| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Malotilate perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Malotilate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.158857 |
| MT2A | metallothionein 2A | 0.140083 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0949268 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0800638 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0793735 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0791927 |
| FAM13A | family with sequence similarity 13, member A | 0.0790063 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0757105 |
| LAMC2 | laminin, gamma 2 | 0.0725616 |
| MKI67 | marker of proliferation Ki-67 | 0.0715788 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0691664 |
| EGFR | epidermal growth factor receptor | 0.0677312 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0652575 |
| ARRDC3 | arrestin domain containing 3 | 0.0625602 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0582581 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0581313 |
| LDHA | lactate dehydrogenase A | 0.0549817 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0543783 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0536613 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0528759 |
| KRT18 | keratin 18, type I | 0.0516462 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0505786 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0487723 |
| DSPP | dentin sialophosphoprotein | 0.0481334 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0472281 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0469194 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0432823 |
| PKM | pyruvate kinase, muscle | 0.0418355 |
| FLNB | filamin B, beta | 0.0414531 |
| MCL1 | myeloid cell leukemia 1 | 0.0411313 |
| NGLY1 | N-glycanase 1 | 0.0399163 |
| RNF149 | ring finger protein 149 | 0.0383373 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0378891 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0367464 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0366062 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0360393 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0346815 |
| CES1 | carboxylesterase 1 | 0.033596 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0332291 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0327163 |
| RPS4X | ribosomal protein S4, X-linked | 0.0323502 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0320757 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0316034 |
| ZNF292 | zinc finger protein 292 | 0.0313196 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.030217 |
| CPE | carboxypeptidase E | 0.0299542 |
| APP | amyloid beta (A4) precursor protein | 0.0298484 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.029603 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0294095 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0290475 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0286998 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0281193 |
| KMT5B | lysine methyltransferase 5B | 0.0278625 |
| ENO1 | enolase 1, (alpha) | 0.0276009 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0269472 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0266996 |
| RNF145 | ring finger protein 145 | 0.0266423 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0266216 |
| TPM3 | tropomyosin 3 | 0.0264767 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0263286 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0262258 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0260612 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0260177 |
| CLTC | clathrin, heavy chain (Hc) | 0.0260014 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.025643 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0255741 |
| ANXA5 | annexin A5 | 0.0252293 |
| PCBP2 | poly(rC) binding protein 2 | 0.0250548 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0247039 |
| PLAUR | plasminogen activator, urokinase receptor | 0.024619 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.024575 |
| CYTH1 | cytohesin 1 | 0.024508 |
| S100A6 | S100 calcium binding protein A6 | 0.0242564 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0241683 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0241163 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0240946 |
| YAP1 | Yes-associated protein 1 | 0.0240524 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0240237 |
| WDR45B | WD repeat domain 45B | 0.0239314 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0238625 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0232851 |
| SBF2 | SET binding factor 2 | 0.0230991 |
| GOLGA4 | golgin A4 | 0.023044 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0229397 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0229277 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0227798 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0227496 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0225755 |
| RIOK3 | RIO kinase 3 | 0.0225505 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0223107 |
| S100A10 | S100 calcium binding protein A10 | 0.0219718 |
| MSN | moesin | 0.0218209 |
| SFTPA2 | surfactant protein A2 | 0.0217814 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0216462 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0215892 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0215089 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0214775 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0212904 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0212854 |
| RNF213 | ring finger protein 213 | 0.0212613 |
| Symbol | Name | Standardized Value |
|---|---|---|
| H1-0 | H1.0 linker histone | -0.125512 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.105088 |
| INTS6 | integrator complex subunit 6 | -0.0971238 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0860363 |
| FTL | ferritin, light polypeptide | -0.0857386 |
| LMO7 | LIM domain 7 | -0.0810855 |
| MYOF | myoferlin | -0.0663773 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0590403 |
| GRAMD1B | GRAM domain containing 1B | -0.0540372 |
| ASPH | aspartate beta-hydroxylase | -0.0529613 |
| ANXA2 | annexin A2 | -0.0525296 |
| NABP1 | nucleic acid binding protein 1 | -0.0516003 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0507316 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.049396 |
| HOMER1 | homer scaffolding protein 1 | -0.0480821 |
| SLTM | SAFB-like, transcription modulator | -0.0472632 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0427807 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0420101 |
| RPLP0 | ribosomal protein, large, P0 | -0.041416 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.0393817 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0384875 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0375975 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0372564 |
| RPS24 | ribosomal protein S24 | -0.0369253 |
| SMYD3 | SET and MYND domain containing 3 | -0.0358159 |
| DSCAM | Down syndrome cell adhesion molecule | -0.035759 |
| ACTG1 | actin gamma 1 | -0.0354616 |
| EGR1 | early growth response 1 | -0.0351926 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.035005 |
| IER3 | immediate early response 3 | -0.0344713 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0341792 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0335222 |
| GM2A | GM2 ganglioside activator | -0.0322839 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.03225 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0320996 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0319937 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0319725 |
| TXNRD1 | thioredoxin reductase 1 | -0.0312855 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0305399 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0304504 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0301909 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0298969 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0298221 |
| HBP1 | HMG-box transcription factor 1 | -0.0286938 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0281694 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0276618 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0271278 |
| MYO5B | myosin VB | -0.0270838 |
| MAP7 | microtubule-associated protein 7 | -0.0267949 |
| AEBP2 | AE binding protein 2 | -0.0264759 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0264056 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0260594 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0253747 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0247954 |
| NBEAL1 | neurobeachin-like 1 | -0.0246266 |
| RPS3 | ribosomal protein S3 | -0.0245186 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0243927 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0240208 |
| SIK3 | SIK family kinase 3 | -0.0238165 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0234693 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0230294 |
| TMSB10 | thymosin beta 10 | -0.0229824 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0228362 |
| XRRA1 | X-ray radiation resistance associated 1 | -0.022553 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0222235 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0221959 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0221697 |
| GOLGB1 | golgin B1 | -0.0220566 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0218616 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0217751 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0213318 |
| OSMR | oncostatin M receptor | -0.0212898 |
| KIAA1328 | KIAA1328 | -0.0211898 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0211752 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0211046 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0210946 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0209775 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0209585 |
| TMEM184B | transmembrane protein 184B | -0.0207573 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0207285 |
| EMP1 | epithelial membrane protein 1 | -0.0206728 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0205435 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0201481 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0201333 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0200356 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.019759 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0197556 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0196115 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0195795 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0194834 |
| LRRC23 | leucine rich repeat containing 23 | -0.0194817 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0193589 |
| HDLBP | high density lipoprotein binding protein | -0.0193327 |
| SP100 | SP100 nuclear antigen | -0.0191797 |
| RBM39 | RNA binding motif protein 39 | -0.0190994 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.019014 |
| DENND4A | DENN/MADD domain containing 4A | -0.0189842 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0189234 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0189153 |
| RUNX1 | runt-related transcription factor 1 | -0.0189081 |
