| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.154196 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.13607 |
| INTS6 | integrator complex subunit 6 | 0.0908921 |
| PHF3 | PHD finger protein 3 | 0.071239 |
| ANXA2 | annexin A2 | 0.0706851 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0687105 |
| SMAD3 | SMAD family member 3 | 0.0680233 |
| PLSCR2 | phospholipid scramblase 2 | 0.060872 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0586735 |
| IFNGR1 | interferon gamma receptor 1 | 0.0552998 |
| EFNB2 | ephrin-B2 | 0.0530819 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0514464 |
| DSPP | dentin sialophosphoprotein | 0.0475116 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0443268 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0443255 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0438674 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.042466 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0404499 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0399767 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0399727 |
| MLPH | melanophilin | 0.0397424 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0391996 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0381035 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0371704 |
| SDC4 | syndecan 4 | 0.0362128 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0357843 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | 0.0356917 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.035371 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0345285 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0342686 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0336851 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.0336506 |
| FAT1 | FAT atypical cadherin 1 | 0.0330523 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0329254 |
| PDZD8 | PDZ domain containing 8 | 0.0322566 |
| LAMA4 | laminin, alpha 4 | 0.0320392 |
| TC2N | tandem C2 domains, nuclear | 0.0301948 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0294803 |
| SERINC5 | serine incorporator 5 | 0.0292628 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0287431 |
| POF1B | premature ovarian failure, 1B | 0.0284246 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0278143 |
| RNF43 | ring finger protein 43 | 0.0277281 |
| SQSTM1 | sequestosome 1 | 0.0262259 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0252506 |
| GOLGB1 | golgin B1 | 0.0247607 |
| DST | dystonin | 0.0246364 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0244039 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0243539 |
| RNF213 | ring finger protein 213 | 0.0242905 |
| POU2F2 | POU class 2 homeobox 2 | 0.0242136 |
| KIAA1217 | KIAA1217 | 0.0239955 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0239468 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0234575 |
| USP53 | ubiquitin specific peptidase 53 | 0.0234129 |
| CTSB | cathepsin B | 0.0227613 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0227334 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0227223 |
| PRELID2 | PRELI domain containing 2 | 0.0226182 |
| USP54 | ubiquitin specific peptidase 54 | 0.0224733 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0224154 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0221122 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | 0.0219881 |
| NABP1 | nucleic acid binding protein 1 | 0.0211034 |
| PRSS3 | protease, serine, 3 | 0.020844 |
| MCU | mitochondrial calcium uniporter | 0.0206208 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.0205998 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0204477 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0200667 |
| TMPRSS2 | transmembrane protease, serine 2 | 0.0200311 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0199695 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0198286 |
| NCKAP5 | NCK-associated protein 5 | 0.0194375 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.019231 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0189867 |
| HKDC1 | hexokinase domain containing 1 | 0.0187834 |
| KYNU | kynureninase | 0.0187114 |
| CFAP44 | cilia and flagella associated protein 44 | 0.0186327 |
| NEBL | nebulette | 0.0185791 |
| FMN1 | formin 1 | 0.0182194 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0181763 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0179617 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0178986 |
| ASPH | aspartate beta-hydroxylase | 0.0177407 |
| SUCLA2 | succinate-CoA ligase, ADP-forming, beta subunit | 0.0175557 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0174289 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0174207 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0170193 |
| LNX1 | ligand of numb-protein X 1, E3 ubiquitin protein ligase | 0.0169336 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0169199 |
| XDH | xanthine dehydrogenase | 0.0168256 |
| AEBP2 | AE binding protein 2 | 0.0166649 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0166639 |
| GLCE | glucuronic acid epimerase | 0.016538 |
| KIF16B | kinesin family member 16B | 0.0165099 |
| ANO6 | anoctamin 6 | 0.0164448 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0163382 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0162487 |
| SP100 | SP100 nuclear antigen | 0.0162115 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0161054 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.195543 |
| B2M | beta-2-microglobulin | -0.18151 |
| PTMA | prothymosin, alpha | -0.121058 |
| LCN2 | lipocalin 2 | -0.116898 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.116342 |
| LYZ | lysozyme | -0.108656 |
| HLA-B | major histocompatibility complex, class I, B | -0.100795 |
| RPS6 | ribosomal protein S6 | -0.0821855 |
| RPL35A | ribosomal protein L35a | -0.0817507 |
| TMSB10 | thymosin beta 10 | -0.0814307 |
| FTL | ferritin, light polypeptide | -0.0768658 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0760433 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0654983 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0618386 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0601015 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0597855 |
| RPL23 | ribosomal protein L23 | -0.0575232 |
| RNF149 | ring finger protein 149 | -0.0560071 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0544713 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.053701 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0527636 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | -0.0523718 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0510992 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0505563 |
| SLC38A1 | solute carrier family 38, member 1 | -0.050017 |
| RPL12 | ribosomal protein L12 | -0.0498828 |
| MT2A | metallothionein 2A | -0.0491841 |
| NDRG1 | N-myc downstream regulated 1 | -0.04699 |
| RPL34 | ribosomal protein L34 | -0.046138 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0453032 |
| MORF4L2 | mortality factor 4 like 2 | -0.0451752 |
| RPS8 | ribosomal protein S8 | -0.044973 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0442921 |
| RPLP1 | ribosomal protein, large, P1 | -0.0435883 |
| RPL19 | ribosomal protein L19 | -0.043512 |
| RPS3 | ribosomal protein S3 | -0.0421146 |
| TPI1 | triosephosphate isomerase 1 | -0.0418941 |
| SPATA13 | spermatogenesis associated 13 | -0.0416978 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0414138 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0409862 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0406949 |
| RPS24 | ribosomal protein S24 | -0.0397213 |
| RPS19 | ribosomal protein S19 | -0.0393538 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0388658 |
| RPL37A | ribosomal protein L37a | -0.038655 |
| EGR1 | early growth response 1 | -0.0381928 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0381724 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0378251 |
| H3-3B | H3.3 histone B | -0.0373902 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0373054 |
| S100A9 | S100 calcium binding protein A9 | -0.0371529 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0371453 |
| CCNL1 | cyclin L1 | -0.0371054 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0368674 |
| ERBIN | erbb2 interacting protein | -0.0363218 |
| RPL11 | ribosomal protein L11 | -0.0357887 |
| SERF2 | small EDRK-rich factor 2 | -0.0354924 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0345854 |
| POTEF | POTE ankyrin domain family, member F | -0.0345572 |
| GNAS | GNAS complex locus | -0.0344474 |
| JUN | jun proto-oncogene | -0.0343202 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0342217 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0341735 |
| HMGB1 | high mobility group box 1 | -0.034061 |
| TPM4 | tropomyosin 4 | -0.033751 |
| RPS13 | ribosomal protein S13 | -0.0335178 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0334493 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0333228 |
| RPS27 | ribosomal protein S27 | -0.0332452 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0332177 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0330524 |
| RPL37 | ribosomal protein L37 | -0.0330214 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.032924 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0326853 |
| HLA-A | major histocompatibility complex, class I, A | -0.0322801 |
| PGK1 | phosphoglycerate kinase 1 | -0.0322267 |
| EZR | ezrin | -0.0319417 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0315442 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0314561 |
| RPS23 | ribosomal protein S23 | -0.0312891 |
| VIM | vimentin | -0.031278 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.03123 |
| CSTB | cystatin B (stefin B) | -0.0308868 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0303495 |
| RPL31 | ribosomal protein L31 | -0.0303279 |
| RPL26 | ribosomal protein L26 | -0.0302663 |
| POMP | proteasome maturation protein | -0.0299138 |
| TMEM87A | transmembrane protein 87A | -0.0298579 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0297467 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.029209 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0292034 |
| TAOK3 | TAO kinase 3 | -0.0291232 |
| MT1X | metallothionein 1X | -0.0290292 |
| RPL8 | ribosomal protein L8 | -0.0290284 |
| RPS29 | ribosomal protein S29 | -0.028867 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0286868 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0286715 |
| MX2 | MX dynamin-like GTPase 2 | -0.0285382 |
| RPS12 | ribosomal protein S12 | -0.0284989 |
| DSTN | destrin (actin depolymerizing factor) | -0.0284172 |
