Malate-aspartate shuttle Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
Description The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle. (Gene Ontology, GO_0043490)
External Link https://reactome.org/PathwayBrowser/#/R-HSA-9856872
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Genes

9 proteins participating in the Malate-aspartate shuttle pathway from the Reactome Pathways 2024 dataset.

Symbol Name
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
MDH1 malate dehydrogenase 1, NAD (soluble)
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A18 solute carrier family 25 (glutamate carrier), member 18
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22