| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.174996 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.133373 |
| VEGFA | vascular endothelial growth factor A | 0.130212 |
| FN1 | fibronectin 1 | 0.119877 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.107347 |
| CADM1 | cell adhesion molecule 1 | 0.104282 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102501 |
| ATP13A3 | ATPase type 13A3 | 0.0977561 |
| GOLGA4 | golgin A4 | 0.0861639 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0771275 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0722834 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0709995 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0693486 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0654802 |
| LDHA | lactate dehydrogenase A | 0.0629305 |
| NAV2 | neuron navigator 2 | 0.0606779 |
| ENO1 | enolase 1, (alpha) | 0.0559582 |
| PDE10A | phosphodiesterase 10A | 0.0543831 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0533832 |
| ZNF292 | zinc finger protein 292 | 0.0532953 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0501384 |
| ARRDC3 | arrestin domain containing 3 | 0.0487651 |
| PTMA | prothymosin, alpha | 0.0477444 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0471596 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0458658 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0449301 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0432981 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0431635 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0424564 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0422842 |
| CDH13 | cadherin 13 | 0.0414496 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0410229 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.040443 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.040406 |
| PTK2 | protein tyrosine kinase 2 | 0.0403646 |
| SPAG9 | sperm associated antigen 9 | 0.0399147 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0398832 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0398541 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0388626 |
| OGA | O-GlcNAcase | 0.0383652 |
| RPL3 | ribosomal protein L3 | 0.0371963 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0371949 |
| MSN | moesin | 0.0368755 |
| COL4A1 | collagen, type IV, alpha 1 | 0.036614 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0350802 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0350618 |
| RPS3 | ribosomal protein S3 | 0.0347533 |
| QKI | QKI, KH domain containing, RNA binding | 0.0342019 |
| FOXJ3 | forkhead box J3 | 0.0340118 |
| MAP4 | microtubule-associated protein 4 | 0.0338393 |
| SMAD3 | SMAD family member 3 | 0.0333092 |
| USP3 | ubiquitin specific peptidase 3 | 0.0332075 |
| KIF1B | kinesin family member 1B | 0.0331036 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0329803 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0327559 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0326502 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0325213 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.032054 |
| MATR3 | matrin 3 | 0.0317034 |
| OPTN | optineurin | 0.0309358 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0309071 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0308152 |
| HYOU1 | hypoxia up-regulated 1 | 0.0304276 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0303284 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0303042 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0301131 |
| POSTN | periostin, osteoblast specific factor | 0.029571 |
| TPR | translocated promoter region, nuclear basket protein | 0.0295217 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0294596 |
| NDRG1 | N-myc downstream regulated 1 | 0.0293482 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0290292 |
| MED15 | mediator complex subunit 15 | 0.029005 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0289726 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0289162 |
| RPS8 | ribosomal protein S8 | 0.0289153 |
| TFG | TRK-fused gene | 0.028912 |
| LOXL2 | lysyl oxidase-like 2 | 0.0288962 |
| PRELID2 | PRELI domain containing 2 | 0.0288021 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0285098 |
| PPME1 | protein phosphatase methylesterase 1 | 0.028337 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0283177 |
| RLF | rearranged L-myc fusion | 0.0280488 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0277599 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0276474 |
| YBX1 | Y box binding protein 1 | 0.0276137 |
| COL5A1 | collagen, type V, alpha 1 | 0.0274931 |
| SETD5 | SET domain containing 5 | 0.0274379 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0273581 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0273043 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0272289 |
| MRTFA | myocardin related transcription factor A | 0.0271697 |
| BRD4 | bromodomain containing 4 | 0.0269217 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0268831 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0267397 |
| CCNY | cyclin Y | 0.0266447 |
| PDE8A | phosphodiesterase 8A | 0.026556 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0264549 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0263138 |
| DEK | DEK proto-oncogene | 0.0261917 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0258868 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.238906 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.237175 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.129932 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.124196 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.110328 |
| TMSB10 | thymosin beta 10 | -0.0968613 |
| FBN1 | fibrillin 1 | -0.0955497 |
| MT2A | metallothionein 2A | -0.0897082 |
| GLIS3 | GLIS family zinc finger 3 | -0.0863599 |
| CD44 | CD44 molecule (Indian blood group) | -0.0817806 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0794651 |
| VCL | vinculin | -0.0769135 |
| LOX | lysyl oxidase | -0.0749536 |
| COL1A2 | collagen, type I, alpha 2 | -0.0732292 |
| VIM | vimentin | -0.0712127 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0631697 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0616892 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0589701 |
| HMGA2 | high mobility group AT-hook 2 | -0.0586907 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0551524 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0545104 |
| OSMR | oncostatin M receptor | -0.0523407 |
| CNTN5 | contactin 5 | -0.0508751 |
| FTL | ferritin, light polypeptide | -0.050221 |
| PALLD | palladin, cytoskeletal associated protein | -0.0494116 |
| EGR1 | early growth response 1 | -0.0465163 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0448411 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0440516 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0436291 |
| NREP | neuronal regeneration related protein | -0.0432787 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0427585 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0421587 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0421145 |
| IER3 | immediate early response 3 | -0.0416041 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0410978 |
| HLA-B | major histocompatibility complex, class I, B | -0.0410132 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0409984 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0392921 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0354308 |
| RPL35A | ribosomal protein L35a | -0.0347893 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0345197 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0341679 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0333827 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0325376 |
| MT1X | metallothionein 1X | -0.0324598 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0321441 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0319913 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0315612 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0308741 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0306785 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0304578 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.029611 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0295898 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0291428 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0288906 |
| RIGI | RNA sensor RIG-I | -0.0287288 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0284922 |
| ASPH | aspartate beta-hydroxylase | -0.0279646 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0275031 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0258497 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0256459 |
| BPTF | bromodomain PHD finger transcription factor | -0.0253446 |
| SVIL | supervillin | -0.0253002 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0247486 |
| CLMP | CXADR-like membrane protein | -0.0246606 |
| EBF1 | early B-cell factor 1 | -0.0246081 |
| AHNAK | AHNAK nucleoprotein | -0.0244993 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0241787 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.023298 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0230359 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0229401 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0224132 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0223157 |
| RSU1 | Ras suppressor protein 1 | -0.0222364 |
| NRP1 | neuropilin 1 | -0.0220222 |
| PRSS23 | protease, serine, 23 | -0.0217171 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0214428 |
| SDC2 | syndecan 2 | -0.0210819 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0209585 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0209323 |
| CPQ | carboxypeptidase Q | -0.0208994 |
| CDK14 | cyclin-dependent kinase 14 | -0.0208705 |
| IL6 | interleukin 6 | -0.0206399 |
| NABP1 | nucleic acid binding protein 1 | -0.0206079 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0205881 |
| CALD1 | caldesmon 1 | -0.0205639 |
| TAPBP | TAP binding protein (tapasin) | -0.020546 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0204179 |
| ACTG1 | actin gamma 1 | -0.0201528 |
| NEK10 | NIMA-related kinase 10 | -0.0201456 |
| TPM1 | tropomyosin 1 (alpha) | -0.0198925 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0193637 |
| INTS6 | integrator complex subunit 6 | -0.0192615 |
| HLA-A | major histocompatibility complex, class I, A | -0.0192578 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0190676 |
| FOXP1 | forkhead box P1 | -0.018845 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0188298 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0185992 |
| S100A10 | S100 calcium binding protein A10 | -0.0185128 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0184348 |
