Macitentan_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Macitentan perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Macitentan_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.100178
PDE4D phosphodiesterase 4D, cAMP-specific 0.0749114
PDE10A phosphodiesterase 10A 0.0688611
EFNA5 ephrin-A5 0.0657172
GDA guanine deaminase 0.0540342
PCBP3 poly(rC) binding protein 3 0.0419353
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0382078
PSD3 pleckstrin and Sec7 domain containing 3 0.0372265
CDH13 cadherin 13 0.0357038
DST dystonin 0.0339254
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.031041
SAMD4A sterile alpha motif domain containing 4A 0.0307758
COL5A2 collagen, type V, alpha 2 0.0279225
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0260072
ADGRD1 adhesion G protein-coupled receptor D1 0.025557
COL4A5 collagen, type IV, alpha 5 0.0242376
NRCAM neuronal cell adhesion molecule 0.0237067
PDLIM5 PDZ and LIM domain 5 0.02306
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0227004
SMOC1 SPARC related modular calcium binding 1 0.0222886
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0214237
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0208168
RPH3AL rabphilin 3A-like (without C2 domains) 0.0202185
DOCK4 dedicator of cytokinesis 4 0.0198096
GRAMD1B GRAM domain containing 1B 0.0196584
NALF1 NALCN channel auxiliary factor 1 0.0187366
NPAS2 neuronal PAS domain protein 2 0.0186645
MAML3 mastermind-like 3 (Drosophila) 0.0186097
GLIS3 GLIS family zinc finger 3 0.0178836
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0167817
COL4A6 collagen, type IV, alpha 6 0.0167243
KYNU kynureninase 0.0165043
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0161833
EXOC4 exocyst complex component 4 0.0161192
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0151443
THSD4 thrombospondin, type I, domain containing 4 0.0150744
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0149681
AUTS2 autism susceptibility candidate 2 0.0146628
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0142506
AOPEP aminopeptidase O (putative) 0.0140474
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0135593
RAD51B RAD51 paralog B 0.0135156
RTN1 reticulon 1 0.0133434
CTIF CBP80/20-dependent translation initiation factor 0.0127837
PRELID2 PRELI domain containing 2 0.0125181
HSPA8 heat shock 70kDa protein 8 0.0117515
BCAR3 breast cancer anti-estrogen resistance 3 0.0116804
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0116756
SMYD3 SET and MYND domain containing 3 0.0116294
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.011449
TRIO trio Rho guanine nucleotide exchange factor 0.011388
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0113867
HDAC4 histone deacetylase 4 0.0110709
DOCK5 dedicator of cytokinesis 5 0.0109769
CTSC cathepsin C 0.0107174
MACF1 microtubule-actin crosslinking factor 1 0.0106865
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0106713
ATXN1 ataxin 1 0.0105693
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0103662
CHL1 cell adhesion molecule L1-like 0.0103111
ANKRD36 ankyrin repeat domain 36 0.0101268
RABGAP1L RAB GTPase activating protein 1-like 0.0101261
TUSC3 tumor suppressor candidate 3 0.0100405
CTNND2 catenin (cadherin-associated protein), delta 2 0.0100366
ALPK2 alpha-kinase 2 0.00986449
WWTR1 WW domain containing transcription regulator 1 0.00984207
BCAS3 breast carcinoma amplified sequence 3 0.00979963
PTPRM protein tyrosine phosphatase, receptor type, M 0.00957584
EXT1 exostosin glycosyltransferase 1 0.00956574
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.00949306
PTEN phosphatase and tensin homolog 0.00931428
TBXT T-box transcription factor T 0.00920124
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.00907913
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00902968
ANKRD11 ankyrin repeat domain 11 0.00890826
GPRIN3 GPRIN family member 3 0.0087917
ZNF462 zinc finger protein 462 0.00876837
SFPQ splicing factor proline/glutamine-rich 0.00866222
FNDC3B fibronectin type III domain containing 3B 0.00860684
MAPK8 mitogen-activated protein kinase 8 0.00857868
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.00857311
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00856171
RLIM ring finger protein, LIM domain interacting 0.00853513
COL8A1 collagen, type VIII, alpha 1 0.00851357
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.00848113
FBXL17 F-box and leucine-rich repeat protein 17 0.00845112
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.00833528
EIF4B eukaryotic translation initiation factor 4B 0.00832628
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.00830572
METTL15 methyltransferase like 15 0.00824806
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.00817436
LIMCH1 LIM and calponin homology domains 1 0.00809958
PDE7B phosphodiesterase 7B 0.00806272
ADGRB3 adhesion G protein-coupled receptor B3 0.00801218
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.00797388
TBC1D22A TBC1 domain family, member 22A 0.00793619
EXOC6B exocyst complex component 6B 0.00792916
IGF1R insulin-like growth factor 1 receptor 0.00789049
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.00788731
UTRN utrophin 0.00788253

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.319318
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.209176
VIM vimentin -0.142245
TMSB10 thymosin beta 10 -0.129916
PTMA prothymosin, alpha -0.127604
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.108381
FTL ferritin, light polypeptide -0.105307
RPS6 ribosomal protein S6 -0.104801
TPT1 tumor protein, translationally-controlled 1 -0.0973009
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0963223
RPLP1 ribosomal protein, large, P1 -0.0948417
CXCL8 chemokine (C-X-C motif) ligand 8 -0.075711
RPS8 ribosomal protein S8 -0.073514
RPS12 ribosomal protein S12 -0.0653712
RPL12 ribosomal protein L12 -0.065266
NAP1L1 nucleosome assembly protein 1-like 1 -0.0640023
RPS19 ribosomal protein S19 -0.0635976
RPS24 ribosomal protein S24 -0.0628012
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0623441
RPL37A ribosomal protein L37a -0.0619469
RPL26 ribosomal protein L26 -0.0612619
RPL31 ribosomal protein L31 -0.0606198
RPS23 ribosomal protein S23 -0.059809
RPL35A ribosomal protein L35a -0.0594558
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0590955
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.058704
RPLP0 ribosomal protein, large, P0 -0.0577966
B2M beta-2-microglobulin -0.056462
RPL19 ribosomal protein L19 -0.0564452
MT2A metallothionein 2A -0.0529159
S100A6 S100 calcium binding protein A6 -0.0528325
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0510804
RPS3 ribosomal protein S3 -0.0508212
S100A10 S100 calcium binding protein A10 -0.0506334
EIF1 eukaryotic translation initiation factor 1 -0.0497367
GNAS GNAS complex locus -0.049156
RPL23 ribosomal protein L23 -0.0490857
PGK1 phosphoglycerate kinase 1 -0.047946
CANX calnexin -0.0452947
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0450314
RPL36A ribosomal protein L36a -0.0445958
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0435738
TFPI2 tissue factor pathway inhibitor 2 -0.0433011
RPS14 ribosomal protein S14 -0.0423775
RPS27A ribosomal protein S27a -0.0422514
RPL7A ribosomal protein L7a -0.0421194
NDRG1 N-myc downstream regulated 1 -0.0420465
RPL11 ribosomal protein L11 -0.0418892
RACK1 receptor for activated C kinase 1 -0.0410072
RPL34 ribosomal protein L34 -0.0409936
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0408506
RPS29 ribosomal protein S29 -0.0407339
RPLP2 ribosomal protein, large, P2 -0.0401242
RPL9 ribosomal protein L9 -0.0399757
SRGN serglycin -0.0396309
RPS27 ribosomal protein S27 -0.0384202
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0379715
TM4SF1 transmembrane 4 L six family member 1 -0.0378119
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0375774
ACTG1 actin gamma 1 -0.0375083
RPL36 ribosomal protein L36 -0.0372985
RPS25 ribosomal protein S25 -0.0371639
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0360116
PDIA3 protein disulfide isomerase family A, member 3 -0.0359982
RGS2 regulator of G-protein signaling 2 -0.0358724
DDIT4 DNA-damage-inducible transcript 4 -0.0357694
VDAC1 voltage-dependent anion channel 1 -0.0354315
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0352196
RPL37 ribosomal protein L37 -0.0350493
HLA-A major histocompatibility complex, class I, A -0.0350339
UBC ubiquitin C -0.0346569
RPS4X ribosomal protein S4, X-linked -0.0346336
RPS21 ribosomal protein S21 -0.0345021
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0343867
RPS16 ribosomal protein S16 -0.0341423
IGFBP3 insulin-like growth factor binding protein 3 -0.0339622
LDHA lactate dehydrogenase A -0.03376
HILPDA hypoxia inducible lipid droplet-associated -0.0332662
PDGFA platelet-derived growth factor alpha polypeptide -0.0328738
WSB1 WD repeat and SOCS box containing 1 -0.0325589
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0320605
RPL35 ribosomal protein L35 -0.0319464
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0316034
MORF4L2 mortality factor 4 like 2 -0.0305485
RPL32 ribosomal protein L32 -0.0300034
ELL2 elongation factor, RNA polymerase II, 2 -0.0299687
PDIA6 protein disulfide isomerase family A, member 6 -0.0299158
TPI1 triosephosphate isomerase 1 -0.0298305
SEPTIN7 septin 7 -0.0293781
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0293455
RPL13A ribosomal protein L13a -0.0292084
RPS13 ribosomal protein S13 -0.0291161
RPS17 ribosomal protein S17 -0.0288029
STC1 stanniocalcin 1 -0.0285593
RPL5 ribosomal protein L5 -0.028167
HLA-B major histocompatibility complex, class I, B -0.0277628
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.027648
BASP1 brain abundant, membrane attached signal protein 1 -0.0276325
IER3 immediate early response 3 -0.0275648
PFN1 profilin 1 -0.0272234