Macitentan_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Macitentan perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Macitentan_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.0573278
SFPQ splicing factor proline/glutamine-rich 0.039824
GRAMD1B GRAM domain containing 1B 0.038891
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0346434
ANKRD36 ankyrin repeat domain 36 0.0336946
THSD4 thrombospondin, type I, domain containing 4 0.0336099
DOCK5 dedicator of cytokinesis 5 0.0300125
ATXN1 ataxin 1 0.0276893
MSN moesin 0.0270582
WWOX WW domain containing oxidoreductase 0.0265465
TPM3 tropomyosin 3 0.026426
PRELID2 PRELI domain containing 2 0.0227248
CCNL1 cyclin L1 0.0223654
PNN pinin, desmosome associated protein 0.0223457
PDE10A phosphodiesterase 10A 0.0221328
EXOC4 exocyst complex component 4 0.0216894
EIF4B eukaryotic translation initiation factor 4B 0.0212148
RPL3 ribosomal protein L3 0.0205271
STAT1 signal transducer and activator of transcription 1, 91kDa 0.020231
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0200819
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0197126
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0196608
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0193359
MYH9 myosin, heavy chain 9, non-muscle 0.0191732
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0186397
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0186367
ANO6 anoctamin 6 0.0185022
RNF145 ring finger protein 145 0.0177995
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0174898
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0174363
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0173715
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0168597
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.016745
MEF2D myocyte enhancer factor 2D 0.0167163
ATP11A ATPase, class VI, type 11A 0.0166602
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0165915
FNIP1 folliculin interacting protein 1 0.0164824
TRIO trio Rho guanine nucleotide exchange factor 0.0157758
BABAM2 BRISC and BRCA1 A complex member 2 0.0157482
CAMTA1 calmodulin binding transcription activator 1 0.0157236
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0152548
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0152089
PRPF8 pre-mRNA processing factor 8 0.0150203
SHB Src homology 2 domain containing adaptor protein B 0.0149804
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0149442
RLIM ring finger protein, LIM domain interacting 0.014881
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.0148701
NOTCH2 notch 2 0.0148629
ANKRD36C ankyrin repeat domain 36C 0.0148535
ZNF462 zinc finger protein 462 0.0148506
IQGAP3 IQ motif containing GTPase activating protein 3 0.0146477
NUP58 nucleoporin 58 0.0146152
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0145289
ERRFI1 ERBB receptor feedback inhibitor 1 0.0143295
ECPAS Ecm29 proteasome adaptor and scaffold 0.0141595
KMT2D lysine (K)-specific methyltransferase 2D 0.0141064
SP3 Sp3 transcription factor 0.0140163
SAMD4A sterile alpha motif domain containing 4A 0.0139115
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0137714
MCL1 myeloid cell leukemia 1 0.0136779
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0134558
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0133261
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0132958
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0129737
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0128926
WDR70 WD repeat domain 70 0.0128034
CENPF centromere protein F, 350/400kDa 0.0127226
SRSF5 serine/arginine-rich splicing factor 5 0.0126358
SMYD3 SET and MYND domain containing 3 0.0126266
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0126033
MACF1 microtubule-actin crosslinking factor 1 0.0124949
PFKP phosphofructokinase, platelet 0.0123687
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0123184
ARF3 ADP-ribosylation factor 3 0.0123168
PTEN phosphatase and tensin homolog 0.0122351
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0120802
HCFC1 host cell factor C1 0.0120724
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0118593
BIRC2 baculoviral IAP repeat containing 2 0.0117838
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0117661
NUMA1 nuclear mitotic apparatus protein 1 0.0117012
CBX5 chromobox homolog 5 0.0115937
NUP153 nucleoporin 153kDa 0.0114989
PBX3 pre-B-cell leukemia homeobox 3 0.0114812
HDAC4 histone deacetylase 4 0.0114232
CEP250 centrosomal protein 250kDa 0.0113996
HYOU1 hypoxia up-regulated 1 0.0113314
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0113196
EGFR epidermal growth factor receptor 0.0112752
KCMF1 potassium channel modulatory factor 1 0.0111631
NCAPG2 non-SMC condensin II complex, subunit G2 0.0111093
ANKRD36B ankyrin repeat domain 36B 0.0110953
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0110499
MAPK8 mitogen-activated protein kinase 8 0.0110239
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0109869
MARCHF7 membrane associated ring-CH-type finger 7 0.0109038
CDYL chromodomain protein, Y-like 0.0108749
DST dystonin 0.0108571
TBK1 TANK-binding kinase 1 0.0107972
RPS18 ribosomal protein S18 0.010789

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.408237
TMSB10 thymosin beta 10 -0.148452
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127048
PTMA prothymosin, alpha -0.0942563
TFPI2 tissue factor pathway inhibitor 2 -0.0900954
VIM vimentin -0.0830941
ACTG1 actin gamma 1 -0.0786732
TPI1 triosephosphate isomerase 1 -0.0757316
RPS21 ribosomal protein S21 -0.0752574
RPL37 ribosomal protein L37 -0.0675339
RPLP1 ribosomal protein, large, P1 -0.0653195
RPL12 ribosomal protein L12 -0.0631344
RPL35A ribosomal protein L35a -0.0625994
RPS3 ribosomal protein S3 -0.0620681
YBX3 Y box binding protein 3 -0.0588863
RPS8 ribosomal protein S8 -0.0576983
RPL26 ribosomal protein L26 -0.0564932
RPL23 ribosomal protein L23 -0.0552597
RPLP0 ribosomal protein, large, P0 -0.0545931
TPT1 tumor protein, translationally-controlled 1 -0.0533853
RPL37A ribosomal protein L37a -0.0530564
RPS27 ribosomal protein S27 -0.0527071
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0505544
FTL ferritin, light polypeptide -0.050186
RPS19 ribosomal protein S19 -0.0490849
RPS29 ribosomal protein S29 -0.0487677
MYL12B myosin, light chain 12B, regulatory -0.048147
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0480748
CAVIN1 caveolae associated protein 1 -0.0473958
RPL34 ribosomal protein L34 -0.0466417
GNAS GNAS complex locus -0.0463093
RPS15 ribosomal protein S15 -0.0459323
RPL32 ribosomal protein L32 -0.0449962
RPL31 ribosomal protein L31 -0.0438969
RPL38 ribosomal protein L38 -0.0432693
RPL19 ribosomal protein L19 -0.0431797
RPL8 ribosomal protein L8 -0.0428312
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0416832
RPL36 ribosomal protein L36 -0.0415977
EIF1 eukaryotic translation initiation factor 1 -0.0413444
EGR1 early growth response 1 -0.0402664
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0395458
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0389975
RACK1 receptor for activated C kinase 1 -0.0388223
RPL11 ribosomal protein L11 -0.0384482
RPS24 ribosomal protein S24 -0.0369118
NAP1L1 nucleosome assembly protein 1-like 1 -0.0368273
NIPBL Nipped-B homolog (Drosophila) -0.0365589
RPLP2 ribosomal protein, large, P2 -0.0363343
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.036299
UBC ubiquitin C -0.0358916
CSDE1 cold shock domain containing E1, RNA-binding -0.0352355
KDM3A lysine (K)-specific demethylase 3A -0.0349207
S100A10 S100 calcium binding protein A10 -0.0342432
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0339697
RPS27A ribosomal protein S27a -0.0338232
RPS25 ribosomal protein S25 -0.0337656
SRP72 signal recognition particle 72kDa -0.0336674
RPS6 ribosomal protein S6 -0.0331678
LOC112694756 uncharaterized LOC112694756 -0.0330418
MORF4L2 mortality factor 4 like 2 -0.0329289
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.032666
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0325392
RPL28 ribosomal protein L28 -0.0324496
RPS10 ribosomal protein S10 -0.0320929
AHNAK AHNAK nucleoprotein -0.0315563
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0312891
RPL36A ribosomal protein L36a -0.0307077
MT2A metallothionein 2A -0.0304997
RPL5 ribosomal protein L5 -0.0304773
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0301495
RPL35 ribosomal protein L35 -0.0296131
TPM4 tropomyosin 4 -0.0295027
S100A11 S100 calcium binding protein A11 -0.0294972
RPS4X ribosomal protein S4, X-linked -0.0293171
LRRC23 leucine rich repeat containing 23 -0.0290979
RPS16 ribosomal protein S16 -0.0284752
WSB1 WD repeat and SOCS box containing 1 -0.0284481
RPS12 ribosomal protein S12 -0.0281263
RPL7A ribosomal protein L7a -0.0279894
FBXO11 F-box protein 11 -0.0279849
VDAC1 voltage-dependent anion channel 1 -0.0275188
KPNB1 karyopherin (importin) beta 1 -0.0272732
RPS14 ribosomal protein S14 -0.0271381
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0269395
RPL18 ribosomal protein L18 -0.0269278
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0266199
PFN1 profilin 1 -0.0264501
S100A6 S100 calcium binding protein A6 -0.0262638
CANX calnexin -0.0257991
RPL13A ribosomal protein L13a -0.0257971
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0257317
PGK1 phosphoglycerate kinase 1 -0.0255738
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0254408
HLA-B major histocompatibility complex, class I, B -0.0252093
RPS13 ribosomal protein S13 -0.0249813
GSTP1 glutathione S-transferase pi 1 -0.0249625
SEPTIN7 septin 7 -0.0248293
RAB7A RAB7A, member RAS oncogene family -0.0247754
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0245937