| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.123677 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0991987 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.095768 |
| SEPTIN9 | septin 9 | 0.0725573 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0686968 |
| ATP13A3 | ATPase type 13A3 | 0.0633165 |
| FLNB | filamin B, beta | 0.0625086 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0570382 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0568576 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0542519 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0524813 |
| SBF2 | SET binding factor 2 | 0.0510644 |
| OPTN | optineurin | 0.0488348 |
| NDRG1 | N-myc downstream regulated 1 | 0.0481883 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0471897 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0460388 |
| NAV2 | neuron navigator 2 | 0.0449603 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0443146 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0442804 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0426531 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0422781 |
| ZNF148 | zinc finger protein 148 | 0.0398548 |
| OGA | O-GlcNAcase | 0.0397809 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0393688 |
| C1D | C1D nuclear receptor corepressor | 0.038595 |
| RTN4 | reticulon 4 | 0.0381776 |
| STC1 | stanniocalcin 1 | 0.0371388 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0369459 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0368538 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0368165 |
| FAM107B | family with sequence similarity 107, member B | 0.0346285 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0344511 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0342347 |
| GOLGA4 | golgin A4 | 0.0339122 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0335747 |
| MSN | moesin | 0.0332538 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0329517 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0328067 |
| ARRDC3 | arrestin domain containing 3 | 0.0325401 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0323579 |
| GPC6 | glypican 6 | 0.031924 |
| FBN1 | fibrillin 1 | 0.0317982 |
| LOXL2 | lysyl oxidase-like 2 | 0.0316125 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0315826 |
| ZNF292 | zinc finger protein 292 | 0.0308514 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0307429 |
| YEATS2 | YEATS domain containing 2 | 0.0305207 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0304848 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0301076 |
| CD44 | CD44 molecule (Indian blood group) | 0.0297897 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.029746 |
| CENPF | centromere protein F, 350/400kDa | 0.0291191 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0289106 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0288292 |
| MYADM | myeloid-associated differentiation marker | 0.0286492 |
| FOSL1 | FOS-like antigen 1 | 0.0283792 |
| TPM3 | tropomyosin 3 | 0.0282135 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0281404 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0279445 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0279123 |
| AUTS2 | autism susceptibility candidate 2 | 0.0273233 |
| MB21D2 | Mab-21 domain containing 2 | 0.0272285 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0271816 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0266699 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0264388 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.026084 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0256174 |
| VEGFA | vascular endothelial growth factor A | 0.0254856 |
| ATXN1 | ataxin 1 | 0.0254673 |
| ANO6 | anoctamin 6 | 0.0254312 |
| PRKD3 | protein kinase D3 | 0.0253689 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0252828 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0252564 |
| XPO1 | exportin 1 | 0.0251751 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0250538 |
| CTSB | cathepsin B | 0.0249759 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0249011 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0246211 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0244231 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0243454 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0243367 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0242163 |
| MMP12 | matrix metallopeptidase 12 | 0.0238704 |
| SNX9 | sorting nexin 9 | 0.0238403 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0238327 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0237898 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0236514 |
| CLU | clusterin | 0.0235937 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0233732 |
| ANXA2 | annexin A2 | 0.0231022 |
| BCL2L1 | BCL2-like 1 | 0.022872 |
| MEF2A | myocyte enhancer factor 2A | 0.0228354 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0227898 |
| HELZ | helicase with zinc finger | 0.0227708 |
| HIP1 | huntingtin interacting protein 1 | 0.0227496 |
| KIAA1217 | KIAA1217 | 0.0227215 |
| INSIG2 | insulin induced gene 2 | 0.0225674 |
| LDHA | lactate dehydrogenase A | 0.022519 |
| NGLY1 | N-glycanase 1 | 0.0224617 |
| SETD5 | SET domain containing 5 | 0.0222004 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.199335 |
| TMSB10 | thymosin beta 10 | -0.195864 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.182966 |
| LOX | lysyl oxidase | -0.134442 |
| RIGI | RNA sensor RIG-I | -0.12603 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.125719 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.122974 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.121712 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.12087 |
| AHNAK | AHNAK nucleoprotein | -0.120731 |
| COL5A1 | collagen, type V, alpha 1 | -0.119351 |
| FN1 | fibronectin 1 | -0.117303 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.104743 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0957429 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.093876 |
| MX2 | MX dynamin-like GTPase 2 | -0.0791085 |
| CDH13 | cadherin 13 | -0.0772999 |
| PRSS23 | protease, serine, 23 | -0.0764833 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0748652 |
| CANX | calnexin | -0.0720833 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0699432 |
| PLAT | plasminogen activator, tissue | -0.0698393 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0639193 |
| HLA-B | major histocompatibility complex, class I, B | -0.0619269 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0600903 |
| MAP1B | microtubule-associated protein 1B | -0.0583922 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.056005 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0488259 |
| LMNA | lamin A/C | -0.0480643 |
| FSTL1 | follistatin-like 1 | -0.0477806 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0472146 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0465708 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0461267 |
| SP100 | SP100 nuclear antigen | -0.0448721 |
| MEIS2 | Meis homeobox 2 | -0.043269 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0431568 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0426776 |
| CAVIN1 | caveolae associated protein 1 | -0.0419245 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.04141 |
| RASAL2 | RAS protein activator like 2 | -0.0413477 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0408451 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0384509 |
| VCL | vinculin | -0.038255 |
| ASPH | aspartate beta-hydroxylase | -0.0379732 |
| PCDH7 | protocadherin 7 | -0.0378424 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0374457 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0372666 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0372357 |
| CUX1 | cut-like homeobox 1 | -0.0372234 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0366017 |
| EFNA5 | ephrin-A5 | -0.0365645 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0356184 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0353916 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0351794 |
| IL7R | interleukin 7 receptor | -0.0351304 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0350964 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0344922 |
| VEGFC | vascular endothelial growth factor C | -0.033288 |
| PLXNA2 | plexin A2 | -0.032877 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0323662 |
| RNF213 | ring finger protein 213 | -0.0322534 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0321529 |
| CYTH3 | cytohesin 3 | -0.0310489 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0309058 |
| SUCNR1 | succinate receptor 1 | -0.0301231 |
| AEBP2 | AE binding protein 2 | -0.0298012 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.029361 |
| S100A10 | S100 calcium binding protein A10 | -0.0289593 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.028865 |
| LRRC17 | leucine rich repeat containing 17 | -0.0287627 |
| HLA-C | major histocompatibility complex, class I, C | -0.0285011 |
| JAZF1 | JAZF zinc finger 1 | -0.0283767 |
| GLIS3 | GLIS family zinc finger 3 | -0.0281289 |
| TNS3 | tensin 3 | -0.0279373 |
| COL1A2 | collagen, type I, alpha 2 | -0.0278579 |
| SLFN5 | schlafen family member 5 | -0.027708 |
| PARD3 | par-3 family cell polarity regulator | -0.0276754 |
| CDK13 | cyclin-dependent kinase 13 | -0.0274867 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0274129 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0273835 |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | -0.0273489 |
| INTS6 | integrator complex subunit 6 | -0.027263 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0271801 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0270004 |
| MT2A | metallothionein 2A | -0.0269834 |
| COL1A1 | collagen, type I, alpha 1 | -0.0269003 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0262535 |
| SYT1 | synaptotagmin I | -0.0262439 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0260858 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | -0.0256451 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.0254841 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0253534 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0251295 |
| EHBP1 | EH domain binding protein 1 | -0.0251243 |
| EGFR | epidermal growth factor receptor | -0.0247864 |
| DCLK2 | doublecortin-like kinase 2 | -0.0245356 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0240005 |
| FMN2 | formin 2 | -0.0239323 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0237624 |
| S100A4 | S100 calcium binding protein A4 | -0.0236682 |
