| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Macitentan perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Macitentan_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.229069 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.151669 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0643668 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0488291 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0484207 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0455039 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0446767 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0432071 |
| OGA | O-GlcNAcase | 0.0414026 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0393689 |
| PRELID2 | PRELI domain containing 2 | 0.0390984 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0386313 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0378744 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0367653 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0364967 |
| LDHA | lactate dehydrogenase A | 0.0359301 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0339688 |
| FAT1 | FAT atypical cadherin 1 | 0.0330235 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0325568 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0322421 |
| GOLGA4 | golgin A4 | 0.0322395 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0320377 |
| RPL13A | ribosomal protein L13a | 0.0308496 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0302995 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0296712 |
| RNF145 | ring finger protein 145 | 0.0296296 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0295185 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0291366 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0284506 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0283025 |
| NUP58 | nucleoporin 58 | 0.0282771 |
| ZNF841 | zinc finger protein 841 | 0.0280789 |
| SDC4 | syndecan 4 | 0.0280404 |
| HDGF | hepatoma-derived growth factor | 0.0269698 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0265536 |
| H1-0 | H1.0 linker histone | 0.0264682 |
| RUNX2 | runt-related transcription factor 2 | 0.0261519 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.025617 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0251448 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0248509 |
| CALR | calreticulin | 0.0247527 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0239909 |
| ZNF292 | zinc finger protein 292 | 0.0236426 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0235744 |
| ANXA2 | annexin A2 | 0.0233317 |
| CFB | complement factor B | 0.0231493 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0230801 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0228923 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0228 |
| RBM39 | RNA binding motif protein 39 | 0.0225138 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0224013 |
| RPL41 | ribosomal protein L41 | 0.0222542 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0217135 |
| RPS3 | ribosomal protein S3 | 0.021617 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0215605 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0214425 |
| CD47 | CD47 molecule | 0.0213668 |
| COPA | coatomer protein complex, subunit alpha | 0.0209869 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0205656 |
| GANAB | glucosidase, alpha; neutral AB | 0.020426 |
| RPL26 | ribosomal protein L26 | 0.0204232 |
| FAM20C | family with sequence similarity 20, member C | 0.0203653 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0202537 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0200161 |
| YME1L1 | YME1-like 1 ATPase | 0.01987 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0198366 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0197913 |
| RPS27A | ribosomal protein S27a | 0.0193788 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0193726 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0191397 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.019049 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0190238 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0188123 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0185923 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0185719 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0185235 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0184952 |
| WDR43 | WD repeat domain 43 | 0.0184566 |
| SRP54 | signal recognition particle 54kDa | 0.0182809 |
| YTHDC1 | YTH domain containing 1 | 0.0182246 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0179395 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0178823 |
| TMEM59 | transmembrane protein 59 | 0.0176497 |
| TMEM263 | transmembrane protein 263 | 0.017644 |
| SCFD2 | sec1 family domain containing 2 | 0.017606 |
| FAM13A | family with sequence similarity 13, member A | 0.0175956 |
| ARF3 | ADP-ribosylation factor 3 | 0.0174272 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0174095 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0173617 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0173345 |
| PTMA | prothymosin, alpha | 0.0173263 |
| ADD3 | adducin 3 (gamma) | 0.0172677 |
| MED15 | mediator complex subunit 15 | 0.0171882 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0171392 |
| SMOX | spermine oxidase | 0.0170551 |
| PNN | pinin, desmosome associated protein | 0.0169158 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0167525 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0166094 |
| MATR3 | matrin 3 | 0.0165892 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0163744 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.225736 |
| NRG1 | neuregulin 1 | -0.136682 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.129161 |
| VCL | vinculin | -0.108332 |
| TMEM156 | transmembrane protein 156 | -0.103419 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.101402 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0886498 |
| ASPH | aspartate beta-hydroxylase | -0.0849398 |
| MT2A | metallothionein 2A | -0.084581 |
| HMGA2 | high mobility group AT-hook 2 | -0.0817979 |
| SFTPA2 | surfactant protein A2 | -0.0779991 |
| S100A6 | S100 calcium binding protein A6 | -0.0725517 |
| HLA-B | major histocompatibility complex, class I, B | -0.0722451 |
| NDRG1 | N-myc downstream regulated 1 | -0.070702 |
| ITGA1 | integrin, alpha 1 | -0.0693606 |
| POTEF | POTE ankyrin domain family, member F | -0.064344 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0601453 |
| FTL | ferritin, light polypeptide | -0.0586909 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0573465 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0568538 |
| NTN4 | netrin 4 | -0.0568044 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0567817 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0558856 |
| TMSB10 | thymosin beta 10 | -0.0549279 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0548863 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0547143 |
| MAP1B | microtubule-associated protein 1B | -0.0530102 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0520421 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0507775 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0486224 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0475223 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0472678 |
| NRP1 | neuropilin 1 | -0.0470872 |
| B2M | beta-2-microglobulin | -0.045534 |
| ETV1 | ets variant 1 | -0.0454998 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0452047 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0443205 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0436825 |
| S100A10 | S100 calcium binding protein A10 | -0.0426212 |
| EGR1 | early growth response 1 | -0.0421216 |
| ACTG1 | actin gamma 1 | -0.0420678 |
| HMGA1 | high mobility group AT-hook 1 | -0.0418173 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0412506 |
| DUSP5 | dual specificity phosphatase 5 | -0.0412161 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0405479 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0401868 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0394358 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0392693 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0392144 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0385729 |
| KLHL5 | kelch-like family member 5 | -0.0384781 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0372272 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0371015 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0362092 |
| SYT1 | synaptotagmin I | -0.0350126 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0349533 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0347761 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0346087 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0345173 |
| FOXP1 | forkhead box P1 | -0.0342493 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0336461 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0336193 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0329893 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0328579 |
| PRKCA | protein kinase C, alpha | -0.0325521 |
| RPS24 | ribosomal protein S24 | -0.032486 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.032474 |
| RASAL2 | RAS protein activator like 2 | -0.0322108 |
| TXNIP | thioredoxin interacting protein | -0.032204 |
| RPL35A | ribosomal protein L35a | -0.0317647 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.03172 |
| FNBP1 | formin binding protein 1 | -0.0316219 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0314375 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0310377 |
| IER3 | immediate early response 3 | -0.0310092 |
| GPATCH2L | G patch domain containing 2-like | -0.0306965 |
| RAI14 | retinoic acid induced 14 | -0.0305694 |
| MCL1 | myeloid cell leukemia 1 | -0.0301945 |
| DUSP6 | dual specificity phosphatase 6 | -0.0301765 |
| UBXN4 | UBX domain protein 4 | -0.0301652 |
| ERBIN | erbb2 interacting protein | -0.0301203 |
| LOXL2 | lysyl oxidase-like 2 | -0.0298283 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0297855 |
| BPTF | bromodomain PHD finger transcription factor | -0.0297096 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0295749 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.029527 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0294233 |
| PALLD | palladin, cytoskeletal associated protein | -0.0293597 |
| AEBP2 | AE binding protein 2 | -0.0293541 |
| RAB10 | RAB10, member RAS oncogene family | -0.0292715 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0291919 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.029143 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0289019 |
| CLTC | clathrin, heavy chain (Hc) | -0.028797 |
| UBC | ubiquitin C | -0.0287214 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0287131 |
| LMNA | lamin A/C | -0.0285155 |
| JMJD1C | jumonji domain containing 1C | -0.0280851 |
| TMSB4X | thymosin beta 4, X-linked | -0.0280082 |
| LYST | lysosomal trafficking regulator | -0.0279843 |
