Malignant Pleural Mesothelioma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A pleural cancer that has_material_basis_in mesothelium cells. (Human Disease Ontology, DOID_7474)
External Link https://www.disgenet.org/browser/0/1/0/C0812413
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Genes

377 genes associated with the disease Malignant Pleural Mesothelioma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACACA acetyl-CoA carboxylase alpha
ACTG2 actin, gamma 2, smooth muscle, enteric
ADA adenosine deaminase
ADAM10 ADAM metallopeptidase domain 10
ADM adrenomedullin
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
ALK anaplastic lymphoma receptor tyrosine kinase
ALPI alkaline phosphatase, intestinal
ALPP alkaline phosphatase, placental
ANGPT1 angiopoietin 1
APRT adenine phosphoribosyltransferase
AQP1 aquaporin 1 (Colton blood group)
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARSA arylsulfatase A
ASS1 argininosuccinate synthase 1
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATN1 atrophin 1
AURKA aurora kinase A
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BBS1 Bardet-Biedl syndrome 1
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BIN1 bridging integrator 1
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BIRC7 baculoviral IAP repeat containing 7
BMS1 BMS1 ribosome biogenesis factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
BST1 bone marrow stromal cell antigen 1
C1QBP complement component 1, q subcomponent binding protein
CACUL1 CDK2-associated, cullin domain 1
CALB2 calbindin 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC6 coiled-coil domain containing 6
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CD27 CD27 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD38 CD38 molecule
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD47 CD47 molecule
CD70 CD70 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDCA5 cell division cycle associated 5
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CIB1 calcium and integrin binding 1 (calmyrin)
CLDN15 claudin 15
CLDN3 claudin 3
CLDN4 claudin 4
CLIC1 chloride intracellular channel 1
CLIC3 chloride intracellular channel 3
CLIC4 chloride intracellular channel 4
CLOCK clock circadian regulator
CLTA clathrin, light chain A
CMA1 chymase 1, mast cell
COL1A2 collagen, type I, alpha 2
COX2
COX5A cytochrome c oxidase subunit Va
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CP ceruloplasmin (ferroxidase)
CPOX coproporphyrinogen oxidase
CRISP2 cysteine-rich secretory protein 2
CSF1R colony stimulating factor 1 receptor
CTAG1A cancer/testis antigen 1A
CTAG1B cancer/testis antigen 1B
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CUL4A cullin 4A
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCLK1 doublecortin-like kinase 1
DCLK3 doublecortin-like kinase 3
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DENR density-regulated protein
DHFR dihydrofolate reductase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNER delta/notch-like EGF repeat containing
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPP10 dipeptidyl-peptidase 10 (non-functional)
DPP4 dipeptidyl-peptidase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EFNB2 ephrin-B2
EGF epidermal growth factor
EGFL7 EGF-like-domain, multiple 7
EGFR epidermal growth factor receptor
EID1 EP300 interacting inhibitor of differentiation 1
EIF6 eukaryotic translation initiation factor 6
EMX2 empty spiracles homeobox 2
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EPX eosinophil peroxidase
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FAM188B family with sequence similarity 188, member B
FECH ferrochelatase
FEN1 flap structure-specific endonuclease 1
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR4 fibroblast growth factor receptor 4
FOLR1 folate receptor 1 (adult)
FOLR2 folate receptor 2 (fetal)
FOSL1 FOS-like antigen 1
FOXK1 forkhead box K1
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FSD1 fibronectin type III and SPRY domain containing 1
FSD1L fibronectin type III and SPRY domain containing 1-like
FST follistatin
FTO fat mass and obesity associated
FUS FUS RNA binding protein
FZD4 frizzled class receptor 4
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GDE1 glycerophosphodiester phosphodiesterase 1
GHRH growth hormone releasing hormone
GHRHR growth hormone releasing hormone receptor
GLI1 GLI family zinc finger 1
GORASP1 golgi reassembly stacking protein 1, 65kDa
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HAPLN1 hyaluronan and proteoglycan link protein 1
HAVCR1 hepatitis A virus cellular receptor 1
HAVCR2 hepatitis A virus cellular receptor 2
HDAC9 histone deacetylase 9
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HPSE heparanase
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNB1 interferon, beta 1, fibroblast
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP4 insulin-like growth factor binding protein 4
IL18 interleukin 18
IL24 interleukin 24
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA7 integrin, alpha 7
JUN jun proto-oncogene
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM6A lysine (K)-specific demethylase 6A
KDM6B lysine (K)-specific demethylase 6B
KDR kinase insert domain receptor
KIF11 kinesin family member 11
KIF23 kinesin family member 23
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
L1CAM L1 cell adhesion molecule
LAG3 lymphocyte-activation gene 3
LBR lamin B receptor
LMNA lamin A/C
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGT1 magnesium transporter 1
MAPK1 mitogen-activated protein kinase 1
MAPK13 mitogen-activated protein kinase 13
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MBD2 methyl-CpG binding domain protein 2
MCAM melanoma cell adhesion molecule
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MCTS1 malignant T cell amplified sequence 1
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MFAP1 microfibrillar-associated protein 1
MGMT O-6-methylguanine-DNA methyltransferase
MIA melanoma inhibitory activity
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MMRN1 multimerin 1
MSLN mesothelin
MST1 macrophage stimulating 1
MST1R macrophage stimulating 1 receptor
MT1A metallothionein 1A
MT1B metallothionein 1B
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MTAP methylthioadenosine phosphorylase
MTDH metadherin
MTNR1A melatonin receptor 1A
MTNR1B melatonin receptor 1B
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO18B myosin XVIIIB
MYO1A myosin IA
NAGLU N-acetylglucosaminidase, alpha
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBAS neuroblastoma amplified sequence
NDC80 NDC80 kinetochore complex component
NF2 neurofibromin 2 (merlin)
NKX2-1 NK2 homeobox 1
NLRP1 NLR family, pyrin domain containing 1
NOX4 NADPH oxidase 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
NTS neurotensin
OSM oncostatin M
PAEP progestagen-associated endometrial protein
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PDCD1 programmed cell death 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPN podoplanin
PEA15 phosphoprotein enriched in astrocytes 15
PEBP1 phosphatidylethanolamine binding protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKP3 plakophilin 3
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PLXNA1 plexin A1
POMC proopiomelanocortin
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PROCR protein C receptor, endothelial
PRSS55 protease, serine, 55
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
PUF60 poly-U binding splicing factor 60KDa
RAD23B RAD23 homolog B (S. cerevisiae)
RAD50 RAD50 homolog (S. cerevisiae)
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RARB retinoic acid receptor, beta
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RET ret proto-oncogene
ROR1 receptor tyrosine kinase-like orphan receptor 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RRM1 ribonucleotide reductase M1
RTN4R reticulon 4 receptor
S100A11 S100 calcium binding protein A11
S100B S100 calcium binding protein B
SCN7A sodium channel, voltage gated, type VII alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SETD2 SET domain containing 2
SETDB1 SET domain, bifurcated 1
SFRP4 secreted frizzled-related protein 4
SFRP5 secreted frizzled-related protein 5
SIM2 single-minded family bHLH transcription factor 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMO smoothened, frizzled class receptor
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SPP1 secreted phosphoprotein 1
SPZ1 spermatogenic leucine zipper 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SST somatostatin
SSTR4 somatostatin receptor 4
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STMN1 stathmin 1
SYT1 synaptotagmin I
TAZ tafazzin
TBXAS1 thromboxane A synthase 1 (platelet)
TERT telomerase reverse transcriptase
TGM2 transglutaminase 2
THBD thrombomodulin
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMELESS timeless circadian clock
TM7SF2 transmembrane 7 superfamily member 2
TMPRSS6 transmembrane protease, serine 6
TNC tenascin C
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TPI1 triosephosphate isomerase 1
TSHR thyroid stimulating hormone receptor
TTF1 transcription termination factor, RNA polymerase I
TUSC2 tumor suppressor candidate 2
TWIST1 twist family bHLH transcription factor 1
TYMS thymidylate synthetase
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEGFA vascular endothelial growth factor A
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase
WIF1 WNT inhibitory factor 1
WNK1 WNK lysine deficient protein kinase 1
WNT2 wingless-type MMTV integration site family member 2
WNT7A wingless-type MMTV integration site family, member 7A
WT1 Wilms tumor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1
ZEB1 zinc finger E-box binding homeobox 1
ZIC1 Zic family member 1
ZNF645 zinc finger protein 645