Malotilate_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Malotilate perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Malotilate_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.320927
ERRFI1 ERBB receptor feedback inhibitor 1 0.138993
PDE4D phosphodiesterase 4D, cAMP-specific 0.0781863
RPS12 ribosomal protein S12 0.0737928
MTAP methylthioadenosine phosphorylase 0.0675813
MKI67 marker of proliferation Ki-67 0.063941
NACA nascent polypeptide-associated complex alpha subunit 0.0574828
TMEM41B transmembrane protein 41B 0.0571343
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0550176
SET SET nuclear proto-oncogene 0.0486958
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0464031
ANKRD12 ankyrin repeat domain 12 0.0458794
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0448259
PTMA prothymosin, alpha 0.0440578
RPL37A ribosomal protein L37a 0.0425856
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0424901
BCHE butyrylcholinesterase 0.042056
PDGFC platelet derived growth factor C 0.041653
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0413173
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0397684
RPL3 ribosomal protein L3 0.0392772
RPL26 ribosomal protein L26 0.0390433
NEBL nebulette 0.0388021
EZR ezrin 0.0382954
ANXA1 annexin A1 0.0370908
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0369021
RPS27A ribosomal protein S27a 0.0358083
RPS3 ribosomal protein S3 0.0349457
VMP1 vacuole membrane protein 1 0.0342101
ASPH aspartate beta-hydroxylase 0.0330787
NCAPD2 non-SMC condensin I complex, subunit D2 0.0325086
HSPA8 heat shock 70kDa protein 8 0.0319497
USP34 ubiquitin specific peptidase 34 0.0318402
TPM3 tropomyosin 3 0.0317407
KLF6 Kruppel-like factor 6 0.0316976
RPL37 ribosomal protein L37 0.030815
INCENP inner centromere protein antigens 135/155kDa 0.0305465
APP amyloid beta (A4) precursor protein 0.030533
SMYD3 SET and MYND domain containing 3 0.0301394
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0299763
RPS17 ribosomal protein S17 0.0293922
SPTBN1 spectrin, beta, non-erythrocytic 1 0.029355
RIMKLB ribosomal modification protein rimK-like family member B 0.0291917
BIRC2 baculoviral IAP repeat containing 2 0.0288125
TM4SF1 transmembrane 4 L six family member 1 0.0284936
YEATS2 YEATS domain containing 2 0.0283236
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0283017
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0282806
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0272954
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0260911
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0260596
KIF5B kinesin family member 5B 0.0260417
SPATS2 spermatogenesis associated, serine-rich 2 0.0258366
ANKRD28 ankyrin repeat domain 28 0.0257439
MCL1 myeloid cell leukemia 1 0.0255567
ZNF217 zinc finger protein 217 0.0255184
MYH9 myosin, heavy chain 9, non-muscle 0.0241514
RBM25 RNA binding motif protein 25 0.0241419
VCL vinculin 0.0240103
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0235039
ZFAND6 zinc finger, AN1-type domain 6 0.0234906
PNN pinin, desmosome associated protein 0.0228805
RPS4X ribosomal protein S4, X-linked 0.02288
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.0228104
RPL36A ribosomal protein L36a 0.0224988
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0223123
MACF1 microtubule-actin crosslinking factor 1 0.0222512
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0221181
RPL11 ribosomal protein L11 0.0220589
HDGF hepatoma-derived growth factor 0.0220191
RABGAP1L RAB GTPase activating protein 1-like 0.021796
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.021761
EDARADD EDAR-associated death domain 0.0215755
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0214594
RAB6A RAB6A, member RAS oncogene family 0.0214527
RPS29 ribosomal protein S29 0.0213037
NFE2L2 nuclear factor, erythroid 2-like 2 0.0212681
TMEM123 transmembrane protein 123 0.0210954
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0209573
NCK1 NCK adaptor protein 1 0.0208584
NONO non-POU domain containing, octamer-binding 0.020843
SBF2 SET binding factor 2 0.0207141
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0206819
NHSL1 NHS-like 1 0.0206278
ANKRD11 ankyrin repeat domain 11 0.0206139
SERINC1 serine incorporator 1 0.0204434
AKAP12 A kinase (PRKA) anchor protein 12 0.020401
TPT1 tumor protein, translationally-controlled 1 0.0202696
CIP2A cellular inhibitor of PP2A 0.0201829
IPO7 importin 7 0.020179
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0200329
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0200165
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0199656
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0199023
RPL23 ribosomal protein L23 0.0195122
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0194576
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.019343
TUBB6 tubulin, beta 6 class V 0.0192652
RSF1 remodeling and spacing factor 1 0.0191715
MYO10 myosin X 0.019063

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.212553
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.186067
TMSB10 thymosin beta 10 -0.117214
FTL ferritin, light polypeptide -0.103249
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.08952
RAB7A RAB7A, member RAS oncogene family -0.0794012
PFN1 profilin 1 -0.0749038
POTEF POTE ankyrin domain family, member F -0.0714894
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0705327
NLGN1 neuroligin 1 -0.0700875
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0685128
TSC22D2 TSC22 domain family, member 2 -0.0643885
HMGA1 high mobility group AT-hook 1 -0.0626914
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.061663
EGR1 early growth response 1 -0.0589426
HSPB1 heat shock 27kDa protein 1 -0.0584315
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0578432
ACTG1 actin gamma 1 -0.0566656
GSK3B glycogen synthase kinase 3 beta -0.0551325
CCND1 cyclin D1 -0.0545234
PCBP2 poly(rC) binding protein 2 -0.0538594
MGAT4C MGAT4 family, member C -0.0526329
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0478775
ATP5F1B ATP synthase F1 subunit beta -0.047865
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0461791
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.045082
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.043452
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0417273
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.041704
CCN2 cellular communication network factor 2 -0.0416077
H1-0 H1.0 linker histone -0.0408783
ADIPOR2 adiponectin receptor 2 -0.0401722
RBM39 RNA binding motif protein 39 -0.0393839
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0390092
ZNF638 zinc finger protein 638 -0.0387087
CELF2 CUGBP, Elav-like family member 2 -0.0386112
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0385712
PEG10 paternally expressed 10 -0.0381833
BIRC3 baculoviral IAP repeat containing 3 -0.0366278
RPL35A ribosomal protein L35a -0.034949
DDIT3 DNA-damage-inducible transcript 3 -0.034587
TFG TRK-fused gene -0.0341802
RLF rearranged L-myc fusion -0.0340517
LDHB lactate dehydrogenase B -0.0334322
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0333214
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0329609
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.0323505
VDAC1 voltage-dependent anion channel 1 -0.0323034
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0321959
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0321957
ZNF207 zinc finger protein 207 -0.0320248
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0315722
RPLP1 ribosomal protein, large, P1 -0.0309386
NIPBL Nipped-B homolog (Drosophila) -0.0307448
SYT1 synaptotagmin I -0.0304487
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.030415
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0302463
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0302402
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0298288
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0296679
BRD2 bromodomain containing 2 -0.0295753
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0294393
MARCHF6 membrane associated ring-CH-type finger 6 -0.0293921
SPDYA speedy/RINGO cell cycle regulator family member A -0.0291454
RAB1A RAB1A, member RAS oncogene family -0.0290889
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0290037
ERBIN erbb2 interacting protein -0.0289969
KMT2E lysine (K)-specific methyltransferase 2E -0.0287599
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0287194
LOC102724023 ES1 protein homolog, mitochondrial -0.0279691
HBP1 HMG-box transcription factor 1 -0.0279534
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0279238
EEF1G eukaryotic translation elongation factor 1 gamma -0.0275894
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0275618
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0274821
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0273422
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.027121
PICALM phosphatidylinositol binding clathrin assembly protein -0.0270611
FTH1 ferritin, heavy polypeptide 1 -0.027056
HMGB1 high mobility group box 1 -0.0269652
OSBPL8 oxysterol binding protein-like 8 -0.0267167
PTMS parathymosin -0.0265835
QKI QKI, KH domain containing, RNA binding -0.0264902
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0260768
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0258766
RPL28 ribosomal protein L28 -0.0258716
RTN3 reticulon 3 -0.0258218
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0257362
AFF4 AF4/FMR2 family, member 4 -0.0256247
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0255187
MMP12 matrix metallopeptidase 12 -0.025396
MSRB3 methionine sulfoxide reductase B3 -0.0252995
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0252912
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0252473
SLC38A1 solute carrier family 38, member 1 -0.025171
TAPBP TAP binding protein (tapasin) -0.0251654
RPL13A ribosomal protein L13a -0.0248341
BCL6 B-cell CLL/lymphoma 6 -0.0247718
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0245798
VAT1 vesicle amine transport 1 -0.0244037