| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.116227 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.104725 |
| CD44 | CD44 molecule (Indian blood group) | 0.078881 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0729507 |
| ATP13A3 | ATPase type 13A3 | 0.0711108 |
| RNF145 | ring finger protein 145 | 0.0686819 |
| MT1X | metallothionein 1X | 0.0672107 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.06513 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0597957 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0586346 |
| YTHDC1 | YTH domain containing 1 | 0.0582312 |
| MAP1B | microtubule-associated protein 1B | 0.057819 |
| NDRG1 | N-myc downstream regulated 1 | 0.0564571 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.053806 |
| GLIS3 | GLIS family zinc finger 3 | 0.0532931 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0526972 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0520848 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0515483 |
| SP100 | SP100 nuclear antigen | 0.048696 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0482486 |
| COL3A1 | collagen, type III, alpha 1 | 0.048057 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0472564 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0470806 |
| NUP58 | nucleoporin 58 | 0.045171 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0435659 |
| COG5 | component of oligomeric golgi complex 5 | 0.0429751 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.0428974 |
| TBC1D23 | TBC1 domain family, member 23 | 0.041835 |
| RBM39 | RNA binding motif protein 39 | 0.0415637 |
| FOSL1 | FOS-like antigen 1 | 0.0413486 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0409047 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0406499 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0403924 |
| DST | dystonin | 0.0403112 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0399315 |
| HDAC9 | histone deacetylase 9 | 0.0394907 |
| VEGFA | vascular endothelial growth factor A | 0.0393947 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0393574 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0390555 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0386412 |
| AAK1 | AP2 associated kinase 1 | 0.0374843 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0374239 |
| SETD5 | SET domain containing 5 | 0.0372925 |
| U2SURP | U2 snRNP-associated SURP domain containing | 0.0372625 |
| APP | amyloid beta (A4) precursor protein | 0.037073 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0362204 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0360675 |
| RSRP1 | arginine/serine-rich protein 1 | 0.0359917 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0352257 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0350337 |
| TNPO3 | transportin 3 | 0.0349203 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.0348521 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0346313 |
| SYNJ2 | synaptojanin 2 | 0.0345147 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0340278 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0335869 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0330986 |
| CCNL1 | cyclin L1 | 0.0330763 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.033071 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0325528 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.032258 |
| WWOX | WW domain containing oxidoreductase | 0.031933 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0316904 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0316742 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0315226 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0313907 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0312412 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0311438 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.030907 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0308938 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0308283 |
| USP3 | ubiquitin specific peptidase 3 | 0.0308142 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0307756 |
| KIAA1217 | KIAA1217 | 0.0307534 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0305568 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0305297 |
| ARRDC3 | arrestin domain containing 3 | 0.0301036 |
| TMEM59 | transmembrane protein 59 | 0.0300583 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0299989 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0298621 |
| NF1 | neurofibromin 1 | 0.0296964 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0291205 |
| RASA3 | RAS p21 protein activator 3 | 0.0291053 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0288744 |
| CSNK1D | casein kinase 1, delta | 0.0288431 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.0287744 |
| PCM1 | pericentriolar material 1 | 0.0286809 |
| LOXL2 | lysyl oxidase-like 2 | 0.0286648 |
| COL1A1 | collagen, type I, alpha 1 | 0.0284989 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0284456 |
| FAM120A | family with sequence similarity 120A | 0.028205 |
| MAP4 | microtubule-associated protein 4 | 0.0281689 |
| FOXJ3 | forkhead box J3 | 0.0281307 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0281104 |
| RAB31 | RAB31, member RAS oncogene family | 0.0280076 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0279217 |
| SFXN1 | sideroflexin 1 | 0.0278558 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0277037 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0276935 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0273857 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.175264 |
| LOX | lysyl oxidase | -0.128045 |
| FN1 | fibronectin 1 | -0.115562 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.105466 |
| AHNAK | AHNAK nucleoprotein | -0.0981506 |
| UBC | ubiquitin C | -0.0893322 |
| HDLBP | high density lipoprotein binding protein | -0.0821746 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0821222 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.081059 |
| ENO1 | enolase 1, (alpha) | -0.077475 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.07654 |
| CANX | calnexin | -0.0695822 |
| ATXN1 | ataxin 1 | -0.0674806 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0661892 |
| TPM4 | tropomyosin 4 | -0.0660227 |
| QKI | QKI, KH domain containing, RNA binding | -0.0642455 |
| TMSB10 | thymosin beta 10 | -0.0625315 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0614878 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0573003 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0548507 |
| VCL | vinculin | -0.0547697 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0541781 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0540987 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0534013 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0530798 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0510612 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0497458 |
| COL5A1 | collagen, type V, alpha 1 | -0.0495375 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0494995 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0493042 |
| ASPH | aspartate beta-hydroxylase | -0.048451 |
| EXOC4 | exocyst complex component 4 | -0.0476699 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0458655 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0455256 |
| SPAG9 | sperm associated antigen 9 | -0.04544 |
| PRELID2 | PRELI domain containing 2 | -0.0447717 |
| ZNF395 | zinc finger protein 395 | -0.0429664 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0427801 |
| PRSS23 | protease, serine, 23 | -0.0415995 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0412631 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0410823 |
| SMYD3 | SET and MYND domain containing 3 | -0.0410346 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0406722 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0406478 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0399744 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0397626 |
| CCDC88A | coiled-coil domain containing 88A | -0.0396008 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0395784 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0394993 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0393373 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0392798 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.038545 |
| NRP1 | neuropilin 1 | -0.0382924 |
| UBN2 | ubinuclein 2 | -0.0379844 |
| RAD51B | RAD51 paralog B | -0.0376002 |
| INTS6 | integrator complex subunit 6 | -0.0374674 |
| ANXA5 | annexin A5 | -0.0369579 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0362621 |
| CENPF | centromere protein F, 350/400kDa | -0.0355346 |
| S100A10 | S100 calcium binding protein A10 | -0.0350368 |
| ZNF207 | zinc finger protein 207 | -0.0348823 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0347701 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0344473 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0342828 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0340506 |
| MEF2A | myocyte enhancer factor 2A | -0.0340303 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0339213 |
| CDK19 | cyclin-dependent kinase 19 | -0.033901 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0337074 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0336815 |
| RAB10 | RAB10, member RAS oncogene family | -0.0333183 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0332293 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0331291 |
| MYO10 | myosin X | -0.0330851 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0329877 |
| SEC24D | SEC24 family member D | -0.0327027 |
| PTMA | prothymosin, alpha | -0.0323858 |
| VIM | vimentin | -0.0322751 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0319365 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0314857 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0313575 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0311968 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0310612 |
| POTEF | POTE ankyrin domain family, member F | -0.0308298 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.030692 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0306832 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0306516 |
| ACTG1 | actin gamma 1 | -0.0305778 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0304193 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0301733 |
| STC1 | stanniocalcin 1 | -0.0301084 |
| MTPN | myotrophin | -0.0300403 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0299461 |
| MORF4L2 | mortality factor 4 like 2 | -0.0298824 |
| PGK1 | phosphoglycerate kinase 1 | -0.0297873 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0297777 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0294853 |
| PMM2 | phosphomannomutase 2 | -0.0292599 |
| RORA | RAR-related orphan receptor A | -0.0292451 |
| PALLD | palladin, cytoskeletal associated protein | -0.0292189 |
