| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Malotilate perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Malotilate_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.125764 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.112317 |
| PDE10A | phosphodiesterase 10A | 0.0865748 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.077919 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0777482 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0727795 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.069379 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0655397 |
| TXNRD1 | thioredoxin reductase 1 | 0.0613774 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.058419 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0554901 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0496894 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.049326 |
| ATOSA | atos homolog A | 0.0483221 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0478593 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0475454 |
| USP34 | ubiquitin specific peptidase 34 | 0.0473223 |
| RPL38 | ribosomal protein L38 | 0.0465868 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0461678 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0459556 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0449991 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0427863 |
| SON | SON DNA binding protein | 0.0420725 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0418712 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0418228 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0408526 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | 0.0408362 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.040499 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0398347 |
| FLNB | filamin B, beta | 0.0397477 |
| RPL26 | ribosomal protein L26 | 0.0391803 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.038554 |
| TMSB4X | thymosin beta 4, X-linked | 0.0382799 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0382652 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0376289 |
| AHNAK | AHNAK nucleoprotein | 0.0374485 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0373157 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0368567 |
| ZNF721 | zinc finger protein 721 | 0.0367608 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0360836 |
| EGFR | epidermal growth factor receptor | 0.0360245 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0356423 |
| PRKCA | protein kinase C, alpha | 0.0353987 |
| PLEC | plectin | 0.0353821 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0351282 |
| AK1 | adenylate kinase 1 | 0.0346992 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0346802 |
| STK24 | serine/threonine kinase 24 | 0.0341034 |
| DSTN | destrin (actin depolymerizing factor) | 0.0340832 |
| RAB2A | RAB2A, member RAS oncogene family | 0.034062 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.033546 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0333007 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0330286 |
| EHBP1 | EH domain binding protein 1 | 0.0327442 |
| RPS24 | ribosomal protein S24 | 0.0326179 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0321054 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0319547 |
| RPL34 | ribosomal protein L34 | 0.0318605 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.031805 |
| OSMR | oncostatin M receptor | 0.0316011 |
| ZNF407 | zinc finger protein 407 | 0.0311016 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0308546 |
| MYOF | myoferlin | 0.0305975 |
| FNBP1 | formin binding protein 1 | 0.0305165 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0302328 |
| ANKRD12 | ankyrin repeat domain 12 | 0.030203 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0297601 |
| RPS27A | ribosomal protein S27a | 0.0293768 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.0293507 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0292016 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0288062 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.028673 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0286371 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.028542 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0284337 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0282629 |
| RPS12 | ribosomal protein S12 | 0.0278694 |
| ATP11A | ATPase, class VI, type 11A | 0.0277965 |
| TMEM87A | transmembrane protein 87A | 0.0276865 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0275941 |
| TPI1 | triosephosphate isomerase 1 | 0.0274367 |
| FNBP1L | formin binding protein 1-like | 0.0269634 |
| NSD1 | nuclear receptor binding SET domain protein 1 | 0.0267754 |
| KYNU | kynureninase | 0.0266802 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 0.0264868 |
| WDR45B | WD repeat domain 45B | 0.0263294 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0262556 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.0261149 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0257423 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0255737 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.025419 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0246523 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0245771 |
| CD2AP | CD2-associated protein | 0.0244575 |
| RPS13 | ribosomal protein S13 | 0.0243366 |
| NEMF | nuclear export mediator factor | 0.0242894 |
| PARD3 | par-3 family cell polarity regulator | 0.0242366 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0242042 |
| RPL19 | ribosomal protein L19 | 0.024158 |
| MAML1 | mastermind-like 1 (Drosophila) | 0.0240599 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0948998 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0906585 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0869774 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.086565 |
| FN1 | fibronectin 1 | -0.0821816 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0819603 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0818189 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0712399 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0664942 |
| SPAG9 | sperm associated antigen 9 | -0.0601854 |
| CD109 | CD109 molecule | -0.0577934 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.055677 |
| PTMA | prothymosin, alpha | -0.0547815 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0540441 |
| PGK1 | phosphoglycerate kinase 1 | -0.0534413 |
| RNF145 | ring finger protein 145 | -0.0522483 |
| RYBP | RING1 and YY1 binding protein | -0.0506136 |
| B2M | beta-2-microglobulin | -0.050529 |
| NDRG1 | N-myc downstream regulated 1 | -0.0501055 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0475734 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.047174 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0471704 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0471509 |
| TFG | TRK-fused gene | -0.0463098 |
| HBP1 | HMG-box transcription factor 1 | -0.045018 |
| STK17A | serine/threonine kinase 17a | -0.0450041 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.044542 |
| YBX3 | Y box binding protein 3 | -0.0444633 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0443861 |
| FMN1 | formin 1 | -0.0436892 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0433099 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0427976 |
| RNF24 | ring finger protein 24 | -0.0425818 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0423729 |
| PAPOLA | poly(A) polymerase alpha | -0.0420527 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0413942 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0403298 |
| S100A6 | S100 calcium binding protein A6 | -0.040246 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0399028 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0396436 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0393777 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0392666 |
| NKTR | natural killer cell triggering receptor | -0.0392551 |
| RIGI | RNA sensor RIG-I | -0.038688 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0386699 |
| SEPTIN7 | septin 7 | -0.0385174 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0372507 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.0371101 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0369141 |
| ACVR1 | activin A receptor, type I | -0.0369139 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0366372 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0365577 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0363728 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0359071 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0356604 |
| ATP11B | ATPase, class VI, type 11B | -0.0354597 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0351938 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0345421 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0344307 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0344177 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0341626 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0340324 |
| YEATS2 | YEATS domain containing 2 | -0.033856 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0338398 |
| VIM | vimentin | -0.0336189 |
| TMSB10 | thymosin beta 10 | -0.0334502 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0332435 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0332381 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0332214 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0329222 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0325694 |
| AUTS2 | autism susceptibility candidate 2 | -0.0314031 |
| RHEB | Ras homolog enriched in brain | -0.0310391 |
| AHR | aryl hydrocarbon receptor | -0.031003 |
| ANK2 | ankyrin 2, neuronal | -0.0309327 |
| FOXP1 | forkhead box P1 | -0.0306726 |
| MATR3 | matrin 3 | -0.0302988 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0297734 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0297415 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0297322 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.029547 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0294347 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0293894 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0292365 |
| PDE8A | phosphodiesterase 8A | -0.0291569 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0291181 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0288659 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0288311 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0287273 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0284849 |
| CCNI | cyclin I | -0.0284048 |
| RPS5 | ribosomal protein S5 | -0.027968 |
| HM13 | histocompatibility (minor) 13 | -0.0278554 |
| POTEF | POTE ankyrin domain family, member F | -0.0276245 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0273194 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.027088 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -0.0268876 |
| HELZ | helicase with zinc finger | -0.0268569 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | -0.0268432 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0267013 |
