| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Macitentan_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.171589 |
| LAMB3 | laminin, beta 3 | 0.108584 |
| PTMA | prothymosin, alpha | 0.100615 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0938056 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0856787 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0783046 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0673365 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0662295 |
| RNF149 | ring finger protein 149 | 0.0661138 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0583583 |
| ENO1 | enolase 1, (alpha) | 0.0558442 |
| B2M | beta-2-microglobulin | 0.0557137 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0556489 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0556428 |
| FAM162A | family with sequence similarity 162, member A | 0.0551061 |
| GPC6 | glypican 6 | 0.0546867 |
| PGK1 | phosphoglycerate kinase 1 | 0.0537936 |
| ZFHX3 | zinc finger homeobox 3 | 0.0510394 |
| PCBP2 | poly(rC) binding protein 2 | 0.0508493 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0489318 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0485724 |
| EZR | ezrin | 0.0482688 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0470174 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.046946 |
| RPS12 | ribosomal protein S12 | 0.0468961 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0465442 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0464007 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0458875 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0449001 |
| RAD51B | RAD51 paralog B | 0.0447424 |
| RBM39 | RNA binding motif protein 39 | 0.0431798 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0424367 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0413755 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0412281 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0411541 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0411143 |
| MORC3 | MORC family CW-type zinc finger 3 | 0.0407437 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0406067 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.0398735 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0397705 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0396042 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0390064 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0382217 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.038042 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.037739 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0372739 |
| TNPO3 | transportin 3 | 0.0372737 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0371859 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0371577 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0370241 |
| USP15 | ubiquitin specific peptidase 15 | 0.0368421 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0368139 |
| SETD5 | SET domain containing 5 | 0.036638 |
| RPS3 | ribosomal protein S3 | 0.0366297 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0365019 |
| NF1 | neurofibromin 1 | 0.036269 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0362541 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0359413 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0358452 |
| PCBP3 | poly(rC) binding protein 3 | 0.0357598 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0357054 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0350427 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0348247 |
| QSER1 | glutamine and serine rich 1 | 0.0347661 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0339561 |
| CANX | calnexin | 0.0333943 |
| LONP2 | lon peptidase 2, peroxisomal | 0.0333631 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0332362 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0332035 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0330628 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0329304 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.0328902 |
| CNOT9 | CCR4-NOT transcription complex subunit 9 | 0.0328615 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.032859 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.032833 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0326639 |
| PDE10A | phosphodiesterase 10A | 0.032414 |
| SDC4 | syndecan 4 | 0.0322006 |
| MLEC | malectin | 0.0321584 |
| DSTN | destrin (actin depolymerizing factor) | 0.0320819 |
| RPL19 | ribosomal protein L19 | 0.0319269 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0312688 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0311557 |
| PDLIM5 | PDZ and LIM domain 5 | 0.031096 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.031075 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0309853 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0306778 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0304552 |
| SMYD3 | SET and MYND domain containing 3 | 0.0303438 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0302089 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0301133 |
| MAP7 | microtubule-associated protein 7 | 0.0299331 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.029877 |
| KRT17 | keratin 17, type I | 0.0298639 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0298597 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0297792 |
| CXXC1 | CXXC finger protein 1 | 0.0294287 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0292373 |
| HYOU1 | hypoxia up-regulated 1 | 0.0288477 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0288442 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.16477 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.120679 |
| FN1 | fibronectin 1 | -0.120054 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.11393 |
| ATOSA | atos homolog A | -0.110196 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.108304 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.105496 |
| EGFR | epidermal growth factor receptor | -0.100754 |
| LAMC2 | laminin, gamma 2 | -0.0969164 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0951512 |
| MUC16 | mucin 16, cell surface associated | -0.0850921 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0844077 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0784338 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.076521 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0709295 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0664504 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0606517 |
| OSMR | oncostatin M receptor | -0.0579546 |
| ACTG1 | actin gamma 1 | -0.0574865 |
| AHNAK | AHNAK nucleoprotein | -0.0571664 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0570964 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0570459 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0558646 |
| MXD1 | MAX dimerization protein 1 | -0.0558561 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0530971 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0530715 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0525561 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0521208 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0516701 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0514294 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0502233 |
| ABHD17C | abhydrolase domain containing 17C | -0.0494338 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0492722 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0485533 |
| SPNS2 | spinster homolog 2 (Drosophila) | -0.0479503 |
| PTK2 | protein tyrosine kinase 2 | -0.0469511 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0462769 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.046158 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0449989 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0447332 |
| TXNRD1 | thioredoxin reductase 1 | -0.0446953 |
| CNKSR3 | CNKSR family member 3 | -0.0439878 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0436914 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0436054 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0434158 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.043086 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0430186 |
| DUSP5 | dual specificity phosphatase 5 | -0.042758 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0423703 |
| POTEF | POTE ankyrin domain family, member F | -0.0422471 |
| ZNF638 | zinc finger protein 638 | -0.0421785 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0414782 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0413786 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0406829 |
| RCOR1 | REST corepressor 1 | -0.0403844 |
| FAM107B | family with sequence similarity 107, member B | -0.0401613 |
| SP100 | SP100 nuclear antigen | -0.03998 |
| FBXO11 | F-box protein 11 | -0.0388762 |
| TMEM165 | transmembrane protein 165 | -0.0384451 |
| TJP2 | tight junction protein 2 | -0.0382665 |
| EXOC6B | exocyst complex component 6B | -0.0382164 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0378569 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0374174 |
| SDCBP | syndecan binding protein (syntenin) | -0.0373615 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0372365 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0368885 |
| IER3 | immediate early response 3 | -0.0366086 |
| TJP1 | tight junction protein 1 | -0.0365412 |
| INTS6 | integrator complex subunit 6 | -0.0364733 |
| MMP1 | matrix metallopeptidase 1 | -0.0364193 |
| RBM47 | RNA binding motif protein 47 | -0.0363047 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0355991 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0355471 |
| WASF2 | WAS protein family, member 2 | -0.0352194 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0352171 |
| STEAP4 | STEAP family member 4 | -0.0351853 |
| HDLBP | high density lipoprotein binding protein | -0.034482 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.034127 |
| RAI14 | retinoic acid induced 14 | -0.0340879 |
| NABP1 | nucleic acid binding protein 1 | -0.0335004 |
| PLSCR1 | phospholipid scramblase 1 | -0.0333077 |
| USP34 | ubiquitin specific peptidase 34 | -0.0332995 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0329302 |
| ERBIN | erbb2 interacting protein | -0.0328157 |
| MED13 | mediator complex subunit 13 | -0.0327274 |
| ABI1 | abl-interactor 1 | -0.0325455 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0322611 |
| UBC | ubiquitin C | -0.0322448 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0319829 |
| SCEL | sciellin | -0.0314492 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0314092 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0313418 |
| IGF2 | insulin-like growth factor 2 | -0.0312709 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0310291 |
| TGFA | transforming growth factor, alpha | -0.030909 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0308989 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0308873 |
| SVIL | supervillin | -0.030631 |
| MMP12 | matrix metallopeptidase 12 | -0.0305847 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0303228 |
