| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Macitentan_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.161786 |
| DST | dystonin | 0.136523 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.12984 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.100139 |
| TMSB4X | thymosin beta 4, X-linked | 0.0700952 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0686581 |
| RPL26 | ribosomal protein L26 | 0.063748 |
| EHBP1 | EH domain binding protein 1 | 0.0633022 |
| LDHA | lactate dehydrogenase A | 0.0623691 |
| SET | SET nuclear proto-oncogene | 0.0618851 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0594767 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0588145 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0529544 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0524732 |
| TNS3 | tensin 3 | 0.0519571 |
| EFNA5 | ephrin-A5 | 0.0496518 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0491065 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0486629 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0483666 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0472913 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0466922 |
| CENPF | centromere protein F, 350/400kDa | 0.0452949 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0448946 |
| RPS3 | ribosomal protein S3 | 0.0446979 |
| KLF6 | Kruppel-like factor 6 | 0.0432783 |
| RPS27A | ribosomal protein S27a | 0.0415823 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.040321 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0392304 |
| PDE10A | phosphodiesterase 10A | 0.0390414 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.038507 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0378428 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0378406 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0351282 |
| MYOF | myoferlin | 0.0346878 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0330634 |
| EPHA4 | EPH receptor A4 | 0.0327991 |
| CFAP299 | cilia and flagella associated protein 299 | 0.0323706 |
| HDAC9 | histone deacetylase 9 | 0.0314999 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0314774 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0311825 |
| CADM2 | cell adhesion molecule 2 | 0.0307574 |
| CANX | calnexin | 0.0307307 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0306805 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0304085 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0302484 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0298364 |
| OGA | O-GlcNAcase | 0.0298247 |
| RPL37A | ribosomal protein L37a | 0.0293936 |
| DENND1A | DENN/MADD domain containing 1A | 0.028977 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0287694 |
| STK17A | serine/threonine kinase 17a | 0.028512 |
| RUNX1 | runt-related transcription factor 1 | 0.0281033 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0280666 |
| YEATS2 | YEATS domain containing 2 | 0.0280634 |
| PRELID2 | PRELI domain containing 2 | 0.0280101 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0279272 |
| CALR | calreticulin | 0.0276452 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0273848 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.027044 |
| RPS12 | ribosomal protein S12 | 0.0270335 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0268157 |
| RASAL2 | RAS protein activator like 2 | 0.0266552 |
| RNF213 | ring finger protein 213 | 0.0265602 |
| SFPQ | splicing factor proline/glutamine-rich | 0.02611 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0260711 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0260166 |
| CD44 | CD44 molecule (Indian blood group) | 0.0255287 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0253771 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0252566 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0252466 |
| OPTN | optineurin | 0.0250546 |
| RPL13A | ribosomal protein L13a | 0.0250154 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0242992 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0237515 |
| RGS4 | regulator of G-protein signaling 4 | 0.0236942 |
| APP | amyloid beta (A4) precursor protein | 0.023573 |
| SQSTM1 | sequestosome 1 | 0.0234138 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0233925 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0233821 |
| RAD51B | RAD51 paralog B | 0.0231258 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0231167 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0225717 |
| EXOC4 | exocyst complex component 4 | 0.0225668 |
| DOCK11 | dedicator of cytokinesis 11 | 0.0220004 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0219868 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | 0.0219316 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0219039 |
| RPS8 | ribosomal protein S8 | 0.0218438 |
| LOXL2 | lysyl oxidase-like 2 | 0.0217305 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.020831 |
| HDGF | hepatoma-derived growth factor | 0.0206731 |
| FNBP4 | formin binding protein 4 | 0.0205102 |
| RAI1 | retinoic acid induced 1 | 0.0204363 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0202049 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.02012 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0199952 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0198417 |
| AHNAK | AHNAK nucleoprotein | 0.019765 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0196631 |
| CAVIN1 | caveolae associated protein 1 | 0.0195603 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.332294 |
| MT2A | metallothionein 2A | -0.284171 |
| POTEF | POTE ankyrin domain family, member F | -0.147136 |
| FTL | ferritin, light polypeptide | -0.0992095 |
| TXNRD1 | thioredoxin reductase 1 | -0.083138 |
| MT1E | metallothionein 1E | -0.0806836 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0762869 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0761082 |
| MT1X | metallothionein 1X | -0.0755251 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0740819 |
| RPL35A | ribosomal protein L35a | -0.0708774 |
| TMSB10 | thymosin beta 10 | -0.0648252 |
| EGR1 | early growth response 1 | -0.0625521 |
| VIM | vimentin | -0.0624533 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0546865 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.051422 |
| HMGA1 | high mobility group AT-hook 1 | -0.0513376 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0481411 |
| AREG | amphiregulin | -0.0470978 |
| TMEM41B | transmembrane protein 41B | -0.0437151 |
| RTN4 | reticulon 4 | -0.0415743 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0402203 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0385533 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0385016 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0383354 |
| ACTG1 | actin gamma 1 | -0.0380611 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0375458 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0374135 |
| RPS19 | ribosomal protein S19 | -0.0358489 |
| JMJD1C | jumonji domain containing 1C | -0.0354851 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0327979 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0324783 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0321701 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0314511 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0313398 |
| CCNL1 | cyclin L1 | -0.0313263 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0301457 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0299011 |
| RPL28 | ribosomal protein L28 | -0.0298807 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0294888 |
| RPLP1 | ribosomal protein, large, P1 | -0.0289474 |
| S100A6 | S100 calcium binding protein A6 | -0.02868 |
| EREG | epiregulin | -0.0283223 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0282638 |
| PRDX1 | peroxiredoxin 1 | -0.0281295 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.028012 |
| HLA-B | major histocompatibility complex, class I, B | -0.0279006 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0277355 |
| FOSL1 | FOS-like antigen 1 | -0.0277286 |
| TAPBP | TAP binding protein (tapasin) | -0.027479 |
| FBXO11 | F-box protein 11 | -0.0272854 |
| ERBIN | erbb2 interacting protein | -0.0257528 |
| PCBP2 | poly(rC) binding protein 2 | -0.0257279 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0257144 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0255057 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.025175 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0250982 |
| ANGPTL4 | angiopoietin-like 4 | -0.025027 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0247913 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0247735 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0246579 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | -0.0245815 |
| S100A10 | S100 calcium binding protein A10 | -0.0242586 |
| RPLP2 | ribosomal protein, large, P2 | -0.0238052 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0232583 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0231231 |
| SEPTIN7 | septin 7 | -0.0224982 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0223682 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0222048 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0221434 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.021759 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0216808 |
| BMERB1 | bMERB domain containing 1 | -0.0215513 |
| CDCP1 | CUB domain containing protein 1 | -0.0213946 |
| UBC | ubiquitin C | -0.0212685 |
| S100A11 | S100 calcium binding protein A11 | -0.0212636 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.021164 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0211426 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0209726 |
| RPS24 | ribosomal protein S24 | -0.0207153 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.02067 |
| RPS25 | ribosomal protein S25 | -0.0206194 |
| PKM | pyruvate kinase, muscle | -0.0203744 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0203377 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0201016 |
| MYL12B | myosin, light chain 12B, regulatory | -0.019754 |
| EMP1 | epithelial membrane protein 1 | -0.0196411 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0196156 |
| HLA-A | major histocompatibility complex, class I, A | -0.0194975 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.01936 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.019067 |
| UBXN4 | UBX domain protein 4 | -0.0185819 |
| RPLP0 | ribosomal protein, large, P0 | -0.018498 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0184559 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0182057 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0181924 |
| TPI1 | triosephosphate isomerase 1 | -0.0181693 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0181595 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0181029 |
| VMP1 | vacuole membrane protein 1 | -0.0180904 |
