| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.090108 |
| MCL1 | myeloid cell leukemia 1 | 0.0645887 |
| WDR43 | WD repeat domain 43 | 0.0593047 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0590196 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0572689 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0498892 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.048806 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0477171 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0445717 |
| RBM39 | RNA binding motif protein 39 | 0.0432634 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.042032 |
| RTN4 | reticulon 4 | 0.0410006 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0397137 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0393261 |
| NUP58 | nucleoporin 58 | 0.0385349 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0378115 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0372843 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0372258 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.036648 |
| CCNL1 | cyclin L1 | 0.0358345 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0357306 |
| BRD2 | bromodomain containing 2 | 0.0343207 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.034164 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0337403 |
| RBM25 | RNA binding motif protein 25 | 0.0325857 |
| NOP58 | NOP58 ribonucleoprotein | 0.032552 |
| FGB | fibrinogen beta chain | 0.0321258 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0317139 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0316121 |
| DENND4A | DENN/MADD domain containing 4A | 0.0304802 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0294152 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0293087 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0290776 |
| MEF2D | myocyte enhancer factor 2D | 0.0289758 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0277491 |
| YBX1 | Y box binding protein 1 | 0.0273274 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0268911 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0268368 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0268256 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0267758 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0263586 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0263429 |
| PNN | pinin, desmosome associated protein | 0.0259097 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0257996 |
| FAM168A | family with sequence similarity 168, member A | 0.0257592 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0256525 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0256254 |
| RPL3 | ribosomal protein L3 | 0.0255609 |
| HDGF | hepatoma-derived growth factor | 0.0254054 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.025208 |
| POU2F1 | POU class 2 homeobox 1 | 0.0251022 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0249352 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0246468 |
| PTK2 | protein tyrosine kinase 2 | 0.0245857 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0243685 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0242389 |
| JAK1 | Janus kinase 1 | 0.0241804 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0241538 |
| SF1 | splicing factor 1 | 0.0234926 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0234423 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0233573 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0232626 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0231813 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0230877 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0229897 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0229709 |
| ENAH | enabled homolog (Drosophila) | 0.0228478 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.022651 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.022554 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0224525 |
| RNF145 | ring finger protein 145 | 0.0223413 |
| MATR3 | matrin 3 | 0.0220733 |
| YTHDC1 | YTH domain containing 1 | 0.0218693 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.021478 |
| NPTN | neuroplastin | 0.0214303 |
| TPD52 | tumor protein D52 | 0.0213569 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0212484 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0211888 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.021129 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0210082 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0206129 |
| TFG | TRK-fused gene | 0.0205309 |
| TPM3 | tropomyosin 3 | 0.02043 |
| YME1L1 | YME1-like 1 ATPase | 0.0202876 |
| NUP93 | nucleoporin 93kDa | 0.0202645 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0202497 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0202069 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0200311 |
| NXF1 | nuclear RNA export factor 1 | 0.0196878 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0194612 |
| AFTPH | aftiphilin | 0.0194609 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0193113 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0191979 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0191849 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0191001 |
| RPS2 | ribosomal protein S2 | 0.0190884 |
| RAB18 | RAB18, member RAS oncogene family | 0.0190835 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.019079 |
| CENPF | centromere protein F, 350/400kDa | 0.0189083 |
| SIN3A | SIN3 transcription regulator family member A | 0.0189068 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.303702 |
| TXNRD1 | thioredoxin reductase 1 | -0.181853 |
| TMSB10 | thymosin beta 10 | -0.177854 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.146118 |
| NRG1 | neuregulin 1 | -0.0849292 |
| BICC1 | BicC family RNA binding protein 1 | -0.0840335 |
| FTL | ferritin, light polypeptide | -0.0710308 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0650954 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.062851 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0577542 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0565569 |
| CMIP | c-Maf inducing protein | -0.0549316 |
| RAD51B | RAD51 paralog B | -0.054404 |
| NEGR1 | neuronal growth regulator 1 | -0.053299 |
| HDAC9 | histone deacetylase 9 | -0.0527837 |
| MT2A | metallothionein 2A | -0.0506172 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0480494 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0477179 |
| EFNA5 | ephrin-A5 | -0.0476176 |
| EGFR | epidermal growth factor receptor | -0.0456635 |
| ASPH | aspartate beta-hydroxylase | -0.0454916 |
| CAVIN1 | caveolae associated protein 1 | -0.04538 |
| UTRN | utrophin | -0.0448055 |
| RPL19 | ribosomal protein L19 | -0.0444187 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0435125 |
| DST | dystonin | -0.043331 |
| ERBIN | erbb2 interacting protein | -0.0427691 |
| NTN4 | netrin 4 | -0.0424756 |
| SVIL | supervillin | -0.0422783 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0415758 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0399203 |
| GLIS3 | GLIS family zinc finger 3 | -0.0397675 |
| AK1 | adenylate kinase 1 | -0.0394509 |
| NAV3 | neuron navigator 3 | -0.0392408 |
| EHBP1 | EH domain binding protein 1 | -0.038551 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0377156 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0371424 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0370498 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0361438 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0360795 |
| STC1 | stanniocalcin 1 | -0.0357825 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0357497 |
| IGF2 | insulin-like growth factor 2 | -0.0355331 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0350208 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0350073 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0346743 |
| DOCK5 | dedicator of cytokinesis 5 | -0.03438 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0342713 |
| FLNB | filamin B, beta | -0.0341153 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0333206 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0333058 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0318538 |
| S100A6 | S100 calcium binding protein A6 | -0.0316787 |
| AHNAK | AHNAK nucleoprotein | -0.0314354 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0307982 |
| LDHA | lactate dehydrogenase A | -0.0304059 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0303097 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0302188 |
| NEBL | nebulette | -0.0298039 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0297321 |
| ZNF609 | zinc finger protein 609 | -0.0295754 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0294663 |
| RPL23 | ribosomal protein L23 | -0.0292766 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0289685 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0289056 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0288539 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0286309 |
| CNKSR3 | CNKSR family member 3 | -0.0285726 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.028431 |
| HMGA2 | high mobility group AT-hook 2 | -0.0280591 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0278767 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0278517 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0278219 |
| MYOF | myoferlin | -0.0277564 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0273123 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0272894 |
| CUX1 | cut-like homeobox 1 | -0.0270545 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0270092 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0266629 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0263547 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0262061 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0247613 |
| USP34 | ubiquitin specific peptidase 34 | -0.0244184 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0242659 |
| IER3 | immediate early response 3 | -0.0240439 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0239237 |
| FMNL2 | formin-like 2 | -0.0238111 |
| FNDC3B | fibronectin type III domain containing 3B | -0.023607 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0235475 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0235122 |
| VCL | vinculin | -0.0235003 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0234423 |
| NHSL1 | NHS-like 1 | -0.02332 |
| AHR | aryl hydrocarbon receptor | -0.0231483 |
| DENND5B | DENN/MADD domain containing 5B | -0.0224388 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0223988 |
| DOCK10 | dedicator of cytokinesis 10 | -0.0223878 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0223164 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0220511 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0219477 |
