| Dataset | KEGG Pathways 2026 |
| Category | structural or functional annotations |
| Type | pathway |
| Description | A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.|Malaria is a parasitic disease characterized as a vector-borne arthropod infectious acute or chronic disease caused by the presence of sporozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. Occurrance is widespread in tropical and subtropical regions, including parts of the Americas, Asia, and Africa.|A protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia.|An Aconoidasida infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. (Experimental Factor Ontology, EFO_0001068) |
| External Link | https://www.kegg.jp/entry/hsa05144 |
| Similar Terms | |
| Downloads & Tools |
50 proteins participating in the Malaria pathway from the KEGG Pathways 2026 dataset.
| Symbol | Name |
|---|---|
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) |
| C1D | C1D nuclear receptor corepressor |
| CCL2 | chemokine (C-C motif) ligand 2 |
| CD36 | CD36 molecule (thrombospondin receptor) |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 |
| CD40LG | CD40 ligand |
| CD81 | CD81 molecule |
| COMP | cartilage oligomeric matrix protein |
| CR1 | complement component (3b/4b) receptor 1 (Knops blood group) |
| CR1L | complement component (3b/4b) receptor 1-like |
| CSF3 | colony stimulating factor 3 (granulocyte) |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| GYPB | glycophorin B (MNS blood group) |
| GYPC | glycophorin C (Gerbich blood group) |
| GYPE | glycophorin E (MNS blood group) |
| HBA1 | hemoglobin, alpha 1 |
| HBA2 | hemoglobin, alpha 2 |
| HBB | hemoglobin, beta |
| ICAM1 | intercellular adhesion molecule 1 |
| IFNG | interferon, gamma |
| IL10 | interleukin 10 |
| IL12A | interleukin 12A |
| IL18 | interleukin 18 |
| IL1B | interleukin 1, beta |
| IL6 | interleukin 6 |
| ITGAL | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 |
| KLRC4-KLRK1 | KLRC4-KLRK1 readthrough |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 |
| MYD88 | myeloid differentiation primary response 88 |
| PECAM1 | platelet/endothelial cell adhesion molecule 1 |
| SDC1 | syndecan 1 |
| SDC2 | syndecan 2 |
| SELE | selectin E |
| SELENOP | selenoprotein P |
| SLTM | SAFB-like, transcription modulator |
| SOS1 | son of sevenless homolog 1 (Drosophila) |
| TGFB1 | transforming growth factor, beta 1 |
| TGFB2 | transforming growth factor, beta 2 |
| TGFB3 | transforming growth factor, beta 3 |
| THBS1 | thrombospondin 1 |
| THBS2 | thrombospondin 2 |
| THBS3 | thrombospondin 3 |
| THBS4 | thrombospondin 4 |
| TLR2 | toll-like receptor 2 |
| TLR4 | toll-like receptor 4 |
| TLR9 | toll-like receptor 9 |
| TNF | tumor necrosis factor |
| VCAM1 | vascular cell adhesion molecule 1 |
