 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | -0.23 |
| RETREG1 | reticulophagy regulator 1 | -0.23 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | -0.23 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | -0.22 |
| NKAPD1 | NKAP domain containing 1 | -0.22 |
| TMOD2 | tropomodulin 2 (neuronal) | -0.22 |
| MISO1 | mitochondrial inner membrane subdomain organizer 1 | -0.22 |
| SGCE | sarcoglycan, epsilon | -0.22 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.22 |
| SNX25 | sorting nexin 25 | -0.22 |
| MAP3K11 | mitogen-activated protein kinase kinase kinase 11 | -0.22 |
| TMEM184A | transmembrane protein 184A | -0.22 |
| ZNF485 | zinc finger protein 485 | -0.22 |
| CRAT | carnitine O-acetyltransferase | -0.22 |
| C2ORF42 | chromosome 2 open reading frame 42 | -0.21 |
| MTRES1 | mitochondrial transcription rescue factor 1 | -0.21 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.21 |
| FN1 | fibronectin 1 | -0.21 |
| KIAA1109 | KIAA1109 | -0.21 |
| STARD3NL | STARD3 N-terminal like | -0.21 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.21 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -0.21 |
| CASKIN1 | CASK interacting protein 1 | -0.21 |
| ZNF200 | zinc finger protein 200 | -0.21 |
| IRF7 | interferon regulatory factor 7 | -0.21 |
| PLCB4 | phospholipase C, beta 4 | -0.21 |
| FBXO44 | F-box protein 44 | -0.2 |
| FAS | Fas cell surface death receptor | -0.2 |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) | -0.2 |
