| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Macitentan_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.202637 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.114655 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0713775 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0659747 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0561186 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0534605 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0503259 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0487317 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0454523 |
| PEG3 | paternally expressed 3 | 0.0425273 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0407642 |
| LDHA | lactate dehydrogenase A | 0.0389846 |
| TNS1 | tensin 1 | 0.0389425 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0380086 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0373947 |
| AHR | aryl hydrocarbon receptor | 0.0373049 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0370551 |
| STK17A | serine/threonine kinase 17a | 0.0368402 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0361087 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0358828 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.035773 |
| ATP10A | ATPase, class V, type 10A | 0.0350789 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0350351 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0343597 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0337462 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0326209 |
| FAT1 | FAT atypical cadherin 1 | 0.0317297 |
| STK39 | serine threonine kinase 39 | 0.0301007 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0298303 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.0297154 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0296974 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0291303 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0291167 |
| CFB | complement factor B | 0.0283484 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0283011 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0273312 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0267901 |
| ATP11A | ATPase, class VI, type 11A | 0.0266729 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0259274 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0258248 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0254742 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0251776 |
| OSMR | oncostatin M receptor | 0.0246433 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0241961 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | 0.024151 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0239076 |
| PHF3 | PHD finger protein 3 | 0.0238376 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0236934 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0236558 |
| PHF21A | PHD finger protein 21A | 0.0234376 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0231814 |
| DST | dystonin | 0.0229926 |
| CENPF | centromere protein F, 350/400kDa | 0.0228525 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0227604 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0225291 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0222393 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0221483 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0221211 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.0218831 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.021785 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0215252 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.021145 |
| SDC4 | syndecan 4 | 0.0207709 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0207521 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.020222 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0200948 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0199819 |
| CCDC146 | coiled-coil domain containing 146 | 0.0198581 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0192522 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0190207 |
| TF | transferrin | 0.01902 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0185179 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0182098 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.0181719 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | 0.018131 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0181282 |
| CKAP5 | cytoskeleton associated protein 5 | 0.018091 |
| TMEM51 | transmembrane protein 51 | 0.0180716 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.018037 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | 0.0177465 |
| NHSL1 | NHS-like 1 | 0.0177456 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0172582 |
| MKI67 | marker of proliferation Ki-67 | 0.0172254 |
| HLF | hepatic leukemia factor | 0.0171365 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.017023 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0169302 |
| RPL41 | ribosomal protein L41 | 0.0166194 |
| LRRC1 | leucine rich repeat containing 1 | 0.0163406 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0160107 |
| BAG6 | BCL2-associated athanogene 6 | 0.0158838 |
| HLA-A | major histocompatibility complex, class I, A | 0.0158705 |
| GPC3 | glypican 3 | 0.0158193 |
| SLC6A4 | solute carrier family 6 (neurotransmitter transporter), member 4 | 0.0157294 |
| AK3 | adenylate kinase 3 | 0.0156582 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0155147 |
| RNF149 | ring finger protein 149 | 0.0155111 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0154695 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0154321 |
| ATP13A3 | ATPase type 13A3 | 0.0154122 |
| H1-0 | H1.0 linker histone | 0.0153197 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.247672 |
| IGF2 | insulin-like growth factor 2 | -0.183207 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.135028 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.113588 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.113481 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.107362 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0969248 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0727141 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0708447 |
| RPS6 | ribosomal protein S6 | -0.0660399 |
| SVIL | supervillin | -0.0599034 |
| MT2A | metallothionein 2A | -0.059895 |
| APOB | apolipoprotein B | -0.0545042 |
| RPS2 | ribosomal protein S2 | -0.0538081 |
| JMJD1C | jumonji domain containing 1C | -0.052915 |
| VCL | vinculin | -0.052038 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0500018 |
| RPL11 | ribosomal protein L11 | -0.0493366 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0490288 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0484352 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.047275 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0458617 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0453726 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0452681 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.045081 |
| RPS24 | ribosomal protein S24 | -0.0449344 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0428462 |
| UBXN4 | UBX domain protein 4 | -0.0415714 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0401401 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0397553 |
| CANX | calnexin | -0.0390349 |
| USP34 | ubiquitin specific peptidase 34 | -0.0389779 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.038849 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0382673 |
| RPS8 | ribosomal protein S8 | -0.0380258 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0373199 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0372058 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0370224 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0363443 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0362585 |
| CLTC | clathrin, heavy chain (Hc) | -0.0351405 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.034855 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0342835 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0341743 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0334004 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0332334 |
| RPS12 | ribosomal protein S12 | -0.0332051 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | -0.0331273 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0331231 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0328227 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0327711 |
| FOXP1 | forkhead box P1 | -0.0323469 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0323421 |
| RBM25 | RNA binding motif protein 25 | -0.0322042 |
| GOLGA4 | golgin A4 | -0.0316699 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0314244 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0312068 |
| CDC42 | cell division cycle 42 | -0.031169 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0310746 |
| SPAG9 | sperm associated antigen 9 | -0.0309837 |
| ITGB5 | integrin, beta 5 | -0.0308417 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0306792 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.0304165 |
| OLA1 | Obg-like ATPase 1 | -0.0301224 |
| MATR3 | matrin 3 | -0.0300489 |
| MRTFA | myocardin related transcription factor A | -0.0294847 |
| RASA2 | RAS p21 protein activator 2 | -0.0294004 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0293545 |
| RPL7 | ribosomal protein L7 | -0.0290686 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0290415 |
| RBM39 | RNA binding motif protein 39 | -0.0289963 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | -0.0289575 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0285834 |
| TMSB10 | thymosin beta 10 | -0.0285247 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0284432 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0283936 |
| ASPH | aspartate beta-hydroxylase | -0.0282488 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0282397 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.0280703 |
| RPL5 | ribosomal protein L5 | -0.0280591 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0280082 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0278478 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0277181 |
| WWC2 | WW and C2 domain containing 2 | -0.0276437 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0276339 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0276223 |
| RPS21 | ribosomal protein S21 | -0.02752 |
| PARD3 | par-3 family cell polarity regulator | -0.0271549 |
| RPL9 | ribosomal protein L9 | -0.0268177 |
| JAK1 | Janus kinase 1 | -0.0267547 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0266535 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0265938 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0265072 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0265072 |
| RPL38 | ribosomal protein L38 | -0.0264356 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0262156 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0259826 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0259081 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0256664 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0256555 |
