| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Malotilate perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Malotilate_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.183104 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.150752 |
| RPS4X | ribosomal protein S4, X-linked | 0.119349 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.115229 |
| VIM | vimentin | 0.11306 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.103983 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0972724 |
| TPI1 | triosephosphate isomerase 1 | 0.0928652 |
| KRT18 | keratin 18, type I | 0.089068 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0877693 |
| RPL23 | ribosomal protein L23 | 0.0765641 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0710184 |
| ACTN1 | actinin, alpha 1 | 0.0633834 |
| MORF4L2 | mortality factor 4 like 2 | 0.0610867 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0608212 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.057146 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.056559 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0564928 |
| KLF6 | Kruppel-like factor 6 | 0.055085 |
| AHNAK | AHNAK nucleoprotein | 0.0545475 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0510941 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0508253 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0485036 |
| RPL3 | ribosomal protein L3 | 0.0484761 |
| PLEC | plectin | 0.0483753 |
| RPL5 | ribosomal protein L5 | 0.0483598 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0480795 |
| GRAMD1B | GRAM domain containing 1B | 0.047757 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0477515 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0445421 |
| RACK1 | receptor for activated C kinase 1 | 0.0440328 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.043746 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0429997 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.042912 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0426238 |
| MKI67 | marker of proliferation Ki-67 | 0.0414781 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0407397 |
| R3HDM2 | R3H domain containing 2 | 0.0390121 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.037809 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0371679 |
| RPS12 | ribosomal protein S12 | 0.035651 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0351098 |
| TXNRD1 | thioredoxin reductase 1 | 0.0339771 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0330794 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0322042 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0321734 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0320914 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0319402 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0317872 |
| RPL12 | ribosomal protein L12 | 0.0317645 |
| LDHA | lactate dehydrogenase A | 0.0313755 |
| RPS3 | ribosomal protein S3 | 0.0311666 |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | 0.0308887 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0308663 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0300508 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0295642 |
| RBM25 | RNA binding motif protein 25 | 0.0289556 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0285865 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0283593 |
| RAD51B | RAD51 paralog B | 0.02825 |
| SET | SET nuclear proto-oncogene | 0.0280316 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0278899 |
| FLNA | filamin A, alpha | 0.0278826 |
| NONO | non-POU domain containing, octamer-binding | 0.0276952 |
| MT2A | metallothionein 2A | 0.0274634 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0274162 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0273379 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.027311 |
| TUBB | tubulin, beta class I | 0.0272628 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0272295 |
| ZNF217 | zinc finger protein 217 | 0.026551 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0263812 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0262854 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0262781 |
| UBC | ubiquitin C | 0.0260084 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0259035 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0258097 |
| RPL37 | ribosomal protein L37 | 0.0249375 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0248708 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.0246625 |
| MCL1 | myeloid cell leukemia 1 | 0.0245379 |
| SERINC3 | serine incorporator 3 | 0.0242479 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0240515 |
| PFKP | phosphofructokinase, platelet | 0.0236543 |
| RPL36A | ribosomal protein L36a | 0.0236269 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0233136 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0232726 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) | 0.0232558 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0231868 |
| YBX1 | Y box binding protein 1 | 0.0230998 |
| TCF20 | transcription factor 20 (AR1) | 0.0229969 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0228157 |
| KIF4A | kinesin family member 4A | 0.0226516 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0222906 |
| EPN2 | epsin 2 | 0.0222504 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0220265 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0220099 |
| CNN2 | calponin 2 | 0.0220044 |
| RRM2 | ribonucleotide reductase M2 | 0.0218078 |
| ARRDC3 | arrestin domain containing 3 | 0.0216179 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.148213 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.104654 |
| RBM39 | RNA binding motif protein 39 | -0.0791607 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0786178 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0692575 |
| GOLGB1 | golgin B1 | -0.0684614 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0680249 |
| POTEF | POTE ankyrin domain family, member F | -0.0636282 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0634633 |
| YBX3 | Y box binding protein 3 | -0.056309 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0550347 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.050897 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.05082 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0493266 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0488276 |
| HLA-B | major histocompatibility complex, class I, B | -0.0477429 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0461944 |
| TMSB10 | thymosin beta 10 | -0.0454374 |
| GOLGA4 | golgin A4 | -0.0437762 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0434595 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0432566 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0413316 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0406471 |
| RPS2 | ribosomal protein S2 | -0.0402668 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0365461 |
| ZNF207 | zinc finger protein 207 | -0.0364551 |
| BRD2 | bromodomain containing 2 | -0.0355906 |
| PFN1 | profilin 1 | -0.0354952 |
| CANX | calnexin | -0.0353809 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0352334 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0350385 |
| XPO1 | exportin 1 | -0.0349315 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0346062 |
| GOLT1B | golgi transport 1B | -0.03396 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0339373 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0339048 |
| SETX | senataxin | -0.0336444 |
| ATF6 | activating transcription factor 6 | -0.0319882 |
| YAP1 | Yes-associated protein 1 | -0.0319717 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.031902 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0317061 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0315153 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0313011 |
| ENO1 | enolase 1, (alpha) | -0.0312132 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.030646 |
| RSF1 | remodeling and spacing factor 1 | -0.0302604 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0301598 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | -0.0300081 |
| PDE10A | phosphodiesterase 10A | -0.0296178 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0295683 |
| NBEAL1 | neurobeachin-like 1 | -0.0295352 |
| ZNF638 | zinc finger protein 638 | -0.0286089 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0286007 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0285496 |
| NLGN1 | neuroligin 1 | -0.0285348 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0278621 |
| EXOC6B | exocyst complex component 6B | -0.0277415 |
| SETD5 | SET domain containing 5 | -0.027632 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0275468 |
| PYGL | phosphorylase, glycogen, liver | -0.0275154 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.027503 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0274938 |
| TPM3 | tropomyosin 3 | -0.0274016 |
| EXOC4 | exocyst complex component 4 | -0.0273316 |
| TMEM263 | transmembrane protein 263 | -0.0269649 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0267474 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0267118 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0266744 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | -0.0265936 |
| TUT4 | terminal uridylyl transferase 4 | -0.0263355 |
| BBX | bobby sox homolog (Drosophila) | -0.025947 |
| GPATCH2L | G patch domain containing 2-like | -0.0258479 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0258468 |
| MAGT1 | magnesium transporter 1 | -0.0258004 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0257482 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0255572 |
| ATXN1 | ataxin 1 | -0.025553 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0247385 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0247271 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.024705 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0246136 |
| RAB10 | RAB10, member RAS oncogene family | -0.0246018 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0244728 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0237448 |
| MED13L | mediator complex subunit 13-like | -0.023666 |
| SEC24A | SEC24 family member A | -0.0236424 |
| WBP11 | WW domain binding protein 11 | -0.023516 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0234361 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0233866 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.023134 |
| SIK3 | SIK family kinase 3 | -0.0231328 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0231026 |
| SVIL | supervillin | -0.0229674 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0227929 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0227829 |
| FTL | ferritin, light polypeptide | -0.0227099 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0226217 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0225276 |
| POGZ | pogo transposable element with ZNF domain | -0.0224959 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | -0.0224914 |
