| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Macitentan_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.262341 |
| VIM | vimentin | 0.173041 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.15419 |
| MT2A | metallothionein 2A | 0.142226 |
| IGF2 | insulin-like growth factor 2 | 0.114473 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.11192 |
| COL6A3 | collagen, type VI, alpha 3 | 0.095175 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0885747 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0856987 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0846592 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0839846 |
| PTMA | prothymosin, alpha | 0.0836756 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0834004 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0762222 |
| RPS3 | ribosomal protein S3 | 0.0749067 |
| NDRG1 | N-myc downstream regulated 1 | 0.0747111 |
| FTL | ferritin, light polypeptide | 0.0739956 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0738697 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0688207 |
| LDHA | lactate dehydrogenase A | 0.0688001 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0663009 |
| RPS6 | ribosomal protein S6 | 0.0626561 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0626371 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.059726 |
| SPAG9 | sperm associated antigen 9 | 0.0588673 |
| TMSB10 | thymosin beta 10 | 0.05868 |
| PGK1 | phosphoglycerate kinase 1 | 0.0550125 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0536501 |
| MYO10 | myosin X | 0.0536477 |
| USP3 | ubiquitin specific peptidase 3 | 0.0525552 |
| CALR | calreticulin | 0.0500157 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0488454 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.048284 |
| JMJD1C | jumonji domain containing 1C | 0.0477179 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0477065 |
| EGR1 | early growth response 1 | 0.0473597 |
| NAV2 | neuron navigator 2 | 0.0469749 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0466862 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0465711 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0465177 |
| ANXA2 | annexin A2 | 0.0458096 |
| FNIP1 | folliculin interacting protein 1 | 0.0443336 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0437396 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0435076 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0430164 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0427416 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0425017 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0421003 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0412781 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0407827 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0401409 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0399153 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0396437 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0380734 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0378003 |
| CANX | calnexin | 0.0348975 |
| STK24 | serine/threonine kinase 24 | 0.0345822 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0340349 |
| ERBIN | erbb2 interacting protein | 0.0335411 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0334868 |
| TENM3 | teneurin transmembrane protein 3 | 0.0331292 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0330102 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0329723 |
| RPL12 | ribosomal protein L12 | 0.0326514 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0326457 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0305885 |
| ZNF644 | zinc finger protein 644 | 0.0301223 |
| RPL13A | ribosomal protein L13a | 0.0300788 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0298674 |
| NF1 | neurofibromin 1 | 0.0293743 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.028974 |
| FN1 | fibronectin 1 | 0.0289622 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0288915 |
| RPS8 | ribosomal protein S8 | 0.028663 |
| PTK2 | protein tyrosine kinase 2 | 0.0281901 |
| CADM1 | cell adhesion molecule 1 | 0.0277106 |
| MED13L | mediator complex subunit 13-like | 0.0275312 |
| CD44 | CD44 molecule (Indian blood group) | 0.0272261 |
| BBX | bobby sox homolog (Drosophila) | 0.0264537 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0261662 |
| ENO1 | enolase 1, (alpha) | 0.0260664 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0260423 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0258736 |
| RPS19 | ribosomal protein S19 | 0.0256917 |
| INHBA | inhibin, beta A | 0.0251457 |
| AFAP1 | actin filament associated protein 1 | 0.0248821 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0247132 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0241142 |
| ZNF638 | zinc finger protein 638 | 0.0230227 |
| STC1 | stanniocalcin 1 | 0.022871 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0227283 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0218998 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0212288 |
| ITGAV | integrin, alpha V | 0.0203584 |
| RPL31 | ribosomal protein L31 | 0.0202536 |
| USP34 | ubiquitin specific peptidase 34 | 0.0194417 |
| RPLP1 | ribosomal protein, large, P1 | 0.0188492 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0166384 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.016568 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0165544 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.19583 |
| PDE10A | phosphodiesterase 10A | -0.168763 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.132769 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.117227 |
| DOCK4 | dedicator of cytokinesis 4 | -0.102617 |
| TBC1D5 | TBC1 domain family, member 5 | -0.101699 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0946055 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0926138 |
| SMYD3 | SET and MYND domain containing 3 | -0.089782 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0897572 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0852251 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0833048 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0815463 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0813729 |
| VCL | vinculin | -0.0804946 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0791117 |
| AOPEP | aminopeptidase O (putative) | -0.0784188 |
| EFNA5 | ephrin-A5 | -0.0778744 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0758246 |
| EGFR | epidermal growth factor receptor | -0.0750377 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0741175 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.072347 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0652147 |
| SLTM | SAFB-like, transcription modulator | -0.0628523 |
| ATP9B | ATPase, class II, type 9B | -0.0623729 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0588342 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.058058 |
| TCF12 | transcription factor 12 | -0.0574505 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0549436 |
| CDKL5 | cyclin-dependent kinase-like 5 | -0.0539442 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0515771 |
| ASPH | aspartate beta-hydroxylase | -0.0511475 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0508666 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0495833 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0465496 |
| CDH13 | cadherin 13 | -0.0456006 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0455436 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0438094 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0437756 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0401682 |
| TLK1 | tousled-like kinase 1 | -0.0397489 |
| FLNB | filamin B, beta | -0.0390948 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0385305 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0381722 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0378115 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0378103 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0374964 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0359401 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0357618 |
| RORA | RAR-related orphan receptor A | -0.0344633 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0336733 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0325855 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0308528 |
| LAMB3 | laminin, beta 3 | -0.0303427 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0300872 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0300808 |
| PKM | pyruvate kinase, muscle | -0.0294912 |
| RIGI | RNA sensor RIG-I | -0.0284165 |
| HDLBP | high density lipoprotein binding protein | -0.0274992 |
| ZNF292 | zinc finger protein 292 | -0.0262846 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0254558 |
| CERS6 | ceramide synthase 6 | -0.0245136 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0242946 |
| PCNX4 | pecanex 4 | -0.0241505 |
| PARD3 | par-3 family cell polarity regulator | -0.0237028 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0236732 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0226395 |
| TXNRD1 | thioredoxin reductase 1 | -0.0224274 |
| COPA | coatomer protein complex, subunit alpha | -0.0222963 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0220144 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0209994 |
| GOLGA4 | golgin A4 | -0.0195765 |
| PRKD3 | protein kinase D3 | -0.0190787 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0183859 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0183772 |
| OGA | O-GlcNAcase | -0.0180212 |
| DENND5B | DENN/MADD domain containing 5B | -0.0176214 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0163877 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.016167 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0161487 |
| MAP4 | microtubule-associated protein 4 | -0.0161122 |
| SYT1 | synaptotagmin I | -0.0157828 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0153129 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0152527 |
| NBEAL1 | neurobeachin-like 1 | -0.0151453 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0146475 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0135214 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0126708 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0125941 |
| SETD5 | SET domain containing 5 | -0.0119733 |
| TOP1 | topoisomerase (DNA) I | -0.0107218 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0105506 |
| XPO1 | exportin 1 | -0.0102243 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.00973163 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.00898509 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | -0.00718999 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.00668781 |
| MYO1E | myosin IE | -0.00585497 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.00489692 |
| CTBP2 | C-terminal binding protein 2 | -0.00424965 |
