| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Malotilate perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Malotilate_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0884144 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0849734 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0751984 |
| SPAG9 | sperm associated antigen 9 | 0.0647479 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0624096 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0606795 |
| RPL5 | ribosomal protein L5 | 0.0589112 |
| RPS12 | ribosomal protein S12 | 0.0555282 |
| CALR | calreticulin | 0.0511824 |
| RPL3 | ribosomal protein L3 | 0.0469605 |
| FN1 | fibronectin 1 | 0.0440144 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0425134 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0419594 |
| RPL23 | ribosomal protein L23 | 0.041639 |
| SET | SET nuclear proto-oncogene | 0.0414083 |
| MYO10 | myosin X | 0.0410944 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0398639 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0388054 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0384848 |
| B2M | beta-2-microglobulin | 0.0375461 |
| RPS4X | ribosomal protein S4, X-linked | 0.0374562 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0372363 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0362711 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0357046 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0340193 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0338246 |
| NDRG1 | N-myc downstream regulated 1 | 0.0326564 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0320847 |
| RAI1 | retinoic acid induced 1 | 0.0317032 |
| VMP1 | vacuole membrane protein 1 | 0.031527 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0314271 |
| FOXG1 | forkhead box G1 | 0.0314048 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0307026 |
| DSTN | destrin (actin depolymerizing factor) | 0.0304868 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0302335 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0299131 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0293262 |
| H1-4 | H1.4 linker histone, cluster member | 0.0291665 |
| SLK | STE20-like kinase | 0.0283567 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0281349 |
| RPL37A | ribosomal protein L37a | 0.0274768 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0271418 |
| ASPH | aspartate beta-hydroxylase | 0.0266611 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0265084 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.0258917 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0258476 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0257511 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0257431 |
| APP | amyloid beta (A4) precursor protein | 0.0257051 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0256103 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0252482 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0251637 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0250894 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0249554 |
| PKM | pyruvate kinase, muscle | 0.0244529 |
| RPL26 | ribosomal protein L26 | 0.0243408 |
| PAPOLA | poly(A) polymerase alpha | 0.024036 |
| SSRP1 | structure specific recognition protein 1 | 0.023914 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0237985 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0235671 |
| FLNB | filamin B, beta | 0.0234994 |
| ENO1 | enolase 1, (alpha) | 0.0234386 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0232219 |
| PCBP2 | poly(rC) binding protein 2 | 0.0231782 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.0231391 |
| DNAJC21 | DnaJ (Hsp40) homolog, subfamily C, member 21 | 0.0230834 |
| COX6C | cytochrome c oxidase subunit VIc | 0.0227771 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0226287 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0226032 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0222669 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0222323 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0221483 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 0.0220528 |
| NBAS | neuroblastoma amplified sequence | 0.0220239 |
| MB21D2 | Mab-21 domain containing 2 | 0.0219951 |
| RPS26 | ribosomal protein S26 | 0.0217952 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0217192 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0216419 |
| PGK1 | phosphoglycerate kinase 1 | 0.0215134 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0215102 |
| SVIL | supervillin | 0.0213256 |
| MCL1 | myeloid cell leukemia 1 | 0.0211442 |
| UPP1 | uridine phosphorylase 1 | 0.0210279 |
| SERINC3 | serine incorporator 3 | 0.0209906 |
| PTMA | prothymosin, alpha | 0.020724 |
| TAPBP | TAP binding protein (tapasin) | 0.0206553 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0205566 |
| DTNA | dystrobrevin, alpha | 0.0205387 |
| MSN | moesin | 0.0204197 |
| YBX1 | Y box binding protein 1 | 0.0203669 |
| MORF4L2 | mortality factor 4 like 2 | 0.020308 |
| NONO | non-POU domain containing, octamer-binding | 0.0203053 |
| NTM | neurotrimin | 0.0200994 |
| CANX | calnexin | 0.0200046 |
| RPS27A | ribosomal protein S27a | 0.0199354 |
| ANXA5 | annexin A5 | 0.0199217 |
| TPI1 | triosephosphate isomerase 1 | 0.0198829 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0198543 |
| USP34 | ubiquitin specific peptidase 34 | 0.0198372 |
| INSIG2 | insulin induced gene 2 | 0.0198268 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.161034 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.145933 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.130913 |
| COL11A1 | collagen, type XI, alpha 1 | -0.11169 |
| PCDH9 | protocadherin 9 | -0.110957 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.105006 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0988391 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0984323 |
| CADM2 | cell adhesion molecule 2 | -0.0909901 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0814643 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0749077 |
| GPC3 | glypican 3 | -0.0745497 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0626134 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0603286 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0595369 |
| ACTG1 | actin gamma 1 | -0.0590668 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0581382 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0580212 |
| THBS1 | thrombospondin 1 | -0.0571219 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0561893 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0561272 |
| MKI67 | marker of proliferation Ki-67 | -0.0558176 |
| GNAS | GNAS complex locus | -0.0552277 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0547074 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0538983 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0538162 |
| PRKD1 | protein kinase D1 | -0.0537905 |
| MEIS2 | Meis homeobox 2 | -0.0536685 |
| PLPP1 | phospholipid phosphatase 1 | -0.0517137 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0514525 |
| CDH19 | cadherin 19, type 2 | -0.0509898 |
| FAM171B | family with sequence similarity 171, member B | -0.0508526 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0497108 |
| TENM3 | teneurin transmembrane protein 3 | -0.0491273 |
| STAG2 | stromal antigen 2 | -0.0482871 |
| VIM | vimentin | -0.0474884 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0474221 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0463127 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0459452 |
| PEG10 | paternally expressed 10 | -0.0458593 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0456414 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0447786 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0447336 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0447059 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0444383 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0442359 |
| RAD21 | RAD21 homolog (S. pombe) | -0.04412 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0433053 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0425001 |
| DEK | DEK proto-oncogene | -0.0416554 |
| FOXP2 | forkhead box P2 | -0.0415025 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0412977 |
| COL5A2 | collagen, type V, alpha 2 | -0.0406228 |
| PRTG | protogenin | -0.0405706 |
| RTN4 | reticulon 4 | -0.0396391 |
| NRG1 | neuregulin 1 | -0.0390936 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0389678 |
| HMGB2 | high mobility group box 2 | -0.0386103 |
| RPS16 | ribosomal protein S16 | -0.038324 |
| LRRC4C | leucine rich repeat containing 4C | -0.0381621 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0379012 |
| RLF | rearranged L-myc fusion | -0.0376059 |
| RASAL2 | RAS protein activator like 2 | -0.0373098 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0372146 |
| RAD51B | RAD51 paralog B | -0.0365628 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0365577 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0358989 |
| TOX | thymocyte selection-associated high mobility group box | -0.0358238 |
| ENAH | enabled homolog (Drosophila) | -0.0358051 |
| ANK2 | ankyrin 2, neuronal | -0.0353451 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.035184 |
| TMSB10 | thymosin beta 10 | -0.0345281 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0345058 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0343744 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0343491 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0340207 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0338951 |
| HMGB1 | high mobility group box 1 | -0.0338408 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0337379 |
| SHROOM3 | shroom family member 3 | -0.033685 |
| RBM39 | RNA binding motif protein 39 | -0.0334566 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0333934 |
| CAVIN1 | caveolae associated protein 1 | -0.0333177 |
| CKAP2 | cytoskeleton associated protein 2 | -0.03329 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.033221 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0326844 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0323929 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0322277 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0320454 |
| ZFHX4 | zinc finger homeobox 4 | -0.0320406 |
| CCNA2 | cyclin A2 | -0.031899 |
| NOP58 | NOP58 ribonucleoprotein | -0.0318262 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0316025 |
| METAP2 | methionyl aminopeptidase 2 | -0.0314213 |
| TFRC | transferrin receptor | -0.0309605 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0308942 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0307735 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0306878 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0305399 |
| ECT2 | epithelial cell transforming 2 | -0.0305182 |
