| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FGFR2 | fibroblast growth factor receptor 2 | 0.358726 |
| GOLGA4 | golgin A4 | 0.0714349 |
| LMO7 | LIM domain 7 | 0.0675178 |
| KLHL29 | kelch-like family member 29 | 0.0600608 |
| AREG | amphiregulin | 0.0599081 |
| HM13 | histocompatibility (minor) 13 | 0.0569616 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0567243 |
| GOLGB1 | golgin B1 | 0.0523682 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0498089 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0487857 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0471565 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0445238 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0431503 |
| PMM2 | phosphomannomutase 2 | 0.0427154 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0425158 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0407264 |
| SQSTM1 | sequestosome 1 | 0.0396215 |
| EMP1 | epithelial membrane protein 1 | 0.0388102 |
| RPS3 | ribosomal protein S3 | 0.0373451 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0365597 |
| INTS6 | integrator complex subunit 6 | 0.0361477 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0347471 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0345379 |
| RBM39 | RNA binding motif protein 39 | 0.0339213 |
| ATXN1 | ataxin 1 | 0.0337124 |
| PTMA | prothymosin, alpha | 0.0330056 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0329978 |
| SCFD1 | sec1 family domain containing 1 | 0.0325415 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0317769 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | 0.0309286 |
| MYOF | myoferlin | 0.0306638 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0302711 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0286546 |
| RPS27A | ribosomal protein S27a | 0.028652 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0286148 |
| RPL13A | ribosomal protein L13a | 0.028151 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0280078 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0276945 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0276903 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0276559 |
| KRT17 | keratin 17, type I | 0.0274815 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.026716 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0266483 |
| RPL37A | ribosomal protein L37a | 0.0266224 |
| CTBP2 | C-terminal binding protein 2 | 0.0265827 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.026382 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0263103 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0262992 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0262557 |
| LAMB3 | laminin, beta 3 | 0.0262378 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0256266 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0255881 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0253526 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0252007 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0250705 |
| RPL26 | ribosomal protein L26 | 0.0249592 |
| TMF1 | TATA element modulatory factor 1 | 0.0249113 |
| RPS12 | ribosomal protein S12 | 0.024911 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0248376 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.024413 |
| SETD5 | SET domain containing 5 | 0.0243142 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0242797 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0240064 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0239138 |
| MYO5B | myosin VB | 0.0237929 |
| PRDM16 | PR domain containing 16 | 0.023491 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0233056 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0231259 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.0230593 |
| ANXA2 | annexin A2 | 0.0230366 |
| SLK | STE20-like kinase | 0.0228405 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0226759 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.0220663 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0219652 |
| RPS17 | ribosomal protein S17 | 0.0217445 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0217289 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0217184 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0217154 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0214923 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | 0.0211025 |
| GAK | cyclin G associated kinase | 0.021034 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.0209192 |
| ANLN | anillin, actin binding protein | 0.0209122 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0208462 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0204966 |
| CDK13 | cyclin-dependent kinase 13 | 0.0204962 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.020419 |
| GOLGA3 | golgin A3 | 0.0202491 |
| PLEC | plectin | 0.0201338 |
| KRT86 | keratin 86, type II | 0.020126 |
| FNIP1 | folliculin interacting protein 1 | 0.0200739 |
| HKDC1 | hexokinase domain containing 1 | 0.0200542 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0200522 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0200318 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0199954 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0197886 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0197233 |
| RMND5A | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.0197068 |
| HYOU1 | hypoxia up-regulated 1 | 0.0196998 |
| DST | dystonin | 0.019679 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.190344 |
| B2M | beta-2-microglobulin | -0.107031 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0938149 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0909873 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0868766 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0826245 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0819611 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0797906 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0729124 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0708762 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0706763 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0681287 |
| ATF5 | activating transcription factor 5 | -0.067839 |
| EPCAM | epithelial cell adhesion molecule | -0.065636 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0651989 |
| TMEM123 | transmembrane protein 123 | -0.0613067 |
| S100A10 | S100 calcium binding protein A10 | -0.0601682 |
| PKM | pyruvate kinase, muscle | -0.0592419 |
| GPX2 | glutathione peroxidase 2 | -0.0582632 |
| RPS19 | ribosomal protein S19 | -0.0563047 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0560907 |
| CLDN4 | claudin 4 | -0.0540264 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0535346 |
| POTEF | POTE ankyrin domain family, member F | -0.0535056 |
| RNF213 | ring finger protein 213 | -0.0524643 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0517651 |
| CBX3 | chromobox homolog 3 | -0.0505551 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0504315 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0496814 |
| S100A11 | S100 calcium binding protein A11 | -0.0472633 |
| WWC1 | WW and C2 domain containing 1 | -0.047209 |
| S100A6 | S100 calcium binding protein A6 | -0.0469302 |
| INSIG1 | insulin induced gene 1 | -0.0461397 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0458352 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0442041 |
| ACTN4 | actinin, alpha 4 | -0.0435816 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0435374 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0427391 |
| RPS21 | ribosomal protein S21 | -0.0427165 |
| S100A9 | S100 calcium binding protein A9 | -0.0414805 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0414623 |
| PGK1 | phosphoglycerate kinase 1 | -0.0414193 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0412963 |
| MUC1 | mucin 1, cell surface associated | -0.041043 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0405989 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0400988 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0384247 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0383574 |
| CLDN7 | claudin 7 | -0.0382407 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0380357 |
| RTN4 | reticulon 4 | -0.0369144 |
| CDK6 | cyclin-dependent kinase 6 | -0.0368899 |
| RPL35A | ribosomal protein L35a | -0.036302 |
| PCBP2 | poly(rC) binding protein 2 | -0.0361902 |
| RPL35 | ribosomal protein L35 | -0.0361497 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.036025 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0352868 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0352533 |
| GNB2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 | -0.0344479 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0340909 |
| FAT1 | FAT atypical cadherin 1 | -0.0340783 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.0336262 |
| AHR | aryl hydrocarbon receptor | -0.0335758 |
| LIMA1 | LIM domain and actin binding 1 | -0.0333057 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0328598 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0325436 |
| FOXP1 | forkhead box P1 | -0.0324141 |
| PFN1 | profilin 1 | -0.0322535 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0321951 |
| CALR | calreticulin | -0.0320647 |
| CST3 | cystatin C | -0.0318755 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0315314 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0314499 |
| LYZ | lysozyme | -0.031312 |
| LCN2 | lipocalin 2 | -0.0311838 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0311596 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0309974 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0304287 |
| BSG | basigin (Ok blood group) | -0.030407 |
| RPL23 | ribosomal protein L23 | -0.0304004 |
| EGR1 | early growth response 1 | -0.030206 |
| RPL19 | ribosomal protein L19 | -0.0301346 |
| TMC5 | transmembrane channel-like 5 | -0.0301025 |
| YAP1 | Yes-associated protein 1 | -0.0300693 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0299096 |
| RBM47 | RNA binding motif protein 47 | -0.0299066 |
| ZNF292 | zinc finger protein 292 | -0.0298713 |
| XPO1 | exportin 1 | -0.0298136 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0297622 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0295192 |
| MED13 | mediator complex subunit 13 | -0.0293222 |
| TAPBP | TAP binding protein (tapasin) | -0.0292203 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0291732 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0291387 |
| RPLP1 | ribosomal protein, large, P1 | -0.0291125 |
| AGR3 | anterior gradient 3 | -0.0282713 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0279599 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.0278089 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0277323 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0276801 |
