Macitentan_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Macitentan perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Macitentan_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.102453
RBM39 RNA binding motif protein 39 0.057701
NAMPT nicotinamide phosphoribosyltransferase 0.0501752
OSMR oncostatin M receptor 0.0421313
VEGFA vascular endothelial growth factor A 0.0401483
SIK3 SIK family kinase 3 0.0348992
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0342035
SDK1 sidekick cell adhesion molecule 1 0.0338991
FNDC3B fibronectin type III domain containing 3B 0.0312313
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.031188
PRELID2 PRELI domain containing 2 0.0310227
FTH1 ferritin, heavy polypeptide 1 0.0307899
NPC1 Niemann-Pick disease, type C1 0.0303819
GRB10 growth factor receptor-bound protein 10 0.0296507
ADD3 adducin 3 (gamma) 0.026452
ZEB2 zinc finger E-box binding homeobox 2 0.0257264
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0246726
RB1CC1 RB1-inducible coiled-coil 1 0.0231556
OGA O-GlcNAcase 0.0229271
SLTM SAFB-like, transcription modulator 0.0225438
FAM13A family with sequence similarity 13, member A 0.0217892
RAB27B RAB27B, member RAS oncogene family 0.0214531
DSCAM Down syndrome cell adhesion molecule 0.0213496
RUNX2 runt-related transcription factor 2 0.0209627
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0206447
KMT2C lysine (K)-specific methyltransferase 2C 0.0204933
NAV2 neuron navigator 2 0.0202726
FAM20C family with sequence similarity 20, member C 0.0202469
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0201873
CHD1 chromodomain helicase DNA binding protein 1 0.0199591
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0198788
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0193996
GOLGA4 golgin A4 0.0193516
YEATS2 YEATS domain containing 2 0.0188128
KIAA1328 KIAA1328 0.0186522
ITCH itchy E3 ubiquitin protein ligase 0.0185884
PEX13 peroxisomal biogenesis factor 13 0.018229
TENT5A terminal nucleotidyltransferase 5A 0.01819
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0180924
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0179854
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0175222
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0171545
COG5 component of oligomeric golgi complex 5 0.0170233
RARB retinoic acid receptor, beta 0.0169
NGLY1 N-glycanase 1 0.0168608
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0166612
DOCK5 dedicator of cytokinesis 5 0.0164676
PTPRR protein tyrosine phosphatase, receptor type, R 0.0163928
UBA6 ubiquitin-like modifier activating enzyme 6 0.0163392
AKAP9 A kinase (PRKA) anchor protein 9 0.0162758
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0162582
FNBP4 formin binding protein 4 0.0161746
MYO1E myosin IE 0.0160232
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0160025
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0160003
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0156231
NF1 neurofibromin 1 0.0152164
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.014987
RND3 Rho family GTPase 3 0.0149677
EFNA5 ephrin-A5 0.0149377
ETV6 ets variant 6 0.014818
IGFBP3 insulin-like growth factor binding protein 3 0.0144066
TNNC1 troponin C type 1 (slow) 0.0143418
KLF6 Kruppel-like factor 6 0.0142566
PDE8A phosphodiesterase 8A 0.0142189
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0141666
PNN pinin, desmosome associated protein 0.0141396
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0141155
GPR107 G protein-coupled receptor 107 0.013999
RSRC2 arginine/serine-rich coiled-coil 2 0.0139956
SBF2 SET binding factor 2 0.0138993
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.0137943
EXOC6B exocyst complex component 6B 0.01368
COPA coatomer protein complex, subunit alpha 0.0136145
TMED2 transmembrane emp24 domain trafficking protein 2 0.0135356
CABIN1 calcineurin binding protein 1 0.013502
ATXN1 ataxin 1 0.0133522
ZFC3H1 zinc finger, C3H1-type containing 0.0132045
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0131996
ANO6 anoctamin 6 0.0129923
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0129043
AOPEP aminopeptidase O (putative) 0.0127914
AGFG1 ArfGAP with FG repeats 1 0.0127709
GMDS GDP-mannose 4,6-dehydratase 0.0127418
GLIPR1 GLI pathogenesis-related 1 0.0126705
TRIO trio Rho guanine nucleotide exchange factor 0.0126516
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0126256
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0125417
SAMD4A sterile alpha motif domain containing 4A 0.0124053
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0123456
VMP1 vacuole membrane protein 1 0.0122373
TAS2R14 taste receptor, type 2, member 14 0.0122027
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0121632
SKAP2 src kinase associated phosphoprotein 2 0.0120058
GLIS3 GLIS family zinc finger 3 0.0119596
TMED5 transmembrane emp24 protein transport domain containing 5 0.0119163
TTC28 tetratricopeptide repeat domain 28 0.0117071
CCNL1 cyclin L1 0.0116262
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0115324
TP53BP1 tumor protein p53 binding protein 1 0.0114315

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.189045
TMSB10 thymosin beta 10 -0.168778
VIM vimentin -0.165993
PCBP2 poly(rC) binding protein 2 -0.0896576
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.089162
UBC ubiquitin C -0.0890164
FTL ferritin, light polypeptide -0.0758138
ENO1 enolase 1, (alpha) -0.0728506
MT2A metallothionein 2A -0.0726656
CD44 CD44 molecule (Indian blood group) -0.0695506
AHNAK AHNAK nucleoprotein -0.0641673
LOX lysyl oxidase -0.062046
IER3 immediate early response 3 -0.0615227
PTMA prothymosin, alpha -0.0607107
RPS19 ribosomal protein S19 -0.054519
CDH13 cadherin 13 -0.0544016
RPL23 ribosomal protein L23 -0.0533287
RPLP1 ribosomal protein, large, P1 -0.0500406
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.048055
SOD2 superoxide dismutase 2, mitochondrial -0.0448653
PKM pyruvate kinase, muscle -0.0433574
BASP1 brain abundant, membrane attached signal protein 1 -0.0431506
NAP1L1 nucleosome assembly protein 1-like 1 -0.04289
RPLP2 ribosomal protein, large, P2 -0.0420942
SYT1 synaptotagmin I -0.0416102
PDE4D phosphodiesterase 4D, cAMP-specific -0.0407232
RPS29 ribosomal protein S29 -0.039122
CANX calnexin -0.0371119
RPL28 ribosomal protein L28 -0.0368628
RPL31 ribosomal protein L31 -0.0365268
FN1 fibronectin 1 -0.0343647
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0343591
RPL19 ribosomal protein L19 -0.0343494
TM4SF1 transmembrane 4 L six family member 1 -0.0325756
RPL12 ribosomal protein L12 -0.0321308
CALR calreticulin -0.031646
B2M beta-2-microglobulin -0.031415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0313872
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0312522
RPS25 ribosomal protein S25 -0.0311184
RPS24 ribosomal protein S24 -0.031049
RPL37A ribosomal protein L37a -0.0310404
LOC112694756 uncharaterized LOC112694756 -0.0307702
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0307033
RPS8 ribosomal protein S8 -0.030483
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0301202
RPS12 ribosomal protein S12 -0.0300789
RPS23 ribosomal protein S23 -0.0277378
ASPH aspartate beta-hydroxylase -0.0277007
RPS16 ribosomal protein S16 -0.0273228
RPLP0 ribosomal protein, large, P0 -0.027294
RPS27A ribosomal protein S27a -0.0271338
RPS5 ribosomal protein S5 -0.0270073
PGK1 phosphoglycerate kinase 1 -0.0269218
GNAS GNAS complex locus -0.0266441
RPL34 ribosomal protein L34 -0.0265957
RPS11 ribosomal protein S11 -0.0265301
TMSB4X thymosin beta 4, X-linked -0.0264627
MYO10 myosin X -0.0262872
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0260751
RPL36 ribosomal protein L36 -0.0259179
ANTXR2 anthrax toxin receptor 2 -0.0258726
DPYD dihydropyrimidine dehydrogenase -0.0256343
P4HB prolyl 4-hydroxylase, beta polypeptide -0.025589
RPL37 ribosomal protein L37 -0.0254259
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0252772
NRG1 neuregulin 1 -0.025205
PDIA4 protein disulfide isomerase family A, member 4 -0.0249047
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.024833
PRKCA protein kinase C, alpha -0.0247643
USP34 ubiquitin specific peptidase 34 -0.0246982
MAML3 mastermind-like 3 (Drosophila) -0.0246373
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0245673
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0244063
RPL35A ribosomal protein L35a -0.0243438
EGFR epidermal growth factor receptor -0.024297
ANGPTL4 angiopoietin-like 4 -0.0242282
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0240597
RPS13 ribosomal protein S13 -0.023935
POTEF POTE ankyrin domain family, member F -0.0238546
PSD3 pleckstrin and Sec7 domain containing 3 -0.0235454
MTSS1 metastasis suppressor 1 -0.0232577
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0232508
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0230281
TOP1 topoisomerase (DNA) I -0.0229939
PARD3 par-3 family cell polarity regulator -0.0229397
EIF1 eukaryotic translation initiation factor 1 -0.0228861
RPL18 ribosomal protein L18 -0.0228771
RPS6 ribosomal protein S6 -0.0224847
RPL32 ribosomal protein L32 -0.0224813
IFI6 interferon, alpha-inducible protein 6 -0.0223671
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0223591
EHBP1 EH domain binding protein 1 -0.0222264
S100A6 S100 calcium binding protein A6 -0.0220874
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0220448
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.021838
TXNRD1 thioredoxin reductase 1 -0.0216022
RPL5 ribosomal protein L5 -0.0213148
S100A10 S100 calcium binding protein A10 -0.0213026
RPS21 ribosomal protein S21 -0.0206987