Malignant Fibrous Histiocytoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Undifferentiated pleomorphic sarcoma (UPS) is an aggressive sarcoma of soft tissues or bone that can arise from any part of the body, clinically presenting as swelling, mass, pain, pathological fracture and occasional systemic features and is characterized by high local recurrence and significant metastasis. (Orphanet Rare Disease Ontology, Orphanet_2023)
External Link https://www.disgenet.org/browser/0/1/0/C0334463
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Genes

143 genes associated with the disease Malignant Fibrous Histiocytoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACTB actin, beta
ACVRL1 activin A receptor type II-like 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMPD2 adenosine monophosphate deaminase 2
AR androgen receptor
AREG amphiregulin
BTC betacellulin
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASQ2 calsequestrin 2 (cardiac muscle)
CCL2 chemokine (C-C motif) ligand 2
CCN2 cellular communication network factor 2
CD163 CD163 molecule
CD274 CD274 molecule
CD6 CD6 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COIL coilin
COL1A1 collagen, type I, alpha 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSF1 colony stimulating factor 1 (macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXADR coxsackie virus and adenovirus receptor
DDIT3 DNA-damage-inducible transcript 3
DES desmin
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
EWSR1 EWS RNA-binding protein 1
EZR ezrin
FBXO32 F-box protein 32
FDPS farnesyl diphosphate synthase
FES FES proto-oncogene, tyrosine kinase
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
FOXC2 forkhead box C2
FOXP1 forkhead box P1
FRS2 fibroblast growth factor receptor substrate 2
FUS FUS RNA binding protein
GKN2 gastrokine 2
GRAP2 GRB2-related adaptor protein 2
HBEGF heparin-binding EGF-like growth factor
HCCS holocytochrome c synthase
HEATR3 HEAT repeat containing 3
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HMBS hydroxymethylbilane synthase
HRAS Harvey rat sarcoma viral oncogene homolog
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPB3 heat shock 27kDa protein 3
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
KEAP1 kelch-like ECH-associated protein 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LMNA lamin A/C
LYZ lysozyme
MACROD2 MACRO domain containing 2
MAGEA3 melanoma antigen family A3
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MCM2 minichromosome maintenance complex component 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MIB1 mindbomb E3 ubiquitin protein ligase 1
MITF microphthalmia-associated transcription factor
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYOCD myocardin
NANS N-acetylneuraminic acid synthase
NCOR1 nuclear receptor corepressor 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTSR1 neurotensin receptor 1 (high affinity)
NUTM1 NUT midline carcinoma, family member 1
PDCD1 programmed cell death 1
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAU plasminogen activator, urokinase
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POU5F1 POU class 5 homeobox 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRDM10 PR domain containing 10
PRKCD protein kinase C, delta
PRM3 protamine 3
PRUNE1 prune exopolyphosphatase 1
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RECQL4 RecQ protein-like 4
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPP14 ribonuclease P/MRP 14kDa subunit
S100A9 S100 calcium binding protein A9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SF3B6 splicing factor 3b, subunit 6, 14kDa
SLMAP sarcolemma associated protein
SLPI secretory leukocyte peptidase inhibitor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUB1 SUB1 homolog (S. cerevisiae)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TNF tumor necrosis factor
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TP53 tumor protein p53
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TSPAN31 tetraspanin 31
UBASH3A ubiquitin associated and SH3 domain containing A
WDR48 WD repeat domain 48
WRN Werner syndrome, RecQ helicase-like
WT1 Wilms tumor 1
WWTR1 WW domain containing transcription regulator 1
YAP1 Yes-associated protein 1