Macitentan_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Macitentan perturbation in SNU-423 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Macitentan_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0384108
CENPF centromere protein F, 350/400kDa 0.0206639
NAV2 neuron navigator 2 0.0190135
MKI67 marker of proliferation Ki-67 0.017705
VEGFA vascular endothelial growth factor A 0.0166186
ANLN anillin, actin binding protein 0.0154608
MSN moesin 0.0150196
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0138148
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.01317
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0129823
TENT5A terminal nucleotidyltransferase 5A 0.0123194
CKAP5 cytoskeleton associated protein 5 0.0122397
KIF4A kinesin family member 4A 0.0110885
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0110557
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0108432
RLIM ring finger protein, LIM domain interacting 0.0108201
TMED2 transmembrane emp24 domain trafficking protein 2 0.0105739
FN1 fibronectin 1 0.0105289
YEATS2 YEATS domain containing 2 0.010489
ESYT2 extended synaptotagmin-like protein 2 0.010483
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0100612
BRWD3 bromodomain and WD repeat domain containing 3 0.00959486
ANO6 anoctamin 6 0.00958436
ZMIZ1 zinc finger, MIZ-type containing 1 0.00933605
RPL21 ribosomal protein L21 0.00919721
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 0.00889344
SRP54 signal recognition particle 54kDa 0.0087963
NGLY1 N-glycanase 1 0.0086466
CCNL1 cyclin L1 0.00862931
FTH1 ferritin, heavy polypeptide 1 0.00853143
NRIP1 nuclear receptor interacting protein 1 0.00844839
DIAPH3 diaphanous-related formin 3 0.00841409
ZNF451 zinc finger protein 451 0.00811088
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00795924
RNF145 ring finger protein 145 0.00784842
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.00781082
CDKN2A cyclin-dependent kinase inhibitor 2A 0.00757508
SPAG5 sperm associated antigen 5 0.00757457
KIFC1 kinesin family member C1 0.00747269
RPL3 ribosomal protein L3 0.00734966
PHRF1 PHD and ring finger domains 1 0.00729381
OGFRL1 opioid growth factor receptor-like 1 0.00724532
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.00722677
CASC3 cancer susceptibility candidate 3 0.00720367
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.00715653
CEP250 centrosomal protein 250kDa 0.00705828
PEX3 peroxisomal biogenesis factor 3 0.00704114
FUBP1 far upstream element (FUSE) binding protein 1 0.00700578
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.00699942
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.00693285
TPM3 tropomyosin 3 0.00691135
RPL41 ribosomal protein L41 0.00689667
USP9X ubiquitin specific peptidase 9, X-linked 0.00685066
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00676296
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.00675136
CAMTA1 calmodulin binding transcription activator 1 0.00672042
UVRAG UV radiation resistance associated 0.00671412
TPX2 TPX2, microtubule-associated 0.00670061
CD47 CD47 molecule 0.00667861
PRR11 proline rich 11 0.00659232
NUP58 nucleoporin 58 0.00657784
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.00657372
ARL5B ADP-ribosylation factor-like 5B 0.00655051
GTPBP2 GTP binding protein 2 0.00651352
BZW1 basic leucine zipper and W2 domains 1 0.00650418
EGLN1 egl-9 family hypoxia-inducible factor 1 0.00648618
NRP2 neuropilin 2 0.00647658
OPTN optineurin 0.0064605
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00645573
EIF4B eukaryotic translation initiation factor 4B 0.00644215
NCAPG2 non-SMC condensin II complex, subunit G2 0.00642139
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.00629797
ARRDC3 arrestin domain containing 3 0.00625486
PCM1 pericentriolar material 1 0.00621041
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.00605376
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 0.00602869
UBA6 ubiquitin-like modifier activating enzyme 6 0.00602782
CENPI centromere protein I 0.00602044
HJURP Holliday junction recognition protein 0.00599827
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.00598447
BAG6 BCL2-associated athanogene 6 0.00579749
SFPQ splicing factor proline/glutamine-rich 0.00579503
MYH9 myosin, heavy chain 9, non-muscle 0.00579152
KDM6A lysine (K)-specific demethylase 6A 0.00576637
SLTM SAFB-like, transcription modulator 0.00576097
IQGAP3 IQ motif containing GTPase activating protein 3 0.0057521
FNBP4 formin binding protein 4 0.00570305
FBXO7 F-box protein 7 0.00569879
AMPD3 adenosine monophosphate deaminase 3 0.00569087
FSD1L fibronectin type III and SPRY domain containing 1-like 0.0056632
KIF18A kinesin family member 18A 0.00555826
ECD ecdysoneless homolog (Drosophila) 0.00555325
DMTF1 cyclin D binding myb-like transcription factor 1 0.00552443
GRIPAP1 GRIP1 associated protein 1 0.00552134
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.00551736
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00548024
H1-4 H1.4 linker histone, cluster member 0.00544641
ANKRD36B ankyrin repeat domain 36B 0.00534272
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.00533654
TBC1D19 TBC1 domain family, member 19 0.00533248

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.309216
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.198594
HLA-B major histocompatibility complex, class I, B -0.139999
TMSB10 thymosin beta 10 -0.126082
MARCKS myristoylated alanine-rich protein kinase C substrate -0.124983
IER3 immediate early response 3 -0.113237
FTL ferritin, light polypeptide -0.112219
TPT1 tumor protein, translationally-controlled 1 -0.110661
CD44 CD44 molecule (Indian blood group) -0.107933
AKAP12 A kinase (PRKA) anchor protein 12 -0.0841997
FRMD4A FERM domain containing 4A -0.081702
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0733301
VCL vinculin -0.0711035
MT2A metallothionein 2A -0.0700601
SOD2 superoxide dismutase 2, mitochondrial -0.0692454
ENO1 enolase 1, (alpha) -0.0686676
PGK1 phosphoglycerate kinase 1 -0.0671462
GLIS3 GLIS family zinc finger 3 -0.0653878
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0647414
B2M beta-2-microglobulin -0.0575529
HLA-A major histocompatibility complex, class I, A -0.0561098
ZMYND8 zinc finger, MYND-type containing 8 -0.0561077
AHNAK AHNAK nucleoprotein -0.0559944
UBC ubiquitin C -0.0554272
RPL23 ribosomal protein L23 -0.0547005
RPS24 ribosomal protein S24 -0.0535096
RPL35A ribosomal protein L35a -0.0525286
COL6A3 collagen, type VI, alpha 3 -0.0514417
NDRG1 N-myc downstream regulated 1 -0.0512494
COL1A1 collagen, type I, alpha 1 -0.0494351
HMGA2 high mobility group AT-hook 2 -0.049393
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.048632
EGR1 early growth response 1 -0.0475404
BASP1 brain abundant, membrane attached signal protein 1 -0.0472665
PTMA prothymosin, alpha -0.0457766
EXT1 exostosin glycosyltransferase 1 -0.045334
RPLP2 ribosomal protein, large, P2 -0.0445421
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0438682
STC1 stanniocalcin 1 -0.0436297
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0431493
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.042724
TMSB4X thymosin beta 4, X-linked -0.0415018
IGFBP3 insulin-like growth factor binding protein 3 -0.0414994
RPS6 ribosomal protein S6 -0.0408907
RPL36A ribosomal protein L36a -0.0382296
LOC112694756 uncharaterized LOC112694756 -0.0377547
ADM adrenomedullin -0.0376548
CDH13 cadherin 13 -0.0374747
NAP1L1 nucleosome assembly protein 1-like 1 -0.0372028
SLC38A1 solute carrier family 38, member 1 -0.0369285
CANX calnexin -0.0368293
SFTPA2 surfactant protein A2 -0.0367263
ACTG1 actin gamma 1 -0.036521
CTSD cathepsin D -0.0362978
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0362231
RPLP1 ribosomal protein, large, P1 -0.0353281
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0353095
IFITM3 interferon induced transmembrane protein 3 -0.0344897
MORF4L2 mortality factor 4 like 2 -0.0343375
EIF1 eukaryotic translation initiation factor 1 -0.0339795
RPS8 ribosomal protein S8 -0.0336857
BICC1 BicC family RNA binding protein 1 -0.0333814
RPS12 ribosomal protein S12 -0.0333283
HLA-E major histocompatibility complex, class I, E -0.0330122
DIAPH2 diaphanous-related formin 2 -0.0328502
RPS21 ribosomal protein S21 -0.0326762
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0325548
CALR calreticulin -0.0321947
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0319857
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0319801
ASPH aspartate beta-hydroxylase -0.0315866
NAMPT nicotinamide phosphoribosyltransferase -0.0313306
RPL37A ribosomal protein L37a -0.0308541
BTG1 B-cell translocation gene 1, anti-proliferative -0.0307941
RPL19 ribosomal protein L19 -0.0307902
IFI16 interferon, gamma-inducible protein 16 -0.0306169
RPS23 ribosomal protein S23 -0.0306012
RPL12 ribosomal protein L12 -0.0305979
RPS27A ribosomal protein S27a -0.0304748
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0303406
SFRP1 secreted frizzled-related protein 1 -0.0302922
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.030132
GNAS GNAS complex locus -0.0301156
VDAC1 voltage-dependent anion channel 1 -0.029844
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0296494
PLIN2 perilipin 2 -0.0296336
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0296155
SLC38A2 solute carrier family 38, member 2 -0.0294309
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0292029
RPS3 ribosomal protein S3 -0.0288044
TPM4 tropomyosin 4 -0.0282415
RPS25 ribosomal protein S25 -0.0282407
RPS13 ribosomal protein S13 -0.02796
PTPRK protein tyrosine phosphatase, receptor type, K -0.0277881
RAI14 retinoic acid induced 14 -0.0275476
ARL4C ADP-ribosylation factor-like 4C -0.0274623
SQSTM1 sequestosome 1 -0.0272697
COL1A2 collagen, type I, alpha 2 -0.0269678
FNDC3B fibronectin type III domain containing 3B -0.0267515
RPS19 ribosomal protein S19 -0.0266165