| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0873045 |
| GOLGA4 | golgin A4 | 0.0829068 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0828841 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0808779 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0800926 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0769155 |
| ZNF292 | zinc finger protein 292 | 0.0761221 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.074921 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0744022 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0731259 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0662898 |
| CD47 | CD47 molecule | 0.0660026 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0634746 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0625175 |
| RBM39 | RNA binding motif protein 39 | 0.0608596 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0602467 |
| RPL3 | ribosomal protein L3 | 0.0593524 |
| TXNIP | thioredoxin interacting protein | 0.0588689 |
| NUP58 | nucleoporin 58 | 0.0575926 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0572514 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0552635 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0537137 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0515048 |
| SET | SET nuclear proto-oncogene | 0.0510867 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0501288 |
| EZR | ezrin | 0.0490973 |
| PLXNA1 | plexin A1 | 0.04804 |
| HELZ | helicase with zinc finger | 0.0478231 |
| LDHA | lactate dehydrogenase A | 0.0473799 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0468179 |
| MKI67 | marker of proliferation Ki-67 | 0.0457314 |
| XPO1 | exportin 1 | 0.0441094 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0421519 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.041224 |
| QKI | QKI, KH domain containing, RNA binding | 0.0407403 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0405461 |
| USP3 | ubiquitin specific peptidase 3 | 0.0404838 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0404217 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0402765 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0400494 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0399711 |
| ZNF451 | zinc finger protein 451 | 0.0393088 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0391542 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0388234 |
| DIAPH3 | diaphanous-related formin 3 | 0.0384057 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0381265 |
| CENPF | centromere protein F, 350/400kDa | 0.0380026 |
| MATR3 | matrin 3 | 0.0378309 |
| HDGF | hepatoma-derived growth factor | 0.0377771 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.036779 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0367093 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.036121 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0357927 |
| FAT1 | FAT atypical cadherin 1 | 0.0357205 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0354254 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0350314 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0348365 |
| OGA | O-GlcNAcase | 0.0342797 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0340231 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0336455 |
| ANXA1 | annexin A1 | 0.0335948 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0335743 |
| PCBP2 | poly(rC) binding protein 2 | 0.0331554 |
| TMF1 | TATA element modulatory factor 1 | 0.0329159 |
| RIOK3 | RIO kinase 3 | 0.0326596 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.0325616 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0322169 |
| SRPK2 | SRSF protein kinase 2 | 0.0318955 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0316208 |
| YAP1 | Yes-associated protein 1 | 0.0314851 |
| BRD2 | bromodomain containing 2 | 0.0305551 |
| KIF5B | kinesin family member 5B | 0.0304083 |
| ENO1 | enolase 1, (alpha) | 0.0303546 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0300237 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0300237 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0299253 |
| FLNB | filamin B, beta | 0.0297596 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0297114 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0296949 |
| SRP54 | signal recognition particle 54kDa | 0.0296542 |
| EVI5 | ecotropic viral integration site 5 | 0.0293736 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0293405 |
| SFPQ | splicing factor proline/glutamine-rich | 0.029339 |
| HJURP | Holliday junction recognition protein | 0.0293389 |
| THOC2 | THO complex 2 | 0.0293148 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0291614 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0291471 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0291342 |
| DENND4A | DENN/MADD domain containing 4A | 0.0288607 |
| POU2F1 | POU class 2 homeobox 1 | 0.0288384 |
| RHOA | ras homolog family member A | 0.0284535 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0284414 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0282829 |
| TPD52 | tumor protein D52 | 0.0282429 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0280189 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0278968 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0278308 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0274956 |
| TFG | TRK-fused gene | 0.0273605 |
| INSIG2 | insulin induced gene 2 | 0.0272374 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.167538 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.151279 |
| VCL | vinculin | -0.14352 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.116735 |
| EGFR | epidermal growth factor receptor | -0.116417 |
| FOXP1 | forkhead box P1 | -0.112947 |
| AHNAK | AHNAK nucleoprotein | -0.090568 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0843078 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0836789 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0758075 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.074669 |
| LOC112694756 | uncharaterized LOC112694756 | -0.072543 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0716009 |
| NBEA | neurobeachin | -0.0636217 |
| RPL35A | ribosomal protein L35a | -0.0626405 |
| ACTG1 | actin gamma 1 | -0.0604632 |
| RPL12 | ribosomal protein L12 | -0.0597971 |
| S100A6 | S100 calcium binding protein A6 | -0.0508421 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0497703 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0492603 |
| RPS6 | ribosomal protein S6 | -0.049015 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0479793 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0473031 |
| RPLP1 | ribosomal protein, large, P1 | -0.0457204 |
| GLI3 | GLI family zinc finger 3 | -0.0445773 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0443918 |
| RPL7A | ribosomal protein L7a | -0.0441789 |
| RPS13 | ribosomal protein S13 | -0.0431437 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0428103 |
| RPS23 | ribosomal protein S23 | -0.042167 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0420622 |
| OSMR | oncostatin M receptor | -0.0415092 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0409493 |
| RIGI | RNA sensor RIG-I | -0.0399342 |
| HLA-B | major histocompatibility complex, class I, B | -0.0396789 |
| RPL34 | ribosomal protein L34 | -0.0395977 |
| RPS24 | ribosomal protein S24 | -0.0394733 |
| RPL11 | ribosomal protein L11 | -0.0389578 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0379044 |
| RPL31 | ribosomal protein L31 | -0.0377499 |
| RPL19 | ribosomal protein L19 | -0.0376033 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0373951 |
| PHF14 | PHD finger protein 14 | -0.0369165 |
| CCND1 | cyclin D1 | -0.0352141 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0349735 |
| MLIP | muscular LMNA-interacting protein | -0.034909 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0346315 |
| SLC38A2 | solute carrier family 38, member 2 | -0.034495 |
| MEIS2 | Meis homeobox 2 | -0.0339311 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0338492 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.0336419 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0327576 |
| RPL36 | ribosomal protein L36 | -0.0322765 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0322616 |
| PKP4 | plakophilin 4 | -0.0321093 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0317944 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0317598 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0316892 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0312798 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.030159 |
| S100A4 | S100 calcium binding protein A4 | -0.0297404 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0297033 |
| CUX1 | cut-like homeobox 1 | -0.028438 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0284338 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0283825 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.028372 |
| DIAPH2 | diaphanous-related formin 2 | -0.0282924 |
| RPS25 | ribosomal protein S25 | -0.0281783 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.028014 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0279491 |
| DUSP6 | dual specificity phosphatase 6 | -0.027509 |
| RPS14 | ribosomal protein S14 | -0.0272282 |
| RPS19 | ribosomal protein S19 | -0.027095 |
| MYO5C | myosin VC | -0.0270404 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0270261 |
| MTAP | methylthioadenosine phosphorylase | -0.0269995 |
| TMSB10 | thymosin beta 10 | -0.0269845 |
| RPLP2 | ribosomal protein, large, P2 | -0.0269669 |
| AEBP2 | AE binding protein 2 | -0.0267399 |
| COMMD10 | COMM domain containing 10 | -0.0265976 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.0263388 |
| RPS16 | ribosomal protein S16 | -0.0262462 |
| RPS21 | ribosomal protein S21 | -0.0261874 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0259571 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.025791 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0255199 |
| RPL32 | ribosomal protein L32 | -0.0252 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0251847 |
| ZNF438 | zinc finger protein 438 | -0.024944 |
| SP100 | SP100 nuclear antigen | -0.0249009 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0248176 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.0243847 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0240736 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.0239586 |
| ARHGAP25 | Rho GTPase activating protein 25 | -0.0237588 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0236434 |
| RPL36A | ribosomal protein L36a | -0.0235019 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | -0.0235014 |
| AHI1 | Abelson helper integration site 1 | -0.0233407 |
| RPS5 | ribosomal protein S5 | -0.0232772 |
