| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Macitentan_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.144631 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.11429 |
| TSC22D2 | TSC22 domain family, member 2 | 0.10704 |
| HDAC9 | histone deacetylase 9 | 0.104382 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0901303 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0873677 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0793805 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0745593 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0709585 |
| ITGAV | integrin, alpha V | 0.0693823 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0680742 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0677174 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0676087 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0675971 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0663079 |
| CALR | calreticulin | 0.0616395 |
| EMP1 | epithelial membrane protein 1 | 0.0587764 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0577386 |
| THBS1 | thrombospondin 1 | 0.0559716 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0548848 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0537418 |
| NOP58 | NOP58 ribonucleoprotein | 0.0513035 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0511 |
| SPAG9 | sperm associated antigen 9 | 0.0508841 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0507782 |
| STAG2 | stromal antigen 2 | 0.0507508 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0506295 |
| NTM | neurotrimin | 0.0502201 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0501921 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0500482 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0488598 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0483058 |
| SET | SET nuclear proto-oncogene | 0.0481854 |
| SFRP4 | secreted frizzled-related protein 4 | 0.0478063 |
| UPP1 | uridine phosphorylase 1 | 0.0478026 |
| FAM171B | family with sequence similarity 171, member B | 0.0459846 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0459208 |
| NCKAP1 | NCK-associated protein 1 | 0.0458327 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.0458072 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0455464 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0445481 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0444456 |
| MATR3 | matrin 3 | 0.0440679 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0438909 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0435363 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0432278 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0428577 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0423142 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.041944 |
| ITSN2 | intersectin 2 | 0.0412284 |
| MYO10 | myosin X | 0.0402764 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0402311 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0394939 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0385889 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0383056 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0382059 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0380801 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0372057 |
| NUP153 | nucleoporin 153kDa | 0.036675 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0365036 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0364952 |
| RPL3 | ribosomal protein L3 | 0.0364595 |
| RBM39 | RNA binding motif protein 39 | 0.0361274 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0359113 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0356904 |
| NRG1 | neuregulin 1 | 0.0356427 |
| RLIM | ring finger protein, LIM domain interacting | 0.0352575 |
| COL3A1 | collagen, type III, alpha 1 | 0.0347419 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0345912 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.034463 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0343965 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0341449 |
| PTMA | prothymosin, alpha | 0.0339014 |
| SRP54 | signal recognition particle 54kDa | 0.0336472 |
| PRTG | protogenin | 0.0336063 |
| RTN4 | reticulon 4 | 0.0335171 |
| MB21D2 | Mab-21 domain containing 2 | 0.033337 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0331022 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0328104 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0326667 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0325632 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0324805 |
| XPO1 | exportin 1 | 0.0323887 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0323055 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0321606 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0315836 |
| FUS | FUS RNA binding protein | 0.0315816 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0313863 |
| COL11A1 | collagen, type XI, alpha 1 | 0.031221 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0311205 |
| RPL21 | ribosomal protein L21 | 0.0308135 |
| GOLGA4 | golgin A4 | 0.0307314 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0306582 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0305214 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0304342 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0303672 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.0302153 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0301741 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0300599 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0298601 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.116637 |
| CADM2 | cell adhesion molecule 2 | -0.0896637 |
| TENM3 | teneurin transmembrane protein 3 | -0.0793946 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0776644 |
| FOXP2 | forkhead box P2 | -0.0593377 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0569476 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0518834 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0516745 |
| GPC3 | glypican 3 | -0.050934 |
| PCDH9 | protocadherin 9 | -0.0502216 |
| MEIS2 | Meis homeobox 2 | -0.049456 |
| HMGA2 | high mobility group AT-hook 2 | -0.0488519 |
| TMSB10 | thymosin beta 10 | -0.0467651 |
| BPTF | bromodomain PHD finger transcription factor | -0.0460667 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0422709 |
| DST | dystonin | -0.0414328 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0410544 |
| VCL | vinculin | -0.0406988 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0392095 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0388992 |
| NBEAL1 | neurobeachin-like 1 | -0.0375816 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0374395 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0366859 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0346463 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0343851 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0329719 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0328385 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0325463 |
| ZNF385D | zinc finger protein 385D | -0.0322421 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0319731 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0309805 |
| RPLP1 | ribosomal protein, large, P1 | -0.0305706 |
| HDAC8 | histone deacetylase 8 | -0.0304131 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0299917 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0299609 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0297015 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0295637 |
| NRXN1 | neurexin 1 | -0.0293266 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0290827 |
| DMD | dystrophin | -0.0290691 |
| TPX2 | TPX2, microtubule-associated | -0.0290305 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0288798 |
| ECT2 | epithelial cell transforming 2 | -0.0287513 |
| KIF4A | kinesin family member 4A | -0.0286133 |
| GNAS | GNAS complex locus | -0.0284796 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0283333 |
| SYT1 | synaptotagmin I | -0.0281021 |
| SGO2 | shugoshin 2 | -0.0278325 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0275107 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0274931 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0271704 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0266906 |
| CENPE | centromere protein E, 312kDa | -0.0264509 |
| AHNAK | AHNAK nucleoprotein | -0.0259844 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0257965 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0256877 |
| RPL35A | ribosomal protein L35a | -0.0256581 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0254632 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.025208 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0251864 |
| PROS1 | protein S (alpha) | -0.0251397 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0249429 |
| MACROD2 | MACRO domain containing 2 | -0.024839 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0246675 |
| MPZL1 | myelin protein zero-like 1 | -0.0246633 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0246513 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.024647 |
| LIN28B | lin-28 homolog B (C. elegans) | -0.0246421 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0245103 |
| RPL37 | ribosomal protein L37 | -0.02387 |
| RAB3GAP2 | RAB3 GTPase activating protein subunit 2 (non-catalytic) | -0.0236879 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0236212 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.023566 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | -0.0234187 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 | -0.0234146 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0233523 |
| ZNF638 | zinc finger protein 638 | -0.0232427 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0231234 |
| NFIA | nuclear factor I/A | -0.023068 |
| KLC1 | kinesin light chain 1 | -0.0230253 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0228685 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0228025 |
| ACTG1 | actin gamma 1 | -0.0227994 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0226634 |
| TXNRD1 | thioredoxin reductase 1 | -0.0226422 |
| TPTE | transmembrane phosphatase with tensin homology | -0.0225116 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0224826 |
| WDR26 | WD repeat domain 26 | -0.0222533 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.022221 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.021933 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0216271 |
| CREB1 | cAMP responsive element binding protein 1 | -0.0214724 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0214518 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0213854 |
| SIK2 | salt-inducible kinase 2 | -0.0213553 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.021165 |
| PCDH7 | protocadherin 7 | -0.021031 |
| WDR70 | WD repeat domain 70 | -0.0210048 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0209148 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0208762 |
