Malotilate_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Malotilate perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Malotilate_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.228293
PODXL podocalyxin-like 0.0978735
KRT6A keratin 6A, type II 0.0883473
BCL2L1 BCL2-like 1 0.0817579
RPS8 ribosomal protein S8 0.0806726
MT2A metallothionein 2A 0.0729913
IGF2 insulin-like growth factor 2 0.0701156
RPS3 ribosomal protein S3 0.0689285
PRRC2C proline-rich coiled-coil 2C 0.0660761
RPS4X ribosomal protein S4, X-linked 0.0629801
RPS12 ribosomal protein S12 0.0587685
RPL23 ribosomal protein L23 0.0531526
ACTN1 actinin, alpha 1 0.0520833
NDRG1 N-myc downstream regulated 1 0.050258
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0488814
KTN1 kinectin 1 (kinesin receptor) 0.0483845
RPL5 ribosomal protein L5 0.0477785
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0461714
RPL11 ribosomal protein L11 0.0453807
SET SET nuclear proto-oncogene 0.045115
RPL37 ribosomal protein L37 0.04467
RPS2 ribosomal protein S2 0.043965
MXI1 MAX interactor 1, dimerization protein 0.0429621
S100A10 S100 calcium binding protein A10 0.0403059
MORF4L2 mortality factor 4 like 2 0.0388346
RPLP2 ribosomal protein, large, P2 0.0385879
LAMC2 laminin, gamma 2 0.0383963
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.037554
RPL12 ribosomal protein L12 0.0360673
NACA nascent polypeptide-associated complex alpha subunit 0.0359647
SEPTIN9 septin 9 0.0357104
DUSP6 dual specificity phosphatase 6 0.03522
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.034903
RPL26 ribosomal protein L26 0.0347635
CAPN2 calpain 2, (m/II) large subunit 0.0344383
RPL36 ribosomal protein L36 0.0340155
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0339851
SQLE squalene epoxidase 0.0339813
PTMA prothymosin, alpha 0.0339602
AKAP9 A kinase (PRKA) anchor protein 9 0.0336906
RPL37A ribosomal protein L37a 0.0324889
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0311158
RPS27 ribosomal protein S27 0.0303156
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0301539
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0297023
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0294779
MEGF6 multiple EGF-like-domains 6 0.0292904
MBNL1 muscleblind-like splicing regulator 1 0.0292647
ACBD3 acyl-CoA binding domain containing 3 0.0292095
GUK1 guanylate kinase 1 0.0290388
UBAP2L ubiquitin associated protein 2-like 0.0289081
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0280389
RACK1 receptor for activated C kinase 1 0.0280124
ITGA6 integrin, alpha 6 0.0277723
RPS29 ribosomal protein S29 0.0275193
ARGLU1 arginine and glutamate rich 1 0.0274357
RPS6 ribosomal protein S6 0.0273046
LMNA lamin A/C 0.0271692
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0271575
SQSTM1 sequestosome 1 0.0269219
RPS19 ribosomal protein S19 0.0268502
PTPRF protein tyrosine phosphatase, receptor type, F 0.026604
MKI67 marker of proliferation Ki-67 0.0264922
FUS FUS RNA binding protein 0.0262165
HLA-B major histocompatibility complex, class I, B 0.0252844
ANGPTL4 angiopoietin-like 4 0.0252727
RPS17 ribosomal protein S17 0.0251537
SFTPA2 surfactant protein A2 0.0249688
ERRFI1 ERBB receptor feedback inhibitor 1 0.02492
EIF1 eukaryotic translation initiation factor 1 0.0248751
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0248572
RPL8 ribosomal protein L8 0.0246342
RPL7A ribosomal protein L7a 0.024627
WSB1 WD repeat and SOCS box containing 1 0.0244925
TMF1 TATA element modulatory factor 1 0.0244801
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.024409
CTNND1 catenin (cadherin-associated protein), delta 1 0.0242724
TPT1 tumor protein, translationally-controlled 1 0.0239596
RPL31 ribosomal protein L31 0.0238116
MED15 mediator complex subunit 15 0.0232778
ZMIZ1 zinc finger, MIZ-type containing 1 0.0231893
TIMP3 TIMP metallopeptidase inhibitor 3 0.0231424
APP amyloid beta (A4) precursor protein 0.0230613
RPL9 ribosomal protein L9 0.0230413
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0229593
SDC1 syndecan 1 0.0229377
ITSN1 intersectin 1 (SH3 domain protein) 0.0225589
RSRP1 arginine/serine-rich protein 1 0.022473
RPL36A ribosomal protein L36a 0.0220506
SLC35F3 solute carrier family 35, member F3 0.0218776
SERINC1 serine incorporator 1 0.0217027
MCL1 myeloid cell leukemia 1 0.0216989
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0216244
CUL4B cullin 4B 0.0213531
RPS14 ribosomal protein S14 0.0212898
RPLP1 ribosomal protein, large, P1 0.0211464
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0210429
ANLN anillin, actin binding protein 0.0209905
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0209403
RPS25 ribosomal protein S25 0.0208919

decreased expression

Symbol Name Standardized Value
H1-0 H1.0 linker histone -0.113317
POTEF POTE ankyrin domain family, member F -0.105451
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.100932
MYOF myoferlin -0.0803312
LOC112694756 uncharaterized LOC112694756 -0.0748095
CLU clusterin -0.0727057
NAMPT nicotinamide phosphoribosyltransferase -0.0715136
CAV1 caveolin 1, caveolae protein, 22kDa -0.0697942
TGM2 transglutaminase 2 -0.0677191
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0674395
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0667592
HSPG2 heparan sulfate proteoglycan 2 -0.0640726
SULF1 sulfatase 1 -0.0619982
DPYD dihydropyrimidine dehydrogenase -0.0616239
FTH1 ferritin, heavy polypeptide 1 -0.0604661
CD44 CD44 molecule (Indian blood group) -0.0590166
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0588899
PTK2 protein tyrosine kinase 2 -0.0576549
PDE4D phosphodiesterase 4D, cAMP-specific -0.0575468
RBM39 RNA binding motif protein 39 -0.0566372
MEF2A myocyte enhancer factor 2A -0.0549263
FOXP1 forkhead box P1 -0.0537221
MTSS1 metastasis suppressor 1 -0.0528384
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.051111
APLP2 amyloid beta (A4) precursor-like protein 2 -0.050262
RAI14 retinoic acid induced 14 -0.0489806
KIAA1217 KIAA1217 -0.0482018
PDIA3 protein disulfide isomerase family A, member 3 -0.0471333
UBE2H ubiquitin-conjugating enzyme E2H -0.045765
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0456577
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0448211
AHNAK AHNAK nucleoprotein -0.0428027
SAMD9 sterile alpha motif domain containing 9 -0.0418226
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0411468
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0408819
CEMIP cell migration inducing protein, hyaluronan binding -0.0389897
STC1 stanniocalcin 1 -0.038759
PALLD palladin, cytoskeletal associated protein -0.0373168
MBNL2 muscleblind-like splicing regulator 2 -0.0368448
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0356609
DOCK9 dedicator of cytokinesis 9 -0.0350316
TXNRD1 thioredoxin reductase 1 -0.0349717
RAB22A RAB22A, member RAS oncogene family -0.0344897
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.033493
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0326251
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0323702
BLCAP bladder cancer associated protein -0.0319355
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0316956
ANXA1 annexin A1 -0.0314858
MSN moesin -0.0314842
PFN1 profilin 1 -0.0314737
ANXA2 annexin A2 -0.0313622
SULF2 sulfatase 2 -0.0309836
NEK7 NIMA-related kinase 7 -0.0306232
SYPL1 synaptophysin-like 1 -0.030581
EFNA5 ephrin-A5 -0.0303877
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0303527
MARCHF6 membrane associated ring-CH-type finger 6 -0.0303494
HBP1 HMG-box transcription factor 1 -0.0301043
FAM3C family with sequence similarity 3, member C -0.0297699
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0297424
MAML2 mastermind-like 2 (Drosophila) -0.0293769
PCDH1 protocadherin 1 -0.028451
DIDO1 death inducer-obliterator 1 -0.0282572
PGK1 phosphoglycerate kinase 1 -0.0282479
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0282424
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0281734
FSTL1 follistatin-like 1 -0.0277052
RLF rearranged L-myc fusion -0.0275
RABGAP1L RAB GTPase activating protein 1-like -0.0274371
SMAD3 SMAD family member 3 -0.0273388
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0272565
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0272389
NFIA nuclear factor I/A -0.0270265
TAPBP TAP binding protein (tapasin) -0.0269676
RAD23B RAD23 homolog B (S. cerevisiae) -0.0267343
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0264806
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0256375
TES testin LIM domain protein -0.0255939
EXOC6B exocyst complex component 6B -0.0255424
PDLIM1 PDZ and LIM domain 1 -0.025486
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0252082
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0250092
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.02499
DLG1 discs, large homolog 1 (Drosophila) -0.0249836
SDCBP syndecan binding protein (syntenin) -0.0247211
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0244542
ADAM9 ADAM metallopeptidase domain 9 -0.0241866
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0240682
KDM6A lysine (K)-specific demethylase 6A -0.0239438
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0237818
LMO7 LIM domain 7 -0.0237106
EXT1 exostosin glycosyltransferase 1 -0.0235877
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0235789
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0235427
ZFAND3 zinc finger, AN1-type domain 3 -0.0233881
FNDC3A fibronectin type III domain containing 3A -0.0232649
RHEB Ras homolog enriched in brain -0.0232161
LAMA5 laminin, alpha 5 -0.0229767
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0229672