| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.285173 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.121386 |
| VEGFA | vascular endothelial growth factor A | 0.10374 |
| ITGA6 | integrin, alpha 6 | 0.0704679 |
| FAT1 | FAT atypical cadherin 1 | 0.0681003 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0642056 |
| LMO7 | LIM domain 7 | 0.0598375 |
| LDHA | lactate dehydrogenase A | 0.0578117 |
| DSPP | dentin sialophosphoprotein | 0.0558741 |
| CD47 | CD47 molecule | 0.0518098 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.047788 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.045773 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0457076 |
| RPL3 | ribosomal protein L3 | 0.0436953 |
| KRT18 | keratin 18, type I | 0.0435823 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.0423554 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.039583 |
| FLNB | filamin B, beta | 0.0395429 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0391776 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0375256 |
| RPL21 | ribosomal protein L21 | 0.0372251 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0367794 |
| GOLGA4 | golgin A4 | 0.0367333 |
| TXNIP | thioredoxin interacting protein | 0.0342114 |
| VASP | vasodilator-stimulated phosphoprotein | 0.0342059 |
| CALB1 | calbindin 1, 28kDa | 0.0339564 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0331785 |
| PTEN | phosphatase and tensin homolog | 0.0325145 |
| SLK | STE20-like kinase | 0.0322271 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0319293 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0315449 |
| ASPH | aspartate beta-hydroxylase | 0.0314887 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.0313816 |
| PNN | pinin, desmosome associated protein | 0.0305227 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0304228 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0304121 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0303444 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0299871 |
| SETD5 | SET domain containing 5 | 0.0293847 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0289772 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0286015 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0276097 |
| SET | SET nuclear proto-oncogene | 0.027357 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0271644 |
| HDGF | hepatoma-derived growth factor | 0.0271499 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0263696 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0262331 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0260376 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0259476 |
| CCNL1 | cyclin L1 | 0.0246559 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0239697 |
| RCOR1 | REST corepressor 1 | 0.023828 |
| TMF1 | TATA element modulatory factor 1 | 0.0237742 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0235287 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0233594 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.023332 |
| EMP1 | epithelial membrane protein 1 | 0.0231554 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0230711 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.022802 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0227411 |
| YTHDC1 | YTH domain containing 1 | 0.0226993 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0225687 |
| MUC17 | mucin 17, cell surface associated | 0.0224117 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0221527 |
| KRT8 | keratin 8, type II | 0.0221336 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0219649 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0217887 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.021689 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0207955 |
| FRYL | FRY-like | 0.0207052 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0206122 |
| SVIL | supervillin | 0.0206006 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0205999 |
| ANXA1 | annexin A1 | 0.0205613 |
| FUT3 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) | 0.0203213 |
| FAM120A | family with sequence similarity 120A | 0.0202615 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0200988 |
| GATAD2A | GATA zinc finger domain containing 2A | 0.0200114 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0199011 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0198709 |
| ABHD2 | abhydrolase domain containing 2 | 0.0198169 |
| TPM3 | tropomyosin 3 | 0.0197589 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0196235 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0195095 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0194941 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0193285 |
| SLTM | SAFB-like, transcription modulator | 0.019321 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0193174 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.019245 |
| SNX9 | sorting nexin 9 | 0.0192174 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.0190759 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | 0.0185902 |
| NUP98 | nucleoporin 98kDa | 0.0184645 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0183924 |
| YBX1 | Y box binding protein 1 | 0.0183684 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0182957 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0182694 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0182205 |
| TFF1 | trefoil factor 1 | 0.0181872 |
| EZR | ezrin | 0.0181152 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.333861 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.191258 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.143764 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.121655 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0961157 |
| AHNAK | AHNAK nucleoprotein | -0.0944817 |
| TMSB10 | thymosin beta 10 | -0.0896678 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0819148 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.076774 |
| RPS24 | ribosomal protein S24 | -0.0761769 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0696532 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0684611 |
| RPL35A | ribosomal protein L35a | -0.062357 |
| CADPS | Ca++-dependent secretion activator | -0.0586719 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0584099 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0553054 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0550295 |
| NPSR1 | neuropeptide S receptor 1 | -0.0550022 |
| RPLP1 | ribosomal protein, large, P1 | -0.0520548 |
| CANX | calnexin | -0.050983 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.049437 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.049271 |
| RPL34 | ribosomal protein L34 | -0.04623 |
| RNF43 | ring finger protein 43 | -0.0438268 |
| SERINC5 | serine incorporator 5 | -0.043136 |
| GPHN | gephyrin | -0.0424611 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0422291 |
| FHIT | fragile histidine triad | -0.0418433 |
| PGK1 | phosphoglycerate kinase 1 | -0.0417667 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0414187 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0405073 |
| NEBL | nebulette | -0.0403541 |
| AGR2 | anterior gradient 2 | -0.0397099 |
| PRSS3 | protease, serine, 3 | -0.0392112 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0378458 |
| IER3 | immediate early response 3 | -0.0378193 |
| RPLP0 | ribosomal protein, large, P0 | -0.0377247 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0370399 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0363091 |
| PRELID2 | PRELI domain containing 2 | -0.0360675 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0357758 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0353451 |
| ONECUT3 | one cut homeobox 3 | -0.035272 |
| ARF1 | ADP-ribosylation factor 1 | -0.0351574 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.035001 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0339834 |
| HMGB1 | high mobility group box 1 | -0.0336658 |
| VCL | vinculin | -0.0330732 |
| EPCAM | epithelial cell adhesion molecule | -0.033061 |
| ABLIM1 | actin binding LIM protein 1 | -0.0329432 |
| RPS21 | ribosomal protein S21 | -0.0328674 |
| TFRC | transferrin receptor | -0.0323616 |
| RPL30 | ribosomal protein L30 | -0.0322486 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.031909 |
| FTL | ferritin, light polypeptide | -0.0317558 |
| RPS19 | ribosomal protein S19 | -0.0314851 |
| RPS6 | ribosomal protein S6 | -0.0313771 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0313005 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0310287 |
| GDF15 | growth differentiation factor 15 | -0.0307801 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0307262 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0304972 |
| ANTXR2 | anthrax toxin receptor 2 | -0.030486 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0300053 |
| GNAS | GNAS complex locus | -0.0299211 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0291224 |
| CCND1 | cyclin D1 | -0.0289166 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0287035 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0279169 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.027872 |
| S100A10 | S100 calcium binding protein A10 | -0.0275258 |
| CD44 | CD44 molecule (Indian blood group) | -0.0274487 |
| RRBP1 | ribosome binding protein 1 | -0.0268874 |
| INSIG1 | insulin induced gene 1 | -0.026628 |
| EREG | epiregulin | -0.026322 |
| HDLBP | high density lipoprotein binding protein | -0.0263217 |
| ACTG1 | actin gamma 1 | -0.0262341 |
| H3-3B | H3.3 histone B | -0.0262147 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.026144 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0258285 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0256288 |
| RPL27A | ribosomal protein L27a | -0.0255845 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0255387 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | -0.0254524 |
| ACTN4 | actinin, alpha 4 | -0.0252048 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0252024 |
| DENND4C | DENN/MADD domain containing 4C | -0.0249566 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0249364 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0249152 |
| RPL11 | ribosomal protein L11 | -0.024859 |
| ZNF292 | zinc finger protein 292 | -0.0248023 |
| RPL38 | ribosomal protein L38 | -0.0246475 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0244967 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0244421 |
| PIGR | polymeric immunoglobulin receptor | -0.0243924 |
| NFIA | nuclear factor I/A | -0.0243294 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0240957 |
| RTN3 | reticulon 3 | -0.0240329 |
| CLTC | clathrin, heavy chain (Hc) | -0.0240261 |
| RPL4 | ribosomal protein L4 | -0.0238067 |
