Malotilate_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Malotilate perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Malotilate_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.343389
SPTBN1 spectrin, beta, non-erythrocytic 1 0.156209
DSPP dentin sialophosphoprotein 0.106906
TF transferrin 0.0993452
DDIT4 DNA-damage-inducible transcript 4 0.0912964
MT2A metallothionein 2A 0.0899306
APOB apolipoprotein B 0.0886575
EEF2 eukaryotic translation elongation factor 2 0.0771183
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0762986
RPS12 ribosomal protein S12 0.0678772
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0620436
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0582183
RPL3 ribosomal protein L3 0.0545745
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.052237
CCL20 chemokine (C-C motif) ligand 20 0.0521982
IGFBP1 insulin-like growth factor binding protein 1 0.0479915
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0472334
PRRC2C proline-rich coiled-coil 2C 0.0451003
SDC4 syndecan 4 0.0437505
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0430889
AFDN afadin, adherens junction formation factor 0.041719
RPL23 ribosomal protein L23 0.0410812
MYH9 myosin, heavy chain 9, non-muscle 0.0409514
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0409362
EFNA1 ephrin-A1 0.0406903
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0400566
A2M alpha-2-macroglobulin 0.0395428
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.038822
PTMA prothymosin, alpha 0.0385904
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0385762
PRELID2 PRELI domain containing 2 0.0356273
TNS1 tensin 1 0.034869
CFB complement factor B 0.0343862
NACA nascent polypeptide-associated complex alpha subunit 0.0342404
ELL2 elongation factor, RNA polymerase II, 2 0.0341065
TRIM26 tripartite motif containing 26 0.032783
RPL37A ribosomal protein L37a 0.0324884
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0308495
NAP1L1 nucleosome assembly protein 1-like 1 0.0290555
MXI1 MAX interactor 1, dimerization protein 0.0287316
PLEC plectin 0.0287161
NCOA7 nuclear receptor coactivator 7 0.0285945
NFE2L1 nuclear factor, erythroid 2-like 1 0.0283404
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.028192
FLNB filamin B, beta 0.0281879
RPS17 ribosomal protein S17 0.0280306
CALR calreticulin 0.0274621
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0273008
ZMYND8 zinc finger, MYND-type containing 8 0.0271991
SERINC1 serine incorporator 1 0.0271414
RPS4X ribosomal protein S4, X-linked 0.0263914
SEPTIN7 septin 7 0.0257688
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0257095
RPL9 ribosomal protein L9 0.02559
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0254533
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0254286
SET SET nuclear proto-oncogene 0.0252281
ENO1 enolase 1, (alpha) 0.024893
SPAG9 sperm associated antigen 9 0.0248875
JAG1 jagged 1 0.024502
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0239651
RORA RAR-related orphan receptor A 0.0236043
PUM1 pumilio RNA-binding family member 1 0.0230966
RPLP2 ribosomal protein, large, P2 0.0229984
RPL10A ribosomal protein L10a 0.0229183
ANGPTL8 angiopoietin like 8 0.0223997
SLC38A2 solute carrier family 38, member 2 0.0222718
STAU1 staufen double-stranded RNA binding protein 1 0.0221489
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0219966
CDC27 cell division cycle 27 0.0215633
RPS27A ribosomal protein S27a 0.0215585
CDK19 cyclin-dependent kinase 19 0.0213223
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0208579
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0208528
ARFGEF3 ARFGEF family member 3 0.020765
KIF5B kinesin family member 5B 0.0206577
KDM7A lysine (K)-specific demethylase 7A 0.0205174
CEP250 centrosomal protein 250kDa 0.0203896
RPL26 ribosomal protein L26 0.0201485
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0200943
CPE carboxypeptidase E 0.0199534
RPL36 ribosomal protein L36 0.0197328
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0197062
MTSS1 metastasis suppressor 1 0.0196644
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0196588
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0196333
TLK1 tousled-like kinase 1 0.0193532
ARRDC3 arrestin domain containing 3 0.0192355
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0189686
EZR ezrin 0.0188534
GDF15 growth differentiation factor 15 0.0187883
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0185664
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0184356
RPL14 ribosomal protein L14 0.0184203
HOOK2 hook microtubule-tethering protein 2 0.0183126
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0183087
LDHA lactate dehydrogenase A 0.0182145
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0181904
ARHGAP5 Rho GTPase activating protein 5 0.0180302
FNBP1L formin binding protein 1-like 0.0180136

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.437513
C3 complement component 3 -0.201885
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.113407
GPC6 glypican 6 -0.100606
ITGAV integrin, alpha V -0.0891877
IGF2 insulin-like growth factor 2 -0.084856
FBF1 Fas (TNFRSF6) binding factor 1 -0.0845545
AKAP12 A kinase (PRKA) anchor protein 12 -0.0749944
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.05981
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0522409
EHBP1 EH domain binding protein 1 -0.0521737
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0470903
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0429507
PTCHD4 patched domain containing 4 -0.0410111
EML4 echinoderm microtubule associated protein like 4 -0.0404156
VCL vinculin -0.0389417
NKD1 naked cuticle homolog 1 (Drosophila) -0.0386395
NPAS2 neuronal PAS domain protein 2 -0.0383021
HMGA1 high mobility group AT-hook 1 -0.0375019
LYZ lysozyme -0.0374401
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0372363
TXNRD1 thioredoxin reductase 1 -0.037083
PARD3 par-3 family cell polarity regulator -0.0366824
MAML2 mastermind-like 2 (Drosophila) -0.0347351
VMP1 vacuole membrane protein 1 -0.0347225
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.034546
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0345031
ZNF644 zinc finger protein 644 -0.0332312
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0325422
JMJD1C jumonji domain containing 1C -0.0324076
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0323299
GMDS GDP-mannose 4,6-dehydratase -0.0321174
UBASH3B ubiquitin associated and SH3 domain containing B -0.0319949
TCF12 transcription factor 12 -0.0299598
LRMDA leucine rich melanocyte differentiation associated -0.0292056
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.02897
FOXP1 forkhead box P1 -0.0285807
PAWR PRKC, apoptosis, WT1, regulator -0.0285649
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0282929
FRMD5 FERM domain containing 5 -0.0278154
FNDC3B fibronectin type III domain containing 3B -0.0277362
DLC1 DLC1 Rho GTPase activating protein -0.0277356
SOX5 SRY (sex determining region Y)-box 5 -0.0277051
RPL35A ribosomal protein L35a -0.02753
ENAH enabled homolog (Drosophila) -0.0274689
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.027413
PTPRK protein tyrosine phosphatase, receptor type, K -0.0267733
PTPRM protein tyrosine phosphatase, receptor type, M -0.0258881
PLIN2 perilipin 2 -0.0258275
CNKSR3 CNKSR family member 3 -0.02563
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0254902
TRIO trio Rho guanine nucleotide exchange factor -0.0249696
ACTN4 actinin, alpha 4 -0.0248928
FTL ferritin, light polypeptide -0.0247257
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0245127
DOCK4 dedicator of cytokinesis 4 -0.0243618
DST dystonin -0.0242635
ITGA1 integrin, alpha 1 -0.0242634
ZNF207 zinc finger protein 207 -0.0240834
DNAH17 dynein, axonemal, heavy chain 17 -0.0239986
PERP PERP, TP53 apoptosis effector -0.0237917
NHSL1 NHS-like 1 -0.0237132
SESTD1 SEC14 and spectrin domains 1 -0.0236967
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0234997
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0233309
OSBPL10 oxysterol binding protein-like 10 -0.0232715
LMCD1 LIM and cysteine-rich domains 1 -0.0231807
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0230825
MAPK8 mitogen-activated protein kinase 8 -0.0230536
TMEM123 transmembrane protein 123 -0.0229748
FCHSD2 FCH and double SH3 domains 2 -0.0229263
CP ceruloplasmin (ferroxidase) -0.0226578
SMAD3 SMAD family member 3 -0.0226306
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0225418
NRIP1 nuclear receptor interacting protein 1 -0.022487
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0222839
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0220495
PDLIM5 PDZ and LIM domain 5 -0.0219241
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0218301
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0217073
WAC WW domain containing adaptor with coiled-coil -0.0215741
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0213998
KIF1B kinesin family member 1B -0.0211855
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0209527
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0208826
MBNL2 muscleblind-like splicing regulator 2 -0.0207418
CMIP c-Maf inducing protein -0.020691
RPLP0 ribosomal protein, large, P0 -0.0206621
ADAM9 ADAM metallopeptidase domain 9 -0.0206062
TRAM1 translocation associated membrane protein 1 -0.0205536
RPLP1 ribosomal protein, large, P1 -0.0205135
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0204609
RAI14 retinoic acid induced 14 -0.0204096
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0203262
TNRC6B trinucleotide repeat containing 6B -0.0202381
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0201676
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0201616
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0200158
LRRC1 leucine rich repeat containing 1 -0.0198936
AFF1 AF4/FMR2 family, member 1 -0.019829