Malignant Mesothelioma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A cell type cancer that has_material_basis_in mesothelial tissue. (Human Disease Ontology, DOID_1790)
External Link https://www.disgenet.org/browser/0/1/0/C4743578
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Genes

402 genes associated with the disease Malignant Mesothelioma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
A1CF APOBEC1 complementation factor
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACVR1B activin A receptor, type IB
ADA adenosine deaminase
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADIPOQ adiponectin, C1Q and collagen domain containing
AGO1 argonaute RISC catalytic component 1
AGO2 argonaute RISC catalytic component 2
AJUBA ajuba LIM protein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALK anaplastic lymphoma receptor tyrosine kinase
ANXA2 annexin A2
ANXA4 annexin A4
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP1 aquaporin 1 (Colton blood group)
AR androgen receptor
ASIP agouti signaling protein
ASPA aspartoacylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
ATG5 autophagy related 5
AXIN2 axin 2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRD1 bromodomain containing 1
BST1 bone marrow stromal cell antigen 1
C17ORF97 chromosome 17 open reading frame 97
C3 complement component 3
C9 complement component 9
CA9 carbonic anhydrase IX
CALB1 calbindin 1, 28kDa
CALB2 calbindin 2
CAPS calcyphosine
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL11 chemokine (C-C motif) ligand 11
CCL23 chemokine (C-C motif) ligand 23
CCL27 chemokine (C-C motif) ligand 27
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCL7 chemokine (C-C motif) ligand 7
CCN2 cellular communication network factor 2
CCND1 cyclin D1
CCND2 cyclin D2
CCNE2 cyclin E2
CCR6 chemokine (C-C motif) receptor 6
CCSER1 coiled-coil serine-rich protein 1
CD24 CD24 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CDA cytidine deaminase
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CFAP45 cilia and flagella associated protein 45
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
CKAP4 cytoskeleton-associated protein 4
CLEC11A C-type lectin domain family 11, member A
COL11A2 collagen, type XI, alpha 2
COL12A1 collagen, type XII, alpha 1
COPG1 coatomer protein complex, subunit gamma 1
COX2
CREB1 cAMP responsive element binding protein 1
CRTAM cytotoxic and regulatory T cell molecule
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSRP1 cysteine and glycine-rich protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CUX1 cut-like homeobox 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DCK deoxycytidine kinase
DCTN6 dynactin 6
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DES desmin
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP4 dipeptidyl-peptidase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EHF ets homologous factor
EID1 EP300 interacting inhibitor of differentiation 1
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EPHA1 EPH receptor A1
EPHA2 EPH receptor A2
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB4 EPH receptor B4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPO erythropoietin
EPOR erythropoietin receptor
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EWSR1 EWS RNA-binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
F9 coagulation factor IX
FAM188B family with sequence similarity 188, member B
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGD6 FYVE, RhoGEF and PH domain containing 6
FGF18 fibroblast growth factor 18
FGF9 fibroblast growth factor 9
FHIT fragile histidine triad
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOLR3 folate receptor 3 (gamma)
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FSD1 fibronectin type III and SPRY domain containing 1
FSD1L fibronectin type III and SPRY domain containing 1-like
FTH1 ferritin, heavy polypeptide 1
FUS FUS RNA binding protein
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GDE1 glycerophosphodiester phosphodiesterase 1
GEMIN2 gem (nuclear organelle) associated protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GLB1 galactosidase, beta 1
GLI2 GLI family zinc finger 2
GPC3 glypican 3
GPR153 G protein-coupled receptor 153
GPR27 G protein-coupled receptor 27
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GREM1 gremlin 1, DAN family BMP antagonist
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HDAC4 histone deacetylase 4
HEPH hephaestin
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HPSE heparanase
HSPA4 heat shock 70kDa protein 4
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
IDUA iduronidase, alpha-L-
IFI27 interferon, alpha-inducible protein 27
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL12B interleukin 12B
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
IL24 interleukin 24
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL3 interleukin 3
IL32 interleukin 32
IL4 interleukin 4
IL6 interleukin 6
ILK integrin-linked kinase
JAG1 jagged 1
JUN jun proto-oncogene
KDR kinase insert domain receptor
KHSRP KH-type splicing regulatory protein
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL1 kelch-like family member 1
KLRC4-KLRK1 KLRC4-KLRK1 readthrough
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT20 keratin 20, type I
LATS1 large tumor suppressor kinase 1
LATS2 large tumor suppressor kinase 2
LEF1 lymphoid enhancer-binding factor 1
LGALS9 lectin, galactoside-binding, soluble, 9
LIMCH1 LIM and calponin homology domains 1
LIMS2 LIM and senescent cell antigen-like domains 2
LIMS3 LIM and senescent cell antigen-like domains 3
LIMS3L LIM and senescent cell antigen-like domains 3-like
LTA lymphotoxin alpha
LTBP1 latent transforming growth factor beta binding protein 1
LTBP2 latent transforming growth factor beta binding protein 2
LTBP3 latent transforming growth factor beta binding protein 3
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MCAM melanoma cell adhesion molecule
MCL1 myeloid cell leukemia 1
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MLANA melan-A
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPEG1 macrophage expressed 1
MRFAP1 Morf4 family associated protein 1
MRPL28 mitochondrial ribosomal protein L28
MSH3 mutS homolog 3
MSLN mesothelin
MTAP methylthioadenosine phosphorylase
MTMR4 myotubularin related protein 4
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOD1 myogenic differentiation 1
MYOG myogenin (myogenic factor 4)
NANOS1 nanos homolog 1 (Drosophila)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCR1 natural cytotoxicity triggering receptor 1
NF2 neurofibromin 2 (merlin)
NFE2L2 nuclear factor, erythroid 2-like 2
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NLRP3 NLR family, pyrin domain containing 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX4 NADPH oxidase 4
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRP1 neuropilin 1
NRP2 neuropilin 2
NXT1 nuclear transport factor 2-like export factor 1
OSCAR osteoclast associated, immunoglobulin-like receptor
OSMR oncostatin M receptor
OTUD4 OTU deubiquitinase 4
PADI4 peptidyl arginine deiminase, type IV
PARP1 poly (ADP-ribose) polymerase 1
PBRM1 polybromo 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDLIM4 PDZ and LIM domain 4
PDLIM7 PDZ and LIM domain 7 (enigma)
PDPN podoplanin
PGF placental growth factor
PIAS3 protein inhibitor of activated STAT, 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKP3 plakophilin 3
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
PLLP plasmolipin
PPP6C protein phosphatase 6, catalytic subunit
PRAME preferentially expressed antigen in melanoma
PRDX3 peroxiredoxin 3
PSEN1 presenilin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGR1 prostaglandin reductase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPA protein phosphatase 2 phosphatase activator
PTPRF protein tyrosine phosphatase, receptor type, F
PVALB parvalbumin
PYCARD PYD and CARD domain containing
RAD23B RAD23 homolog B (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
REN renin
RGCC regulator of cell cycle
ROPN1L rhophilin associated tail protein 1-like
RPE65 retinal pigment epithelium-specific protein 65kDa
RPS27 ribosomal protein S27
RRM1 ribonucleotide reductase M1
RXRA retinoid X receptor, alpha
RYR2 ryanodine receptor 2 (cardiac)
SAV1 salvador family WW domain containing protein 1
SCAF11 SR-related CTD-associated factor 11
SCGB3A1 secretoglobin, family 3A, member 1
SDC1 syndecan 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SETD2 SET domain containing 2
SETDB1 SET domain, bifurcated 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFRP4 secreted frizzled-related protein 4
SIGLEC7 sialic acid binding Ig-like lectin 7
SIRT1 sirtuin 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SMAD2 SMAD family member 2
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMO smoothened, frizzled class receptor
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOD2 superoxide dismutase 2, mitochondrial
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUB1 SUB1 homolog (S. cerevisiae)
SUFU suppressor of fused homolog (Drosophila)
SYCE1L synaptonemal complex central element protein 1-like
SYK spleen tyrosine kinase
TAZ tafazzin
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBXAS1 thromboxane A synthase 1 (platelet)
TCF3 transcription factor 3
TERT telomerase reverse transcriptase
TF transferrin
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGFB2 transforming growth factor, beta 2
TGM2 transglutaminase 2
THBD thrombomodulin
TICAM2 toll-like receptor adaptor molecule 2
TLR3 toll-like receptor 3
TMED7 transmembrane emp24 protein transport domain containing 7
TMED7-TICAM2 TMED7-TICAM2 readthrough
TMEM127 transmembrane protein 127
TNC tenascin C
TNF tumor necrosis factor
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNXB tenascin XB
TP53 tumor protein p53
TP63 tumor protein p63
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TTF1 transcription termination factor, RNA polymerase I
TTK TTK protein kinase
TXN thioredoxin
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
ULK2 unc-51 like autophagy activating kinase 2
UVRAG UV radiation resistance associated
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIM vimentin
VSIR V-set immunoregulatory receptor
WIF1 WNT inhibitory factor 1
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WT1 Wilms tumor 1
WWC1 WW and C2 domain containing 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YAP1 Yes-associated protein 1
YY1 YY1 transcription factor
ZDHHC8 zinc finger, DHHC-type containing 8
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2