| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | 0.109777 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0806507 |
| PODXL | podocalyxin-like | 0.0520147 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0519226 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0501945 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0497609 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0481996 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0472034 |
| LMO7 | LIM domain 7 | 0.0378613 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0356999 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0335673 |
| SULF1 | sulfatase 1 | 0.0329415 |
| CD47 | CD47 molecule | 0.0314834 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0308435 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0278207 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.0276497 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0275429 |
| AMOTL1 | angiomotin like 1 | 0.0270645 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0267175 |
| NAV2 | neuron navigator 2 | 0.0254577 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0252642 |
| SQLE | squalene epoxidase | 0.0249827 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0244468 |
| LAMA5 | laminin, alpha 5 | 0.0242875 |
| ITGB4 | integrin, beta 4 | 0.0242294 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.024022 |
| RNF217 | ring finger protein 217 | 0.0239062 |
| PLS3 | plastin 3 | 0.0231733 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0227223 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0226454 |
| NRCAM | neuronal cell adhesion molecule | 0.0222455 |
| MTSS1 | metastasis suppressor 1 | 0.0213655 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0211823 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0211272 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0210216 |
| LAMC2 | laminin, gamma 2 | 0.0204776 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0201396 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0190384 |
| MEGF6 | multiple EGF-like-domains 6 | 0.0189793 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0186599 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0183823 |
| MXRA5 | matrix-remodelling associated 5 | 0.0182984 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.017878 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 0.0170629 |
| HDAC9 | histone deacetylase 9 | 0.0168344 |
| SULF2 | sulfatase 2 | 0.0162129 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0161773 |
| YOD1 | YOD1 deubiquitinase | 0.0159587 |
| KLF10 | Kruppel-like factor 10 | 0.015953 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0158661 |
| RCOR1 | REST corepressor 1 | 0.015832 |
| UTRN | utrophin | 0.0158223 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0153295 |
| EXOC4 | exocyst complex component 4 | 0.0153237 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0149022 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0148287 |
| STK10 | serine/threonine kinase 10 | 0.0145474 |
| SDC4 | syndecan 4 | 0.0145292 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0144426 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0142887 |
| PALLD | palladin, cytoskeletal associated protein | 0.0142181 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0142016 |
| RAD51B | RAD51 paralog B | 0.0140855 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0139783 |
| H1-0 | H1.0 linker histone | 0.0137838 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | 0.0136932 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0136843 |
| C4BPB | complement component 4 binding protein, beta | 0.0136561 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0133521 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.0132359 |
| PEDS1 | plasmanylethanolamine desaturase 1 | 0.0129858 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0128779 |
| TBC1D2 | TBC1 domain family, member 2 | 0.0128308 |
| ARHGAP23 | Rho GTPase activating protein 23 | 0.0127799 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.0127145 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.0126791 |
| DR1 | down-regulator of transcription 1, TBP-binding (negative cofactor 2) | 0.0126763 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0126727 |
| PLXNA2 | plexin A2 | 0.0126659 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0125447 |
| SH3RF3 | SH3 domain containing ring finger 3 | 0.0125038 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0123738 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0122862 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0122593 |
| FZD4 | frizzled class receptor 4 | 0.0121116 |
| PIR | pirin (iron-binding nuclear protein) | 0.012001 |
| C1D | C1D nuclear receptor corepressor | 0.0119002 |
| PLXNA3 | plexin A3 | 0.0118329 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0117992 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.011792 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0117893 |
| KLF6 | Kruppel-like factor 6 | 0.0117568 |
| TNS3 | tensin 3 | 0.0117346 |
| HMGA2 | high mobility group AT-hook 2 | 0.0115377 |
| IGF2 | insulin-like growth factor 2 | 0.0114618 |
| KIAA1671 | KIAA1671 | 0.0114237 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0111956 |
| MEF2D | myocyte enhancer factor 2D | 0.0111845 |
| MECOM | MDS1 and EVI1 complex locus | 0.0111077 |
| KRT6A | keratin 6A, type II | 0.0110876 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.157651 |
| NDRG1 | N-myc downstream regulated 1 | -0.125118 |
| RPS6 | ribosomal protein S6 | -0.100404 |
| MYOF | myoferlin | -0.0976181 |
| MT2A | metallothionein 2A | -0.0927537 |
| RPS2 | ribosomal protein S2 | -0.0773071 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0765465 |
| RPS21 | ribosomal protein S21 | -0.073504 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0734275 |
| RPS8 | ribosomal protein S8 | -0.0718924 |
| CANX | calnexin | -0.0665772 |
| TMSB4X | thymosin beta 4, X-linked | -0.0633185 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0609381 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0609174 |
| RPL11 | ribosomal protein L11 | -0.0603453 |
| CUL4B | cullin 4B | -0.0594871 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0594454 |
| RPS13 | ribosomal protein S13 | -0.0566386 |
| PTMA | prothymosin, alpha | -0.0562406 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0559391 |
| RPLP2 | ribosomal protein, large, P2 | -0.0542815 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0520201 |
| B2M | beta-2-microglobulin | -0.0516914 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0487292 |
| LMNA | lamin A/C | -0.0484508 |
| RPS12 | ribosomal protein S12 | -0.045963 |
| S100A10 | S100 calcium binding protein A10 | -0.0455564 |
| CLU | clusterin | -0.0450324 |
| TMSB10 | thymosin beta 10 | -0.0449238 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0444599 |
| RPS25 | ribosomal protein S25 | -0.0438451 |
| ASPH | aspartate beta-hydroxylase | -0.0438344 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0437754 |
| GOLGA4 | golgin A4 | -0.0434462 |
| MORF4L2 | mortality factor 4 like 2 | -0.0430728 |
| DSTN | destrin (actin depolymerizing factor) | -0.0429918 |
| RPS24 | ribosomal protein S24 | -0.0427165 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0426802 |
| RBM39 | RNA binding motif protein 39 | -0.0420394 |
| RPLP1 | ribosomal protein, large, P1 | -0.0418613 |
| GNAS | GNAS complex locus | -0.0414116 |
| RPL7A | ribosomal protein L7a | -0.041355 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0413539 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0406925 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0405763 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0399805 |
| CD44 | CD44 molecule (Indian blood group) | -0.0396675 |
| RIN2 | Ras and Rab interactor 2 | -0.0394574 |
| RPL7 | ribosomal protein L7 | -0.0390527 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0387981 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0380643 |
| RPL37 | ribosomal protein L37 | -0.0378479 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0375154 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0374209 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0367582 |
| YBX3 | Y box binding protein 3 | -0.0365148 |
| RPL12 | ribosomal protein L12 | -0.0362958 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0362835 |
| PKM | pyruvate kinase, muscle | -0.0361357 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0354977 |
| AHNAK | AHNAK nucleoprotein | -0.0354382 |
| TPX2 | TPX2, microtubule-associated | -0.0349628 |
| RPL37A | ribosomal protein L37a | -0.0349336 |
| MEF2A | myocyte enhancer factor 2A | -0.0346597 |
| TOP1 | topoisomerase (DNA) I | -0.0345155 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0343854 |
| CLTC | clathrin, heavy chain (Hc) | -0.0338761 |
| PGK1 | phosphoglycerate kinase 1 | -0.033755 |
| TPM3 | tropomyosin 3 | -0.0337528 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0330102 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0329584 |
| EFHD2 | EF-hand domain family, member D2 | -0.0328796 |
| TXNIP | thioredoxin interacting protein | -0.0328267 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0327753 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0326937 |
| CALU | calumenin | -0.0324985 |
| SMAD3 | SMAD family member 3 | -0.0323749 |
| RPL23 | ribosomal protein L23 | -0.0322523 |
| RPL26 | ribosomal protein L26 | -0.0321238 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0320561 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0317698 |
| RPS3 | ribosomal protein S3 | -0.031372 |
| KRT17 | keratin 17, type I | -0.0313576 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0313391 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0312882 |
| RPL8 | ribosomal protein L8 | -0.0307168 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0306366 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0303916 |
| RPS19 | ribosomal protein S19 | -0.030305 |
| MATR3 | matrin 3 | -0.0301841 |
| RPS29 | ribosomal protein S29 | -0.0299488 |
| ADAR | adenosine deaminase, RNA-specific | -0.0297007 |
| UBC | ubiquitin C | -0.029662 |
| HLA-B | major histocompatibility complex, class I, B | -0.0288897 |
| RPL5 | ribosomal protein L5 | -0.0288599 |
| ARRDC3 | arrestin domain containing 3 | -0.0288475 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0287614 |
| RPL27A | ribosomal protein L27a | -0.0286965 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0284389 |
| JMJD1C | jumonji domain containing 1C | -0.0284305 |
