| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.0948914 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0758391 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0705094 |
| POTEF | POTE ankyrin domain family, member F | 0.0506126 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0483902 |
| SPAG9 | sperm associated antigen 9 | 0.0483606 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0468977 |
| RPL26 | ribosomal protein L26 | 0.0460266 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0457388 |
| PKM | pyruvate kinase, muscle | 0.0443534 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0412979 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0406388 |
| SET | SET nuclear proto-oncogene | 0.0400084 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.039545 |
| LMO7 | LIM domain 7 | 0.0390284 |
| RBM6 | RNA binding motif protein 6 | 0.0385518 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0382284 |
| EGFR | epidermal growth factor receptor | 0.0375545 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0369093 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0368561 |
| TOP1 | topoisomerase (DNA) I | 0.0358124 |
| USP3 | ubiquitin specific peptidase 3 | 0.035027 |
| NCKAP1 | NCK-associated protein 1 | 0.0349482 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0336575 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0334662 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0334239 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.03312 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.032887 |
| B2M | beta-2-microglobulin | 0.0328105 |
| RPS3 | ribosomal protein S3 | 0.0321746 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0319145 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0315307 |
| DST | dystonin | 0.0312612 |
| RUNX1 | runt-related transcription factor 1 | 0.0312089 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0312019 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0309955 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0309159 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0309083 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.0308573 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0304816 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0303189 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0303155 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0301817 |
| SQSTM1 | sequestosome 1 | 0.0300153 |
| RANBP2 | RAN binding protein 2 | 0.0299923 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0296727 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | 0.029583 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0295801 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0295305 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0294616 |
| DTNA | dystrobrevin, alpha | 0.0294544 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0293387 |
| PCBP2 | poly(rC) binding protein 2 | 0.0293128 |
| NPTN | neuroplastin | 0.0291767 |
| CALR | calreticulin | 0.028972 |
| RPL3 | ribosomal protein L3 | 0.028957 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0282504 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0281125 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.028044 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0277887 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0275356 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0274811 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | 0.0274476 |
| FEM1C | fem-1 homolog c (C. elegans) | 0.0273988 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0272703 |
| CCDC88A | coiled-coil domain containing 88A | 0.0269145 |
| UBE3A | ubiquitin protein ligase E3A | 0.0268672 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0268579 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0264512 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0263384 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0262538 |
| MED4 | mediator complex subunit 4 | 0.0260541 |
| FAM168A | family with sequence similarity 168, member A | 0.0260522 |
| KLC1 | kinesin light chain 1 | 0.0259686 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0258135 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0254586 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0252372 |
| CLIC4 | chloride intracellular channel 4 | 0.025195 |
| RPS4X | ribosomal protein S4, X-linked | 0.0251458 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0250562 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0249439 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0249187 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0248983 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0248749 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0248641 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0248158 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0245872 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0243958 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.024284 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0242279 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0242117 |
| PRC1 | protein regulator of cytokinesis 1 | 0.0241915 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.0241571 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0239341 |
| MSN | moesin | 0.0238437 |
| TNPO1 | transportin 1 | 0.02381 |
| SLTM | SAFB-like, transcription modulator | 0.0237922 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0237533 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | 0.0236864 |
| DIAPH1 | diaphanous-related formin 1 | 0.0236494 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.0987021 |
| SMYD3 | SET and MYND domain containing 3 | -0.0781804 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0755418 |
| OSMR | oncostatin M receptor | -0.0744866 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.070921 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0706642 |
| CANX | calnexin | -0.0675047 |
| TMSB10 | thymosin beta 10 | -0.0660671 |
| ATM | ATM serine/threonine kinase | -0.0616604 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0611556 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0595483 |
| SMAD3 | SMAD family member 3 | -0.0573136 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0553742 |
| CD44 | CD44 molecule (Indian blood group) | -0.0552053 |
| YAP1 | Yes-associated protein 1 | -0.0543266 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0537552 |
| VCL | vinculin | -0.0518618 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0504406 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0501007 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0479596 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0473893 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0472104 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0469697 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0463134 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0459564 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0457463 |
| DSCAM | Down syndrome cell adhesion molecule | -0.045279 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0443073 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0439502 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0438406 |
| RPL35A | ribosomal protein L35a | -0.0437268 |
| PARD3 | par-3 family cell polarity regulator | -0.0431317 |
| AHNAK | AHNAK nucleoprotein | -0.0426105 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0410152 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0406458 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0405067 |
| IER3 | immediate early response 3 | -0.0398759 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0396204 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0388668 |
| YBX3 | Y box binding protein 3 | -0.0382838 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0378503 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0374671 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0369818 |
| NALCN | sodium leak channel, non selective | -0.0362792 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0362618 |
| NDRG1 | N-myc downstream regulated 1 | -0.0356818 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0354943 |
| GPC6 | glypican 6 | -0.0353459 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0349572 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.034618 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0345589 |
| RFX7 | regulatory factor X, 7 | -0.0345131 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0344342 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0343757 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0335892 |
| HLA-C | major histocompatibility complex, class I, C | -0.0335338 |
| PGK1 | phosphoglycerate kinase 1 | -0.0333938 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | -0.0329122 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0327625 |
| NAV2 | neuron navigator 2 | -0.0325776 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0324611 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0322182 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0319004 |
| PAPOLA | poly(A) polymerase alpha | -0.03164 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0315354 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0314944 |
| RAD51B | RAD51 paralog B | -0.0314816 |
| RPL4 | ribosomal protein L4 | -0.0312877 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0311805 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0311178 |
| ZBTB44 | zinc finger and BTB domain containing 44 | -0.0309169 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0308877 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0307613 |
| GNAS | GNAS complex locus | -0.0307545 |
| RPL30 | ribosomal protein L30 | -0.0304978 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0304788 |
| ERCC8 | excision repair cross-complementation group 8 | -0.0303216 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0297291 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0297134 |
| TMEM123 | transmembrane protein 123 | -0.0294789 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0291162 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0289957 |
| CBFB | core-binding factor, beta subunit | -0.0288501 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0286801 |
| ATG7 | autophagy related 7 | -0.028405 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0283519 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0282772 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.028261 |
| FAF2 | Fas associated factor family member 2 | -0.0282515 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0279432 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0279193 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0278622 |
| CEP95 | centrosomal protein 95kDa | -0.0277438 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0277301 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0276305 |
| RPS24 | ribosomal protein S24 | -0.0275764 |
| RECQL | RecQ helicase-like | -0.0275096 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0274491 |
| CCDC138 | coiled-coil domain containing 138 | -0.0271663 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0271243 |
