Macular degeneration_Fibroblast_GSE1719 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE1719
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Genes

600 genes differentially expressed during Macular degeneration_Fibroblast_GSE1719 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
PLIN2 perilipin 2 3.19568
ELK1 ELK1, member of ETS oncogene family 3.06715
GNPDA1 glucosamine-6-phosphate deaminase 1 2.8128
ALAS1 5'-aminolevulinate synthase 1 2.74911
MRPL49 mitochondrial ribosomal protein L49 2.65458
SRSF9 serine/arginine-rich splicing factor 9 2.57066
RPP38 ribonuclease P/MRP 38kDa subunit 2.53004
GSTO1 glutathione S-transferase omega 1 2.52327
MRPL9 mitochondrial ribosomal protein L9 2.50358
TXN thioredoxin 2.47891
TUSC2 tumor suppressor candidate 2 2.4663
XPO1 exportin 1 2.46469
FGF5 fibroblast growth factor 5 2.43946
EFNA5 ephrin-A5 2.43138
PRDX1 peroxiredoxin 1 2.41897
EIF3D eukaryotic translation initiation factor 3, subunit D 2.40508
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.36689
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 2.3663
IRAK1 interleukin-1 receptor-associated kinase 1 2.35743
THAP11 THAP domain containing 11 2.35656
STX3 syntaxin 3 2.34477
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.34044
CIAO1 cytosolic iron-sulfur assembly component 1 2.31402
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 2.31372
SLC10A3 solute carrier family 10, member 3 2.31321
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) 2.30284
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.29928
HBP1 HMG-box transcription factor 1 2.26032
HMGXB3 HMG box domain containing 3 2.25249
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.22593
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 2.20837
VIM vimentin 2.20795
TGIF1 TGFB-induced factor homeobox 1 2.20687
SERINC3 serine incorporator 3 2.20167
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.19916
STK24 serine/threonine kinase 24 2.19609
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.19522
NPC2 Niemann-Pick disease, type C2 2.18507
PPIA peptidylprolyl isomerase A (cyclophilin A) 2.18382
IRF3 interferon regulatory factor 3 2.17669
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.17571
TTLL5 tubulin tyrosine ligase-like family member 5 2.168
KLF5 Kruppel-like factor 5 (intestinal) 2.16428
ZNF143 zinc finger protein 143 2.1279
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 2.12618
ERCC3 excision repair cross-complementation group 3 2.11825
N4BP2L1 NEDD4 binding protein 2-like 1 2.11084
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 2.10681
TM9SF1 transmembrane 9 superfamily member 1 2.09696
BCAP31 B-cell receptor-associated protein 31 2.09318
H2AFY H2A histone family, member Y 2.09287
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.08492
ANXA5 annexin A5 2.06118
FAM134C family with sequence similarity 134, member C 2.05269
TRAFD1 TRAF-type zinc finger domain containing 1 2.05113
CCNG2 cyclin G2 2.04581
NOS2 nitric oxide synthase 2, inducible 2.04512
TRIP6 thyroid hormone receptor interactor 6 2.04375
BCL7B B-cell CLL/lymphoma 7B 2.04313
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 2.04234
KDM1A lysine (K)-specific demethylase 1A 2.03239
KAT8 K(lysine) acetyltransferase 8 2.03236
PRPS2 phosphoribosyl pyrophosphate synthetase 2 2.02938
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 2.02287
MSL1 male-specific lethal 1 homolog (Drosophila) 2.01921
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.01855
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 2.01432
CAPZB capping protein (actin filament) muscle Z-line, beta 2.00449
HDAC5 histone deacetylase 5 2.00339
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.99452
CLP1 cleavage and polyadenylation factor I subunit 1 1.99057
PCGF1 polycomb group ring finger 1 1.98191
ANK1 ankyrin 1, erythrocytic 1.97886
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1.97733
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.97347
CSNK1G2 casein kinase 1, gamma 2 1.96777
USP20 ubiquitin specific peptidase 20 1.96691
TALDO1 transaldolase 1 1.9657
SLC25A42 solute carrier family 25, member 42 1.95906
BAG1 BCL2-associated athanogene 1.9554
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 1.95489
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 1.95191
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1.9372
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 1.93066
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 1.92603
IL1B interleukin 1, beta 1.91524
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 1.91226
CLTA clathrin, light chain A 1.88263
PRPF31 pre-mRNA processing factor 31 1.88259
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 1.87547
PDHX pyruvate dehydrogenase complex, component X 1.87416
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit 1.87107
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 1.86936
NQO1 NAD(P)H dehydrogenase, quinone 1 1.86909
OPRL1 opiate receptor-like 1 1.86825
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 1.8678
PFKM phosphofructokinase, muscle 1.86357
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 1.86006
RABEPK Rab9 effector protein with kelch motifs 1.85874
TMED1 transmembrane emp24 protein transport domain containing 1 1.85659
ZNF23 zinc finger protein 23 1.85463
FANCG Fanconi anemia, complementation group G 1.85447
ADGRA3 adhesion G protein-coupled receptor A3 1.84979
SYF2 SYF2 pre-mRNA-splicing factor 1.84934
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 1.84479
ZNF266 zinc finger protein 266 1.83819
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 1.83787
HMGA2 high mobility group AT-hook 2 1.83037
FOXE1 forkhead box E1 1.82744
HMGN1 high mobility group nucleosome binding domain 1 1.81641
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 1.81367
AFG3L2 AFG3-like AAA ATPase 2 1.81092
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 1.80952
NR0B1 nuclear receptor subfamily 0, group B, member 1 1.80927
CCNF cyclin F 1.80677
LYPLA2 lysophospholipase II 1.80243
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 1.79768
LPCAT3 lysophosphatidylcholine acyltransferase 3 1.79512
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 1.79294
PABPN1 poly(A) binding protein, nuclear 1 1.79079
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.78663
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1.78369
BCL2L1 BCL2-like 1 1.78311
IFNAR2 interferon (alpha, beta and omega) receptor 2 1.78252
PIAS2 protein inhibitor of activated STAT, 2 1.78003
DTNB dystrobrevin, beta 1.77844
STOML2 stomatin (EPB72)-like 2 1.77532
CA9 carbonic anhydrase IX 1.77476
KCTD2 potassium channel tetramerization domain containing 2 1.77064
TPST2 tyrosylprotein sulfotransferase 2 1.7688
NONO non-POU domain containing, octamer-binding 1.76622
SOCS3 suppressor of cytokine signaling 3 1.76614
ARHGAP22 Rho GTPase activating protein 22 1.76575
LRRC37A2 leucine rich repeat containing 37, member A2 1.76563
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 1.76401
AK1 adenylate kinase 1 1.76108
JOSD1 Josephin domain containing 1 1.76083
LARP4B La ribonucleoprotein domain family, member 4B 1.75902
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.75768
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 1.7573
EI24 etoposide induced 2.4 1.75697
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 1.75636
TDRD7 tudor domain containing 7 1.75534
SP3 Sp3 transcription factor 1.75487
LIPE lipase, hormone-sensitive 1.75474
SPHK2 sphingosine kinase 2 1.7505
LIMK2 LIM domain kinase 2 1.74712
PPOX protoporphyrinogen oxidase 1.74292
ATG9A autophagy related 9A 1.73552
LAMC2 laminin, gamma 2 1.73504
MOAP1 modulator of apoptosis 1 1.73472
UBE2D3 ubiquitin-conjugating enzyme E2D 3 1.73097
SSRP1 structure specific recognition protein 1 1.73076
IST1 increased sodium tolerance 1 homolog (yeast) 1.7298
YIPF3 Yip1 domain family, member 3 1.72064
RER1 retention in endoplasmic reticulum sorting receptor 1 1.71559
CSNK2A1 casein kinase 2, alpha 1 polypeptide 1.71078
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 1.70948
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.7078
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 1.70116
RIBC2 RIB43A domain with coiled-coils 2 1.69806
STEAP1 six transmembrane epithelial antigen of the prostate 1 1.69469
HIPK3 homeodomain interacting protein kinase 3 1.69304
CD59 CD59 molecule, complement regulatory protein 1.69048
BAIAP3 BAI1-associated protein 3 1.68716
FLT1 fms-related tyrosine kinase 1 1.68418
CSNK2A2 casein kinase 2, alpha prime polypeptide 1.68363
LAPTM4B lysosomal protein transmembrane 4 beta 1.68164
NPEPPS aminopeptidase puromycin sensitive 1.68088
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 1.68063
PRKD2 protein kinase D2 1.68059
BUB3 BUB3 mitotic checkpoint protein 1.67839
CD247 CD247 molecule 1.67413
CLN3 ceroid-lipofuscinosis, neuronal 3 1.67105
MMD monocyte to macrophage differentiation-associated 1.67041
TSG101 tumor susceptibility 101 1.66873
LHCGR luteinizing hormone/choriogonadotropin receptor 1.66704
WIPI2 WD repeat domain, phosphoinositide interacting 2 1.65439
KIAA0430 KIAA0430 1.65287
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 1.65168
VRK2 vaccinia related kinase 2 1.65028
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 1.64782
CNOT8 CCR4-NOT transcription complex, subunit 8 1.64694
ODC1 ornithine decarboxylase 1 1.64545
FAM189B family with sequence similarity 189, member B 1.64347
DOLK dolichol kinase 1.64052
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 1.63802
NCOA4 nuclear receptor coactivator 4 1.63601
EXTL3 exostosin-like glycosyltransferase 3 1.63417
INPP1 inositol polyphosphate-1-phosphatase 1.63162
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 1.62717
RPIA ribose 5-phosphate isomerase A 1.62519
TDP2 tyrosyl-DNA phosphodiesterase 2 1.62157
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 1.62033
CNGB1 cyclic nucleotide gated channel beta 1 1.61955
PRRC1 proline-rich coiled-coil 1 1.61901
DNPEP aspartyl aminopeptidase 1.61834
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 1.61389
ARF1 ADP-ribosylation factor 1 1.6119
CTNS cystinosin, lysosomal cystine transporter 1.61113
MAP2K1 mitogen-activated protein kinase kinase 1 1.60933
BTG1 B-cell translocation gene 1, anti-proliferative 1.60623
GMPS guanine monphosphate synthase 1.60329
BTG3 BTG family, member 3 1.60292
ZNF324 zinc finger protein 324 1.60259
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 1.60152
NMB neuromedin B 1.59689
RCC1 regulator of chromosome condensation 1 1.59606
BRMS1 breast cancer metastasis suppressor 1 1.59505
OXA1L oxidase (cytochrome c) assembly 1-like 1.59503
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.5933
ZBTB22 zinc finger and BTB domain containing 22 1.59245
ARL4C ADP-ribosylation factor-like 4C 1.59232
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 1.59196
MCL1 myeloid cell leukemia 1 1.59119
CCT8 chaperonin containing TCP1, subunit 8 (theta) 1.58665
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 1.586
ZNHIT3 zinc finger, HIT-type containing 3 1.58562
TUBGCP2 tubulin, gamma complex associated protein 2 1.58392
CCDC85B coiled-coil domain containing 85B 1.58175
ESRRA estrogen-related receptor alpha 1.57754
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 1.57404
MRPL28 mitochondrial ribosomal protein L28 1.57188
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 1.57094
GLUD1 glutamate dehydrogenase 1 1.56995
STARD5 StAR-related lipid transfer (START) domain containing 5 1.56875
PACS2 phosphofurin acidic cluster sorting protein 2 1.56745
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 1.56394
STX4 syntaxin 4 1.56292
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 1.56231
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.5622
ACP1 acid phosphatase 1, soluble 1.56219
THOP1 thimet oligopeptidase 1 1.55926
NPTN neuroplastin 1.55812
ARID5A AT rich interactive domain 5A (MRF1-like) 1.55654
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 1.55639
TUFM Tu translation elongation factor, mitochondrial 1.55496
PNPLA2 patatin-like phospholipase domain containing 2 1.5542
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 1.55312
MAP3K12 mitogen-activated protein kinase kinase kinase 12 1.55284
UMPS uridine monophosphate synthetase 1.55018
SPATA2L spermatogenesis associated 2-like 1.54956
ZNF184 zinc finger protein 184 1.5492
PLK3 polo-like kinase 3 1.54823
COIL coilin 1.54732
CIB1 calcium and integrin binding 1 (calmyrin) 1.54614
ASTN1 astrotactin 1 1.54475
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 1.54112
CCNC cyclin C 1.54065
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 1.53904
EIF3M eukaryotic translation initiation factor 3, subunit M 1.53883
HMGN4 high mobility group nucleosomal binding domain 4 1.53636
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 1.53608
RPL34 ribosomal protein L34 1.53603
ACY1 aminoacylase 1 1.53486
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 1.53079
PTP4A1 protein tyrosine phosphatase type IVA, member 1 1.52664
PCBP2 poly(rC) binding protein 2 1.52512
GPR137B G protein-coupled receptor 137B 1.52337
IQSEC2 IQ motif and Sec7 domain 2 1.52319
CREM cAMP responsive element modulator 1.52198
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 1.52114
PDCD2 programmed cell death 2 1.51697
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 1.51526
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) 1.51026
DUSP6 dual specificity phosphatase 6 1.50929
STK25 serine/threonine kinase 25 1.50889
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 1.50749
ALDOA aldolase A, fructose-bisphosphate 1.50735
MPHOSPH6 M-phase phosphoprotein 6 1.50567
GLB1L2 galactosidase, beta 1-like 2 1.5046
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 1.50383
HMG20B high mobility group 20B 1.50375
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 1.50293
RAB9A RAB9A, member RAS oncogene family 1.50161
HSF2 heat shock transcription factor 2 1.49901
SUMO1 small ubiquitin-like modifier 1 1.49707
ST7 suppression of tumorigenicity 7 1.49472
CHD8 chromodomain helicase DNA binding protein 8 1.49426
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 1.49313
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 1.49292
CYB5R1 cytochrome b5 reductase 1 1.49064
DOLPP1 dolichyldiphosphatase 1 1.49064
KIFC3 kinesin family member C3 1.49059
MAP2K2 mitogen-activated protein kinase kinase 2 1.49028
VDAC3 voltage-dependent anion channel 3 1.48797
HYAL2 hyaluronoglucosaminidase 2 1.48508
SLC16A6 solute carrier family 16, member 6 1.48285
PRPF4 pre-mRNA processing factor 4 1.48235
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 1.47922
MED6 mediator complex subunit 6 1.4789
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 1.47878
GRAP2 GRB2-related adaptor protein 2 1.47732
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 1.477
CD44 CD44 molecule (Indian blood group) 1.47677
ZNF330 zinc finger protein 330 1.47427
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.47199
BECN1 beclin 1, autophagy related 1.46925
CFDP1 craniofacial development protein 1 1.46591
CRYBB1 crystallin, beta B1 1.46421

decreased expression

Symbol Name Standardized Value
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -2.86752
NFYC nuclear transcription factor Y, gamma -2.69809
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.61407
IL11RA interleukin 11 receptor, alpha -2.57704
NFE2L1 nuclear factor, erythroid 2-like 1 -2.56809
IARS isoleucyl-tRNA synthetase -2.56507
GABARAP GABA(A) receptor-associated protein -2.55577
KLC1 kinesin light chain 1 -2.52589
RFTN1 raftlin, lipid raft linker 1 -2.52583
PYGB phosphorylase, glycogen; brain -2.52049
KLF7 Kruppel-like factor 7 (ubiquitous) -2.51014
CARS cysteinyl-tRNA synthetase -2.48247
CSK c-src tyrosine kinase -2.47755
DHCR7 7-dehydrocholesterol reductase -2.4668
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -2.46157
DSTN destrin (actin depolymerizing factor) -2.44352
DGUOK deoxyguanosine kinase -2.43499
OCRL oculocerebrorenal syndrome of Lowe -2.42941
WARS tryptophanyl-tRNA synthetase -2.42011
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) -2.41414
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -2.39517
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta -2.39085
LOXL1 lysyl oxidase-like 1 -2.3682
SLC30A4 solute carrier family 30 (zinc transporter), member 4 -2.31285
RBM3 RNA binding motif (RNP1, RRM) protein 3 -2.31222
TXN2 thioredoxin 2 -2.29079
EPRS glutamyl-prolyl-tRNA synthetase -2.28064
TP53I11 tumor protein p53 inducible protein 11 -2.23661
PDIA4 protein disulfide isomerase family A, member 4 -2.22819
COPS6 COP9 signalosome subunit 6 -2.20603
RAD23B RAD23 homolog B (S. cerevisiae) -2.20484
GUCA2A guanylate cyclase activator 2A (guanylin) -2.20129
ACO1 aconitase 1, soluble -2.19365
FLNB filamin B, beta -2.18638
E2F1 E2F transcription factor 1 -2.18575
CACNB1 calcium channel, voltage-dependent, beta 1 subunit -2.18381
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.18096
CTBS chitobiase, di-N-acetyl- -2.16977
RPN2 ribophorin II -2.16312
S100A10 S100 calcium binding protein A10 -2.15089
METTL1 methyltransferase like 1 -2.12077
CALCA calcitonin-related polypeptide alpha -2.11766
TCF20 transcription factor 20 (AR1) -2.1037
SMYD5 SMYD family member 5 -2.09701
HAL histidine ammonia-lyase -2.08192
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -2.07103
USP34 ubiquitin specific peptidase 34 -2.07028
FYN FYN proto-oncogene, Src family tyrosine kinase -2.06418
MID1 midline 1 -2.06203
PHGDH phosphoglycerate dehydrogenase -2.05802
WDR1 WD repeat domain 1 -2.05778
KLF1 Kruppel-like factor 1 (erythroid) -2.05603
PPIB peptidylprolyl isomerase B (cyclophilin B) -2.05026
SREBF2 sterol regulatory element binding transcription factor 2 -2.04531
YARS tyrosyl-tRNA synthetase -2.0418
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -2.03698
EGR4 early growth response 4 -2.03363
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -2.02956
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -2.01584
TUBA3D tubulin, alpha 3d -2.00949
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -2.00819
TFDP1 transcription factor Dp-1 -2.00315
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.00261
GCDH glutaryl-CoA dehydrogenase -1.99263
SRR serine racemase -1.98569
SAG S-antigen; retina and pineal gland (arrestin) -1.98411
SRRM2 serine/arginine repetitive matrix 2 -1.98366
NRCAM neuronal cell adhesion molecule -1.97233
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -1.95916
TREH trehalase (brush-border membrane glycoprotein) -1.94779
GPD1L glycerol-3-phosphate dehydrogenase 1-like -1.93912
IDUA iduronidase, alpha-L- -1.93247
CTSZ cathepsin Z -1.93045
HBE1 hemoglobin, epsilon 1 -1.92685
SARS seryl-tRNA synthetase -1.9243
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -1.92381
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -1.92075
NISCH nischarin -1.91784
TUBB3 tubulin, beta 3 class III -1.91168
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -1.91008
DHCR24 24-dehydrocholesterol reductase -1.90502
B9D1 B9 protein domain 1 -1.88775
COL2A1 collagen, type II, alpha 1 -1.88502
RBM12 RNA binding motif protein 12 -1.88425
DYNLL1 dynein, light chain, LC8-type 1 -1.8787
GPR6 G protein-coupled receptor 6 -1.87853
VASH1 vasohibin 1 -1.87413
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -1.86957
XBP1 X-box binding protein 1 -1.86243
TARS threonyl-tRNA synthetase -1.85861
GARS glycyl-tRNA synthetase -1.85847
HCG26 HLA complex group 26 (non-protein coding) -1.84925
CTNND1 catenin (cadherin-associated protein), delta 1 -1.83501
MAP4 microtubule-associated protein 4 -1.83445
FAM20B family with sequence similarity 20, member B -1.82796
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -1.82643
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -1.82009
HDGF hepatoma-derived growth factor -1.81225
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -1.80887
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -1.8071
CEL carboxyl ester lipase -1.80366
APOE apolipoprotein E -1.80246
VCAN versican -1.80216
AHNAK AHNAK nucleoprotein -1.79821
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -1.79706
AGRN agrin -1.78379
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -1.78279
ITGAV integrin, alpha V -1.78241
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit -1.78008
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -1.77864
OXCT1 3-oxoacid CoA transferase 1 -1.77687
FERMT2 fermitin family member 2 -1.77343
RPS24 ribosomal protein S24 -1.77343
CSRP1 cysteine and glycine-rich protein 1 -1.7725
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide -1.76647
EDA ectodysplasin A -1.76308
WDR61 WD repeat domain 61 -1.75725
ECM2 extracellular matrix protein 2, female organ and adipocyte specific -1.75125
PDLIM1 PDZ and LIM domain 1 -1.74732
UBE3A ubiquitin protein ligase E3A -1.74684
SELENBP1 selenium binding protein 1 -1.74518
ACAT2 acetyl-CoA acetyltransferase 2 -1.74497
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -1.74079
PRDX4 peroxiredoxin 4 -1.73836
PKP4 plakophilin 4 -1.72857
SNTA1 syntrophin, alpha 1 -1.72678
TLN2 talin 2 -1.72529
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E -1.72448
AMOT angiomotin -1.72013
TCTA T-cell leukemia translocation altered -1.71817
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -1.71659
MARS methionyl-tRNA synthetase -1.71554
STX2 syntaxin 2 -1.70736
BAZ1B bromodomain adjacent to zinc finger domain, 1B -1.70561
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 -1.70089
ALOX5 arachidonate 5-lipoxygenase -1.70065
UBE3B ubiquitin protein ligase E3B -1.69761
TTC28 tetratricopeptide repeat domain 28 -1.69385
AP3M2 adaptor-related protein complex 3, mu 2 subunit -1.69318
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -1.68979
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -1.68949
EFNA1 ephrin-A1 -1.68894
SNX1 sorting nexin 1 -1.68688
RAP1GAP RAP1 GTPase activating protein -1.68562
PRDX6 peroxiredoxin 6 -1.6832
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) -1.68051
ARCN1 archain 1 -1.67916
WISP2 WNT1 inducible signaling pathway protein 2 -1.67343
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -1.66824
CELF1 CUGBP, Elav-like family member 1 -1.66383
ADAM15 ADAM metallopeptidase domain 15 -1.66362
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2 -1.66012
OLFML2A olfactomedin-like 2A -1.65966
HIST1H2AC histone cluster 1, H2ac -1.6573
FILIP1L filamin A interacting protein 1-like -1.65444
SDC1 syndecan 1 -1.65306
ICMT isoprenylcysteine carboxyl methyltransferase -1.65291
KIAA0922 KIAA0922 -1.6497
MTMR2 myotubularin related protein 2 -1.6496
AFAP1 actin filament associated protein 1 -1.64939
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -1.648
RCVRN recoverin -1.64287
YTHDC2 YTH domain containing 2 -1.64274
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -1.6395
APP amyloid beta (A4) precursor protein -1.6385
ADCY7 adenylate cyclase 7 -1.63663
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -1.63652
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -1.63237
HSPG2 heparan sulfate proteoglycan 2 -1.6323
ETFA electron-transfer-flavoprotein, alpha polypeptide -1.63029
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -1.62416
WNT1 wingless-type MMTV integration site family, member 1 -1.61891
FAM155B family with sequence similarity 155, member B -1.6189
SLC26A10 solute carrier family 26, member 10 -1.61798
TPP2 tripeptidyl peptidase II -1.61718
NMT1 N-myristoyltransferase 1 -1.61714
SYK spleen tyrosine kinase -1.61492
MXRA8 matrix-remodelling associated 8 -1.61486
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 -1.61236
AQP1 aquaporin 1 (Colton blood group) -1.61195
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -1.60895
CBLN1 cerebellin 1 precursor -1.60716
GUSBP11 glucuronidase, beta pseudogene 11 -1.60622
CRABP2 cellular retinoic acid binding protein 2 -1.60597
TTLL3 tubulin tyrosine ligase-like family member 3 -1.60414
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -1.60132
GOT1 glutamic-oxaloacetic transaminase 1, soluble -1.60077
SALL2 spalt-like transcription factor 2 -1.59984
GRHPR glyoxylate reductase/hydroxypyruvate reductase -1.59875
ALB albumin -1.59842
PLAU plasminogen activator, urokinase -1.59675
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -1.59292
EHD1 EH-domain containing 1 -1.58898
GSTA4 glutathione S-transferase alpha 4 -1.58734
KPNB1 karyopherin (importin) beta 1 -1.58499
CD63 CD63 molecule -1.58235
SFPQ splicing factor proline/glutamine-rich -1.58207
RGR retinal G protein coupled receptor -1.57612
TMEM109 transmembrane protein 109 -1.57565
SOCS7 suppressor of cytokine signaling 7 -1.5753
PLA2G5 phospholipase A2, group V -1.57185
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -1.56808
SEPT2 septin 2 -1.56693
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) -1.56582
SPTBN1 spectrin, beta, non-erythrocytic 1 -1.56523
CAPN1 calpain 1, (mu/I) large subunit -1.56522
TRAF5 TNF receptor-associated factor 5 -1.56484
GALNS galactosamine (N-acetyl)-6-sulfatase -1.56399
HTRA1 HtrA serine peptidase 1 -1.55522
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon -1.55414
TNRC6B trinucleotide repeat containing 6B -1.5541
SPTAN1 spectrin, alpha, non-erythrocytic 1 -1.55351
LY6G6C lymphocyte antigen 6 complex, locus G6C -1.55264
CTTN cortactin -1.552
THY1 Thy-1 cell surface antigen -1.55156
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B -1.55092
TSPAN3 tetraspanin 3 -1.54851
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -1.54846
TUBB4A tubulin, beta 4A class IVa -1.54842
FHL1 four and a half LIM domains 1 -1.54732
PLXND1 plexin D1 -1.54594
PHIP pleckstrin homology domain interacting protein -1.54386
ITGB1BP1 integrin beta 1 binding protein 1 -1.54339
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -1.53988
SRSF7 serine/arginine-rich splicing factor 7 -1.53952
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -1.53939
PARD6B par-6 family cell polarity regulator beta -1.53823
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) -1.53747
CAV1 caveolin 1, caveolae protein, 22kDa -1.5367
SH3GL3 SH3-domain GRB2-like 3 -1.53604
ACOX1 acyl-CoA oxidase 1, palmitoyl -1.53188
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -1.5256
GRB10 growth factor receptor-bound protein 10 -1.52435
TSPO translocator protein (18kDa) -1.52235
FICD FIC domain containing -1.51609
MPPE1 metallophosphoesterase 1 -1.51552
MBTPS1 membrane-bound transcription factor peptidase, site 1 -1.51496
ZIC2 Zic family member 2 -1.5145
MSMO1 methylsterol monooxygenase 1 -1.5139
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -1.51209
SMTN smoothelin -1.51144
C9ORF3 chromosome 9 open reading frame 3 -1.50943
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -1.50789
COPA coatomer protein complex, subunit alpha -1.50427
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -1.50346
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -1.50336
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene -1.50321
C5 complement component 5 -1.5029
PCNT pericentrin -1.50247
SQLE squalene epoxidase -1.50205
PPP1R12B protein phosphatase 1, regulatory subunit 12B -1.49583
LDB3 LIM domain binding 3 -1.49516
SDC3 syndecan 3 -1.49455
CHD3 chromodomain helicase DNA binding protein 3 -1.4942
TUG1 taurine up-regulated 1 (non-protein coding) -1.49319
CPQ carboxypeptidase Q -1.49214
PNMT phenylethanolamine N-methyltransferase -1.48611
WNT10B wingless-type MMTV integration site family, member 10B -1.48486
RPL17 ribosomal protein L17 -1.48434
ZDHHC3 zinc finger, DHHC-type containing 3 -1.47673
CKAP5 cytoskeleton associated protein 5 -1.4767
HSPB2 heat shock 27kDa protein 2 -1.47597
ACTN4 actinin, alpha 4 -1.47388
HNF4A hepatocyte nuclear factor 4, alpha -1.47386
DCHS1 dachsous cadherin-related 1 -1.47047
RAB11FIP2 RAB11 family interacting protein 2 (class I) -1.47003
DPYSL3 dihydropyrimidinase-like 3 -1.47002
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -1.46554
NR0B2 nuclear receptor subfamily 0, group B, member 2 -1.46227
AOX1 aldehyde oxidase 1 -1.46155
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -1.46087
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -1.45964
KRT75 keratin 75, type II -1.45937
HEPH hephaestin -1.45895
CCDC93 coiled-coil domain containing 93 -1.45876
IFNW1 interferon, omega 1 -1.45851
BAG2 BCL2-associated athanogene 2 -1.45748
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 -1.45703
GGT5 gamma-glutamyltransferase 5 -1.45674
PYCR1 pyrroline-5-carboxylate reductase 1 -1.45547
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -1.45535
WNT8B wingless-type MMTV integration site family, member 8B -1.45286
DNM1 dynamin 1 -1.45097
DIAPH1 diaphanous-related formin 1 -1.45034
PARVA parvin, alpha -1.45023
VARS valyl-tRNA synthetase -1.44879
COL16A1 collagen, type XVI, alpha 1 -1.44685
ASGR2 asialoglycoprotein receptor 2 -1.44678
FNDC3A fibronectin type III domain containing 3A -1.44469
PTRF polymerase I and transcript release factor -1.44424
NTNG1 netrin G1 -1.44351
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -1.44074
REN renin -1.43992
PDLIM7 PDZ and LIM domain 7 (enigma) -1.43962
NKX2-8 NK2 homeobox 8 -1.43935
CALCR calcitonin receptor -1.43817
PCCB propionyl CoA carboxylase, beta polypeptide -1.43653
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -1.43498
PTTG1IP pituitary tumor-transforming 1 interacting protein -1.43108
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -1.43011
Funding