Macitentan_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Macitentan perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Macitentan_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0373297
MEIS2 Meis homeobox 2 0.0351657
FMN1 formin 1 0.0276462
SOS1 son of sevenless homolog 1 (Drosophila) 0.0257187
LPIN1 lipin 1 0.0243022
DSCAM Down syndrome cell adhesion molecule 0.0222218
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0211805
TENT5A terminal nucleotidyltransferase 5A 0.020457
ITPRID2 ITPR interacting domain containing 2 0.020438
PTEN phosphatase and tensin homolog 0.0203194
ZFC3H1 zinc finger, C3H1-type containing 0.0200626
FAM13A family with sequence similarity 13, member A 0.0199093
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0197103
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0183585
TMED2 transmembrane emp24 domain trafficking protein 2 0.0179664
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.017534
MEF2A myocyte enhancer factor 2A 0.0174004
CASC3 cancer susceptibility candidate 3 0.0172273
VEGFA vascular endothelial growth factor A 0.0171714
ADGRG6 adhesion G protein-coupled receptor G6 0.0170699
TRIO trio Rho guanine nucleotide exchange factor 0.0170562
WDR43 WD repeat domain 43 0.0166668
NAMPT nicotinamide phosphoribosyltransferase 0.0162515
ARHGAP9 Rho GTPase activating protein 9 0.0158083
NFE2L1 nuclear factor, erythroid 2-like 1 0.0154132
FNDC3B fibronectin type III domain containing 3B 0.0148488
ZMIZ1 zinc finger, MIZ-type containing 1 0.0142624
UBAP2L ubiquitin associated protein 2-like 0.0138821
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0134753
UBA6 ubiquitin-like modifier activating enzyme 6 0.0134365
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0130381
COPA coatomer protein complex, subunit alpha 0.0129598
RPL3 ribosomal protein L3 0.0128841
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0128156
FDXR ferredoxin reductase 0.0127509
SUCO SUN domain containing ossification factor 0.0125892
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0125566
ZEB1 zinc finger E-box binding homeobox 1 0.012454
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0124369
ARRDC3 arrestin domain containing 3 0.0120183
YEATS2 YEATS domain containing 2 0.0116873
COL18A1 collagen, type XVIII, alpha 1 0.0116658
SEPTIN9 septin 9 0.0114725
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0113749
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.011232
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0111449
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0111277
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0109294
RCOR1 REST corepressor 1 0.0108351
HSPA8 heat shock 70kDa protein 8 0.0108192
CCNL1 cyclin L1 0.0106581
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0105171
ZNF148 zinc finger protein 148 0.0104013
NCAM2 neural cell adhesion molecule 2 0.0103911
PELI1 pellino E3 ubiquitin protein ligase 1 0.0103752
ANGPT1 angiopoietin 1 0.0103169
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0102758
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0101176
ADARB1 adenosine deaminase, RNA-specific, B1 0.0100449
ANO6 anoctamin 6 0.0100219
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0100167
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.00986025
ZCCHC7 zinc finger, CCHC domain containing 7 0.00977665
FHIT fragile histidine triad 0.0097728
ANK2 ankyrin 2, neuronal 0.00970278
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.00968322
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.00967711
TOX thymocyte selection-associated high mobility group box 0.00962459
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.00954595
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0094307
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.00936884
PRPF39 pre-mRNA processing factor 39 0.00936771
FRMD6 FERM domain containing 6 0.00936167
XPO1 exportin 1 0.00935087
ETNK1 ethanolamine kinase 1 0.00935025
NRG1 neuregulin 1 0.00934531
CNOT1 CCR4-NOT transcription complex, subunit 1 0.00928549
H1-3 H1.3 linker histone, cluster member 0.00925338
ANKRD50 ankyrin repeat domain 50 0.00924413
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.00922266
CAB39 calcium binding protein 39 0.00915657
SPRED1 sprouty-related, EVH1 domain containing 1 0.00912538
TNRC6B trinucleotide repeat containing 6B 0.00908576
USP12 ubiquitin specific peptidase 12 0.00902381
SREBF2 sterol regulatory element binding transcription factor 2 0.0089668
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.00896004
PAPOLA poly(A) polymerase alpha 0.00888582
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.00885047
PTPRE protein tyrosine phosphatase, receptor type, E 0.00883133
ARHGAP21 Rho GTPase activating protein 21 0.00879024
PUM2 pumilio RNA-binding family member 2 0.00873795
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.00872502
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0087009
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.00859495
ITGAV integrin, alpha V 0.00858043
RLIM ring finger protein, LIM domain interacting 0.00852157
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.00852081
LINGO2 leucine rich repeat and Ig domain containing 2 0.00849125
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.00848867
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0084823

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.26271
PTMA prothymosin, alpha -0.164357
IGF2 insulin-like growth factor 2 -0.146484
VIM vimentin -0.113657
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.10966
RPS6 ribosomal protein S6 -0.10872
RPL23 ribosomal protein L23 -0.103474
ACTG1 actin gamma 1 -0.093674
RPLP1 ribosomal protein, large, P1 -0.0898137
RPL19 ribosomal protein L19 -0.0861071
RPL35A ribosomal protein L35a -0.0802441
TPT1 tumor protein, translationally-controlled 1 -0.0751012
VCL vinculin -0.0734129
TMSB10 thymosin beta 10 -0.0730846
EIF1 eukaryotic translation initiation factor 1 -0.0729691
RPL34 ribosomal protein L34 -0.0718145
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0653254
RPL38 ribosomal protein L38 -0.0633059
RPL37A ribosomal protein L37a -0.0612346
RPS19 ribosomal protein S19 -0.0559878
RPS24 ribosomal protein S24 -0.0559393
FTL ferritin, light polypeptide -0.0552894
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0545939
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0506897
COL1A1 collagen, type I, alpha 1 -0.0506513
RPL26 ribosomal protein L26 -0.047074
LSAMP limbic system-associated membrane protein -0.0468935
RPL12 ribosomal protein L12 -0.046781
RPS3 ribosomal protein S3 -0.0463506
RPL31 ribosomal protein L31 -0.0460305
PTPRD protein tyrosine phosphatase, receptor type, D -0.0448104
RPS12 ribosomal protein S12 -0.0444683
RPS23 ribosomal protein S23 -0.0441568
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0429207
RPL32 ribosomal protein L32 -0.0410055
RPL7A ribosomal protein L7a -0.0401483
RPS14 ribosomal protein S14 -0.0393541
RPS27 ribosomal protein S27 -0.039204
RPS27A ribosomal protein S27a -0.0390128
IER3 immediate early response 3 -0.038997
RPL37 ribosomal protein L37 -0.038927
RPL36 ribosomal protein L36 -0.0384332
RPS8 ribosomal protein S8 -0.0378083
RPS21 ribosomal protein S21 -0.037246
RPL27 ribosomal protein L27 -0.0365988
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0363053
S100A9 S100 calcium binding protein A9 -0.0357136
NAP1L1 nucleosome assembly protein 1-like 1 -0.0355751
RPLP0 ribosomal protein, large, P0 -0.0354041
RPS25 ribosomal protein S25 -0.0353067
S100A6 S100 calcium binding protein A6 -0.0352215
RPL35 ribosomal protein L35 -0.0347069
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0346827
RACK1 receptor for activated C kinase 1 -0.0345619
RPS29 ribosomal protein S29 -0.0340059
RPS11 ribosomal protein S11 -0.0339775
B2M beta-2-microglobulin -0.0336143
RPL28 ribosomal protein L28 -0.0334326
TLE4 transducin-like enhancer of split 4 -0.0331204
EGR1 early growth response 1 -0.033113
BPTF bromodomain PHD finger transcription factor -0.032933
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0321208
RPS17 ribosomal protein S17 -0.0316894
DCAF7 DDB1 and CUL4 associated factor 7 -0.0308615
AKAP12 A kinase (PRKA) anchor protein 12 -0.0307355
H3-3B H3.3 histone B -0.0304971
RPL7 ribosomal protein L7 -0.0302833
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0301519
RPL9 ribosomal protein L9 -0.0300997
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0300778
RPS15 ribosomal protein S15 -0.0299371
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0296188
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0294413
RPS16 ribosomal protein S16 -0.0293456
RPL30 ribosomal protein L30 -0.0277588
RPL18 ribosomal protein L18 -0.0270017
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0263915
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0260586
RPS20 ribosomal protein S20 -0.025742
RPS5 ribosomal protein S5 -0.0255425
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0255307
PKM pyruvate kinase, muscle -0.0254055
RPS13 ribosomal protein S13 -0.025403
RPL11 ribosomal protein L11 -0.0253891
RPLP2 ribosomal protein, large, P2 -0.0251962
RPL36A ribosomal protein L36a -0.0235748
LMNA lamin A/C -0.0232152
TPM1 tropomyosin 1 (alpha) -0.0230648
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0229037
GNAS GNAS complex locus -0.0228372
RPL5 ribosomal protein L5 -0.0223689
TPI1 triosephosphate isomerase 1 -0.0222408
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0215645
RPL8 ribosomal protein L8 -0.0212582
RPL10A ribosomal protein L10a -0.0211788
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0211717
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.020948
PFN1 profilin 1 -0.0207937
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.020784
WSB1 WD repeat and SOCS box containing 1 -0.0206765