Malotilate_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Malotilate perturbation in SNU-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Malotilate_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.171777
RPS8 ribosomal protein S8 0.0773435
TJP1 tight junction protein 1 0.0687684
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0594152
RPS12 ribosomal protein S12 0.0566654
SET SET nuclear proto-oncogene 0.0561388
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0551123
WSB1 WD repeat and SOCS box containing 1 0.0536713
RPS6 ribosomal protein S6 0.0536168
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0527057
ANKRD12 ankyrin repeat domain 12 0.0505055
PRELID2 PRELI domain containing 2 0.0504246
FLNB filamin B, beta 0.0503708
MXI1 MAX interactor 1, dimerization protein 0.0502689
RPS4X ribosomal protein S4, X-linked 0.049416
RPL12 ribosomal protein L12 0.0489667
GOLGA4 golgin A4 0.0475356
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0471213
RPL9 ribosomal protein L9 0.0453912
TPM4 tropomyosin 4 0.0447432
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0444115
RPS2 ribosomal protein S2 0.0443856
RPL35A ribosomal protein L35a 0.0442665
RPS17 ribosomal protein S17 0.0438519
RPL34 ribosomal protein L34 0.0437885
RACK1 receptor for activated C kinase 1 0.0432833
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0431322
SQSTM1 sequestosome 1 0.0428791
RPL31 ribosomal protein L31 0.0427864
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0426757
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0424233
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0418399
ARL4C ADP-ribosylation factor-like 4C 0.0413802
PYGB phosphorylase, glycogen; brain 0.0413378
TMSB4X thymosin beta 4, X-linked 0.0406339
SBF2 SET binding factor 2 0.0396081
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0388817
EVI5 ecotropic viral integration site 5 0.03837
RPL11 ribosomal protein L11 0.0376493
RPL23 ribosomal protein L23 0.0373652
PRRC2C proline-rich coiled-coil 2C 0.036938
ZMYM2 zinc finger, MYM-type 2 0.0346667
ZNF292 zinc finger protein 292 0.0339383
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.033858
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0338432
RPLP1 ribosomal protein, large, P1 0.0337055
TPT1 tumor protein, translationally-controlled 1 0.0332941
PNISR PNN-interacting serine/arginine-rich protein 0.0329425
THOC2 THO complex 2 0.032867
CAMTA1 calmodulin binding transcription activator 1 0.0326351
RPS11 ribosomal protein S11 0.0325391
SOX6 SRY (sex determining region Y)-box 6 0.0321332
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0319298
YEATS2 YEATS domain containing 2 0.0319194
BIRC6 baculoviral IAP repeat containing 6 0.0317398
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.031642
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.031542
SERINC1 serine incorporator 1 0.0312396
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 0.0310505
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0310026
USP34 ubiquitin specific peptidase 34 0.0307891
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0307168
RPL37 ribosomal protein L37 0.0304066
AKAP9 A kinase (PRKA) anchor protein 9 0.0302307
RPL5 ribosomal protein L5 0.0302012
TOB1 transducer of ERBB2, 1 0.0295379
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0292707
RBM25 RNA binding motif protein 25 0.0291463
TMEM65 transmembrane protein 65 0.0290962
ENOSF1 enolase superfamily member 1 0.0289071
CENPF centromere protein F, 350/400kDa 0.0288167
RPL26 ribosomal protein L26 0.0274121
RPS19 ribosomal protein S19 0.027396
ANKRD36C ankyrin repeat domain 36C 0.0271717
LPP LIM domain containing preferred translocation partner in lipoma 0.0265477
GYS1 glycogen synthase 1 (muscle) 0.0262385
OGA O-GlcNAcase 0.0259442
MKI67 marker of proliferation Ki-67 0.0257462
TXNIP thioredoxin interacting protein 0.0255459
CHSY1 chondroitin sulfate synthase 1 0.0254466
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0253383
FAM162A family with sequence similarity 162, member A 0.0251633
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0251474
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0251453
TENT4A terminal nucleotidyltransferase 4A 0.024297
RPS21 ribosomal protein S21 0.0242685
RPS10 ribosomal protein S10 0.0240578
ANKRD36 ankyrin repeat domain 36 0.0239939
HSPA8 heat shock 70kDa protein 8 0.0238463
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.0237905
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0236378
RPL32 ribosomal protein L32 0.0234511
NFIA nuclear factor I/A 0.0233606
DENND4A DENN/MADD domain containing 4A 0.0231015
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.022928
RPL7 ribosomal protein L7 0.0228977
RPL36 ribosomal protein L36 0.0228665
ASXL1 additional sex combs like transcriptional regulator 1 0.0222906
EIF5B eukaryotic translation initiation factor 5B 0.0222372
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0221753

decreased expression

Symbol Name Standardized Value
PKM pyruvate kinase, muscle -0.132691
PDE4D phosphodiesterase 4D, cAMP-specific -0.128929
EEF2 eukaryotic translation elongation factor 2 -0.112766
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.1115
AHNAK AHNAK nucleoprotein -0.0934728
FOXP1 forkhead box P1 -0.0910786
HDAC9 histone deacetylase 9 -0.0893747
EGFR epidermal growth factor receptor -0.0784255
VCL vinculin -0.0703675
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0690009
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0647531
UBC ubiquitin C -0.0626312
POTEF POTE ankyrin domain family, member F -0.0613345
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.060018
GLI3 GLI family zinc finger 3 -0.0599605
ZFAND3 zinc finger, AN1-type domain 3 -0.058763
RHOA ras homolog family member A -0.0565377
PDE4B phosphodiesterase 4B, cAMP-specific -0.0564168
NBEA neurobeachin -0.0547188
BMP10 bone morphogenetic protein 10 -0.0529419
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0501956
TSC22D1 TSC22 domain family, member 1 -0.0481706
PDIA3 protein disulfide isomerase family A, member 3 -0.0474224
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0455855
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0454132
ENO2 enolase 2 (gamma, neuronal) -0.044564
IFI16 interferon, gamma-inducible protein 16 -0.0428513
RABGAP1L RAB GTPase activating protein 1-like -0.0421986
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0419516
PARD3 par-3 family cell polarity regulator -0.0413859
EFNA5 ephrin-A5 -0.0410305
EXOC4 exocyst complex component 4 -0.0398834
NCEH1 neutral cholesterol ester hydrolase 1 -0.0397721
ZMYND8 zinc finger, MYND-type containing 8 -0.0388603
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0375758
EEF1G eukaryotic translation elongation factor 1 gamma -0.036976
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0369665
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.036759
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0361555
JUN jun proto-oncogene -0.0358154
PDGFC platelet derived growth factor C -0.0357994
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.035156
EML4 echinoderm microtubule associated protein like 4 -0.0342613
PRUNE2 prune homolog 2 (Drosophila) -0.0340476
EXOC6B exocyst complex component 6B -0.0336785
SPRY4 sprouty homolog 4 (Drosophila) -0.033538
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0332623
ZNF438 zinc finger protein 438 -0.0321458
SSBP2 single-stranded DNA binding protein 2 -0.0316016
MLIP muscular LMNA-interacting protein -0.0315744
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0313624
PICALM phosphatidylinositol binding clathrin assembly protein -0.0307942
ANKRD11 ankyrin repeat domain 11 -0.0306985
ZBTB20 zinc finger and BTB domain containing 20 -0.0304372
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0299341
ZNF207 zinc finger protein 207 -0.029668
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0295234
TMSB10 thymosin beta 10 -0.029517
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0294511
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0293613
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0293274
PCBP2 poly(rC) binding protein 2 -0.0292387
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0287982
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0287055
ZNF638 zinc finger protein 638 -0.0285118
SLC38A2 solute carrier family 38, member 2 -0.0279559
DOCK1 dedicator of cytokinesis 1 -0.0278835
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0277132
SCFD2 sec1 family domain containing 2 -0.0275542
PDE7B phosphodiesterase 7B -0.0274882
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0274009
PTPRG protein tyrosine phosphatase, receptor type, G -0.027023
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0267684
SFPQ splicing factor proline/glutamine-rich -0.0267625
PHF14 PHD finger protein 14 -0.0266353
TASOR2 transcription activation suppressor family member 2 -0.0265744
FER fer (fps/fes related) tyrosine kinase -0.0263878
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0262989
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0262361
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0261785
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0254869
ACACA acetyl-CoA carboxylase alpha -0.0252616
IARS1 isoleucyl-tRNA synthetase 1 -0.0252428
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0251215
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.024722
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0246827
PTEN phosphatase and tensin homolog -0.0246391
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0245439
ETNK1 ethanolamine kinase 1 -0.0242434
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0242018
TCF12 transcription factor 12 -0.0240131
SEC24D SEC24 family member D -0.0235266
AHI1 Abelson helper integration site 1 -0.0234802
PARD3B par-3 family cell polarity regulator beta -0.023403
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.023292
CCNL1 cyclin L1 -0.02301
TTC28 tetratricopeptide repeat domain 28 -0.0228907
ENO1 enolase 1, (alpha) -0.0227476
ECT2 epithelial cell transforming 2 -0.0227444
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0227408