Macroautophagy Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
Description The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded. (Gene Ontology, GO_0016236)
External Link https://reactome.org/PathwayBrowser/#/R-HSA-1632852
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Genes

141 proteins participating in the Macroautophagy pathway from the Reactome Pathways 2024 dataset.

Symbol Name
AMBRA1 autophagy/beclin-1 regulator 1
ARL13B ADP-ribosylation factor-like 13B
ATG10 autophagy related 10
ATG101 autophagy related 101
ATG12 autophagy related 12
ATG13 autophagy related 13
ATG14 autophagy related 14
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATG3 autophagy related 3
ATG4A autophagy related 4A, cysteine peptidase
ATG4B autophagy related 4B, cysteine peptidase
ATG4C autophagy related 4C, cysteine peptidase
ATG4D autophagy related 4D, cysteine peptidase
ATG5 autophagy related 5
ATG7 autophagy related 7
ATG9A autophagy related 9A
ATG9B autophagy related 9B
ATM ATM serine/threonine kinase
BECN1 beclin 1, autophagy related
CETN1 centrin, EF-hand protein, 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHMP2A charged multivesicular body protein 2A
CHMP2B charged multivesicular body protein 2B
CHMP3 charged multivesicular body protein 3
CHMP4A charged multivesicular body protein 4A
CHMP4B charged multivesicular body protein 4B
CHMP4C charged multivesicular body protein 4C
CHMP6 charged multivesicular body protein 6
CHMP7 charged multivesicular body protein 7
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
FUNDC1 FUN14 domain containing 1
GABARAP GABA(A) receptor-associated protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
HDAC6 histone deacetylase 6
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
IFT88 intraflagellar transport 88
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma
MFN1 mitofusin 1
MFN2 mitofusin 2
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MTERF3 mitochondrial transcription termination factor 3
MTMR14 myotubularin related protein 14
MTMR3 myotubularin related protein 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NBR1 neighbor of BRCA1 gene 1
OPTN optineurin
PARK7 parkinson protein 7
PCNT pericentrin
PEX5 peroxisomal biogenesis factor 5
PGAM5 phosphoglycerate mutase family member 5
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PINK1 PTEN induced putative kinase 1
PLIN2 perilipin 2
PLIN3 perilipin 3
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PRKN parkin RBR E3 ubiquitin protein ligase
RB1CC1 RB1-inducible coiled-coil 1
RHEB Ras homolog enriched in brain
RPS27A ribosomal protein S27a
RPTOR regulatory associated protein of MTOR, complex 1
RRAGA Ras-related GTP binding A
RRAGB Ras-related GTP binding B
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
SLC38A9 solute carrier family 38, member 9
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TBK1 TANK-binding kinase 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast)
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast)
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast)
TOMM70 translocase of outer mitochondrial membrane 70
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBA3E tubulin, alpha 3e
TUBA4A tubulin, alpha 4a
TUBA4B tubulin, alpha 4b
TUBA8 tubulin, alpha 8
TUBAL3 tubulin, alpha-like 3
TUBB1 tubulin, beta 1 class VI
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBB8 tubulin, beta 8 class VIII
TUBB8B tubulin beta 8B
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
ULK1 unc-51 like autophagy activating kinase 1
USP30 ubiquitin specific peptidase 30
UVRAG UV radiation resistance associated
VCP valosin containing protein
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VDAC3 voltage-dependent anion channel 3
VIM vimentin
WDR45 WD repeat domain 45
WDR45B WD repeat domain 45B
WIPI1 WD repeat domain, phosphoinositide interacting 1
WIPI2 WD repeat domain, phosphoinositide interacting 2