| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.085054 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0614905 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0602895 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0588354 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0395938 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0358655 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.03459 |
| RRM2 | ribonucleotide reductase M2 | 0.0328174 |
| YAP1 | Yes-associated protein 1 | 0.03192 |
| RTN4 | reticulon 4 | 0.0313286 |
| TMEM41B | transmembrane protein 41B | 0.0310033 |
| MKI67 | marker of proliferation Ki-67 | 0.030902 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0306446 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0300591 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0284972 |
| YBX3 | Y box binding protein 3 | 0.0275059 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0274634 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0267502 |
| BCHE | butyrylcholinesterase | 0.0265242 |
| LDHA | lactate dehydrogenase A | 0.0261187 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.025875 |
| TNPO1 | transportin 1 | 0.0251533 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0245358 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0243096 |
| ATP11A | ATPase, class VI, type 11A | 0.0243091 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.024263 |
| ASPH | aspartate beta-hydroxylase | 0.0239123 |
| YBX1 | Y box binding protein 1 | 0.0237699 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0235147 |
| SMYD3 | SET and MYND domain containing 3 | 0.0232563 |
| WWOX | WW domain containing oxidoreductase | 0.0232447 |
| XPO1 | exportin 1 | 0.0232095 |
| CENPF | centromere protein F, 350/400kDa | 0.0230533 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0229325 |
| CKAP5 | cytoskeleton associated protein 5 | 0.022815 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.022425 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0222203 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.02177 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0216478 |
| PNN | pinin, desmosome associated protein | 0.0214946 |
| AFG3L2 | AFG3-like AAA ATPase 2 | 0.0213194 |
| THOC1 | THO complex 1 | 0.0212866 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0212397 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.020868 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0200525 |
| KLF6 | Kruppel-like factor 6 | 0.0200159 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0199789 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0195899 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | 0.0194687 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.019443 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0193496 |
| DEK | DEK proto-oncogene | 0.0192964 |
| SP3 | Sp3 transcription factor | 0.019296 |
| OGA | O-GlcNAcase | 0.0190705 |
| TBK1 | TANK-binding kinase 1 | 0.0190463 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.019034 |
| RPS4X | ribosomal protein S4, X-linked | 0.0189302 |
| TENM3 | teneurin transmembrane protein 3 | 0.0186831 |
| CLTC | clathrin, heavy chain (Hc) | 0.0185969 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0185768 |
| AXIN2 | axin 2 | 0.0184646 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0183329 |
| HMGB2 | high mobility group box 2 | 0.0182778 |
| ETNK1 | ethanolamine kinase 1 | 0.0181698 |
| CIP2A | cellular inhibitor of PP2A | 0.0180152 |
| GOLGB1 | golgin B1 | 0.0179483 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.0179421 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | 0.0176859 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0175567 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0174371 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0171427 |
| GASK1B | golgi associated kinase 1B | 0.0171106 |
| RACK1 | receptor for activated C kinase 1 | 0.0170736 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0170282 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0169835 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0168101 |
| PCBP3 | poly(rC) binding protein 3 | 0.0167817 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0167281 |
| BRD2 | bromodomain containing 2 | 0.016636 |
| CCDC88A | coiled-coil domain containing 88A | 0.0165792 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0165186 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0162616 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.0161904 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0161613 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0161425 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0161329 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0160826 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0160138 |
| SET | SET nuclear proto-oncogene | 0.0159982 |
| NEK7 | NIMA-related kinase 7 | 0.0159634 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.0158938 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0158918 |
| RBM25 | RNA binding motif protein 25 | 0.0158471 |
| VCL | vinculin | 0.015805 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0157467 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0156214 |
| TPX2 | TPX2, microtubule-associated | 0.0154865 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0154123 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0153653 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0153579 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.117975 |
| TMSB10 | thymosin beta 10 | -0.0828732 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0801727 |
| EHBP1 | EH domain binding protein 1 | -0.0688555 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0594552 |
| USP34 | ubiquitin specific peptidase 34 | -0.0593525 |
| DPYD | dihydropyrimidine dehydrogenase | -0.055131 |
| AREG | amphiregulin | -0.0501074 |
| RASAL2 | RAS protein activator like 2 | -0.0483293 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0482929 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0465489 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0444311 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.044325 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0417937 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0416402 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0399212 |
| SYT1 | synaptotagmin I | -0.0387292 |
| PTMA | prothymosin, alpha | -0.0376411 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0365259 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0362491 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0358484 |
| ANXA1 | annexin A1 | -0.0355681 |
| FSTL5 | follistatin-like 5 | -0.0354615 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.034846 |
| HMGA2 | high mobility group AT-hook 2 | -0.03388 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0338061 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0337737 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0325359 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0320434 |
| MED13L | mediator complex subunit 13-like | -0.031711 |
| NEBL | nebulette | -0.0315692 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0313206 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0312834 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0311263 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0301266 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0288443 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.028721 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0283479 |
| CLDN1 | claudin 1 | -0.0283188 |
| RPS3 | ribosomal protein S3 | -0.0281615 |
| EGR1 | early growth response 1 | -0.0277977 |
| DTNA | dystrobrevin, alpha | -0.0276614 |
| PCDH7 | protocadherin 7 | -0.0275654 |
| EGFR | epidermal growth factor receptor | -0.0274863 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0273821 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0271113 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.026935 |
| NHSL1 | NHS-like 1 | -0.0267845 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0266698 |
| SBF2 | SET binding factor 2 | -0.0265737 |
| KSR2 | kinase suppressor of ras 2 | -0.0264204 |
| NLGN1 | neuroligin 1 | -0.026162 |
| BPTF | bromodomain PHD finger transcription factor | -0.025993 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.025582 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0251991 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0251503 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0246868 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0244192 |
| NF1 | neurofibromin 1 | -0.0242736 |
| PHF14 | PHD finger protein 14 | -0.024217 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0240251 |
| RPS19 | ribosomal protein S19 | -0.0235087 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0234493 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.022846 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0228211 |
| RPL37A | ribosomal protein L37a | -0.0225157 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0222995 |
| RPS29 | ribosomal protein S29 | -0.0222119 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0220809 |
| HMGA1 | high mobility group AT-hook 1 | -0.0220789 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0220474 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0216021 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0214825 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0214558 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0213008 |
| TPI1 | triosephosphate isomerase 1 | -0.0212446 |
| CCN2 | cellular communication network factor 2 | -0.021139 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0211292 |
| TSPAN5 | tetraspanin 5 | -0.0210767 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0210224 |
| S100A11 | S100 calcium binding protein A11 | -0.0208863 |
| RPL12 | ribosomal protein L12 | -0.020871 |
| RAD50 | RAD50 homolog (S. cerevisiae) | -0.0208362 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0208117 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0206645 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0206564 |
| NABP1 | nucleic acid binding protein 1 | -0.0206174 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0205877 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0205211 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.0205088 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0204682 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0203519 |
| FNIP1 | folliculin interacting protein 1 | -0.0201612 |
| EPHA5 | EPH receptor A5 | -0.0200091 |
| TMEM135 | transmembrane protein 135 | -0.0195975 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0195459 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0194776 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0193239 |
| RPL35A | ribosomal protein L35a | -0.0191938 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0191759 |
