| Dataset | DISEASES Experimental Gene-Disease Association Evidence Scores 2025 |
| Category | disease or phenotype associations |
| Type | disease |
| Description | A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.|Malaria is a parasitic disease characterized as a vector-borne arthropod infectious acute or chronic disease caused by the presence of sporozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. Occurrance is widespread in tropical and subtropical regions, including parts of the Americas, Asia, and Africa.|A protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia.|An Aconoidasida infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. (Experimental Factor Ontology, EFO_0001068) |
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39 genes associated with the disease Malaria in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SURF2 | surfeit 2 | 1.959 |
| SURF1 | surfeit 1 | 1.959 |
| GBGT1 | globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 | 1.959 |
| SURF6 | surfeit 6 | 1.959 |
| OBP2B | odorant binding protein 2B | 1.959 |
| MED22 | mediator complex subunit 22 | 1.959 |
| RPL7A | ribosomal protein L7a | 1.959 |
| OR51F1 | olfactory receptor, family 51, subfamily F, member 1 (gene/pseudogene) | 1.746 |
| OR51E2 | olfactory receptor, family 51, subfamily E, member 2 | 1.746 |
| OR52R1 | olfactory receptor, family 52, subfamily R, member 1 (gene/pseudogene) | 1.746 |
| MMP26 | matrix metallopeptidase 26 | 1.746 |
| OR51F2 | olfactory receptor, family 51, subfamily F, member 2 | 1.746 |
| OR51S1 | olfactory receptor, family 51, subfamily S, member 1 | 1.746 |
| HBG2 | hemoglobin, gamma G | 1.723 |
| HBE1 | hemoglobin, epsilon 1 | 1.723 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 1.723 |
| OR52B6 | olfactory receptor, family 52, subfamily B, member 6 | 1.652 |
| OR52H1 | olfactory receptor, family 52, subfamily H, member 1 | 1.652 |
| OR52D1 | olfactory receptor, family 52, subfamily D, member 1 | 1.652 |
| TRIM5 | tripartite motif containing 5 | 1.652 |
| TRIM6 | tripartite motif containing 6 | 1.652 |
| UBQLN3 | ubiquilin 3 | 1.652 |
| UBQLNL | ubiquilin-like | 1.652 |
| OR51Q1 | olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene) | 1.652 |
| OR51I1 | olfactory receptor, family 51, subfamily I, member 1 | 1.652 |
| OR51I2 | olfactory receptor, family 51, subfamily I, member 2 | 1.652 |
| GYPE | glycophorin E (MNS blood group) | 1.428 |
| FREM3 | FRAS1 related extracellular matrix 3 | 1.428 |
| LAX1 | lymphocyte transmembrane adaptor 1 | 1.379 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 1.379 |
| WRNIP1 | Werner helicase interacting protein 1 | 0.93 |
| MYLK4 | myosin light chain kinase family, member 4 | 0.93 |
| OR51B4 | olfactory receptor, family 51, subfamily B, member 4 | 0.748 |
| OR52A5 | olfactory receptor, family 52, subfamily A, member 5 | 0.748 |
| HBB | hemoglobin, beta | 0.748 |
| HBD | hemoglobin, delta | 0.748 |
| OR52A1 | olfactory receptor, family 52, subfamily A, member 1 | 0.748 |
| OR51V1 | olfactory receptor, family 51, subfamily V, member 1 | 0.748 |
| HBG1 | hemoglobin, gamma A | 0.748 |
