Malotilate_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Malotilate perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Malotilate_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.160314
KRT18 keratin 18, type I 0.123904
NDRG1 N-myc downstream regulated 1 0.115127
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.111247
RPS12 ribosomal protein S12 0.0981283
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0889952
RPL3 ribosomal protein L3 0.0838913
EEF2 eukaryotic translation elongation factor 2 0.0801557
AREG amphiregulin 0.0791948
EREG epiregulin 0.0718254
CEMIP cell migration inducing protein, hyaluronan binding 0.0651942
PTMA prothymosin, alpha 0.0630639
RPL37A ribosomal protein L37a 0.0600787
RPS3 ribosomal protein S3 0.0541969
DDIT4 DNA-damage-inducible transcript 4 0.0529062
FAM13A family with sequence similarity 13, member A 0.0524308
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0517186
ESYT2 extended synaptotagmin-like protein 2 0.0515057
EZR ezrin 0.0508432
ITPRID2 ITPR interacting domain containing 2 0.0493675
NACA nascent polypeptide-associated complex alpha subunit 0.0488434
MXI1 MAX interactor 1, dimerization protein 0.0487471
ERRFI1 ERBB receptor feedback inhibitor 1 0.0487065
RPS4X ribosomal protein S4, X-linked 0.0479783
MYH9 myosin, heavy chain 9, non-muscle 0.0463671
PLAUR plasminogen activator, urokinase receptor 0.0454806
PTPRR protein tyrosine phosphatase, receptor type, R 0.0445234
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0442703
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0438065
TNS4 tensin 4 0.043804
ITGB4 integrin, beta 4 0.0431033
PIGR polymeric immunoglobulin receptor 0.0423824
RPL26 ribosomal protein L26 0.0421113
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0420232
RPL23 ribosomal protein L23 0.0416904
SET SET nuclear proto-oncogene 0.0405929
RPL5 ribosomal protein L5 0.0400653
TMSB4X thymosin beta 4, X-linked 0.0400464
HSPA8 heat shock 70kDa protein 8 0.0377851
TXNIP thioredoxin interacting protein 0.0375584
RNF43 ring finger protein 43 0.0366263
RPS29 ribosomal protein S29 0.0351083
DSPP dentin sialophosphoprotein 0.0337423
DNM2 dynamin 2 0.0334606
CALR calreticulin 0.0328739
EHF ets homologous factor 0.0319237
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.031417
UBA6 ubiquitin-like modifier activating enzyme 6 0.0311779
ACBD3 acyl-CoA binding domain containing 3 0.0311255
KLF3 Kruppel-like factor 3 (basic) 0.0310247
RPL7A ribosomal protein L7a 0.0308988
CSDE1 cold shock domain containing E1, RNA-binding 0.0306464
TM9SF2 transmembrane 9 superfamily member 2 0.0303898
CDK19 cyclin-dependent kinase 19 0.0302384
RPS17 ribosomal protein S17 0.0301607
RPL18 ribosomal protein L18 0.0299363
EPHA2 EPH receptor A2 0.0299039
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0295297
PLEC plectin 0.0293007
PRRC2C proline-rich coiled-coil 2C 0.0291715
RPS8 ribosomal protein S8 0.0291516
KIF5B kinesin family member 5B 0.0284553
ESRP1 epithelial splicing regulatory protein 1 0.0282677
KTN1 kinectin 1 (kinesin receptor) 0.0280265
RPS2 ribosomal protein S2 0.0277212
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0276168
CDCP1 CUB domain containing protein 1 0.0275032
PNN pinin, desmosome associated protein 0.0273965
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0269776
TPM3 tropomyosin 3 0.0269374
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0268507
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0266377
RPL36 ribosomal protein L36 0.026459
MINK1 misshapen-like kinase 1 0.0263016
MORF4L2 mortality factor 4 like 2 0.0262956
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0260996
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0259238
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0258437
RPS27A ribosomal protein S27a 0.0254869
RPLP2 ribosomal protein, large, P2 0.0253162
ABHD17C abhydrolase domain containing 17C 0.0252971
TMF1 TATA element modulatory factor 1 0.0251552
EIF4H eukaryotic translation initiation factor 4H 0.024978
BCL2L1 BCL2-like 1 0.024874
RPL9 ribosomal protein L9 0.0247667
USP34 ubiquitin specific peptidase 34 0.0247098
PTPRF protein tyrosine phosphatase, receptor type, F 0.0246887
ARHGAP5 Rho GTPase activating protein 5 0.0243004
ATXN1 ataxin 1 0.0242855
RPS18 ribosomal protein S18 0.0242333
SERINC1 serine incorporator 1 0.0241781
COX6C cytochrome c oxidase subunit VIc 0.0239266
AVL9 AVL9 homolog (S. cerevisiase) 0.0238499
TNIP1 TNFAIP3 interacting protein 1 0.0238212
MCL1 myeloid cell leukemia 1 0.0236304
TPM4 tropomyosin 4 0.0236229
H1-4 H1.4 linker histone, cluster member 0.0235428
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0234418
AFDN afadin, adherens junction formation factor 0.0233971
JAG1 jagged 1 0.0233875

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.174881
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.172339
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.165137
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.150008
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.115391
TMSB10 thymosin beta 10 -0.106168
FTH1 ferritin, heavy polypeptide 1 -0.0994332
GMDS GDP-mannose 4,6-dehydratase -0.0902587
ALCAM activated leukocyte cell adhesion molecule -0.07941
MYO1E myosin IE -0.0712547
ACTG1 actin gamma 1 -0.069387
NPSR1 neuropeptide S receptor 1 -0.0685669
LMO7 LIM domain 7 -0.06344
GPHN gephyrin -0.0629199
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0587604
RPL35A ribosomal protein L35a -0.058298
HMGA1 high mobility group AT-hook 1 -0.0564401
NALF1 NALCN channel auxiliary factor 1 -0.0542712
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.053828
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0528679
RPLP0 ribosomal protein, large, P0 -0.0528624
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0517773
EXT1 exostosin glycosyltransferase 1 -0.0514637
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0503715
POTEF POTE ankyrin domain family, member F -0.0488409
H1-0 H1.0 linker histone -0.0444751
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0432712
CCND1 cyclin D1 -0.04064
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0398554
MT2A metallothionein 2A -0.0391504
VCL vinculin -0.0384581
PDIA3 protein disulfide isomerase family A, member 3 -0.037669
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0369455
IARS1 isoleucyl-tRNA synthetase 1 -0.0362407
ANXA2 annexin A2 -0.0351726
HMGB1 high mobility group box 1 -0.0347886
PTPRK protein tyrosine phosphatase, receptor type, K -0.0346045
TTC3 tetratricopeptide repeat domain 3 -0.0340456
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0340111
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0336234
POF1B premature ovarian failure, 1B -0.0317114
AGR2 anterior gradient 2 -0.0315868
RNF145 ring finger protein 145 -0.0311194
SVIL supervillin -0.030994
TUBB4B tubulin, beta 4B class IVb -0.0309607
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0301213
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0299258
RPLP1 ribosomal protein, large, P1 -0.0291307
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0290126
LOC102724023 ES1 protein homolog, mitochondrial -0.0287327
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0286584
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0286377
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0286153
RTN3 reticulon 3 -0.0283589
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0282424
RAB7A RAB7A, member RAS oncogene family -0.0281689
BTG1 B-cell translocation gene 1, anti-proliferative -0.027962
PDLIM5 PDZ and LIM domain 5 -0.027929
ANKRD17 ankyrin repeat domain 17 -0.0276974
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0272537
TUBA1B tubulin, alpha 1b -0.0268185
SIK3 SIK family kinase 3 -0.0267384
VDAC1 voltage-dependent anion channel 1 -0.0265193
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0261735
FOXO1 forkhead box O1 -0.0261159
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0257429
RAB10 RAB10, member RAS oncogene family -0.0255929
KPNB1 karyopherin (importin) beta 1 -0.0255598
PGK1 phosphoglycerate kinase 1 -0.0253828
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0252491
EPHB2 EPH receptor B2 -0.0247202
CSNK1G3 casein kinase 1, gamma 3 -0.0246488
ATP5F1B ATP synthase F1 subunit beta -0.0246288
JMJD1C jumonji domain containing 1C -0.0244814
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0244515
TSC22D2 TSC22 domain family, member 2 -0.0244315
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0243746
PALLD palladin, cytoskeletal associated protein -0.0242286
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.024153
CENPF centromere protein F, 350/400kDa -0.0240739
GREB1L growth regulation by estrogen in breast cancer-like -0.0240089
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0237993
ZNRF3 zinc and ring finger 3 -0.0237433
CTBP2 C-terminal binding protein 2 -0.0236924
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0236619
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0236361
MED13 mediator complex subunit 13 -0.0236286
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0235889
ABLIM1 actin binding LIM protein 1 -0.0233214
ARHGAP42 Rho GTPase activating protein 42 -0.0233138
MT1X metallothionein 1X -0.0232712
USP3 ubiquitin specific peptidase 3 -0.0231377
FBXO11 F-box protein 11 -0.0230315
MT1E metallothionein 1E -0.0229644
ENO1 enolase 1, (alpha) -0.0229628
VWA8 von Willebrand factor A domain containing 8 -0.0229622
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -0.0228246
MGST1 microsomal glutathione S-transferase 1 -0.0225768
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0225659
CADPS Ca++-dependent secretion activator -0.0224729