Malotilate_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Malotilate perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Malotilate_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.30698
STC1 stanniocalcin 1 0.145141
MT2A metallothionein 2A 0.144859
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.116072
CALR calreticulin 0.111605
MYH9 myosin, heavy chain 9, non-muscle 0.0971087
CXCL8 chemokine (C-X-C motif) ligand 8 0.093634
TM4SF1 transmembrane 4 L six family member 1 0.0837999
ERRFI1 ERBB receptor feedback inhibitor 1 0.0747296
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0729813
EEF2 eukaryotic translation elongation factor 2 0.0526378
ARRDC3 arrestin domain containing 3 0.0503747
RPL3 ribosomal protein L3 0.0479344
APP amyloid beta (A4) precursor protein 0.0459537
PTMA prothymosin, alpha 0.044572
IFI6 interferon, alpha-inducible protein 6 0.0443847
TIMP1 TIMP metallopeptidase inhibitor 1 0.0441527
HLA-B major histocompatibility complex, class I, B 0.0417917
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0406841
PRRC2C proline-rich coiled-coil 2C 0.0363086
ECE1 endothelin converting enzyme 1 0.035094
PLAUR plasminogen activator, urokinase receptor 0.0333841
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0332873
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0330461
POSTN periostin, osteoblast specific factor 0.0307363
RPS8 ribosomal protein S8 0.0292779
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0292458
B2M beta-2-microglobulin 0.0290382
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0282734
FLNB filamin B, beta 0.0281727
PLEC plectin 0.0273671
CLIC4 chloride intracellular channel 4 0.0259328
MTSS1 metastasis suppressor 1 0.0249686
NFE2L1 nuclear factor, erythroid 2-like 1 0.024955
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0248575
SERINC1 serine incorporator 1 0.024844
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0245316
TNIP1 TNFAIP3 interacting protein 1 0.0240954
SDF4 stromal cell derived factor 4 0.0240294
ANKRD12 ankyrin repeat domain 12 0.023542
SRGN serglycin 0.0234486
RACK1 receptor for activated C kinase 1 0.022904
RPS4X ribosomal protein S4, X-linked 0.0224037
HAS2 hyaluronan synthase 2 0.0222389
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0218487
LDHA lactate dehydrogenase A 0.021722
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0214396
ACTN1 actinin, alpha 1 0.0211798
MCL1 myeloid cell leukemia 1 0.0210395
SET SET nuclear proto-oncogene 0.0205145
EIF1 eukaryotic translation initiation factor 1 0.0204474
IGFBP7 insulin-like growth factor binding protein 7 0.0204408
ICAM1 intercellular adhesion molecule 1 0.0204258
WNT5A wingless-type MMTV integration site family, member 5A 0.0202154
SFTPA2 surfactant protein A2 0.0199925
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0198755
CCL5 chemokine (C-C motif) ligand 5 0.0198719
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0198624
SEC61G Sec61 gamma subunit 0.0196778
SEPTIN9 septin 9 0.0195659
RIPK2 receptor-interacting serine-threonine kinase 2 0.0195136
MKI67 marker of proliferation Ki-67 0.0194
EZR ezrin 0.0193834
AKAP12 A kinase (PRKA) anchor protein 12 0.0193476
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0191255
ANGPTL4 angiopoietin-like 4 0.0190653
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0188022
COL3A1 collagen, type III, alpha 1 0.0183083
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0182648
PTPRF protein tyrosine phosphatase, receptor type, F 0.01799
SYAP1 synapse associated protein 1 0.0177633
KLF6 Kruppel-like factor 6 0.0177414
PAIP2 poly(A) binding protein interacting protein 2 0.0177072
MYO9B myosin IXB 0.0176067
DDIT4 DNA-damage-inducible transcript 4 0.0174414
RPS2 ribosomal protein S2 0.0174277
CD59 CD59 molecule, complement regulatory protein 0.0170052
NACA nascent polypeptide-associated complex alpha subunit 0.016947
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0169209
COX6C cytochrome c oxidase subunit VIc 0.0169123
HLA-A major histocompatibility complex, class I, A 0.0168656
FLNA filamin A, alpha 0.0168602
SNX6 sorting nexin 6 0.0167359
RPL9 ribosomal protein L9 0.0167011
FAM107B family with sequence similarity 107, member B 0.0166223
SQLE squalene epoxidase 0.0165858
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0163142
CLIP2 CAP-GLY domain containing linker protein 2 0.0161855
CCDC9 coiled-coil domain containing 9 0.0159782
CD63 CD63 molecule 0.0158753
RPL31 ribosomal protein L31 0.015793
SERF2 small EDRK-rich factor 2 0.0156253
NRIP1 nuclear receptor interacting protein 1 0.0155986
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0155926
PKM pyruvate kinase, muscle 0.0155901
RPS29 ribosomal protein S29 0.0154629
SCARA3 scavenger receptor class A, member 3 0.0152787
BACE2 beta-site APP-cleaving enzyme 2 0.0152182
RPL36 ribosomal protein L36 0.0151747
CSNK1E casein kinase 1, epsilon 0.0151227

decreased expression

Symbol Name Standardized Value
CDH13 cadherin 13 -0.167065
COL6A3 collagen, type VI, alpha 3 -0.143736
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.139773
CADM1 cell adhesion molecule 1 -0.138107
FNDC3B fibronectin type III domain containing 3B -0.125865
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.108088
FN1 fibronectin 1 -0.093232
TRIO trio Rho guanine nucleotide exchange factor -0.0927382
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0846482
PDE10A phosphodiesterase 10A -0.0747418
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.068982
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0648494
PTK2 protein tyrosine kinase 2 -0.0608549
QKI QKI, KH domain containing, RNA binding -0.0593121
CALD1 caldesmon 1 -0.0562491
DPYD dihydropyrimidine dehydrogenase -0.0544429
CD44 CD44 molecule (Indian blood group) -0.0534834
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0531104
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0526745
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0501979
EXT1 exostosin glycosyltransferase 1 -0.0491274
CNTN5 contactin 5 -0.0489511
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0484771
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.048444
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.048096
COL1A1 collagen, type I, alpha 1 -0.0479425
IER3 immediate early response 3 -0.0478724
FTH1 ferritin, heavy polypeptide 1 -0.0473437
ALCAM activated leukocyte cell adhesion molecule -0.0472748
NDRG1 N-myc downstream regulated 1 -0.0468453
BHLHE40 basic helix-loop-helix family, member e40 -0.0437799
ZBTB20 zinc finger and BTB domain containing 20 -0.0432383
COL1A2 collagen, type I, alpha 2 -0.043011
F3 coagulation factor III (thromboplastin, tissue factor) -0.0428591
ASPH aspartate beta-hydroxylase -0.0415301
COL5A1 collagen, type V, alpha 1 -0.0414764
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0414705
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0407887
RTN4 reticulon 4 -0.0404995
ABI3BP ABI family, member 3 (NESH) binding protein -0.0404692
SOD2 superoxide dismutase 2, mitochondrial -0.0394768
TRPS1 trichorhinophalangeal syndrome I -0.0391023
AHNAK AHNAK nucleoprotein -0.0381
TRAM1 translocation associated membrane protein 1 -0.0379478
BBX bobby sox homolog (Drosophila) -0.0379272
GLIS3 GLIS family zinc finger 3 -0.0379242
LTBP1 latent transforming growth factor beta binding protein 1 -0.0374323
MT1X metallothionein 1X -0.0368918
MAP1B microtubule-associated protein 1B -0.0365664
ZFPM2 zinc finger protein, FOG family member 2 -0.0362223
LPP LIM domain containing preferred translocation partner in lipoma -0.0356094
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0353386
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0348902
SEC24D SEC24 family member D -0.0342707
JARID2 jumonji, AT rich interactive domain 2 -0.0341951
USP3 ubiquitin specific peptidase 3 -0.0341455
ZFAND3 zinc finger, AN1-type domain 3 -0.033693
ATXN1 ataxin 1 -0.0331418
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0330953
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0330464
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0330283
IL6ST interleukin 6 signal transducer -0.0327602
TSC22D2 TSC22 domain family, member 2 -0.032604
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0324378
PSD3 pleckstrin and Sec7 domain containing 3 -0.032092
HILPDA hypoxia inducible lipid droplet-associated -0.032008
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0319556
FGFR1 fibroblast growth factor receptor 1 -0.0315487
POTEF POTE ankyrin domain family, member F -0.0313343
MRTFA myocardin related transcription factor A -0.030887
NAMPT nicotinamide phosphoribosyltransferase -0.0304678
FBN1 fibrillin 1 -0.0304549
LMAN1 lectin, mannose-binding, 1 -0.0303138
RUNX1 runt-related transcription factor 1 -0.0300312
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0300248
AFF4 AF4/FMR2 family, member 4 -0.0299538
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0299454
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0297239
VCAN versican -0.0296605
H1-0 H1.0 linker histone -0.0295659
TRAM2 translocation associated membrane protein 2 -0.029451
PDE4D phosphodiesterase 4D, cAMP-specific -0.0289089
COL6A2 collagen, type VI, alpha 2 -0.0286816
HIPK2 homeodomain interacting protein kinase 2 -0.0286159
ADAM9 ADAM metallopeptidase domain 9 -0.028409
RHEB Ras homolog enriched in brain -0.0283458
BNC2 basonuclin 2 -0.0283186
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0282814
PDIA3 protein disulfide isomerase family A, member 3 -0.0282343
RPL35A ribosomal protein L35a -0.0281304
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0281094
VEGFC vascular endothelial growth factor C -0.0279908
PRRC1 proline-rich coiled-coil 1 -0.0278944
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0276473
TENM3 teneurin transmembrane protein 3 -0.0273645
CD109 CD109 molecule -0.0269606
MTDH metadherin -0.0269281
CLINT1 clathrin interactor 1 -0.0267705
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.026761
OXR1 oxidation resistance 1 -0.0264927