| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Macitentan_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.153105 |
| GRB10 | growth factor receptor-bound protein 10 | 0.111663 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0844312 |
| LDHA | lactate dehydrogenase A | 0.0649485 |
| ANXA2 | annexin A2 | 0.0638747 |
| VEGFA | vascular endothelial growth factor A | 0.0400549 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0376621 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0355452 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0352138 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0346113 |
| CD47 | CD47 molecule | 0.0332231 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0318148 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.030708 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0304172 |
| KRT8 | keratin 8, type II | 0.0299237 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0293798 |
| PLAU | plasminogen activator, urokinase | 0.029218 |
| CTSB | cathepsin B | 0.0285901 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0283434 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | 0.0279898 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0274232 |
| KLF10 | Kruppel-like factor 10 | 0.0269554 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0255089 |
| FOSL1 | FOS-like antigen 1 | 0.0254972 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0247752 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0246609 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0243073 |
| USP3 | ubiquitin specific peptidase 3 | 0.0230801 |
| CD109 | CD109 molecule | 0.0223701 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0219738 |
| MSI2 | musashi RNA-binding protein 2 | 0.0215616 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0212311 |
| NUP58 | nucleoporin 58 | 0.0207685 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0205264 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.020116 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0200698 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0195487 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0194999 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0193892 |
| RNF145 | ring finger protein 145 | 0.0191829 |
| TSPAN15 | tetraspanin 15 | 0.0191162 |
| KLF6 | Kruppel-like factor 6 | 0.0189589 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0187503 |
| YBX1 | Y box binding protein 1 | 0.0184692 |
| G0S2 | G0/G1 switch 2 | 0.0183353 |
| TOP1 | topoisomerase (DNA) I | 0.0181647 |
| VIM | vimentin | 0.018145 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0180179 |
| ARF6 | ADP-ribosylation factor 6 | 0.017984 |
| FLNC | filamin C, gamma | 0.0178696 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0175725 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0168638 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.016802 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.016653 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0165445 |
| CALR | calreticulin | 0.0163849 |
| RPL13A | ribosomal protein L13a | 0.016263 |
| RPS4X | ribosomal protein S4, X-linked | 0.0161085 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0161083 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0158376 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0157067 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.015579 |
| SDC4 | syndecan 4 | 0.0154871 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0152638 |
| CD24 | CD24 molecule | 0.0151316 |
| STC2 | stanniocalcin 2 | 0.0149903 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0149815 |
| ARF3 | ADP-ribosylation factor 3 | 0.0149184 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0147363 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0146658 |
| CCNL1 | cyclin L1 | 0.0146105 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0140943 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0140461 |
| LMAN2 | lectin, mannose-binding 2 | 0.0136067 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0135835 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0134885 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0134815 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0132933 |
| DEK | DEK proto-oncogene | 0.0132209 |
| TMEM59 | transmembrane protein 59 | 0.0130126 |
| VASP | vasodilator-stimulated phosphoprotein | 0.0128621 |
| YME1L1 | YME1-like 1 ATPase | 0.0126884 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0126147 |
| BAG6 | BCL2-associated athanogene 6 | 0.0125564 |
| CASC3 | cancer susceptibility candidate 3 | 0.0121661 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0121186 |
| WDR43 | WD repeat domain 43 | 0.0120796 |
| PLIN2 | perilipin 2 | 0.0120267 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0119507 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0119495 |
| ENO1 | enolase 1, (alpha) | 0.0118896 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.0118874 |
| DR1 | down-regulator of transcription 1, TBP-binding (negative cofactor 2) | 0.0118855 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0118035 |
| RPL41 | ribosomal protein L41 | 0.0117811 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0117414 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | 0.01151 |
| LSR | lipolysis stimulated lipoprotein receptor | 0.0114298 |
| KRT18 | keratin 18, type I | 0.0114268 |
| HDGF | hepatoma-derived growth factor | 0.0114171 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.246498 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.172768 |
| NDRG1 | N-myc downstream regulated 1 | -0.157567 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.157347 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.156967 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.120818 |
| POTEF | POTE ankyrin domain family, member F | -0.115145 |
| ACTG1 | actin gamma 1 | -0.111853 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0878629 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0875341 |
| FBXO32 | F-box protein 32 | -0.0853648 |
| ASPH | aspartate beta-hydroxylase | -0.0754056 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0741372 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0723352 |
| S100A6 | S100 calcium binding protein A6 | -0.0707846 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.067391 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0647452 |
| GOLGA4 | golgin A4 | -0.0640677 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0623084 |
| LAMC2 | laminin, gamma 2 | -0.0609187 |
| ERBIN | erbb2 interacting protein | -0.0599889 |
| RPS2 | ribosomal protein S2 | -0.0582362 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0577605 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.057289 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0566021 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0562764 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0559601 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0555308 |
| HMGB2 | high mobility group box 2 | -0.0552252 |
| UBC | ubiquitin C | -0.0550959 |
| TSC22D2 | TSC22 domain family, member 2 | -0.053024 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0527558 |
| MYO6 | myosin VI | -0.0519691 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0518748 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0517366 |
| RPS6 | ribosomal protein S6 | -0.0514858 |
| EFNA5 | ephrin-A5 | -0.0508681 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0507935 |
| TMSB4X | thymosin beta 4, X-linked | -0.0507137 |
| DTNA | dystrobrevin, alpha | -0.0501649 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0489816 |
| DSG2 | desmoglein 2 | -0.0471537 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0466667 |
| RCOR1 | REST corepressor 1 | -0.0460502 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0451037 |
| TXNRD1 | thioredoxin reductase 1 | -0.0450363 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0447761 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0435732 |
| CLTC | clathrin, heavy chain (Hc) | -0.0428321 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0427593 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0424968 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0421579 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.041993 |
| EPCAM | epithelial cell adhesion molecule | -0.0419747 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0418313 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0401762 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.038844 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.037867 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.037855 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0375683 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0369828 |
| TMF1 | TATA element modulatory factor 1 | -0.036767 |
| CANX | calnexin | -0.0367528 |
| GOLT1B | golgi transport 1B | -0.0364811 |
| TPM3 | tropomyosin 3 | -0.0362355 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.03598 |
| RPL15 | ribosomal protein L15 | -0.0356744 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0355739 |
| NAV2 | neuron navigator 2 | -0.0355516 |
| S100A10 | S100 calcium binding protein A10 | -0.0352606 |
| BBX | bobby sox homolog (Drosophila) | -0.0346069 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0343096 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0336953 |
| MT2A | metallothionein 2A | -0.0331701 |
| CDCP1 | CUB domain containing protein 1 | -0.0330757 |
| H3-3B | H3.3 histone B | -0.0324343 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0324308 |
| ADAR | adenosine deaminase, RNA-specific | -0.0324086 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0323592 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0322154 |
| RPL34 | ribosomal protein L34 | -0.031953 |
| MYO10 | myosin X | -0.0318403 |
| TJP1 | tight junction protein 1 | -0.031652 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0311281 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.0309706 |
| AHNAK | AHNAK nucleoprotein | -0.0309331 |
| RPL7 | ribosomal protein L7 | -0.0308615 |
| RYBP | RING1 and YY1 binding protein | -0.0306945 |
| RASA2 | RAS p21 protein activator 2 | -0.0304036 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0300652 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0300442 |
| RPS23 | ribosomal protein S23 | -0.029691 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0296779 |
| MKI67 | marker of proliferation Ki-67 | -0.0295097 |
| CEP350 | centrosomal protein 350kDa | -0.0292833 |
| TRAM1 | translocation associated membrane protein 1 | -0.0292625 |
| RPL32 | ribosomal protein L32 | -0.0290481 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0290111 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0289407 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0288993 |
