| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Macitentan_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLTM | SAFB-like, transcription modulator | 0.0707215 |
| CES1 | carboxylesterase 1 | 0.0675601 |
| FAM13A | family with sequence similarity 13, member A | 0.0651453 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0650147 |
| MKI67 | marker of proliferation Ki-67 | 0.0620738 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0601432 |
| NGLY1 | N-glycanase 1 | 0.0585303 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0534793 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0511433 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0468825 |
| LAMC2 | laminin, gamma 2 | 0.0426227 |
| TXNRD1 | thioredoxin reductase 1 | 0.0419705 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0401252 |
| SPAG9 | sperm associated antigen 9 | 0.0400651 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0389968 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0377349 |
| LAMA4 | laminin, alpha 4 | 0.0368211 |
| OGA | O-GlcNAcase | 0.035946 |
| TMEM165 | transmembrane protein 165 | 0.0353879 |
| SON | SON DNA binding protein | 0.0340493 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0340199 |
| RUNX1 | runt-related transcription factor 1 | 0.0337479 |
| H1-0 | H1.0 linker histone | 0.0335438 |
| SMAD3 | SMAD family member 3 | 0.0326643 |
| LAMB3 | laminin, beta 3 | 0.0325536 |
| ARRDC3 | arrestin domain containing 3 | 0.0323354 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0317564 |
| ATP13A3 | ATPase type 13A3 | 0.0317417 |
| ZNF638 | zinc finger protein 638 | 0.0314403 |
| OSMR | oncostatin M receptor | 0.0313892 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0311567 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0307005 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0301545 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0299073 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0294828 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0285575 |
| GRAMD1B | GRAM domain containing 1B | 0.0277743 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0275181 |
| ANO6 | anoctamin 6 | 0.0267453 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0265991 |
| EP300 | E1A binding protein p300 | 0.0262377 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0260881 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0257181 |
| NDE1 | nudE neurodevelopment protein 1 | 0.024533 |
| RNF145 | ring finger protein 145 | 0.024243 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0242095 |
| ZNF292 | zinc finger protein 292 | 0.024043 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.023683 |
| TES | testin LIM domain protein | 0.0236361 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0232131 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0229711 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0229506 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0226548 |
| CSNK1E | casein kinase 1, epsilon | 0.0224713 |
| YEATS2 | YEATS domain containing 2 | 0.0224247 |
| YTHDC1 | YTH domain containing 1 | 0.022245 |
| CDCP1 | CUB domain containing protein 1 | 0.0221292 |
| MT2A | metallothionein 2A | 0.0220193 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0219322 |
| RTN4 | reticulon 4 | 0.0219026 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.021723 |
| MSN | moesin | 0.0214047 |
| HELZ | helicase with zinc finger | 0.0213517 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0213007 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0210662 |
| NCKAP1 | NCK-associated protein 1 | 0.0209478 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0206667 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0202308 |
| FAT1 | FAT atypical cadherin 1 | 0.0202177 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.020193 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0201767 |
| CCNL1 | cyclin L1 | 0.020032 |
| TET2 | tet methylcytosine dioxygenase 2 | 0.019945 |
| MYO1B | myosin IB | 0.0197986 |
| RBM39 | RNA binding motif protein 39 | 0.0197905 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0196884 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.019485 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0194564 |
| SUCO | SUN domain containing ossification factor | 0.0192249 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0191863 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0190597 |
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | 0.0189441 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0188462 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0188421 |
| ATP11B | ATPase, class VI, type 11B | 0.0187124 |
| TMEM87A | transmembrane protein 87A | 0.0181206 |
| CENPF | centromere protein F, 350/400kDa | 0.0180793 |
| EGFR | epidermal growth factor receptor | 0.0180346 |
| TPM3 | tropomyosin 3 | 0.0178403 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.0177563 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0177535 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0174688 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.0174653 |
| PAPOLA | poly(A) polymerase alpha | 0.0173738 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0173134 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.0172382 |
| RLIM | ring finger protein, LIM domain interacting | 0.0171353 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0170653 |
| ATXN7 | ataxin 7 | 0.017048 |
| RASA2 | RAS p21 protein activator 2 | 0.0169258 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.270144 |
| TMSB10 | thymosin beta 10 | -0.190457 |
| ACTG1 | actin gamma 1 | -0.128899 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.128059 |
| ASPH | aspartate beta-hydroxylase | -0.114369 |
| PTMA | prothymosin, alpha | -0.108945 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.102936 |
| S100A10 | S100 calcium binding protein A10 | -0.0983094 |
| INTS6 | integrator complex subunit 6 | -0.0957572 |
| RPL35A | ribosomal protein L35a | -0.0928852 |
| EGR1 | early growth response 1 | -0.0769691 |
| CST3 | cystatin C | -0.0747781 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0731578 |
| RPS25 | ribosomal protein S25 | -0.0708356 |
| RPS24 | ribosomal protein S24 | -0.0673643 |
| FTL | ferritin, light polypeptide | -0.0670855 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0670301 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0655122 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0606269 |
| RPL31 | ribosomal protein L31 | -0.0586409 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0581519 |
| RPLP1 | ribosomal protein, large, P1 | -0.0579882 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0567973 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0555952 |
| EFNA5 | ephrin-A5 | -0.0551312 |
| PKM | pyruvate kinase, muscle | -0.0530446 |
| AREG | amphiregulin | -0.0529782 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0527756 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0520938 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0519981 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0509775 |
| RPL34 | ribosomal protein L34 | -0.0506436 |
| HLA-B | major histocompatibility complex, class I, B | -0.0502571 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0486988 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0481543 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0470514 |
| KRT7 | keratin 7, type II | -0.0463012 |
| RPL37A | ribosomal protein L37a | -0.0456728 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0448536 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0442579 |
| RPS29 | ribosomal protein S29 | -0.0441662 |
| IER3 | immediate early response 3 | -0.043822 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0430556 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0430367 |
| RPS27A | ribosomal protein S27a | -0.0430348 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0411429 |
| CUX1 | cut-like homeobox 1 | -0.04069 |
| RPL11 | ribosomal protein L11 | -0.0403081 |
| FBXO11 | F-box protein 11 | -0.040222 |
| AGR2 | anterior gradient 2 | -0.0398472 |
| RPL37 | ribosomal protein L37 | -0.0395662 |
| RPS23 | ribosomal protein S23 | -0.039516 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.039271 |
| CCND1 | cyclin D1 | -0.0390214 |
| HOMER1 | homer scaffolding protein 1 | -0.0382431 |
| S100P | S100 calcium binding protein P | -0.0381169 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0379622 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0379109 |
| SP100 | SP100 nuclear antigen | -0.0376688 |
| RPS6 | ribosomal protein S6 | -0.037376 |
| RPS8 | ribosomal protein S8 | -0.0373365 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0370861 |
| B2M | beta-2-microglobulin | -0.0365605 |
| RPLP2 | ribosomal protein, large, P2 | -0.0354219 |
| SLC38A1 | solute carrier family 38, member 1 | -0.035344 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0347798 |
| FUS | FUS RNA binding protein | -0.0346192 |
| MCL1 | myeloid cell leukemia 1 | -0.0345893 |
| RPL19 | ribosomal protein L19 | -0.0339182 |
| ENO1 | enolase 1, (alpha) | -0.0338981 |
| TMEM184B | transmembrane protein 184B | -0.03364 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0336 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0332872 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0329577 |
| VCL | vinculin | -0.0326825 |
| SEC61G | Sec61 gamma subunit | -0.0325212 |
| S100A11 | S100 calcium binding protein A11 | -0.0321039 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0320052 |
| MYO1D | myosin ID | -0.031628 |
| AHNAK | AHNAK nucleoprotein | -0.0307451 |
| FNDC3B | fibronectin type III domain containing 3B | -0.030507 |
| PRKCA | protein kinase C, alpha | -0.0303075 |
| S100A9 | S100 calcium binding protein A9 | -0.0302948 |
| RPS17 | ribosomal protein S17 | -0.0297781 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.029601 |
| KPNB1 | karyopherin (importin) beta 1 | -0.029557 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0293933 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0293269 |
| RPS27 | ribosomal protein S27 | -0.0288811 |
| RPS14 | ribosomal protein S14 | -0.028733 |
| NDRG1 | N-myc downstream regulated 1 | -0.0285663 |
| STC1 | stanniocalcin 1 | -0.0277937 |
| RPL38 | ribosomal protein L38 | -0.0277278 |
| RPS13 | ribosomal protein S13 | -0.0275779 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0273558 |
| TRIM56 | tripartite motif containing 56 | -0.0273508 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0267369 |
| KDM3B | lysine (K)-specific demethylase 3B | -0.0266733 |
| RPL23 | ribosomal protein L23 | -0.0265919 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0262813 |
